The specificity of the medical profession, which involves constant communication with sufferers and their loved ones; the need to quickly master rapidly developing medical technologies and the digital environment; organizational and economic changes in the healthcare system that are increasingly intensifying the work of medical workers create a risk of expanding the scope and aggravation of the problem of professional burnout. The article presents an analysis of approaches to identifying signs and classifying the stages of professional burnout among medical workers, as well as methods for preventing and relieving this syndrome in domestic and foreign practice. In addition, the results of two mass surveys of medical specialists employed in the Moscow healthcare system, conducted at five-year intervals, are presented.