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The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)最新文献

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Liquid-liquid phase separator for synthesizing gold nanoparticles in toluene 用于在甲苯中合成金纳米颗粒的液-液相分离器
Ho-Cheng Lee, Che-Hsin Lin
It is challenging to separate the immiscible liquid of low surface tension from water using the microfluidic device. This study presents a microfluidic chip composed of a T-junction, reaction channel and a novel liquid-liquid phase separator for continuously synthesizing fine gold nanoparticles in the organic solvent of toluene. The designed glass chip is used to separate two immiscible liquids via with the microfluidic channels of different depths. The surface tension and the capillary force differences are used to separate the two immiscible fluids. The stable segmented flow is initially produced by the T-junction and the gold salt is then reduced due at the reaction channel. The toluene with reduced AuNPs is finally collected via the designed separator downstream. Results show that the separator is capable for separating water (surface tension = 72.75 mN/m) and toluene (surface tension = 30.9 mN/m) with 92% separation efficiency. Results indicate that the gold nanoparticle (AuNPs) synthesized in the microdevice exhibits a narrower size distribution and better dispersion, comparing to the typical batch synthesis process. This study develops an efficient microfluidic system for stable chemical reaction and liquid-liquid phase separation in the microchannel.
利用微流控装置将低表面张力的不混相液体与水分离是一个挑战。本研究提出了一种由t型结、反应通道和新型液液相分离器组成的微流控芯片,用于在甲苯有机溶剂中连续合成金纳米颗粒。所设计的玻璃芯片通过不同深度的微流控通道分离两种不混相液体。利用表面张力和毛细管力差来分离两种不混相流体。稳定的分段流最初由t型结产生,然后金盐在反应通道处被还原。还原后的甲苯最终通过设计的分离器在下游收集。结果表明,该分离器可分离水(表面张力为72.75 mN/m)和甲苯(表面张力为30.9 mN/m),分离效率为92%。结果表明,与典型的间歇合成工艺相比,在该微装置中合成的金纳米颗粒具有更窄的粒径分布和更好的分散性。本研究开发了一种高效的微流控系统,用于微通道内稳定的化学反应和液-液相分离。
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引用次数: 1
Nanorobotic processing of graphene for rapid device prototyping 石墨烯的纳米机器人加工用于快速器件原型设计
S. Zimmermann, S. A. Barragan, S. Fatikow
This paper presents a nanorobotic platform tailored for rapid prototyping of graphene based devices. Applying the capabilities of this platform, a nanorobotic strategy is proposed that enables the identification, electrical characterization and integration of graphene into device structures without using any time-consuming lithography procedures. In this way, graphene based devices can be fabricated and classified within few hours, significantly reducing the effort and consequently the costs of device prototyping. As an example of this strategy, graphene flakes are characterized and subsequently transferred onto trench structures resulting in partially suspended areas suitable to study graphene based nanoelectromechanical systems.
本文提出了一种为石墨烯基器件的快速原型设计量身定制的纳米机器人平台。利用该平台的功能,提出了一种纳米机器人策略,可以在不使用任何耗时的光刻程序的情况下,将石墨烯识别、电学表征和集成到器件结构中。通过这种方式,基于石墨烯的器件可以在几个小时内制造和分类,从而大大减少了器件原型制作的工作量和成本。作为该策略的一个例子,石墨烯薄片被表征并随后转移到沟槽结构上,从而形成适合研究基于石墨烯的纳米机电系统的部分悬浮区域。
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引用次数: 2
Silicon microspeaker with out-of-plane displacement 具有面外位移的硅微扬声器
C. Glacer, A. Dehé, D. Tumpold, R. Laur
In this paper a new way of increasing the enclosed air volume between the stator and the membrane of an electrostatic loudspeaker is introduced. Instead of using a thicker sacrificial layer, a stress-induced self-raising of the stator is utilized. Corrugation grooves in combination with highly tensile silicon nitride rings are causing a deflection of the stator after the release etch. For a stator diameter of 1 mm an out of plane deflection of up to 59 μm could be measured. On the electrical side, a pull-in voltage between 4 V and 16 V for the membrane and 27 V to 67 V for different stator variants was detected. In the free-field, a sound pressure level of 50 dB SPL at 10 kHz in 10 cm distance was measured for a small array. Variations of design and layout as well as technology parameters were varied to determine the ideal system with regard to maximum deflection, displaced volume and mechanical stability.
本文介绍了一种增加静电扬声器定子与膜间封闭风量的新方法。代替使用较厚的牺牲层,利用应力诱导的定子自升。波纹槽与高强度氮化硅环相结合,在释放蚀刻后引起定子的偏转。对于直径为1mm的定子,可以测量到最大59 μm的面外偏转。在电气方面,检测到膜的拉入电压在4 V到16 V之间,不同定子变体的拉入电压在27 V到67 V之间。在自由场中,测量了一个小型阵列在10 cm距离上的声压级,声压级为50 dB SPL。设计和布局的变化以及技术参数的变化,以确定关于最大挠度,位移体积和机械稳定性的理想系统。
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引用次数: 8
A microfluidic device for automatic embryo trapping and coculture with stromal cells in vitro 一种用于胚胎自动捕获及与基质细胞体外共培养的微流控装置
Chi-Fan Chen, Kuo-Wei Chang, Ting-Ru Yueh, Hong-Yuan Huang, Chen-Shien Liu
Nowadays, infertility is one of the major problems for many of married couples. Thus, there are a wide range of researches on infertility where the in vitro fertilization is the best known. However, the conventional approach to fertilize embryo requires more on manual operation times that may causes some damage of embryos. To overcome the drawback of conventional method, we present a microfluidic chip to trap cells and mimic a uterus in vitro by co-culturing stromal cells and mouse embryos. By dynamic resistance design, mouse embryos can be trapped individually. In this way, we can grow them by co-culturing with stromal cells in an open system with constant medium supply, known as dynamic perfusion. The novel method can reduce the manual operation and the possibility of damage to embryos. Also, the chip can track and manage individual embryos easily.
如今,不孕不育是许多已婚夫妇的主要问题之一。因此,对不孕症的研究范围很广,其中体外受精最为人所知。然而,传统的胚胎受精方法需要更多的人工操作时间,可能会对胚胎造成一定的损伤。为了克服传统方法的缺点,我们提出了一种微流控芯片,通过间质细胞和小鼠胚胎的共培养来捕获细胞并模拟体外子宫。通过动态阻力设计,可以单独捕获小鼠胚胎。通过这种方式,我们可以在一个开放的系统中与基质细胞共培养,培养基供应恒定,称为动态灌注。该方法减少了人工操作,减少了胚胎损伤的可能性。此外,该芯片可以很容易地跟踪和管理单个胚胎。
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引用次数: 0
Laser direct nano-structuring assisted by water droplets 水滴辅助激光直接纳米结构
Y. J. Chang, C. H. Chang, C. Ho, J. Hsu, C. Kuo
Nano-structuring using laser direct writing technology has shown a great potential for industrial applications. A novel application of water droplets to this technology is proposed in this paper. With a hydrophobic layer and a controlled substrate temperature, a layer of randomly distributed water droplets with a high contact angle is formed on the substrate. These liquid droplets can be used as lenses to enhance the laser intensity at the bottom of the droplets. As a result, nanoscale holes can be fabricated on the substrate by controlling the laser energy density. We successfully fabricate holes with a diameter of 600nm at a substrate temperature of 12°C and a power density of 1.2×108 mW/cm2 in our experiments.
利用激光直写技术制备纳米结构,显示出巨大的工业应用潜力。本文提出了一种将水滴应用于该技术的新方法。通过疏水层和控制衬底温度,在衬底上形成具有高接触角的随机分布的水滴层。这些液滴可以用作透镜,以增强液滴底部的激光强度。结果表明,通过控制激光能量密度,可以在衬底上制备纳米级孔。我们在衬底温度为12°C,功率密度为1.2×108 mW/cm2的条件下成功制备了直径为600nm的孔。
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引用次数: 0
Study on compatible CMOS-MEMS process with surface micromachining for the application of monolithic integration 面向单片集成应用的表面微加工兼容CMOS-MEMS工艺研究
D. Zhao, Xian Huang, Jun He, Li Zhang, Peng Liu, Fang Yang, Dacheng Zhang
In this work, compatible CMOS-MEMS process with surface micromachining is investigated. Surface micromachining method for cantilever fabrication has been merged with conventional CMOS process, and release of MEMS structure is conducted after CMOS process. We designed polysilicon MEMS structures as well as CMOS devices and circuits on a monolithic sensor chip for the investigation of the influence of stress induced by non-adequate post-CMOS annealing. The impact of step coverage and the releasing process on both the MEMS and CMOS components are also discussed.
本文研究了与表面微加工兼容的CMOS-MEMS工艺。将表面微加工方法与传统的CMOS工艺相结合,在CMOS工艺之后进行MEMS结构的释放。我们在单片传感器芯片上设计了多晶硅MEMS结构以及CMOS器件和电路,以研究CMOS后退火不充分引起的应力的影响。讨论了阶跃覆盖和释放过程对MEMS和CMOS元件的影响。
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引用次数: 0
A clogging-free microfluidic platform for size independent single cancer cellular electrical property characterization 一个无堵塞的微流控平台,用于大小无关的单个癌细胞电学特性表征
Song-Bin Huang, Yang Zhao, Deyong Chen, Yana Luo, Hsin-Chieh Lee, T. Chiu, Junbo Wang, Jing Chen, Min-Hsien Wu
This study reports a microfluidic platform for clogging-free electrical property analysis of cancer cells. A pneumatically-driven membrane-based active valve was integrated in this platform to unblock clogging events of constriction microchannels where pneumatic pressures were used to tune the deformation of a polydimethylsiloxan (PDMS) membrane serving as one wall of the constriction microchannel. The proposed platform was first used to unblock trapped polystyrene beads (30 μm in diameter) at the entrance of constriction microchannels and then the characterization of the cellular electrical properties of lung cancer cells was successfully demonstrated. Results showed that the measured cytoplasm conductivity (0.74±0.20 S/m) and specific membrane capacitance (2.17±0.58 μF/cm2) of cells were consistent with the results from the previous publications (0.73±0.17 S/m, and 2.00±0.60 μF/cm2, respectively). Overall, this study has presented a microfluidic platform for single cell analysis with an enhanced function for unblocking cell aggregates at the entrance of microchannels, which may function as a platform technology enabling cancer-cell electrical property characterization in the near future.
本研究报告了一种用于癌细胞无堵塞电学特性分析的微流控平台。该平台集成了一个气动驱动的基于膜的主动阀,用于疏通收缩微通道的堵塞事件,其中气动压力用于调节作为收缩微通道壁的聚二甲基硅氧烷(PDMS)膜的变形。该平台首先用于解封收缩微通道入口处的聚苯乙烯珠(直径30 μm),然后成功地证明了肺癌细胞的细胞电学特性。结果表明,细胞的胞质电导率(0.74±0.20 S/m)和比膜电容(2.17±0.58 μF/cm2)与文献结果(分别为0.73±0.17 S/m和2.00±0.60 μF/cm2)基本一致。总体而言,本研究提出了一种用于单细胞分析的微流控平台,该平台具有增强的功能,可以在微通道入口处解锁细胞聚集体,这可能在不久的将来成为一种平台技术,可以实现癌细胞电学特性的表征。
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引用次数: 0
The efficiency of transdermal α-Arbutin delivery after albumin microbubbles treatment with ultrasound in mice 超声处理白蛋白微泡后小鼠经皮α-熊果苷的传递效率
A. Liao, Wan-Chun Ma, H. Chuang, C. Yeh, Chih-Chung Huang
The application of transdermal delivery to a wider range of drugs is limited due to the significant barrier to penetration across the skin which is associated with the stratum corneum layer of the epidermis. In previous study in the literature, the feasibility and effects of the ultrasound (US) contrast agent, microbubbles (MBs) as the penetration enhancers for transdermal delivery in vivo were firstly demonstrated. In this study, the penetration depth, concentration, and efficiency of transdermal α-Arbutin delivery after MBs treatment with US in mice were demonstrated for 4 weeks. The penetration of α-arbutin on skin was enhanced by using ultrasound energy and MBs either for in vitro or for in vivo experiments. Experiment parameters were randomly divided into four groups (n=5 animals per group): (1) only penetrating α-Arbutin (C); (2) US combines with penetrating α-arbutin (U) (3) US combines with MBs contrast agent and penetrating α-arbutin (UB); (4) US combines with diluted MBs and penetrating α-arbutin (UBD). According to the results, the penetration depth of agarose phantom and pigskin of UBD group increase 47% and 84%, respectively. The in vitro skin permeation of 2% α-arbutin, UBD group was 83% greater than control group after 3 hour of permeation study. For in vivo study, the whitening effect (luminosity index) of mice skin in UBD group significantly increase 25% in one week, 34% in two weeks and tends towards stability in three weeks (37%) in C57BL/6J mice over a 4-week experimental period. Our results investigated that the treatments of ultrasound and MBs can increase skin permeability, enhance α-arbutin delivery to inhibit melanogenesis and not damage the skin in mice.
由于与表皮角质层有关的穿透皮肤的重大障碍,经皮给药在更大范围内的应用受到限制。在以往的文献研究中,首次论证了超声造影剂(US)、微泡(mb)作为促渗剂在体内经皮给药的可行性和效果。在本研究中,我们用US对小鼠MBs经皮递送α-熊果苷的渗透深度、浓度和效率进行了为期4周的观察。体外和体内实验均通过超声能和mb增强α-熊果苷在皮肤上的渗透。实验参数随机分为4组(每组n=5只):(1)只穿透α-熊果苷(C);(2) US与穿透性α-熊果苷(U)联用(3)US与MBs造影剂与穿透性α-熊果苷(UB)联用;(4) US与稀释的mb和穿透性α-熊果苷(UBD)结合。结果表明,UBD组琼脂糖幻膜和猪皮的穿透深度分别增加了47%和84%。2% α-熊果苷UBD组体外皮肤透性3 h后比对照组提高83%。在体内研究中,在4周的实验期内,UBD组小鼠皮肤的美白效果(亮度指数)在一周内显著提高25%,在两周内显著提高34%,在三周内趋于稳定(37%)。我们的研究结果表明,超声和MBs处理可增加小鼠皮肤通透性,增加α-熊果苷的递送,抑制黑色素生成,且不损伤皮肤。
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引用次数: 0
A low-noise CMOS interface circuit for resonant pressure sensor 一种用于谐振压力传感器的低噪声CMOS接口电路
Xiaodong Sun, W. Yuan, Sen Ren, Jinjun Deng, C. Jiang
This paper presents a low-noise CMOS interface circuit of the resonant pressure sensor. A high-frequency carrier is employed to extract the small vibration signal of the resonator and suppress the low-frequency coupling signal. A differential detection circuit is implemented to suppress common mode noise. Sensor chip is packaged together with the interface ASIC, reducing the coupling capacitor of the resonator and the sensing electrode. The AS IC is fabricated in a 0.18 um CMOS process and the sensor chip is fabricated using a commercially available silicon-on-insulator wafer. The test result shows that the resonant pressure sensor has a nonlinearity of 0.045%FS, a hysteresis error of 0.14%FS, and a repeatability error of 0.18%FS.
本文提出了一种低噪声的CMOS谐振压力传感器接口电路。利用高频载波提取谐振腔的小振动信号,抑制低频耦合信号。差分检测电路用于抑制共模噪声。传感器芯片与接口专用集成电路封装在一起,减少了谐振器与传感电极的耦合电容。AS IC采用0.18 um CMOS工艺制造,传感器芯片采用市售的绝缘体上硅晶圆制造。测试结果表明,谐振式压力传感器的非线性为0.045%FS,滞后误差为0.14%FS,重复性误差为0.18%FS。
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引用次数: 1
Silicon substrate strength enhancement depending on nanostructure morphology 硅衬底强度增强取决于纳米结构形态
Kunal Kashyap, Amarendra Kumar, Chung-Yao Yang, M. T. Hou, J. Yeh
Silicon nanostructures are extensively being researched for many different applications for industries. Here we present two different types of nanostructures, silicon nanoplates and nanoholes fabricated by electroless metal assisted wet etching for enhancing the bending strength by ~3.7 fold and ~6 fold respectively as compared to polished silicon samples which emphasize the dependence of bending strength on nanostructure morphologies. Roughness at the nanostructure bottom cause stress concentration to increase which degrades the bending strength. Moreover, this technology can open a pathway of flexible silicon substrates for flexible and bendable electronics.
硅纳米结构在许多不同的工业应用中得到了广泛的研究。在这里,我们提出了两种不同类型的纳米结构,硅纳米板和纳米孔由化学金属辅助湿法蚀刻制备,与抛光硅样品相比,它们的抗弯强度分别提高了3.7倍和6倍,强调了抗弯强度与纳米结构形态的依赖性。纳米结构底部的粗糙度导致应力集中增加,从而降低了抗弯强度。此外,该技术为柔性和可弯曲电子器件开辟了柔性硅衬底的途径。
{"title":"Silicon substrate strength enhancement depending on nanostructure morphology","authors":"Kunal Kashyap, Amarendra Kumar, Chung-Yao Yang, M. T. Hou, J. Yeh","doi":"10.1109/NEMS.2014.6908834","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908834","url":null,"abstract":"Silicon nanostructures are extensively being researched for many different applications for industries. Here we present two different types of nanostructures, silicon nanoplates and nanoholes fabricated by electroless metal assisted wet etching for enhancing the bending strength by ~3.7 fold and ~6 fold respectively as compared to polished silicon samples which emphasize the dependence of bending strength on nanostructure morphologies. Roughness at the nanostructure bottom cause stress concentration to increase which degrades the bending strength. Moreover, this technology can open a pathway of flexible silicon substrates for flexible and bendable electronics.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"13 1","pages":"390-393"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77263708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
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