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Chitosan-calcium carbonate scaffold with high mineral content and hierarchical structure for bone regeneration 高矿物质、分级结构的壳聚糖-碳酸钙骨再生支架
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.04.004
Xiaoyang Liu, Zhengke Wang

Bone regeneration scaffolds loaded with osteoblast-related cells or cytokines exhibit outstanding therapeutic potential during large-scale bone defect repair. However, limited sources of cells, opportune choosing of growth factors and their concentration, as well as immunological rejection, seriously hinder its clinical application. Developing a scaffold that can effectively recruit MSCs in situ and achieve endogenous bone regeneration is a viable strategy. Herein, we report a chitosan-calcium carbonate scaffold with high mineral content and centripetal pore arrangement using a simple in situ mineralization method. In vivo results first time demonstrate that the scaffold with high calcium carbonate content can effectively recruit MSCs near the defect area, induce their osteogenic differentiation, and ultimately accelerate the process of bone regeneration. Considering the accessible preparation and excellent osteogenicity, the chitosan-calcium carbonate scaffold possesses high potential for the therapeutics of massive bone defects.

载成骨细胞相关细胞或细胞因子的骨再生支架在大规模骨缺损修复中表现出突出的治疗潜力。然而,细胞来源有限、生长因子及其浓度选择不当、免疫排斥等因素严重阻碍了其临床应用。开发一种能够原位有效募集MSCs并实现内源性骨再生的支架是一种可行的策略。在此,我们报告了一个壳聚糖-碳酸钙支架具有高矿物质含量和向心孔排列使用简单的原位矿化方法。体内实验结果首次证明,高碳酸钙含量的支架能够有效募集缺损区域附近的MSCs,诱导其成骨分化,最终加速骨再生过程。壳聚糖-碳酸钙支架材料制备方便,成骨性好,在治疗大面积骨缺损方面具有很大的应用潜力。
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引用次数: 2
Biosensor-based therapy powered by synthetic biology 基于合成生物学的生物传感器疗法
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.10.003
Chi Wang , Han-Shi Zeng , Kai-Xuan Liu , Yi-Na Lin , Hao Yang , Xin-Ying Xie , Dai-Xu Wei , Jian-Wen Ye

The study of synthetic biology focusing on biosensor systems has resulted from a growing interest in developing customized biological devices with desired cellular functions. Recently, biosensors have been used for a variety of medical applications such as disease diagnosis, prevention, rehabilitation, patient health monitoring, and human health management. Meanwhile, the ability to track biomarkers based on biosensors allows researchers and medical practitioners to provide patients with individualized treatment regimens and health management. Biosensors that respond to electrochemical, optical, thermal, piezoelectric and magnetic signals have been developed and utilized for various disease therapies and biomedical applications. This study reviews recent developments in biosensor-based therapeutic tools by sensing diverse biomarkers in many diseases (e.g. cancer, infections, metabolic diseases), such as physical biomarkers (e.g. pressure, temperature) and chemical biomarkers (e.g. dissolved oxygen, glucose). Additionally, we highlight the challenges and problems of biosensor-based therapeutics and possible solutions for biosensor engineering thereof. Current biosensors enable for coarsely programable personal treatment and health management, however, new sensors with optimized dose-response functions, for example, fast response and tight-control performances, could significantly boost versatile uses in medical treatment in the coming future.

合成生物学的研究重点是生物传感器系统,这是由于人们对开发具有所需细胞功能的定制生物设备越来越感兴趣。近年来,生物传感器已广泛应用于疾病诊断、预防、康复、患者健康监测、人体健康管理等医疗领域。同时,追踪基于生物传感器的生物标记物的能力使研究人员和医疗从业者能够为患者提供个性化的治疗方案和健康管理。对电化学、光学、热、压电和磁信号作出反应的生物传感器已被开发并用于各种疾病治疗和生物医学应用。本研究综述了基于生物传感器的治疗工具的最新进展,通过传感多种生物标志物在许多疾病(如癌症,感染,代谢性疾病),如物理生物标志物(如压力,温度)和化学生物标志物(如溶解氧,葡萄糖)。此外,我们强调了基于生物传感器的治疗方法的挑战和问题,以及生物传感器工程的可能解决方案。目前的生物传感器能够实现大致可编程的个人治疗和健康管理,然而,具有优化剂量响应功能的新型传感器,例如,快速响应和严格控制性能,可以在未来显著促进医疗的多用途应用。
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引用次数: 3
Epidermal growth factor-loaded microspheres/hydrogel composite for instant hemostasis and liver regeneration 表皮生长因子负载微球/水凝胶复合材料用于即时止血和肝脏再生
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.09.006
Rui Ding , Xinbo Wei , Youlan Liu, Yuqing Wang, Zheng Xing, Li Wang, Haifeng Liu, Yubo Fan

Rapid hemostasis and effective healing for the non-compressible liver wounds which are not able to be sewn, especially for those large-area wounds, remain great clinical challenges. In this study, we fabricated epidermal growth factor (EGF)-loaded chitosan microspheres (CM) and then incorporated them into a photo-crosslinking gelatin methacryloyl (GelMA) hydrogel. The results showed that the EGF-loaded CM/GelMA precursor solution could transform into a hydrogel and cease bleeding at laceration sites without external stress. Subsequently, the sustained release of EGF accelerated wound closure and promoted liver regeneration. The in vitro experiments demonstrated that the microsphere/hydrogel composite could promote the proliferation and migration of L02 ​cells. Moreover, the histological and immunohistological analyses indicated that EGF-CM/GelMA composite could alleviate inflammation in the mouse liver and promote liver remodeling. Overall, this multi-functional microsphere/hydrogel composite will inspire the development of clinical applications for noncompressible hemostasis and successive wound closure.

对于无法缝合的不可压缩性肝伤口,特别是大面积肝伤口的快速止血和有效愈合,仍然是临床面临的巨大挑战。本研究制备了负载表皮生长因子(EGF)的壳聚糖微球(CM),并将其加入光交联明胶甲基丙烯酰(GelMA)水凝胶中。结果表明,负载egf的CM/GelMA前体溶液可以转化为水凝胶,并在无外部应力的情况下在撕裂处止血。随后,EGF的持续释放加速伤口愈合,促进肝脏再生。体外实验表明,微球/水凝胶复合材料能促进L02细胞的增殖和迁移。此外,组织学和免疫组织学分析表明,EGF-CM/GelMA复合物可以减轻小鼠肝脏炎症,促进肝脏重塑。总之,这种多功能微球/水凝胶复合材料将激发不可压缩止血和连续伤口闭合的临床应用的发展。
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引用次数: 4
Tube-shaped nanostructures for enhancing resin-based dental materials: A landscape of evidence and research advancement 增强树脂基牙科材料的管状纳米结构:证据和研究进展
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.03.002
Isadora Martini Garcia , Lamia Sami Mokeem , Yasmin Shahkarami , Lauren Blum , Victoria Sheraphim , Robert Leonardo , Abdulrahman A. Balhaddad , Mary Anne S. Melo

With the advent of nanotechnology, incorporating nanoscale fillers in dental resins seems promising to improve therapeutic features and provide more excellent physicochemical properties for dental materials. The use of nanotubes has been raised due to their excellent mechanical properties, carry and delivery of drugs capabilities, and bioactive properties. These features depend on the composition of nanotubes and their application. This scoping review aims to describe previous studies about incorporating nanotubes in restorative resin-based materials. The main goals here addresses are: (1) to identify which are the most used nanotubes in the development of these dental materials; (2) to verify which the molecules/particles associated with these nanotubes; (3) to report the objectives of the incorporation of nanotubes to these dental materials and main results. The searches were performed using PubMed and Scopus databases in December 2022, identifying 534 manuscripts. After the selection process, 43 studies were included in the review. We mainly analyzed and discussed the nanotubes' composition, the parental materials in which the nanotubes were incorporated, the purposes of adding these particles to the dental materials, how the materials were analyzed, and the primary studies' outcomes. The outcomes are stimulating and reveal a promising advance in dental resins with the possibility of improving the maintenance of restorations and patients' quality of life. Further studies should address the abovementioned topics to expand the understanding and options of using nanotubes in resin-based restorative materials.

随着纳米技术的出现,在牙科树脂中加入纳米级填料有望改善牙科材料的治疗特性,并为牙科材料提供更优异的物理化学性能。纳米管由于其优异的机械性能、携带和输送药物的能力以及生物活性特性而得到了广泛的应用。这些特性取决于纳米管的组成及其应用。本文综述了在修复性树脂基材料中加入纳米管的研究进展。本文的主要目标是:(1)确定哪些是在这些牙科材料的开发中使用最多的纳米管;(2)验证与这些纳米管相关的分子/粒子;(3)报道纳米管掺入口腔材料的目的及主要结果。检索于2022年12月使用PubMed和Scopus数据库进行,确定了534篇手稿。经过筛选,43项研究被纳入综述。我们主要分析和讨论了纳米管的组成、纳米管的母材、纳米管加入口腔材料的目的、纳米管的分析方法以及初步的研究结果。结果是令人兴奋的,揭示了牙科树脂有希望的进步,有可能改善修复体的维护和患者的生活质量。进一步的研究应该解决上述问题,以扩大对纳米管在树脂基修复材料中使用的理解和选择。
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引用次数: 0
Recent advances on nerve guide conduits based on textile methods 基于纺织方法的神经导管研究进展
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.12.001
Shihan Gao, Xiangshang Chen, Beining Lu, Kai Meng, Ke-Qin Zhang, Huijing Zhao

Peripheral nerve injury (PNI) is a common and complex clinical disease with high morbidity, limited treatment options and poor clinical outcomes. Several million cases of PNI in the world every year have brought a heavy burden to the patients and the social economy. Autologous nerve grafting has long been the “gold standard” in the treatment of PNI repair, but it still has some shortcomings, such as donor area injury, limited graft source and mismatch of nerve thickness after transplantation. In recent years, many artificial nerve guidance conduits (NGCs) have emerged for replacing autologous nerve grafts, and their effectiveness has been proven. Currently, there are already clinical products obtained from the European CE Certification, and approved by the Food and Drug Administration (FDA), China Food and Drug Administration (CFDA), Therapeutic Goods Administration (TGA) in Australia, etc. The preparation of NGCs requires interdisciplinary studies and has received considerable attention from researchers in recent years. At present, among emerging and mature manufacturing technologies, textile methods to prepare NGCs are relatively simple and have wide material sources, which has become a hotspot in textile research. This paper mainly reviewed the current situation and recent technological achievements of NGCs that were prepared by textile methods. Several other common methods were also briefly summarized. Furthermore, current NGCs products and their clinical applications were reported. Finally, the future development direction of textile-based NGCs is discussed in this review.

周围神经损伤(PNI)是一种常见而复杂的临床疾病,发病率高,治疗方案有限,临床疗效差。全球每年有数百万例PNI病例,给患者和社会经济带来了沉重的负担。自体神经移植一直是治疗PNI修复的“金标准”,但仍存在供体区损伤、移植物来源受限、移植后神经粗细不匹配等缺点。近年来,出现了许多人工神经引导导管(NGCs)来替代自体神经移植物,其有效性已得到证实。目前已经有临床产品获得了欧洲CE认证,并获得了美国食品药品监督管理局(FDA)、中国食品药品监督管理局(CFDA)、澳大利亚治疗用品管理局(TGA)等的批准。NGCs的制备需要跨学科的研究,近年来受到了研究人员的广泛关注。目前,在新兴和成熟的制造技术中,纺织方法制备NGCs相对简单,材料来源广泛,已成为纺织研究的热点。本文主要综述了纺织法制备NGCs的现状和最新技术成果。还简要总结了其他几种常用方法。并对目前NGCs产品及其临床应用进行了综述。最后,对纺织基NGCs的未来发展方向进行了展望。
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引用次数: 2
Developments of microfluidics for orthopedic applications: A review 微流体在骨科应用中的发展综述
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.07.001
Miao Sun , Jiaxing Gong , Wushi Cui , Congsun Li , Mengfei Yu , Hua Ye , Zhanfeng Cui , Jing Chen , Yong He , An Liu , Huiming Wang

With the development of modern medicine, the research methods of occurrence, development and treatment of orthopedic diseases are developing rapidly. The microenvironment provided by traditional orthopedic research methods differ considerably from the human body, resulting in poor or inconsistent conclusions in previous studies. Microfluidic technology has shown its advantages in the field of orthopedic research, especially in providing bionic mechanical stimulation environment. The microfluidic device can simulate the complex internal environment through the fine and complex structure and perfusion control system, and provide a stable, controllable and efficient culture system. Moreover, it can serve as a manufacturing device, which can produce bone grafts or bone like organs for tissue engineering with bionic structure. It can also simultaneously act as a detection device, which can realize high-throughput detection of small samples at low cost. In addition, we can establish in vitro physiological or pathological models on microfluidic systems to assist in the diagnosis and treatment of orthopedic diseases. This paper reviews the medical application of microfluidic devices in orthopedics.

随着现代医学的发展,骨科疾病的发生、发展和治疗的研究方法也在迅速发展。传统骨科研究方法提供的微环境与人体存在较大差异,导致以往研究结论不佳或不一致。微流控技术在骨科研究领域,特别是在提供仿生机械刺激环境方面已显示出其优势。微流控装置可以通过精细复杂的结构和灌注控制系统模拟复杂的内部环境,提供稳定、可控、高效的培养系统。此外,它还可以作为一种制造装置,用于生产具有仿生结构的组织工程的骨移植物或骨样器官。也可同时作为检测装置,以低成本实现小样本的高通量检测。此外,我们还可以在体外建立微流控系统的生理或病理模型,以辅助骨科疾病的诊断和治疗。本文综述了微流控装置在骨科中的应用。
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引用次数: 4
Design of 3D smart scaffolds using natural, synthetic and hybrid derived polymers for skin regenerative applications 使用天然、合成和混合衍生聚合物设计用于皮肤再生应用的3D智能支架
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.09.005
Laldinthari Suamte, Akriti Tirkey, Punuri Jayasekhar Babu

Effective wound care is a major concern as many conventional wound healing methods and materials have failed in facilitating proper healing, instead disrupts the overall healing process, leading to the development of chronic wounds. Advancement in tissue engineering has led to the development of scaffolds; a 3D construct which can be utilized as a template for cell growth and regeneration while preventing infection along with acceleration of the wound healing process. Natural and synthetic polymers are used extensively for scaffold production and hybrid scaffolds are also introduced which constitutes a combination of natural and synthetic polymers. This review highlights the design of scaffolds using different kinds of polymers for skin tissue engineering.

有效的伤口护理是一个主要问题,因为许多传统的伤口愈合方法和材料在促进适当愈合方面失败了,相反,破坏了整体愈合过程,导致慢性伤口的发展。组织工程的进步导致了支架的发展;这是一种3D结构,可以用作细胞生长和再生的模板,同时防止感染,加速伤口愈合过程。天然聚合物和合成聚合物被广泛用于支架的生产,同时也介绍了由天然聚合物和合成聚合物组成的杂化支架。本文综述了不同类型聚合物用于皮肤组织工程支架的设计。
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引用次数: 24
Emerging polymeric biomaterials and manufacturing-based tissue engineering approaches for neuro regeneration-A critical review on recent effective approaches 新兴的高分子生物材料和基于制造的神经再生组织工程方法-对最近有效方法的重要回顾
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.11.007
Amna Akhtar , Vahideh Farzam Rad , Ali-Reza Moradi , Muhammad Yar , Masoomeh Bazzar

The nervous system is a crucial part of the human body that is damaged by traumatic injury, stroke, and neurodegenerative diseases. Recent studies also have shown that neurodegenerative diseases are associated with a subsequently increased risk of COVID-19-related death. Presently used pharmacological and therapeutic strategies are only the symptomatic treatments that involve the disruption of axonal tracts and are unable to repair and regenerate damaged CNS tissue thereby leading to significant unmet clinical needs involved in neural degeneration. The use of stem cell based regenerative medicine approaches is also limited due to heavy cost, ethical concerns and graft rejection. To address all these limitations, the neural tissue engineering philosophy has been developed that focuses on exploring and developing smart biomaterials for neural tissue repair and regeneration. A scaffold based upon natural and synthetic polymers has meant a very potential role to mimic the extracellular matrix of cells and permit the growth of different types of cells thereby improving the biological behavior in vitro and in vivo effects. They treat neurological disorders without the classic drug delivery limitations. Among these biopolymers, the collagen-based hydrogel is successfully applied conduits for clinical trials that ultimately replicate the native physiological environment of the neural tissues and control cell behavior and favor the regeneration of the damaged nerve tissue. The main objective of this review is to investigate the recent approaches and applications of next-generation polymeric biomaterials useful in the management of neurodegenerative diseases. We also discuss the outlook of the polymeric scaffolds that could pave the way for successful clinical practices.

神经系统是人体的重要组成部分,会因创伤、中风和神经退行性疾病而受损。最近的研究还表明,神经退行性疾病与随后增加的新冠肺炎相关死亡风险有关。目前使用的药理学和治疗策略只是涉及轴突束破坏的症状性治疗,并且不能修复和再生受损的中枢神经系统组织,从而导致涉及神经变性的严重临床需求未得到满足。基于干细胞的再生医学方法的使用也由于高昂的成本、伦理问题和移植物排斥而受到限制。为了解决所有这些局限性,神经组织工程哲学已经发展起来,专注于探索和开发用于神经组织修复和再生的智能生物材料。基于天然和合成聚合物的支架具有非常潜在的作用,可以模拟细胞的细胞外基质,并允许不同类型的细胞生长,从而改善体外和体内的生物学行为。他们治疗神经系统疾病没有典型的药物输送限制。在这些生物聚合物中,基于胶原的水凝胶被成功应用于临床试验的导管,最终复制神经组织的天然生理环境,控制细胞行为,并有利于受损神经组织的再生。这篇综述的主要目的是研究下一代聚合物生物材料在神经退行性疾病治疗中的最新方法和应用。我们还讨论了聚合物支架的前景,这可能为成功的临床实践铺平道路。
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引用次数: 7
Silk sericin-based biomaterials shine in food and pharmaceutical industries 丝胶基生物材料在食品和制药行业大放异彩
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2023.01.003
Chao Yang , Liang Yao , Lei Zhang

Silk sericin (SS) is a byproduct of the silk production process that consists of 18 ​amino acids and numerous polar groups. SS has a range of unique physical, chemical, and biological properties, such as mechanical strength, antioxidant activity, pH responsiveness, low immunogenicity, biocompatibility, and the ability to promote cell proliferation. These properties make SS useful in various fields, including food and biomedicine. It can also be easily modified into biomaterials through cross-linking, copolymerization, and combination with other polymers. This review summarizes the potential applications of SS-based biomaterials in the food and biomedicine industries, including as food additives, food packaging, in vitro/vivo monitoring, drug delivery systems, and wound healing. In addition, the future development possibilities of SS or SS-based biomaterials are also discussed.

丝胶蛋白(SS)是丝绸生产过程中的副产物,由18个氨基酸和许多极性基团组成。SS具有一系列独特的物理、化学和生物学特性,如机械强度、抗氧化活性、pH响应性、低免疫原性、生物相容性和促进细胞增殖的能力。这些特性使得SS在包括食品和生物医药在内的各个领域都很有用。它也可以很容易地通过交联、共聚和与其他聚合物的结合修饰成生物材料。本文综述了ss基生物材料在食品和生物医药行业的潜在应用,包括食品添加剂、食品包装、体外/体内监测、药物输送系统和伤口愈合等。此外,还对SS或SS基生物材料的未来发展前景进行了展望。
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引用次数: 10
Promotion of wound healing by a thermosensitive and sprayable hydrogel with nanozyme activity and anti-inflammatory properties 具有纳米酶活性和抗炎特性的热敏和可喷雾水凝胶促进伤口愈合
Q1 Engineering Pub Date : 2023-01-01 DOI: 10.1016/j.smaim.2022.08.004
Wei Zhang , Xingliang Dai , Xu Jin , Muchen Huang , Jie Shan , Xulin Chen , Haisheng Qian , Zenghong Chen , Xianwen Wang

The rapid healing of wounds requires strategies that relieve oxidative stress resulting from overloaded free radicals and which promote angiogenesis, collagen deposition, and re-epithelialization of the wound. Nickel ions have been reported to be correlated with angiogenesis. However, several applications of metal salts or oxides to wounds lead to increased toxicity. The nickel metal-organic framework (Ni MOF) nanorods described herein can slowly release nickel ions, resulting in reduced toxicity and improved wound healing rates. More importantly, the Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 (Ni3(HITP)2) nanorods with well-defined structures, superior conductivity and many catalytic sites showed superoxide dismutase (SOD)-like enzyme activity and scavenged various free radicals. In addition, the Ni3(HITP)2 nanomaterials contributed to promotion of the migration of fibroblasts, angiogenesis and macrophage polarization from M1 to M2. The aqueous solution of Pluronic F127, a temperature-sensitive, nontoxic and phase-changing hydrogel material, was shown to be an effective choice for injectable and sprayable medical dressings. The Ni3(HITP)2 MOF nanomaterials can be effectively encapsulated with the F127 hydrogel to achieve continuous long-term therapeutic effects. The toxicity test results suggested that the Ni3(HITP)2 MOF nanomaterials exhibited excellent biosafety and no observable toxicity or side effects in mice. Therefore, the Ni3(HITP)2 MOF nanorods hold promising potential in the biomedical field, and this work provides an effective solution to wound therapy.

伤口的快速愈合需要缓解自由基超载引起的氧化应激,促进血管生成、胶原沉积和伤口的再上皮化。据报道,镍离子与血管生成有关。然而,金属盐或氧化物在伤口上的几种应用会导致毒性增加。本文所述的镍金属有机框架(Ni MOF)纳米棒可以缓慢释放镍离子,从而降低毒性并提高伤口愈合率。更重要的是,Ni3(2,3,6,7,10,11-六亚胺-三苯)2 (Ni3(HITP)2)纳米棒具有明确的结构,优越的导电性和许多催化位点,具有超氧化物歧化酶(SOD)样酶活性,并清除各种自由基。此外,Ni3(HITP)2纳米材料有助于促进成纤维细胞的迁移、血管生成和巨噬细胞从M1向M2的极化。Pluronic F127的水溶液是一种对温度敏感、无毒和相变的水凝胶材料,被证明是注射和喷雾医用敷料的有效选择。Ni3(HITP)2 MOF纳米材料可以被F127水凝胶有效封装,从而达到持续的长期治疗效果。毒性试验结果表明,Ni3(HITP)2 MOF纳米材料具有良好的生物安全性,对小鼠无明显的毒副作用。因此,Ni3(HITP)2 MOF纳米棒在生物医学领域具有广阔的应用前景,为伤口治疗提供了一种有效的解决方案。
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引用次数: 14
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