Pub Date : 2021-03-31DOI: 10.1163/22238980-BJA10028
Ademola Ezekiel Adekoya, S. Chusri, Eugene Ong Boon Beng, A. Idowu
Ya-Tri-Kasornmas and Ya-Tri-Phigut are polyherbal tea that have been listed as essential medicines in the National List of Essential Medicines, Thailand. They are widely consumed among the Thai populace. Thus, aqueous extracts of Ya-Tri-Karsornmas and Ya-Tri-Phigut polyherbal formulations were subjected to screening against oxidative stress promoters such as reactive oxygen species using in vitro antioxidant models. In addition, their capacities to lower lipid peroxidation were measured. Yield of the extract from Ya-Tri-Phigut polyherbal formulation was 7.22% (w/w), while that from Ya-Tri-Kasornmas was 5.50% (w/w) (P < 0.05). The study revealed that the aqueous extract of Ya-Tri-Phigut showed better antioxidant capacities to inhibit reactive oxygen species and lipid peroxidation activities than Ya-Tri-Karsornmas (P <0 .05). Thus, Ya-Tri-Phigut polyherbal tea may potentially serve as a rich nutraceutical agent to combat oxidative stress and health related diseases.
Ya-Ti-Kasornmas和Ya-Ti-Phigut是一种多羟基茶，已被列为泰国国家基本药物清单中的基本药物。它们在泰国民众中被广泛食用。因此，使用体外抗氧化模型对Ya-Ti-Karsornmas和Ya-Ti-Phigut多羟基制剂的水提取物进行抗氧化促进剂如活性氧的筛选。此外，还测定了它们降低脂质过氧化的能力。Ya Tri Phigut多醇提取物的得率为7.22%（w/w），而Ya Tri-Casornmas的得率则为5.50%（w/w）（P<0.05），Ya Tri Phigut多糖茶可能是一种丰富的营养制剂，可以对抗氧化应激和健康相关疾病。
{"title":"In vitro inhibitory potentials of Thai formulated polyherbal tea against oxidative stress promoters","authors":"Ademola Ezekiel Adekoya, S. Chusri, Eugene Ong Boon Beng, A. Idowu","doi":"10.1163/22238980-BJA10028","DOIUrl":"https://doi.org/10.1163/22238980-BJA10028","url":null,"abstract":"\u0000Ya-Tri-Kasornmas and Ya-Tri-Phigut are polyherbal tea that have been listed as essential medicines in the National List of Essential Medicines, Thailand. They are widely consumed among the Thai populace. Thus, aqueous extracts of Ya-Tri-Karsornmas and Ya-Tri-Phigut polyherbal formulations were subjected to screening against oxidative stress promoters such as reactive oxygen species using in vitro antioxidant models. In addition, their capacities to lower lipid peroxidation were measured. Yield of the extract from Ya-Tri-Phigut polyherbal formulation was 7.22% (w/w), while that from Ya-Tri-Kasornmas was 5.50% (w/w) (P < 0.05). The study revealed that the aqueous extract of Ya-Tri-Phigut showed better antioxidant capacities to inhibit reactive oxygen species and lipid peroxidation activities than Ya-Tri-Karsornmas (P <0 .05). Thus, Ya-Tri-Phigut polyherbal tea may potentially serve as a rich nutraceutical agent to combat oxidative stress and health related diseases.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":"1 1","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46145353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-23DOI: 10.1163/22238980-BJA10025
Firdose R. Kolar, S. Kambhar, M. Chavan, S. Kadam, Peerambi Nadaf
The current study was intended to examine the difference in the phytochemical and antioxidant profile of nine Indigofera species. With this aim, the species were assessed for total phenolic content, flavonoid content, and antioxidant activity using ferric reducing antioxidant power (FRAP), DPPH free radical scavenging, ferrous ion chelating activity, phosphomolybdenum reducing power, deoxyribose degradation, β-carotene bleaching, nitric oxide scavenging, and superoxide radical scavenging assays. The content of total phenolics and flavonoids ranged from 1.33 to 22.5 mg TAE/g plant material and 0.47 to 5.02 mg QE/g plant material respectively in the various species, while the antioxidant activity as tested with different antioxidant test models varied with the species studied as well as with the solvents used for the extraction. Interestingly, all the tested extracts demonstrated considerable free radical scavenging activity, moreover, I. hirsuta, I. glandulosa, I. linnaei, I. hochstetteri, I. linifolia, and I. trita were found to be the most effective among the species studied. The results indicated the significant differences in phytochemical constituents and the antioxidant activity among the species. The Pearson correlation coefficient analysis exhibited a significant correlation of phenolics and flavonoids with the antioxidant activity.
{"title":"Disparities of phytochemical constituents and antioxidant activities of some Indigofera species","authors":"Firdose R. Kolar, S. Kambhar, M. Chavan, S. Kadam, Peerambi Nadaf","doi":"10.1163/22238980-BJA10025","DOIUrl":"https://doi.org/10.1163/22238980-BJA10025","url":null,"abstract":"\u0000The current study was intended to examine the difference in the phytochemical and antioxidant profile of nine Indigofera species. With this aim, the species were assessed for total phenolic content, flavonoid content, and antioxidant activity using ferric reducing antioxidant power (FRAP), DPPH free radical scavenging, ferrous ion chelating activity, phosphomolybdenum reducing power, deoxyribose degradation, β-carotene bleaching, nitric oxide scavenging, and superoxide radical scavenging assays. The content of total phenolics and flavonoids ranged from 1.33 to 22.5 mg TAE/g plant material and 0.47 to 5.02 mg QE/g plant material respectively in the various species, while the antioxidant activity as tested with different antioxidant test models varied with the species studied as well as with the solvents used for the extraction. Interestingly, all the tested extracts demonstrated considerable free radical scavenging activity, moreover, I. hirsuta, I. glandulosa, I. linnaei, I. hochstetteri, I. linifolia, and I. trita were found to be the most effective among the species studied. The results indicated the significant differences in phytochemical constituents and the antioxidant activity among the species. The Pearson correlation coefficient analysis exhibited a significant correlation of phenolics and flavonoids with the antioxidant activity.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":"1 1","pages":"1-10"},"PeriodicalIF":1.0,"publicationDate":"2021-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43077158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-18DOI: 10.1163/22238980-BJA10029
Jian Wang, Gang Li, Haixiu Zhang, Ying Xie
Atopic dermatitis (AD) is a serious inflammatory condition associated with severe itching and persistent eczematous lesion. Therefore, the present study was intended to scrutinize the beneficial effect of Luteolin (LT) on the atopic dermatitis murine model. The effect of LT was investigated on the various parameters, such as oxidative stress and inflammation after induction of AD. The serum level of IgE, and cells of the WBC family (neutrophils, basophils, eosinophils, monocytes, lymphocytes, and total WBC) and histopathological analysis of skin tissue were also examined to confirm the effect of LT. Results of the study suggested that LT significantly inhibited the elevated IgE level together with improvement in injured skin tissue architecture. It also reduces oxidative stress (MDA, SOD, and GSH) and inflammation (IL-1β, IL-6, TNF-α, IFN-γ, IL-4, and IL-17A) as evidenced by ELISA analysis. The level of examined WBC family cells was found reduced significantly as compared to the AD model group. In western blot analysis, LT showed significant down-regulation of NF-ĸB and TLR-4. Collectively, our results suggest that LT can effectively reverse the effect of atopic dermatitis via improving immunological response.
{"title":"Protective effect of Luteolin on atopic dermatitis murine model via IgE mediated immune response","authors":"Jian Wang, Gang Li, Haixiu Zhang, Ying Xie","doi":"10.1163/22238980-BJA10029","DOIUrl":"https://doi.org/10.1163/22238980-BJA10029","url":null,"abstract":"\u0000Atopic dermatitis (AD) is a serious inflammatory condition associated with severe itching and persistent eczematous lesion. Therefore, the present study was intended to scrutinize the beneficial effect of Luteolin (LT) on the atopic dermatitis murine model. The effect of LT was investigated on the various parameters, such as oxidative stress and inflammation after induction of AD. The serum level of IgE, and cells of the WBC family (neutrophils, basophils, eosinophils, monocytes, lymphocytes, and total WBC) and histopathological analysis of skin tissue were also examined to confirm the effect of LT. Results of the study suggested that LT significantly inhibited the elevated IgE level together with improvement in injured skin tissue architecture. It also reduces oxidative stress (MDA, SOD, and GSH) and inflammation (IL-1β, IL-6, TNF-α, IFN-γ, IL-4, and IL-17A) as evidenced by ELISA analysis. The level of examined WBC family cells was found reduced significantly as compared to the AD model group. In western blot analysis, LT showed significant down-regulation of NF-ĸB and TLR-4. Collectively, our results suggest that LT can effectively reverse the effect of atopic dermatitis via improving immunological response.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42371443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-18DOI: 10.1163/22238980-BJA10026
Jian Wang, Xiao Liu, Zhi Liu, Yanxia Ge, Shu-Jin He
Allergic rhinitis (AR) is a serious health concern across the globe. Despite its non-fatal character, it accounts for affecting millions of people across the world and is deemed responsible to affect their quality of life and put a significant economic burden. In the current study, we aimed to assess the anti-allergic and anti-inflammatory effects and the underlying molecular mechanisms of ellipticine (ETC) against AR using ovalbumin (OVA)-induced murine model of allergic rhinitis. The ETC was administered to mice via intra-peritoneal route after suspending in 5% CMC after sensitization by OVA. Results of the study suggested that ETC causes a significant reduction the nose rubs as compared to disease control. A significant reduction in the serum level of histamine, IgG1, TNF-α, IL-1β, MIP-2, and IL-6 was found in ETC treated group in a dose-dependent manner as compared to OVA challenged mice. It also reduces eosinophils in BALF of AR mice. In western blot analysis, the expression of aberrantly activated COX-2 and NF-ĸB found significantly reduced in ETC treated group due to inhibition of TLR-4 and caspase-1 as compared to disease-control mice. ETC showed significant interaction with residues of the active site of COX-2 and NF-ĸB. Collectively, our results indicated that ETC can be used to improve present therapeutic strategies against AR.
{"title":"Protective effect of Ellipticine in ovalbumin (OVA)-induced murine model of allergic rhinitis via dual inhibition of COX-2 and NF-κB","authors":"Jian Wang, Xiao Liu, Zhi Liu, Yanxia Ge, Shu-Jin He","doi":"10.1163/22238980-BJA10026","DOIUrl":"https://doi.org/10.1163/22238980-BJA10026","url":null,"abstract":"\u0000Allergic rhinitis (AR) is a serious health concern across the globe. Despite its non-fatal character, it accounts for affecting millions of people across the world and is deemed responsible to affect their quality of life and put a significant economic burden. In the current study, we aimed to assess the anti-allergic and anti-inflammatory effects and the underlying molecular mechanisms of ellipticine (ETC) against AR using ovalbumin (OVA)-induced murine model of allergic rhinitis. The ETC was administered to mice via intra-peritoneal route after suspending in 5% CMC after sensitization by OVA. Results of the study suggested that ETC causes a significant reduction the nose rubs as compared to disease control. A significant reduction in the serum level of histamine, IgG1, TNF-α, IL-1β, MIP-2, and IL-6 was found in ETC treated group in a dose-dependent manner as compared to OVA challenged mice. It also reduces eosinophils in BALF of AR mice. In western blot analysis, the expression of aberrantly activated COX-2 and NF-ĸB found significantly reduced in ETC treated group due to inhibition of TLR-4 and caspase-1 as compared to disease-control mice. ETC showed significant interaction with residues of the active site of COX-2 and NF-ĸB. Collectively, our results indicated that ETC can be used to improve present therapeutic strategies against AR.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49120294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-18DOI: 10.1163/22238980-BJA10027
D. Ananth, V. Mahalakshmi, Sivasudha Thilagar, Liron Klipcan, Zipora Tietel
Cassia auriculata is an Ayurvedic medicinal herb, traditionally indicated for diabetes and hyperlipidemia. Several works have demonstrated its antioxidant, antidiabetic and anti-hyperlipidemic activity in vivo and in vitro. Nevertheless, only a few works have investigated its phytochemical composition, and specifically, the polyphenolic composition of the various plant parts that are traditionally used. In this work, the polyphenolic composition of C. auriculata leaves, flowers and flower buds were evaluated using UPLC-QqQ-MS/MS. Our results demonstrated the polyphenolic profile of C. auriculata plant parts. A total of five benzoic acids, four hydroxycinnamic acids, three flavonoids and two other phenolic compounds were identified and quantified. Our results show that in C. auriculata leaves, flavonoids were most abundant (4204 µg/g DW), while in flowers benzoic acids were the most prominent (3924 µg/g DW). Total benzoic acid contents ranged from 1580 to 3924 µg/g DW in leaf and flower, respectively. Hydroxycinnamic acids ranged from 404 µg/g DW in flower buds to 2623 µg/g DW in leaves. Flavonoids showed the highest contents in leaves, while the lowest levels were observed in flowers (2626 µg/g DW). The meaning of the results is discussed in light of the bioactivities of phenolic compounds, concomitant with C. auriculata reported medicinal bioactivities. To our knowledge, this is the first work to identify and quantify polyphenolic compounds in flower and bud of C. auriculata.
{"title":"Identification and quantification of polyphenols from Cassia auriculata L. leaf, flower and flower bud using UPLC-QqQ-MS/MS","authors":"D. Ananth, V. Mahalakshmi, Sivasudha Thilagar, Liron Klipcan, Zipora Tietel","doi":"10.1163/22238980-BJA10027","DOIUrl":"https://doi.org/10.1163/22238980-BJA10027","url":null,"abstract":"\u0000Cassia auriculata is an Ayurvedic medicinal herb, traditionally indicated for diabetes and hyperlipidemia. Several works have demonstrated its antioxidant, antidiabetic and anti-hyperlipidemic activity in vivo and in vitro. Nevertheless, only a few works have investigated its phytochemical composition, and specifically, the polyphenolic composition of the various plant parts that are traditionally used. In this work, the polyphenolic composition of C. auriculata leaves, flowers and flower buds were evaluated using UPLC-QqQ-MS/MS. Our results demonstrated the polyphenolic profile of C. auriculata plant parts. A total of five benzoic acids, four hydroxycinnamic acids, three flavonoids and two other phenolic compounds were identified and quantified. Our results show that in C. auriculata leaves, flavonoids were most abundant (4204 µg/g DW), while in flowers benzoic acids were the most prominent (3924 µg/g DW). Total benzoic acid contents ranged from 1580 to 3924 µg/g DW in leaf and flower, respectively. Hydroxycinnamic acids ranged from 404 µg/g DW in flower buds to 2623 µg/g DW in leaves. Flavonoids showed the highest contents in leaves, while the lowest levels were observed in flowers (2626 µg/g DW). The meaning of the results is discussed in light of the bioactivities of phenolic compounds, concomitant with C. auriculata reported medicinal bioactivities. To our knowledge, this is the first work to identify and quantify polyphenolic compounds in flower and bud of C. auriculata.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47576691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-18DOI: 10.1163/22238980-BJA10030
Rajani Sharma, G. K. Prajapati, Gargi Akhoury
COVID-19 is the current health challenge across the world. It originated in Wuhan, China, and has now spread to more than 180 countries. It is a zoonotic disease which spreads through droplets. The severity of disease is likely to end with the discovery of vaccines only. Researchers are repurposing drugs to fill the gap between COVID-19 and vaccine designing. Broad-spectrum antiviral drugs are preferred but they exhibit side effects. We have screened pentagalloylglucose present in Terminalia chebula which can prevent SARS-CoV-2 entry to the host cell. In this study, we have taken 8 active phytochemicals of Terminalia chebula which include gallic acid, chebulic acid, chebulanin, neochebulinic acid, ellagic acid, chebulagic acid, chebulinic acid, and pentagalloyglucose against spike proteins (S1 and S2), Replicase Polyprotein, 3C-like protease (3CL pro), Papain-like protease (PLpro), RNA dependent RNA polymerase (RdRp) of SARS-CoV-2. HADDOCK online server, Discovery Studio Visualizer and PyRx Vina tools were used to screen the potential component from T. chebula. It was analysed that pentagalloylglucose can be a better phytochemical against spike protein S1 similar to hemagglutinin of influenza virus. This phytochemical can be further used as a drug against SARS-CoV-2.
COVID-19是当前全球面临的卫生挑战。它起源于中国武汉，现已传播到180多个国家。这是一种通过飞沫传播的人畜共患疾病。疾病的严重性很可能只随着疫苗的发现而结束。研究人员正在重新利用药物来填补COVID-19和疫苗设计之间的空白。广谱抗病毒药物是首选，但它们有副作用。我们已经筛选了chebula中存在的可以阻止SARS-CoV-2进入宿主细胞的五烯丙基葡萄糖。在本研究中，我们对chebula Terminalia的8种活性植物化学物质，包括没食子酸、chebullic酸、chebulanin、新chebullinic酸、鞣花酸、chebulagic酸、chebullinic酸、chebullinic acid和pentagalglyglucose，进行了抗SARS-CoV-2的刺突蛋白(S1和S2)、复制酶多蛋白、3c样蛋白酶(3CL pro)、木瓜蛋白酶(PLpro)、RNA依赖性RNA聚合酶(RdRp)的研究。利用HADDOCK在线服务器、Discovery Studio Visualizer和PyRx Vina工具对天牛的潜在成分进行筛选。分析表明，五没食子糖是一种较好的抗穗蛋白S1的植物化学物质，与流感病毒的血凝素相似。这种植物化学物质可以进一步用作对抗SARS-CoV-2的药物。
{"title":"Pentagalloylglucose, a phytochemical from Terminalia chebula can efficiently prevent SARS-CoV-2 entry: In Silico study","authors":"Rajani Sharma, G. K. Prajapati, Gargi Akhoury","doi":"10.1163/22238980-BJA10030","DOIUrl":"https://doi.org/10.1163/22238980-BJA10030","url":null,"abstract":"\u0000COVID-19 is the current health challenge across the world. It originated in Wuhan, China, and has now spread to more than 180 countries. It is a zoonotic disease which spreads through droplets. The severity of disease is likely to end with the discovery of vaccines only. Researchers are repurposing drugs to fill the gap between COVID-19 and vaccine designing. Broad-spectrum antiviral drugs are preferred but they exhibit side effects. We have screened pentagalloylglucose present in Terminalia chebula which can prevent SARS-CoV-2 entry to the host cell. In this study, we have taken 8 active phytochemicals of Terminalia chebula which include gallic acid, chebulic acid, chebulanin, neochebulinic acid, ellagic acid, chebulagic acid, chebulinic acid, and pentagalloyglucose against spike proteins (S1 and S2), Replicase Polyprotein, 3C-like protease (3CL pro), Papain-like protease (PLpro), RNA dependent RNA polymerase (RdRp) of SARS-CoV-2. HADDOCK online server, Discovery Studio Visualizer and PyRx Vina tools were used to screen the potential component from T. chebula. It was analysed that pentagalloylglucose can be a better phytochemical against spike protein S1 similar to hemagglutinin of influenza virus. This phytochemical can be further used as a drug against SARS-CoV-2.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":"62 1","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43434296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-16DOI: 10.1163/22238980-BJA10024
C. Azhagumeena, P. Padma
Nature has provided man with a bountiful supply of components that have the potential to improve the life of man on earth. Among the foremost widely recognized in this category are medicinal plants. Medicinal plants have been a rich source of therapeutic compounds used in various traditional medicines worldwide for thousands of years, due to the presence of active phytocomponents, which help in preventing various diseases. The betel (Piper betle L.) is that the leaf of a vine belonging to the Piperaceae family, which is taken into account a medicinal plant in Southeast Asia. Piper betle leaves have a number of bioactivities and are utilized in traditional medicinal systems. Cloves (Syzygium aromaticum L.) is a tree belonging to the family Myrtaceae. Unopened flowering buds are used as a spice in food preparations all over the world. Eugenol is present abundantly in both Piper betle leaves and Syzygium aromaticum flowers. In the splendid of the above, we thought it significant to aggregate the exceptional review of writing on Piper betle, Syzygium aromaticum and their bioactive component eugenol, covering its, chemical constituents, therapeutic role and medicinal uses.
{"title":"A review on the therapeutic role of Piper betle, Syzygium aromaticum and their bioactive component eugenol in cancer research","authors":"C. Azhagumeena, P. Padma","doi":"10.1163/22238980-BJA10024","DOIUrl":"https://doi.org/10.1163/22238980-BJA10024","url":null,"abstract":"\u0000Nature has provided man with a bountiful supply of components that have the potential to improve the life of man on earth. Among the foremost widely recognized in this category are medicinal plants. Medicinal plants have been a rich source of therapeutic compounds used in various traditional medicines worldwide for thousands of years, due to the presence of active phytocomponents, which help in preventing various diseases. The betel (Piper betle L.) is that the leaf of a vine belonging to the Piperaceae family, which is taken into account a medicinal plant in Southeast Asia. Piper betle leaves have a number of bioactivities and are utilized in traditional medicinal systems. Cloves (Syzygium aromaticum L.) is a tree belonging to the family Myrtaceae. Unopened flowering buds are used as a spice in food preparations all over the world. Eugenol is present abundantly in both Piper betle leaves and Syzygium aromaticum flowers. In the splendid of the above, we thought it significant to aggregate the exceptional review of writing on Piper betle, Syzygium aromaticum and their bioactive component eugenol, covering its, chemical constituents, therapeutic role and medicinal uses.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":"1 1","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46075648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-09DOI: 10.1163/22238980-BJA10017
Reena Sharma, A. Shachter, Limor Almog, Gila Oren, Hagar Roynik-Toshner, N. Dudai
Clinopodium serpyllifolium is a perennial medicinal plant generally used as herbal tea in folk medicine. Leaves of C. serpyllifolium from the representative exemplars in the Newe Ya’ar living germplasm collection were analyzed for their polyphenolic and volatiles composition, and tested for their antioxidant activity. The oxygenated monoterpenes pulegone (10.4–50.6%), piperitenone oxide (3.2–28.6%), piperitenone (0.9–14.6%), trans-piperitone oxide (0.3–11.2%), iso-menthol (0.3–8.8%) and sesquiterpene β-caryophyllene (7.4–13.7%) were found to be the major constituents from the solvent extraction of C. serpyllifolium analyzed by gc-ms. The representative exemplars were grouped into two chemotypes: one rich in pulegone and the second rich in piperitenone oxide and piperitenone. The total polyphenolics content, determined range from 26.6 to 62.9 mg gallic acid equivalents/g dry weight (dw). The antioxidant activity ranged from (42.8–77.1 mg chlorogenic acid equivalents/g dw). hplc analysis revealed the rosmarinic acid content also showed remarkable differences in C. serpyllifolium (0.3–1.8 dry weight %). The results indicate that there is chemical diversity and also difference in the content of polyphenols of the representative exemplars. Antioxidant activity was in correlation with phenolic components.
{"title":"Genetic chemical variability of the volatiles and phenolic compounds in Clinopodium serpyllifolium subsp. fruticosum (L.) Bräuchler syn. Micromeria fruticosa (L.) Druce grown in Israel","authors":"Reena Sharma, A. Shachter, Limor Almog, Gila Oren, Hagar Roynik-Toshner, N. Dudai","doi":"10.1163/22238980-BJA10017","DOIUrl":"https://doi.org/10.1163/22238980-BJA10017","url":null,"abstract":"\u0000Clinopodium serpyllifolium is a perennial medicinal plant generally used as herbal tea in folk medicine. Leaves of C. serpyllifolium from the representative exemplars in the Newe Ya’ar living germplasm collection were analyzed for their polyphenolic and volatiles composition, and tested for their antioxidant activity. The oxygenated monoterpenes pulegone (10.4–50.6%), piperitenone oxide (3.2–28.6%), piperitenone (0.9–14.6%), trans-piperitone oxide (0.3–11.2%), iso-menthol (0.3–8.8%) and sesquiterpene β-caryophyllene (7.4–13.7%) were found to be the major constituents from the solvent extraction of C. serpyllifolium analyzed by gc-ms. The representative exemplars were grouped into two chemotypes: one rich in pulegone and the second rich in piperitenone oxide and piperitenone. The total polyphenolics content, determined range from 26.6 to 62.9 mg gallic acid equivalents/g dry weight (dw). The antioxidant activity ranged from (42.8–77.1 mg chlorogenic acid equivalents/g dw). hplc analysis revealed the rosmarinic acid content also showed remarkable differences in C. serpyllifolium (0.3–1.8 dry weight %). The results indicate that there is chemical diversity and also difference in the content of polyphenols of the representative exemplars. Antioxidant activity was in correlation with phenolic components.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":" ","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47548873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-03DOI: 10.1163/22238980-BJA10018
J. Mulagund, M. Dinesh, C. Vasugi, A. Rekha, K. Ravishankar
The present investigation was carried out with an aim to determine the cross compatibility between Psidium species (P. chinensis, P. guineense, P. cattleianum and P. molle) and commercial guava cultivars (Arka Kiran, Arka Rashmi, Arka Mridula and Allahabad Safed). The results revealed that, P. chinensis and P. guineense were found to be good cross compatible male parents whereas, Allahabad Safeda and Arka Kiran were found to be good cross compatible female parents. However, no fruit set and seed set were obtained when P. cattleianum and P. molle were used as male parent indicating the cross incompatibility of these species with commercial guava cultivars which is reconfirmed using florescence microscopy technique to understand the pollen-pistil interaction between incompatible P. cattleianum and P. molle species with P. guajava cv. Allahabad Safeda. Result indicated that low fluorescence intensity along with poor pollen germination and improper pollen-tube growth could be the reason for incompatibility. In order to break this incompatibility, a modified pollination technique called stigma maceration technique was followed wherein stigma of the male parent macerated with different chemicals viz., carbohydrate source (2% sucrose), growth regulators (50 ppm GA3 and iaa) and micronutrients (50 ppm of each Boric acid, MgSO4, CaNO3 and KNO3) and pollinated twice i.e., on the day of flower opening and the same time of next day resulted in cross compatibility of P. cattleianum and P. molle with commercial guava cultivars. Further hybridity confirmation of interspecific hybrids using ssr markers revealed that, 8 markers were found to be co-dominant and confirmed the hybridity of interspecific hybrid combinations.
{"title":"Studies on sexual compatibility and or incompatibility among Psidium species and their hybridity confirmation through ssr markers","authors":"J. Mulagund, M. Dinesh, C. Vasugi, A. Rekha, K. Ravishankar","doi":"10.1163/22238980-BJA10018","DOIUrl":"https://doi.org/10.1163/22238980-BJA10018","url":null,"abstract":"\u0000The present investigation was carried out with an aim to determine the cross compatibility between Psidium species (P. chinensis, P. guineense, P. cattleianum and P. molle) and commercial guava cultivars (Arka Kiran, Arka Rashmi, Arka Mridula and Allahabad Safed). The results revealed that, P. chinensis and P. guineense were found to be good cross compatible male parents whereas, Allahabad Safeda and Arka Kiran were found to be good cross compatible female parents. However, no fruit set and seed set were obtained when P. cattleianum and P. molle were used as male parent indicating the cross incompatibility of these species with commercial guava cultivars which is reconfirmed using florescence microscopy technique to understand the pollen-pistil interaction between incompatible P. cattleianum and P. molle species with P. guajava cv. Allahabad Safeda. Result indicated that low fluorescence intensity along with poor pollen germination and improper pollen-tube growth could be the reason for incompatibility. In order to break this incompatibility, a modified pollination technique called stigma maceration technique was followed wherein stigma of the male parent macerated with different chemicals viz., carbohydrate source (2% sucrose), growth regulators (50 ppm GA3 and iaa) and micronutrients (50 ppm of each Boric acid, MgSO4, CaNO3 and KNO3) and pollinated twice i.e., on the day of flower opening and the same time of next day resulted in cross compatibility of P. cattleianum and P. molle with commercial guava cultivars. Further hybridity confirmation of interspecific hybrids using ssr markers revealed that, 8 markers were found to be co-dominant and confirmed the hybridity of interspecific hybrid combinations.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":"1 1","pages":"1-14"},"PeriodicalIF":1.0,"publicationDate":"2021-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42760324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.1163/22238980-BJA10019
Wenli Sun, M. H. Shahrajabian, Q. Cheng
Barberry is a resistant shrub which is able to grow up in semi-arid region with low-water or salty fields. Its red fruit widely used in Iranian foods because of its color and delicious taste. Berberis known as Zereshk in Persian has been consumed as both a remedy and traditional food additive. Its fruits are used mainly in Persian food in preparing juices, jam, chocolates, sauces and also a garniture. In both traditional and folkore medicine, it has been applied for its many biological and pharmacological activities. The most important compounds of B. Vulgaris are lupeol, oleanolic acid, stigmasterol, stigmasterolglucoside, berberamine, palmatine, berberine, oxyberberine, columbamine, isocorydie, lambertine, magniflorine, and oxycanthine. Barberry which are high in nutrients, contain beneficial plant compounds, which may help to manage diabetes, treat diarrhea, protect against metabolic syndrome, maintain dental health, and help fight acne. It also has anti-cancer effects, and it is appropriate to add to the diet. This review summarizes the beneficial effects of Barberry which is recommended for consumption.
{"title":"Barberry (Berberis vulgaris), a medicinal fruit and food with traditional and modern pharmaceutical uses","authors":"Wenli Sun, M. H. Shahrajabian, Q. Cheng","doi":"10.1163/22238980-BJA10019","DOIUrl":"https://doi.org/10.1163/22238980-BJA10019","url":null,"abstract":"\u0000Barberry is a resistant shrub which is able to grow up in semi-arid region with low-water or salty fields. Its red fruit widely used in Iranian foods because of its color and delicious taste. Berberis known as Zereshk in Persian has been consumed as both a remedy and traditional food additive. Its fruits are used mainly in Persian food in preparing juices, jam, chocolates, sauces and also a garniture. In both traditional and folkore medicine, it has been applied for its many biological and pharmacological activities. The most important compounds of B. Vulgaris are lupeol, oleanolic acid, stigmasterol, stigmasterolglucoside, berberamine, palmatine, berberine, oxyberberine, columbamine, isocorydie, lambertine, magniflorine, and oxycanthine. Barberry which are high in nutrients, contain beneficial plant compounds, which may help to manage diabetes, treat diarrhea, protect against metabolic syndrome, maintain dental health, and help fight acne. It also has anti-cancer effects, and it is appropriate to add to the diet. This review summarizes the beneficial effects of Barberry which is recommended for consumption.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":"-1 1","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42978598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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