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Fatty acid composition of erythrocyte membranes in carries of rs174544 polymorphism of FADS1 gene and rs174583 polymorphism of FADS2 gene from central region of the Russian Federation before and after supplementation of their diet with ω-3 PUFAs 俄罗斯联邦中部地区 FADS1 基因 rs174544 多态性和 FADS2 基因 rs174583 多态性携带者在饮食中补充 ω-3 PUFAs 之前和之后红细胞膜的脂肪酸组成。
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-04-23 DOI: 10.1016/j.hnm.2024.200269
Nataliya Mikhailovna Shilina , Elena Yurievna Sorokina , Mariia Andreevna Makarenko , Vladimir Vladimirovich Bessonov
<div><p>Numerous publications have demonstrated that polymorphisms in <em>FADS1</em> and <em>FADS2</em> gene cluster influence the levels of long chain polyunsaturated fatty acids (LC PUFAs) synthesized in the body from essential precursors. They can be consumed through the diet as well. These LC PUFAs perform important plastic and regulatory functions in the body. The associations between the polymorphisms of <em>FADS</em> genes and the fatty acid (FA) composition of the body with some inflammatory and chronic diseases were shown. To date, very few studies in the Russian Federation researched the distribution of polymorphic variants in <em>FADS1</em> and <em>FADS2</em> genes and no studies examined the effects of these polymorphisms on the level of FAs in tissues.</p><p>So, the <em>purpose</em> of this paper was to study the frequency of genotypes and alleles of the <em>rs</em>174544 polymorphism of the <em>FADS1</em> gene and the <em>rs</em>174583 polymorphism of the <em>FADS2</em> gene and their influence on the FA composition of erythrocyte membranes in residents of the Central region of the Russian Federation (RF). Additionally, the effect of ω-3 PUFAs fortified food products on this composition was examined.</p></div><div><h3>Methods</h3><p>The study included 70 volunteers aged 23–69 years from Moscow region who provided informed consent. They were genotyped for <em>rs</em>174544 polymorphism of <em>FADS1</em> gene and <em>rs</em>174583 polymorphism of <em>FADS2</em> gene by real-time PCR. The participants of the study consumed fruit or vegetable smoothies enriched with either vegetable (chia seeds flour) or animal (fish oil flour) sources of ω-3 PUFAs for 1 month. The fatty acid composition of erythrocyte membranes in some of the volunteers was analysed using gas-chromatography before and after fortification of their diet with ω-3 PUFAs. Statistical analysis was performed using SPSS 23.</p></div><div><h3>Results</h3><p>The frequency of genotypes and alleles of polymorphisms studied were similar to those published for the European region. For <em>rs</em>174544, the genotype frequencies were CC (61%), CA (29%), and AA (10%), frequency of allele A was 24%. For <em>rs</em>174583, the genotype frequencies were CC (51%), CT (39%), and TT (10%), frequency of allele T was 29%. Carriers of minor alleles of both polymorphisms studied had significantly higher levels of ω-6 and ω-3 LC PUFAs in erythrocyte membranes compared to those carrying other genotypes. This differs from the results of other studies where carriers of minor alleles as were shown to be slow converters of precursors to LC PUFAs. The reason of the discrepancy was most likely associated with the obesity and dietary preferences of our study participants who carry the minor alleles. Over the period of one-month consumption of food sources providing an additional intake of either 2 g/day ω-3 PUFAs from fish oil or 6.5 g/day of ω-3 PUFAs from chia seed flour markedly reduced the incorpora
大量文献表明,FADS1 和 FADS2 基因簇的多态性会影响体内由必需前体合成的长链多不饱和脂肪酸(LC PUFAs)的含量。它们也可以通过饮食摄入。这些长链多不饱和脂肪酸在体内具有重要的塑性和调节功能。FADS 基因的多态性和体内脂肪酸(FA)组成与一些炎症和慢性疾病之间存在关联。迄今为止,俄罗斯联邦很少有研究对 FADS1 和 FADS2 基因多态性变异的分布进行研究,也没有研究探讨这些多态性对组织中脂肪酸水平的影响。因此,本文旨在研究俄罗斯联邦(RF)中部地区居民的 FADS1 基因 rs174544 多态性和 FADS2 基因 rs174583 多态性的基因型和等位基因的频率及其对红细胞膜中 FA 组成的影响。此外,还研究了ω-3 PUFAs 强化食品对该成分的影响。通过实时 PCR 对他们进行了 FADS1 基因 rs174544 多态性和 FADS2 基因 rs174583 多态性的基因分型。研究参与者在一个月内食用富含植物(奇亚籽粉)或动物(鱼油粉)来源ω-3 PUFA的水果或蔬菜冰沙。在膳食中添加ω-3 PUFAs前后,使用气相色谱法分析了部分志愿者红细胞膜的脂肪酸组成。结果所研究的多态性基因型和等位基因的频率与欧洲地区公布的频率相似。rs174544的基因型频率为CC(61%)、CA(29%)和AA(10%),等位基因A的频率为24%。rs174583的基因型频率为CC(51%)、CT(39%)和TT(10%),等位基因T的频率为29%。与携带其他基因型的人相比,两种多态性的小等位基因携带者的红细胞膜中ω-6和ω-3 LC PUFA的含量明显较高。这与其他研究结果不同,在其他研究中,小等位基因携带者被证明是低聚糖前体转化为低聚α烯烃的缓慢者。造成这种差异的原因很可能与携带小等位基因的研究参与者的肥胖和饮食偏好有关。在一个月的时间里,小等位基因携带者每天从鱼油中额外摄入 2 克ω-3 PUFAs 或从奇异籽粉中额外摄入 6.5 克ω-3 PUFAs 的食物来源明显减少了红细胞膜中ω-6 PUFAs 的掺入量。此外,红细胞膜中饱和棕榈酸的含量增加,明显改变了红细胞膜的脂肪酸组成。当饮食中添加ω-3 PUFAs 时,红细胞膜中的ω-6 PUFAs 含量会减少。这种减少有助于减少促炎性二十烷酸的形成,降低各种炎症和慢性疾病的风险,尤其是对所研究的基因多态性的小等位基因携带者而言。
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引用次数: 0
Prevalence of hyperuricemia and associated factors among pregnant women in Vietnam: A cross-sectional study 越南孕妇的高尿酸血症患病率及相关因素:横断面研究
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-06-08 DOI: 10.1016/j.hnm.2024.200277
Lieu Thi Thu Nguyen , Huyen Thu Doan , Hai Thanh Phan , Bach Viet Hoang , Khanh Nam Do , Dung Quang Nguyen , Anh Mai Thi Than , Huong Thi Le

Purpose

Hyperuricemia is a significant health concern worldwide. It is important to identify pregnant women who may be at risk to enhance pregnancy care. This study aims to investigate the prevalence of hyperuricemia and identify some factors associated with hyperuricemia among Vietnamese pregnant women.

Methods

In this cross-sectional study, 340 pregnant women were enrolled from May 2021 to December 2021. Demographic information, anthropometric data, and food frequency consumption (within 1 month before delivery) were collected from the participants. In addition, the biochemical indices of the participants were collected from medical records. Multivariate logistic regression was deployed to identify associated factors (p < 0.05).

Results

The prevalence of hyperuricemia was estimated at 20.3 %. Factors associated with hyperuricemia risk among Vietnamese pregnant women include eating red meat (aOR: 2.3), eating animal organs (aOR: 2.5), not meeting vegetable recommendations (aOR: 6.7), hyper-total cholesterol (aOR: 2.4), disease during pregnancy (aOR: 3.5) and gestational weight gain below recommendations (aOR: 0.2).

Conclusions

The prevalence of hyperuricemia among pregnant women was relatively high at the National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam. Consuming red meat and animal organs, not meeting vegetable recommendations, having high total cholesterol, and experiencing pregnancy-related diseases are the major factors associated with higher rates of hyperuricemia in this study.

目的 高尿酸血症是全球关注的重大健康问题。识别高危孕妇以加强孕期保健非常重要。本研究旨在调查越南孕妇中高尿酸血症的患病率,并确定与高尿酸血症相关的一些因素。方法在这项横断面研究中,从 2021 年 5 月至 2021 年 12 月共登记了 340 名孕妇。研究收集了参与者的人口统计学信息、人体测量数据和食物摄入频率(分娩前 1 个月内)。此外,还从医疗记录中收集了参与者的生化指标。结果高尿酸血症的患病率估计为 20.3%。与越南孕妇高尿酸血症风险相关的因素包括:吃红肉(aOR:2.3)、吃动物内脏(aOR:2.5)、不符合蔬菜建议(aOR:6.7)、总胆固醇过高(aOR:2.结论越南河内国立妇产科医院的孕妇高尿酸血症发病率相对较高。在这项研究中,食用红肉和动物内脏、不符合蔬菜推荐标准、总胆固醇过高以及妊娠相关疾病是导致高尿酸血症发病率较高的主要因素。
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引用次数: 0
The effect of giving sweet potato leaf-based functional drink to increase HB levels 给予红薯叶功能饮料以提高 HB 水平的效果
IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-06-28 DOI: 10.1016/j.hnm.2024.200280
Entin Jubaedah , Suratmi , Moh Hisyam Hermawan

Beckground

Menstruating young women experience twice as much iron loss as young men. One alternative effort that can be made is to provide functional drinks that are useful for overcoming anemia. Functional beverages must provide nutritional intake and sensory satisfaction, such as good taste and good texture, using sweet potato leaves (Ipomoea Batatas L). Sweet potato leaves are chosen as raw material because, besides being abundantly available and accessible to cultivate, they are also very cheap, so that they can reduce production costs. Pancalang Health Center is one of the Health Centers in the Kuningan Regency Area with reasonably high sweet potato cultivation.

Aims

This study aims to determine the level of compliance with functional drink consumption, determine hemoglobin levels before and after functional drink intervention, describe anemia status before and after functional drink intervention, describe the effects of functional drink consumption, and nutritional status picture before and after consuming functional drink products.

Research methode

The study was conducted by quasi-experiment in one group (nonrandomized pre-test and post-test without control group design). Purposive sampling was carried out by Purposive Sampling on adolescents at the Pancalang Health Center, Kuningan Regency. Data collection was done by checking HB levels before the intervention and after the intervention. The intervention is carried out for 52 days.

Results

and Conclussion: The majority of respondents were compliant in consuming functional drinks, and only 7.5 % were non-compliant. The median before the intervention is 11 and after the intervention is 12 and a p value of <0,001 is obtained, meaning that statistically there is a significant difference between HB before the intervention and after the intervention.

Contribution

There was a significant difference between Hb levels before the intervention and after the intervention, obtaining a p-value of <0.001.

Beckground月经期年轻女性的铁流失量是年轻男性的两倍。一种可供选择的方法是提供有助于克服贫血的功能性饮料。使用甘薯叶(Ipomoea Batatas L)制作的功能饮料必须能提供营养摄入和感官满足,如良好的口感和质地。之所以选择甘薯叶作为原料,是因为甘薯叶不仅资源丰富,易于种植,而且价格低廉,可以降低生产成本。本研究旨在确定饮用功能饮料的依从性水平,确定功能饮料干预前后的血红蛋白水平,描述功能饮料干预前后的贫血状况,描述饮用功能饮料的效果,以及饮用功能饮料产品前后的营养状况。在库宁甘地区的潘卡朗保健中心对青少年进行了有目的的抽样调查。数据收集是通过检查干预前和干预后的 HB 水平来完成的。干预为期 52 天:大多数受访者遵守饮用功能饮料的规定,只有 7.5%的受访者不遵守规定。干预前的中位数为 11,干预后的中位数为 12,P 值为 <0,001,这意味着干预前和干预后的 HB 存在显著差异。
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引用次数: 0
Association of hypertension with overweight and obesity among adults in Rangpur region of Bangladesh: A cross-sectional study 孟加拉国兰普尔地区成人高血压与超重和肥胖的关系:横断面研究
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-05-22 DOI: 10.1016/j.hnm.2024.200273
Sukanta Das

Background

Hypertension is a major public health concern in both developing and developed countries. However, there is a lack of hypertension research at the local level, particularly in the Rangpur region of Bangladesh.

Aim

The study aims to estimate the prevalence of hypertension as well as the specific association of hypertension with overweight and obesity among adults in the Rangpur region of Bangladesh.

Methods

This cross-sectional study was conducted in the Rangpur division of Bangladesh from July to September 2021. A total of 1302 individual data were collected by the simple random sampling method. A multivariate logistic regression model was used to identify the factors associated with hypertension. To show the strength of association, both the unadjusted Crude Odds Ratio (COR) and the Adjusted Odds Ratio (AOR) were reported with a 95 % confidence interval (CI).

Results

The overall prevalence of hypertension, overweight, and obesity in the sample population were 23.0 %, 40.6 %, and 7.0 %, respectively. The study identified a significant association between hypertension and overweight and obesity (p-value <0.001). Overweight adults had a 61 % higher risk of hypertension (AOR: 1.61; 95 % CI: 1.22–2.14), while the risk was 2.35 times higher for obese individuals (AOR: 2.35; 95 % CI: 1.43–3.87), compared to those with normal weight.

Conclusion

Given the high prevalence of hypertension in the study area, immediate public health initiatives are imperative. It is crucial to prioritize overweight and obesity as key factors in designing effective interventions for hypertension prevention and control.

背景高血压是发展中国家和发达国家的一个主要公共卫生问题。本研究旨在估算孟加拉国兰普尔地区成人高血压患病率以及高血压与超重和肥胖的具体关联。方法本横断面研究于 2021 年 7 月至 9 月在孟加拉国兰普尔省进行。研究采用简单随机抽样方法,共收集了 1302 个个体数据。研究采用多变量逻辑回归模型来确定与高血压相关的因素。为了显示关联的强度,报告了未经调整的粗略比值比(COR)和调整比值比(AOR)以及 95 % 的置信区间(CI)。研究发现,高血压与超重和肥胖之间存在明显关联(p 值为 0.001)。与体重正常者相比,超重成年人患高血压的风险高出 61%(AOR:1.61;95 % CI:1.22-2.14),而肥胖者患高血压的风险是正常人的 2.35 倍(AOR:2.35;95 % CI:1.43-3.87)。在设计预防和控制高血压的有效干预措施时,必须优先考虑超重和肥胖这一关键因素。
{"title":"Association of hypertension with overweight and obesity among adults in Rangpur region of Bangladesh: A cross-sectional study","authors":"Sukanta Das","doi":"10.1016/j.hnm.2024.200273","DOIUrl":"https://doi.org/10.1016/j.hnm.2024.200273","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension is a major public health concern in both developing and developed countries. However, there is a lack of hypertension research at the local level, particularly in the Rangpur region of Bangladesh.</p></div><div><h3>Aim</h3><p>The study aims to estimate the prevalence of hypertension as well as the specific association of hypertension with overweight and obesity among adults in the Rangpur region of Bangladesh.</p></div><div><h3>Methods</h3><p>This cross-sectional study was conducted in the Rangpur division of Bangladesh from July to September 2021. A total of 1302 individual data were collected by the simple random sampling method. A multivariate logistic regression model was used to identify the factors associated with hypertension. To show the strength of association, both the unadjusted Crude Odds Ratio (COR) and the Adjusted Odds Ratio (AOR) were reported with a 95 % confidence interval (CI).</p></div><div><h3>Results</h3><p>The overall prevalence of hypertension, overweight, and obesity in the sample population were 23.0 %, 40.6 %, and 7.0 %, respectively. The study identified a significant association between hypertension and overweight and obesity (p-value &lt;0.001). Overweight adults had a 61 % higher risk of hypertension (AOR: 1.61; 95 % CI: 1.22–2.14), while the risk was 2.35 times higher for obese individuals (AOR: 2.35; 95 % CI: 1.43–3.87), compared to those with normal weight.</p></div><div><h3>Conclusion</h3><p>Given the high prevalence of hypertension in the study area, immediate public health initiatives are imperative. It is crucial to prioritize overweight and obesity as key factors in designing effective interventions for hypertension prevention and control.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"37 ","pages":"Article 200273"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666149724000355/pdfft?md5=8b523e7f14553854e22a552e711294b5&pid=1-s2.0-S2666149724000355-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141096194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of distress on the nutritional status of patients with type 2 diabetes mellitus at the National Hospital of Endocrinology in 2022 困扰对 2022 年国立内分泌医院 2 型糖尿病患者营养状况的影响
IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI: 10.1016/j.hnm.2024.200278
Nguyen Phuong Thao , Bui Thi Cam Tra , Le Xuan Hung , Nguyen Trong Hung

Diabetes Mellitus (DM), particularly Type 2 Diabetes Mellitus (T2DM), is one of the most prevalent non-communicable chronic diseases and poses significant challenges for the healthcare sector and the community. Distress in patients with T2DM leads to severe physical and mental consequences. This study aims to analyze the relationship between distress and the nutritional status of T2DM patients. A cross-sectional descriptive study was conducted on 203 T2DM patients at the National Hospital of Endocrinology from October to December 2022. Of the participants, 54.2 % were female with an average age of 62.1 (±12.4). The waist circumference (WC) and waist-to-hip ratio (WHR) were significantly different between genders (p < 0.05). The prevalence of overweight/obesity was high at 46.7 %, with females having a 2.3 times higher WC and a 1.5 times higher WHR compared to males. The study identified several factors related to the nutritional status and distress in T2DM patients, including age, gender, residence, family history of T2DM, lifestyle habits, and nutritional status (p < 0.05). Early and comprehensive evaluation of T2DM patients is essential to improve treatment outcomes and quality of life.

糖尿病(DM),尤其是 2 型糖尿病(T2DM),是最普遍的非传染性慢性疾病之一,给医疗保健部门和社区带来了巨大挑战。T2DM 患者的苦恼会导致严重的身心后果。本研究旨在分析困扰与 T2DM 患者营养状况之间的关系。研究于 2022 年 10 月至 12 月期间在国家内分泌医院对 203 名 T2DM 患者进行了横断面描述性研究。参与者中,54.2%为女性,平均年龄为62.1(±12.4)岁。不同性别的腰围(WC)和腰臀比(WHR)有显著差异(P < 0.05)。超重/肥胖率高达 46.7%,女性的腰围和腰臀比分别是男性的 2.3 倍和 1.5 倍。研究发现了与 T2DM 患者营养状况和困扰有关的几个因素,包括年龄、性别、居住地、T2DM 家族史、生活习惯和营养状况(p < 0.05)。对 T2DM 患者进行早期全面评估对于改善治疗效果和生活质量至关重要。
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引用次数: 0
Evaluation of the on-diagnosis nutritional status of patients with gastric cancer via different nutritional assessment tools and their association with three-year mortality 通过不同的营养评估工具评估胃癌患者确诊时的营养状况及其与三年死亡率的关系
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-05-26 DOI: 10.1016/j.hnm.2024.200274
Zeinab Nikniaz, Mohammad Hossein Somi, Shahnaz Naghashi

Aim

This study aimed to evaluate the on-diagnosis nutritional status of patients with gastric cancer via different nutritional assessment tools and their association with three-year mortality.

Materials and method

In the present prospective study, 303 participants with GC, aged≥18 years old were included. The nutritional status assessment was performed after diagnosis and before initiation of any treatment using PG-SGA, NRS-2002, and MUST tests. All patients were followed up every six months for three years. The overall survival (OS) was calculated from the diagnosis date to the date of death or last visit.

Results

The prevalence of malnutrition was 74.6 %, 66.7 %, and 64.2 % according to NRS-2002, MUST, and PG-SGA tools respectively. There was a slight agreement between PG-SGA and NRS2002 and MUST; and NRS2002 and MUST. Considering the PG-SGA as a reference tool, the sensitivity for NRS2002 was high (83.5 %), but MUST showed low sensitivity (71.6 %). The specificity for both tests was low. There was a significant association between three-year mortality and patients at risk of malnutrition based on the PG-SGA tool (P = 0.04).

Conclusion

The present study showed the high prevalence of malnutrition in GC patients on admission. At diagnosis, PG-SGA should be applied to screen nutritional status, and based on this tool results, proper nutritional interventions should be implemented to improve nutritional status in patients with GC.

本研究旨在通过不同的营养评估工具评估胃癌患者确诊时的营养状况及其与三年死亡率的关系。在确诊后和开始任何治疗前,使用 PG-SGA、NRS-2002 和 MUST 测试进行营养状况评估。所有患者每六个月接受一次随访,为期三年。结果根据 NRS-2002、MUST 和 PG-SGA 工具,营养不良发生率分别为 74.6%、66.7% 和 64.2%。PG-SGA 与 NRS2002 和 MUST,以及 NRS2002 与 MUST 之间略有一致。将 PG-SGA 作为参考工具,NRS2002 的灵敏度较高(83.5%),但 MUST 的灵敏度较低(71.6%)。两种测试的特异性都很低。根据 PG-SGA 工具,三年死亡率与有营养不良风险的患者之间存在明显关联(P = 0.04)。诊断时应使用 PG-SGA 筛查营养状况,并根据该工具的结果实施适当的营养干预,以改善 GC 患者的营养状况。
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引用次数: 0
Influence of omega n-6/n-3 ratio on cardiovascular disease and nutritional interventions 欧米伽 n-6/n-3 比率对心血管疾病和营养干预的影响
IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-01 Epub Date: 2024-06-11 DOI: 10.1016/j.hnm.2024.200275
Maral Bishehkolaei , Yashwant Pathak

According to the World Health Organization (WHO), cardiovascular disease (CVD) is the number one cause of death globally. According to the Centers for Disease Control and Prevention (CDC), in 2022, nearly 8 in 10 individuals who suffered from a stroke showed a history of hypertension, and over 60 % of those with Diabetes have hypertension with high triglycerides and low-density lipoprotein (LDL, bad cholesterol). Both high LDL and Diabetes double the threat of CVD incidence, with the probability of all the previous risk factors being higher in adults who are overweight and obese. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio is critical to developing metabolic disorders that increase the risk of cardiovascular disease. The elaboration of the mechanisms by which n-6 and n-3 polyunsaturated fatty acids operate and convert to the essential fatty acids in the body will allow us to clearly understand the significance of the optimum ratio of the two. According to research, the human body can maintain optimum health with an intake ratio of n-6/n-3 of 5:1; however, the current ratio of n-6/n-3 PUFA intake is 20:1 in the Western diet. As the intake of n-6 PUFA heavy diet increases, we notice an incline in the incidence rate of metabolic syndromes through activating the inflammatory pathways. Omega 6 and omega 3 compete for the same enzyme binding site, and depending on which is bound, the resulting essential fatty acid signals a cascade of pro-inflammatory or anti-inflammatory factors. This review discusses the importance of the n-6/n-3 polyunsaturated fatty acid (PUFA) ratio in preventing, developing, and progressing cardiovascular disease.

世界卫生组织(WHO)指出,心血管疾病(CVD)是全球第一大死因。根据美国疾病控制和预防中心(CDC)的数据,2022 年,每 10 个中风患者中就有近 8 人有高血压病史,60% 以上的糖尿病患者有高血压、高甘油三酯和低密度脂蛋白(LDL,坏胆固醇)。高低密度脂蛋白和糖尿病都会使心血管疾病的发病率增加一倍,而超重和肥胖的成年人出现前述所有风险因素的概率更高。n-6/n-3多不饱和脂肪酸(PUFA)的比例对代谢紊乱的发展至关重要,而代谢紊乱会增加心血管疾病的风险。详细阐述 n-6 和 n-3 多不饱和脂肪酸在人体内的运作和转化为必需脂肪酸的机制,可以让我们清楚地了解这两种脂肪酸最佳比例的意义。根据研究,人体摄入的 n-6/n-3 的比例为 5:1,就能保持最佳健康状态;然而,目前西方饮食中 n-6/n-3 多不饱和脂肪酸的摄入比例为 20:1。随着 n-6 PUFA 摄入量的增加,我们注意到,通过激活炎症途径,代谢综合征的发病率呈上升趋势。欧米伽 6 和欧米伽 3 会竞争同一个酶结合位点,根据哪一个被结合,所产生的必需脂肪酸就会发出一连串促炎或抗炎因子的信号。本综述讨论了 n-6/n-3 多不饱和脂肪酸 (PUFA) 的比例在预防、发展和恶化心血管疾病中的重要性。
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引用次数: 0
Consumption of a variety of plant foods, ultra-processed foods, and risk for chronic disease: A dietary intervention 各种植物食品、超加工食品的摄入量与慢性病风险:膳食干预
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI: 10.1016/j.hnm.2024.200258
Anaya Mitra , Kathy Thames , Anna Brown , Isabelle Shuster , Molly Rosenfield , Megan D. Baumler

Background

The reliance on ultra-processed foods (UPF) as a source of energy has increased over the last decade. Consumption of UPF is associated with increased calorie intake and increased risk for chronic disease. An intentional increase of a variety of non-ultra-processed plant foods may decrease UPF intake and reduce risk for chronic disease.

Methods

The objective of this study was to determine whether an intervention to increase in the number of varieties of non-ultra-processed plant foods consumed each week along with grocery reimbursement was associated with reduced intake of UPF and reduced risk of chronic disease. An 8-week dietary intervention with the intention for subjects (22 were recruited and started the study, while 19 subjects completed the study) to consume at least 30 varieties of non-ultra-processed plant foods per week was conducted. Subjects watched a weekly educational module, received recipes and grocery lists, and received reimbursement for non-ultra-processed plant foods that were purchased. Diet assessments were conducted by 24-h recall and 3-day diet records. Fasting plasma glucose, C-reactive protein, LDL and HDL cholesterol, and anthropomorphic measurements were assessed at four time points.

Results

The number of different types of non-ultra-processed plant foods consumed each week was significantly increased after the 8-week intervention compared to before (34.7 ± 10.8 vs 23.1 ± 12.1; p < 0.001). The number of ultra-processed foods consumed per day was significantly lower during the intervention compared to the control period (5.32 ± 1.65 vs 6.54 ± 2.04; p = 0.02). There were no significant changes to biochemical or anthropomorphic following the 8-week intervention.

Discussion

Educating individuals on the importance of the variety of plant foods intake along with reducing the financial barrier for purchasing plant foods may be an effective way to reduce reliance on ultra-processed foods. More research is needed to determine whether an increase in varieties of plant foods and reduction in ultra-processed food intake impacts risk for chronic disease.

背景过去十年来,人们越来越依赖超加工食品(UPF)作为能量来源。摄入超高加工食品与热量摄入增加和慢性病风险增加有关。本研究的目的是确定每周增加非超高加工植物性食品品种的干预措施是否与减少超高加工食品摄入量和降低慢性病风险有关。研究人员对受试者(22 名受试者被招募并开始研究,19 名受试者完成研究)进行了为期 8 周的饮食干预,目的是让他们每周至少摄入 30 种未经过度加工的植物性食品。受试者每周观看一个教育模块,获得食谱和杂货清单,并在购买非超高加工植物食品时获得报销。饮食评估通过 24 小时回忆和 3 天饮食记录进行。在四个时间点对空腹血浆葡萄糖、C 反应蛋白、低密度脂蛋白和高密度脂蛋白胆固醇以及人体形态测量进行评估。结果与干预前相比,干预 8 周后每周摄入不同类型的非超标加工植物食品的数量显著增加(34.7 ± 10.8 vs 23.1 ± 12.1; p <0.001)。与对照组相比,干预期间每天摄入的超加工食品数量明显减少(5.32 ± 1.65 vs 6.54 ± 2.04;p = 0.02)。讨论教育个人认识到摄入多种植物食品的重要性,同时减少购买植物食品的经济障碍,可能是减少对超加工食品依赖的有效方法。还需要进行更多的研究,以确定增加植物食品的种类和减少超加工食品的摄入量是否会影响慢性疾病的风险。
{"title":"Consumption of a variety of plant foods, ultra-processed foods, and risk for chronic disease: A dietary intervention","authors":"Anaya Mitra ,&nbsp;Kathy Thames ,&nbsp;Anna Brown ,&nbsp;Isabelle Shuster ,&nbsp;Molly Rosenfield ,&nbsp;Megan D. Baumler","doi":"10.1016/j.hnm.2024.200258","DOIUrl":"10.1016/j.hnm.2024.200258","url":null,"abstract":"<div><h3>Background</h3><p>The reliance on ultra-processed foods (UPF) as a source of energy has increased over the last decade. Consumption of UPF is associated with increased calorie intake and increased risk for chronic disease. An intentional increase of a variety of non-ultra-processed plant foods may decrease UPF intake and reduce risk for chronic disease.</p></div><div><h3>Methods</h3><p>The objective of this study was to determine whether an intervention to increase in the number of varieties of non-ultra-processed plant foods consumed each week along with grocery reimbursement was associated with reduced intake of UPF and reduced risk of chronic disease. An 8-week dietary intervention with the intention for subjects (22 were recruited and started the study, while 19 subjects completed the study) to consume at least 30 varieties of non-ultra-processed plant foods per week was conducted. Subjects watched a weekly educational module, received recipes and grocery lists, and received reimbursement for non-ultra-processed plant foods that were purchased. Diet assessments were conducted by 24-h recall and 3-day diet records. Fasting plasma glucose, C-reactive protein, LDL and HDL cholesterol, and anthropomorphic measurements were assessed at four time points.</p></div><div><h3>Results</h3><p>The number of different types of non-ultra-processed plant foods consumed each week was significantly increased after the 8-week intervention compared to before (34.7 ± 10.8 vs 23.1 ± 12.1; p &lt; 0.001). The number of ultra-processed foods consumed per day was significantly lower during the intervention compared to the control period (5.32 ± 1.65 vs 6.54 ± 2.04; p = 0.02). There were no significant changes to biochemical or anthropomorphic following the 8-week intervention.</p></div><div><h3>Discussion</h3><p>Educating individuals on the importance of the variety of plant foods intake along with reducing the financial barrier for purchasing plant foods may be an effective way to reduce reliance on ultra-processed foods. More research is needed to determine whether an increase in varieties of plant foods and reduction in ultra-processed food intake impacts risk for chronic disease.</p></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"36 ","pages":"Article 200258"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666149724000203/pdfft?md5=108d5849d7b3c3ee59893ecfc1a6d055&pid=1-s2.0-S2666149724000203-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140082962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between overweight/obesity perception, actual body weight and cardiometabolic risk among healthy Ghanaian adults 加纳健康成年人对超重/肥胖的认知、实际体重与心脏代谢风险之间的关系
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-01 Epub Date: 2024-02-18 DOI: 10.1016/j.hnm.2024.200253
Abdul-Malik Bawah , Annan Reginald A , Haadi Abdul-Rahman

Background

The global rise in obesity, particularly among black Africans in developing nations experiencing nutritional transitions, underscores the importance of exploring Overweight/Obesity Perception (OP) as a crucial factor in maintaining an optimal body weight. Incorrect body image perception may impede efforts to achieve the desired body weight, leading to adverse outcomes related to Cardiometabolic Diseases (CMD). This cross-sectional study investigated the interplay between overweight/obesity perception, actual body weight, and CMD risk in a cohort of healthy Ghanaian adults.

Methods

A total of 302 apparently healthy adults, aged 25–60 years, with Dagomba ancestry, were recruited from three communities. Participants were screened based on age, ancestry, history of communicable and Non-Communicable Diseases (NCD), and use of antidiabetic, lipid-lowering, and antihypertensive drugs. Anthropometric assessments and blood sample collections for biochemical analysis were conducted. Body image perception was measured using the Stunkard Figure Rating Scale (SFRS). Data were analyzed using descriptive statistics, chi-square tests, correlation analysis, logistic regression, and multivariate analysis.

Results

Participants had a mean age of 38.28 ± 10.88, with 61.6% being women. While 47% accurately perceived their body weight, 53% had incorrect perceptions. Notably, 47.2% underestimated and 8.5% overestimated their weight status. Among overweight individuals, 33% underestimated and 9.4% overestimated their weight, whereas among the obese, 66.7% and 33.3% respectively had inaccurate perceptions. Gender, serum triglyceride levels, and waist circumference were significantly associated with weight perception. About 55% of overweight/obese participants and 62.1% with high waist circumference did not express a desire to lose weight. Multiple logistic regression revealed that both overweight (AOR = 6, 95% CI (1.8–20.2), p < 0.05) and obesity (AOR = 20.5, 95% CI (5–84.9), p < 0.05) significantly increased the odds of CMD.

Conclusion

The findings underscore the association between overweight/obesity and an elevated risk of CMD. This emphasizes the imperative for public health interventions aimed at promoting an ideal body weight and highlighting the impact of overweight/obesity on CMD risk factors.

背景肥胖症在全球范围内呈上升趋势,尤其是在经历营养转型的发展中国家的非洲黑人中,这凸显了探讨超重/肥胖感知(OP)作为保持最佳体重的关键因素的重要性。不正确的身体形象认知可能会阻碍实现理想体重的努力,从而导致与心脏代谢疾病(CMD)相关的不良后果。这项横断面研究调查了加纳健康成年人队列中超重/肥胖认知、实际体重和 CMD 风险之间的相互作用。根据年龄、血统、传染病和非传染性疾病(NCD)病史以及抗糖尿病、降血脂和降血压药物的使用情况对参与者进行筛选。此外,还进行了人体测量评估和血液样本采集以进行生化分析。身体形象感知采用斯通卡德体型评定量表(SFRS)进行测量。采用描述性统计、卡方检验、相关分析、逻辑回归和多变量分析对数据进行了分析。47%的人对自己的体重感知准确,53%的人感知错误。值得注意的是,47.2%的人低估了自己的体重状况,8.5%的人高估了自己的体重状况。在超重者中,33%的人低估了自己的体重,9.4%的人高估了自己的体重,而在肥胖者中,分别有66.7%和33.3%的人对自己的体重认知不准确。性别、血清甘油三酯水平和腰围与体重感知显著相关。约 55% 的超重/肥胖参与者和 62.1% 的高腰围者没有表达过减肥的愿望。多重逻辑回归显示,超重(AOR = 6,95% CI (1.8-20.2),p < 0.05)和肥胖(AOR = 20.5,95% CI (5-84.9),p < 0.05)都会明显增加患慢性阻塞性肺病的几率。研究结果强调了超重/肥胖与慢性阻塞性肺病风险升高之间的关系,这就强调了必须采取公共卫生干预措施,以促进理想体重,并强调超重/肥胖对慢性阻塞性肺病风险因素的影响。
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引用次数: 0
Paleolithic diet as a potential dietary management option for type 2 diabetes: A scoping review 将旧石器时代饮食作为治疗 2 型糖尿病的潜在饮食管理方案:范围综述
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-06-01 Epub Date: 2024-04-10 DOI: 10.1016/j.hnm.2024.200264
Ruolin Yan , Jimmy Chun Yu Louie

Background and aims

Despite its prevalence in the media, uncertainty surrounds the effectiveness of the paleolithic diet for the management of type 2 diabetes. Our scoping review aims to assess the efficacy of the paleolithic diet in managing body weight, glycemia, and lipidemia in comparison to recommended diets for type 2 diabetes management.

Methods and results

We conducted searches in Medline, Scopus, Embase, and CINAHL to identify pertinent randomized controlled trials up to Mar 2024. Our review incorporated 3 reports from 2 randomized controlled trials involving 37 Caucasian participants. Comparative analysis of the paleolithic diet against recommended diabetic diets revealed encouraging outcomes, manifesting in the improvement of glycemic and lipid profiles in type 2 diabetes patients. However, there were mixed results in high-density lipoprotein cholesterol and triglyceride levels.

Conclusions

Paleolithic diet hints at potentially favorable effects on type 2 diabetes, but evidence is severely limited. Rigorously designed larger trials evaluating distinct paleolithic diets on clinical outcomes while monitoring safety and feasibility are critically needed before making recommendations.

Registration

This scoping review has been registered at https://www.crd.york.ac.uk/prospero as CRD42021226788.

背景和目的尽管旧石器时代饮食在媒体上很常见,但其对 2 型糖尿病的治疗效果仍存在不确定性。我们的范围综述旨在评估与 2 型糖尿病管理推荐饮食相比,旧石器时代饮食在控制体重、血糖和脂质血症方面的功效。我们的综述纳入了来自 2 项随机对照试验的 3 份报告,这些试验涉及 37 名白种人。将旧石器时代饮食与推荐的糖尿病饮食进行比较分析,结果令人鼓舞,2 型糖尿病患者的血糖和血脂状况得到改善。然而,在高密度脂蛋白胆固醇和甘油三酯水平方面,结果不一。在提出建议之前,亟需进行严格设计的大型试验,评估不同的旧石器时代饮食对临床结果的影响,同时监测其安全性和可行性。注册本范围界定综述已在 https://www.crd.york.ac.uk/prospero 注册,编号为 CRD42021226788。
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引用次数: 0
期刊
Human Nutrition and Metabolism
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