Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V4I1.48445
Y. Tanwar, A. Sharma
Drug-free films of different polymers were prepared by casting solvent technique employing mercury as a substrate. The physical and chemical properties of the films were evaluated for their potential transdermal use. The films were found to be stable and intact at ambient temperature and humidity conditions. The results indicate that the polymeric films of hydroxypropyl methyl cellulose (HPMC), polyvinyl acetate (PVA), carboxymethyl cellulose (CMC), cellulose acetate (CA), ethyl acetate (EC) and Eudragit RL100 & S100 along with those of polyvinyl pyrrolidone (PVP), and propylene glycol (PPG) as plasticizer appear promising for the development of suitable transdermal drug delivery systems (TDDS).
{"title":"Characterization of polymeric films for transdermal drug delivery","authors":"Y. Tanwar, A. Sharma","doi":"10.4314/JOPHAS.V4I1.48445","DOIUrl":"https://doi.org/10.4314/JOPHAS.V4I1.48445","url":null,"abstract":"Drug-free films of different polymers were prepared by casting solvent technique employing mercury as a substrate. The physical and chemical properties of the films were evaluated for their potential transdermal use. The films were found to be stable and intact at ambient temperature and humidity conditions. The results indicate that the polymeric films of hydroxypropyl methyl cellulose (HPMC), polyvinyl acetate (PVA), carboxymethyl cellulose (CMC), cellulose acetate (CA), ethyl acetate (EC) and Eudragit RL100 & S100 along with those of polyvinyl pyrrolidone (PVP), and propylene glycol (PPG) as plasticizer appear promising for the development of suitable transdermal drug delivery systems (TDDS).","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89457262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V3I2.48442
O. Olonitola, B. Olayinka, M. Salawu, S. Yakubu
Staphylococcus aureus isolates were collected from anterior nares of fifty healthy adults in Zaria and their antibiotic susceptibility patterns determined. Seventy-two percent (72%) of the isolates were methicillin-resistant S. aureus, while 20% were methicillin-susceptible. The isolates were generally resistant to multiple antibiotics including chloramphenicol [78% resistance], penicillin [100% resistance], and tetracycline [66% resistance]. Vancomycin susceptibility studies revealed that 86% of the isolates were Vancomycin intermediate. There is a need to observe antibiotic use policies faithfully in order to prevent the spread of resistances.
{"title":"Nasal carriage of methicilli-resistant staphylococcus aureus with reduced vancomycin susceptibility [mrsa-rvs] by healthy adults in Zaria, Nigeria.","authors":"O. Olonitola, B. Olayinka, M. Salawu, S. Yakubu","doi":"10.4314/JOPHAS.V3I2.48442","DOIUrl":"https://doi.org/10.4314/JOPHAS.V3I2.48442","url":null,"abstract":"Staphylococcus aureus isolates were collected from anterior nares of fifty healthy adults in Zaria and their antibiotic susceptibility patterns determined. Seventy-two percent (72%) of the isolates were methicillin-resistant S. aureus, while 20% were methicillin-susceptible. The isolates were generally resistant to multiple antibiotics including chloramphenicol [78% resistance], penicillin [100% resistance], and tetracycline [66% resistance]. Vancomycin susceptibility studies revealed that 86% of the isolates were Vancomycin intermediate. There is a need to observe antibiotic use policies faithfully in order to prevent the spread of resistances.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79741614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V5I1.48464
Kr Srivivan, V. Reddy
Leaves of Aerva javanica (Family:Amaranthaceae) were extracted with petroleum ether, ethyl acetate and methanol. The crude extracts were investigated for its antibacterial activity against Bacillus subtilis ,Bacillus cerus, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Shigella dysenteriae and antifungal activity against Aspergillus flavus, Aspergillus niger and Candida albicans. The extracts showed significant antibacterial activity in the order methanol, ethyl acetate and petroleum ether and methanol and ethyl acetate extract showed moderate antifungal activity while petroleum ether extract did not showed any activity against all the microorganisms tested. How ever, the antibacterial, antifungal activity of the methanol extract of the leaves was found to be most effective against all the organisms.
{"title":"Antimicrobial studies on the leaves of Earva Javanica","authors":"Kr Srivivan, V. Reddy","doi":"10.4314/JOPHAS.V5I1.48464","DOIUrl":"https://doi.org/10.4314/JOPHAS.V5I1.48464","url":null,"abstract":"Leaves of Aerva javanica (Family:Amaranthaceae) were extracted with petroleum ether, ethyl acetate and methanol. The crude extracts were investigated for its antibacterial activity against Bacillus subtilis ,Bacillus cerus, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Shigella dysenteriae and antifungal activity against Aspergillus flavus, Aspergillus niger and Candida albicans. The extracts showed significant antibacterial activity in the order methanol, ethyl acetate and petroleum ether and methanol and ethyl acetate extract showed moderate antifungal activity while petroleum ether extract did not showed any activity against all the microorganisms tested. How ever, the antibacterial, antifungal activity of the methanol extract of the leaves was found to be most effective against all the organisms.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78173296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V4I2.48461
A. Attama, M. Adikwu
This work studied the effect of trona on the release and permeation of salicylic acid from ointments formulated with beeswax processed from native honeycombs. Pure trona was obtained by re-crystallisation. The test (extracted) beeswax was characterized using standard physicochemical procedures. Trona was incorporated into salicylic acid ointment at concentrations of 0.5 - 2.0 %w/w and the ointments evaluated. Consistencies of the ointments were determined by penetrometry while release studies were carried out by studying diffusion of salicylic acid from the ointments on ferric chloride agar. The permeation of salicylic acid from optimised ointments was also studied. Results obtained indicated that the physicochemical properties of the beeswax processed from native honeycombs compared favourably with the standard beeswax. Release enhancement by trona was in the order: 0.5 %w/w > 1.0 %w/w > 1.5 %w/w > 2.0 %w/w while in the permeation experiment, enhancement was mostly observed at trona concentrations of 1.5 %w/w and 2.0 %w/w. Trona could be used as a release and permeation enhancer in salicylic acid ointments.
{"title":"Use of trona as a permeation enhancer for ointments prepared with beeswax extracted from native honeycombs","authors":"A. Attama, M. Adikwu","doi":"10.4314/JOPHAS.V4I2.48461","DOIUrl":"https://doi.org/10.4314/JOPHAS.V4I2.48461","url":null,"abstract":"This work studied the effect of trona on the release and permeation of salicylic acid from ointments formulated with beeswax processed from native honeycombs. Pure trona was obtained by re-crystallisation. The test (extracted) beeswax was characterized using standard physicochemical procedures. Trona was incorporated into salicylic acid ointment at concentrations of 0.5 - 2.0 %w/w and the ointments evaluated. Consistencies of the ointments were determined by penetrometry while release studies were carried out by studying diffusion of salicylic acid from the ointments on ferric chloride agar. The permeation of salicylic acid from optimised ointments was also studied. Results obtained indicated that the physicochemical properties of the beeswax processed from native honeycombs compared favourably with the standard beeswax. Release enhancement by trona was in the order: 0.5 %w/w > 1.0 %w/w > 1.5 %w/w > 2.0 %w/w while in the permeation experiment, enhancement was mostly observed at trona concentrations of 1.5 %w/w and 2.0 %w/w. Trona could be used as a release and permeation enhancer in salicylic acid ointments.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83162743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V4I1.48446
A. Attama, P. Akpa, Cw Nwokeabia
The mucoadhesiveness, swelling characteristics and release profile of diclofenac sodium from mucoadhesive tablets prepared with Carbopol 675 and polyvinyl pyrrolidone (PVP) and their physical mixtures were studied to evaluate their applicability in sustained drug delivery. The ex-vivo mucoadhesive strengths of the tablet compacts were determined by tensiometry using Lecomte du Nuoy tensiometer and everted pig jejunum. Release studies were carried out in three different pH media (1.2, 7.0 and 7.5). The results of mucoadhesive test revealed that tablets formulated from 1:1 physical mixture of Carbopol 675 and PVP had the highest mucoadhesive strength, which showed they bound tightly to the mucus pig jejunum. Their low swelling and release behaviours also indicated that the tablet compacts are very good candidates for sustained release formulation since release of diclofenac sodium was sustained by the compacts.
研究了卡波波尔675与聚乙烯吡咯烷酮(PVP)及其物理混合物制备的黏附片对双氯芬酸钠的黏附性、溶胀特性和释放特性，以评价其在持续给药中的适用性。采用leomte du Nuoy张力仪和猪空肠张力法测定片剂的离体黏附强度。在三种不同pH培养基(1.2、7.0和7.5)中进行释放研究。黏附试验结果表明，以卡波波尔675与PVP 1:1物理混合配制的片剂黏附强度最高，表明其与猪空肠黏附紧密。它们的低溶胀和低释放特性也表明该片剂是缓释型制剂的很好候选，因为该片剂能维持双氯芬酸钠的释放。
{"title":"Mucoadhesive sustained delivery of diclofenac sodium using carbopol 675 and PVP admixtures as mucoadhesive motif","authors":"A. Attama, P. Akpa, Cw Nwokeabia","doi":"10.4314/JOPHAS.V4I1.48446","DOIUrl":"https://doi.org/10.4314/JOPHAS.V4I1.48446","url":null,"abstract":"The mucoadhesiveness, swelling characteristics and release profile of diclofenac sodium from mucoadhesive tablets prepared with Carbopol 675 and polyvinyl pyrrolidone (PVP) and their physical mixtures were studied to evaluate their applicability in sustained drug delivery. The ex-vivo mucoadhesive strengths of the tablet compacts were determined by tensiometry using Lecomte du Nuoy tensiometer and everted pig jejunum. Release studies were carried out in three different pH media (1.2, 7.0 and 7.5). The results of mucoadhesive test revealed that tablets formulated from 1:1 physical mixture of Carbopol 675 and PVP had the highest mucoadhesive strength, which showed they bound tightly to the mucus pig jejunum. Their low swelling and release behaviours also indicated that the tablet compacts are very good candidates for sustained release formulation since release of diclofenac sodium was sustained by the compacts.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88600806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V4I2.48460
E. Ejike, L. Ezeanyika
Benign prostate Hyperplasia (BPH) is an age-related neoplastic condition of the prostate gland that is characterised by lower urinary tract symptoms (LUTS), in the clinical setting. A variety of factors, especially weather conditions and diet, impart on the nature of the manifestations of LUTS experienced by sufferers, suggesting a possible difference in the clinical presentation of BPH across cultures. One of the tools used in the screening and diagnosis of BPH is the American Urological Association’s (AUA’s) symptom index. However, the validity of this instrument in Nigeria has not been tested. This work used two biochemical markers of prostate pathologies – prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) – to test the validity of the AUA symptom index in Nigeria. Our results show a positive correlation between PAP and the AUA symptom index (r = +0.275, p <0.01). The AUA symptom index is thus recommended for screening and diagnostic purposes in Nigeria.
良性前列腺增生(BPH)是一种与年龄相关的前列腺肿瘤，临床表现为下尿路症状(LUTS)。多种因素，特别是天气条件和饮食，会影响患者所经历的LUTS表现的性质，这表明不同文化背景下BPH的临床表现可能存在差异。用于BPH筛查和诊断的工具之一是美国泌尿协会(AUA)的症状指数。然而，这一文书在尼日利亚的有效性尚未得到检验。本工作采用前列腺特异性抗原(PSA)和前列腺酸性磷酸酶(PAP)两种前列腺病理生化标志物，对尼日利亚AUA症状指数的有效性进行了检验。结果显示PAP与AUA症状指数呈正相关(r = +0.275, p <0.01)。因此，建议将AUA症状指数用于尼日利亚的筛查和诊断目的。
{"title":"Usefulness of the American urological association's benign prostate hyperplasia symptom index in Nigeria: Validation using biochemical markers","authors":"E. Ejike, L. Ezeanyika","doi":"10.4314/JOPHAS.V4I2.48460","DOIUrl":"https://doi.org/10.4314/JOPHAS.V4I2.48460","url":null,"abstract":"Benign prostate Hyperplasia (BPH) is an age-related neoplastic condition of the prostate gland that is characterised by lower urinary tract symptoms (LUTS), in the clinical setting. A variety of factors, especially weather conditions and diet, impart on the nature of the manifestations of LUTS experienced by sufferers, suggesting a possible difference in the clinical presentation of BPH across cultures. One of the tools used in the screening and diagnosis of BPH is the American Urological Association’s (AUA’s) symptom index. However, the validity of this instrument in Nigeria has not been tested. This work used two biochemical markers of prostate pathologies – prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) – to test the validity of the AUA symptom index in Nigeria. Our results show a positive correlation between PAP and the AUA symptom index (r = +0.275, p <0.01). The AUA symptom index is thus recommended for screening and diagnostic purposes in Nigeria.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85658319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V4I1.48448
I. Uzochukwu, P. O. Osadebe
The antidiabetic activities of flavonoids extract (FE) and crude methanol extract (CME) of Loranthus micranthus parasitic on Kola acuminata were studied in alloxan-induced diabetic rats. Four groups of rats (n=4) were given 100 and 200 mg/kg of FE and CME respectively by the intraperitoneal route. Glibenclamide (10 mg/kg) and tween 80 (2 ml/kg) were also administered intraperitoneally as positive and negative control respectively. While the FE (200 mg/kg) caused significant (P< 0.001) antidiabetic activity within one hour of administration in the treated rats, the CME (200 mg/kg) caused significant (P< 0.001) antidiabetic activity within three hour of administration in the treated rats. The result shows that the antidiabetic activities of L. micranthus parasitic on K. acuminata may be attributable to the flavonoids contents of the leaves.
{"title":"Comparative evaluation of antidiabetic activities of Flavonoids extract and crude methanol extract of loranthus Micranthus parasitic on","authors":"I. Uzochukwu, P. O. Osadebe","doi":"10.4314/JOPHAS.V4I1.48448","DOIUrl":"https://doi.org/10.4314/JOPHAS.V4I1.48448","url":null,"abstract":"The antidiabetic activities of flavonoids extract (FE) and crude methanol extract (CME) of Loranthus micranthus parasitic on Kola acuminata were studied in alloxan-induced diabetic rats. Four groups of rats (n=4) were given 100 and 200 mg/kg of FE and CME respectively by the intraperitoneal route. Glibenclamide (10 mg/kg) and tween 80 (2 ml/kg) were also administered intraperitoneally as positive and negative control respectively. While the FE (200 mg/kg) caused significant (P< 0.001) antidiabetic activity within one hour of administration in the treated rats, the CME (200 mg/kg) caused significant (P< 0.001) antidiabetic activity within three hour of administration in the treated rats. The result shows that the antidiabetic activities of L. micranthus parasitic on K. acuminata may be attributable to the flavonoids contents of the leaves.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82453881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V5I2.48476
K. Pandey, A. Pandey, E. Ibezim
Natural products have shown an unflinching promise as antifertility agents. Interestingly, most of them are heterocyclic in nature. The extraordinary capability of these compounds to mimic the activity of estrogenic compounds imparts them a remarkable characteristic of being able to regulate female fertility. Nitrogen and oxygen heterocycles form the majority of these compounds of which, in majority of cases, the pharmacologically active part of the molecule is non-aromatic, thus non planar, just as is the steroid ring system. This fact may be responsible for their steroid mimicking activity. This review presents the active compounds identified and pharmacologically evaluated till date.
{"title":"Natural heterocycles as antifertility agents","authors":"K. Pandey, A. Pandey, E. Ibezim","doi":"10.4314/JOPHAS.V5I2.48476","DOIUrl":"https://doi.org/10.4314/JOPHAS.V5I2.48476","url":null,"abstract":"Natural products have shown an unflinching promise as antifertility agents. Interestingly, most of them are heterocyclic in nature. The extraordinary capability of these compounds to mimic the activity of estrogenic compounds imparts them a remarkable characteristic of being able to regulate female fertility. Nitrogen and oxygen heterocycles form the majority of these compounds of which, in majority of cases, the pharmacologically active part of the molecule is non-aromatic, thus non planar, just as is the steroid ring system. This fact may be responsible for their steroid mimicking activity. This review presents the active compounds identified and pharmacologically evaluated till date.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73058361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V4I1.48450
F. Okoye, G. Ebi
The leaves of Alchornea floribunda were collected, identified and reduced to coarse powder. Using various solvent treatments, the powdered drug leaf was fractionated into A1, A2, B, C and D. The fractions were subjected to anti-microbial screening and phytochemical analysis. Phytochemical analysis of the extracts showed the presence of terpenes, sterols, flavonoids, tannins, carbohydrate, glycoside, saponins and alkaloids. Only fraction A2 (the terpenoid fraction) showed promising antimicrobial activity against Pseudomonas aeruginosa (IZD 42 mm) Salmonella keitambii (IZD 34mm) and Bacillus subtilis (IZD 32mm). A2 was further separated into 14 major column chromatographic fractions. The fractions were subjected to anti-microbial and phytochemical investigation. Fraction Af7, Af9, Af12 and Af13 (all terpenoids) showed mild activity against Pseudomonas aeruginosa and Salmonella keitambii. In conclusion, the anti-microbial activity of Alchornea floribunda leaves can be attributed to the presence of the terpenoids which may interact synergistically to cause inhibition of the sensitive bacteria.
{"title":"Preliminary anti-microbial and phytochemical investigation of the extracts and column fractions of Alchornea Floribunda leaves","authors":"F. Okoye, G. Ebi","doi":"10.4314/JOPHAS.V4I1.48450","DOIUrl":"https://doi.org/10.4314/JOPHAS.V4I1.48450","url":null,"abstract":"The leaves of Alchornea floribunda were collected, identified and reduced to coarse powder. Using various solvent treatments, the powdered drug leaf was fractionated into A1, A2, B, C and D. The fractions were subjected to anti-microbial screening and phytochemical analysis. Phytochemical analysis of the extracts showed the presence of terpenes, sterols, flavonoids, tannins, carbohydrate, glycoside, saponins and alkaloids. Only fraction A2 (the terpenoid fraction) showed promising antimicrobial activity against Pseudomonas aeruginosa (IZD 42 mm) Salmonella keitambii (IZD 34mm) and Bacillus subtilis (IZD 32mm). A2 was further separated into 14 major column chromatographic fractions. The fractions were subjected to anti-microbial and phytochemical investigation. Fraction Af7, Af9, Af12 and Af13 (all terpenoids) showed mild activity against Pseudomonas aeruginosa and Salmonella keitambii. In conclusion, the anti-microbial activity of Alchornea floribunda leaves can be attributed to the presence of the terpenoids which may interact synergistically to cause inhibition of the sensitive bacteria.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73233676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.4314/JOPHAS.V5I1.48467
U. Georgewill, O. Georgewill
The effect of leaf extract of Abrus precatorius on blood glucose level of alloxan- induced diabetic albino wistar rats was evaluated. Experimental animals received daily oral administration of extract of Abrus precatorius for 14 days. The effect of 200 mg/kg dose was studied during the treatment period. There was a significant reduction in blood glucose level (p for normal control, 7.0 ± 0.40 for diabetic control group and 4.0 ± 0.24 for diabetic treated group. The findings of this study suggest that extract of Abrus precatorius has hypoglycemic effect.
{"title":"Effect of extract of Abrs Precatorius on blood glucose concentration of alloxan induced diabeticc albino westar rats","authors":"U. Georgewill, O. Georgewill","doi":"10.4314/JOPHAS.V5I1.48467","DOIUrl":"https://doi.org/10.4314/JOPHAS.V5I1.48467","url":null,"abstract":"The effect of leaf extract of Abrus precatorius on blood glucose level of alloxan- induced diabetic albino wistar rats was evaluated. Experimental animals received daily oral administration of extract of Abrus precatorius for 14 days. The effect of 200 mg/kg dose was studied during the treatment period. There was a significant reduction in blood glucose level (p for normal control, 7.0 ± 0.40 for diabetic control group and 4.0 ± 0.24 for diabetic treated group. The findings of this study suggest that extract of Abrus precatorius has hypoglycemic effect.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"16 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76988463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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