Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102044
Bochen Zhao , Zeqin Xin , Yi-Chi Wang , Chenghui Wu , Wenxin Wang , Run Shi , Ruixuan Peng , Yonghuang Wu , Longlong Xu , Ting Pan , Zonglin Li , Lin Gu , Kai Liu
Two-dimensional (2D) transition-metal dichalcogenide (TMDC)-based artificial synaptic devices are promising for neuromorphic computing. However, 2D TMDCs are difficult to heavily dope reversibly, which limits their resistive switching performances. Inspired by the biological gas-receptor signaling pathway, we report a gas (H2O)-receptor (defect) synergistic interaction (GRSI) mechanism to greatly enhance the resistive switching capabilities of 2D TMDC-based memristors by over 10,000 times. Employing the GRSI, the synaptic device emulates multiple synaptic plasticities and exhibits outstanding long-term potentiation and depression with a large dynamic range (>200), multiple resistance states (28 levels), and ultralow programming/reading powers (Pprog < 100 pW, Pread < 1 pW). As an artificial nociceptor, the device precisely simulates characteristic behaviors of biological nociceptors. More importantly, the GRSI is universally applicable to various 2D TMDCs including MoS2, WS2, SnS2, and ReS2. This work provides a bioinspired solution to high-performance, multifunctional 2D neuromorphic devices, stepping further toward their practical applications.
{"title":"Bioinspired gas-receptor synergistic interaction for high-performance two-dimensional neuromorphic devices","authors":"Bochen Zhao , Zeqin Xin , Yi-Chi Wang , Chenghui Wu , Wenxin Wang , Run Shi , Ruixuan Peng , Yonghuang Wu , Longlong Xu , Ting Pan , Zonglin Li , Lin Gu , Kai Liu","doi":"10.1016/j.matt.2025.102044","DOIUrl":"10.1016/j.matt.2025.102044","url":null,"abstract":"<div><div>Two-dimensional (2D) transition-metal dichalcogenide (TMDC)-based artificial synaptic devices are promising for neuromorphic computing. However, 2D TMDCs are difficult to heavily dope reversibly, which limits their resistive switching performances. Inspired by the biological gas-receptor signaling pathway, we report a gas (H<sub>2</sub>O)-receptor (defect) synergistic interaction (GRSI) mechanism to greatly enhance the resistive switching capabilities of 2D TMDC-based memristors by over 10,000 times. Employing the GRSI, the synaptic device emulates multiple synaptic plasticities and exhibits outstanding long-term potentiation and depression with a large dynamic range (>200), multiple resistance states (2<sup>8</sup> levels), and ultralow programming/reading powers (<em>P</em><sub>prog</sub> < 100 pW, <em>P</em><sub>read</sub> < 1 pW). As an artificial nociceptor, the device precisely simulates characteristic behaviors of biological nociceptors. More importantly, the GRSI is universally applicable to various 2D TMDCs including MoS<sub>2</sub>, WS<sub>2</sub>, SnS<sub>2</sub>, and ReS<sub>2</sub>. This work provides a bioinspired solution to high-performance, multifunctional 2D neuromorphic devices, stepping further toward their practical applications.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102044"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the natural world, microorganisms constantly navigate through confined spaces—such as those found in tissues, biological gels, and soil—yet their behavior in such environments remains poorly understood. Here, we explore this phenomenon by examining the navigation of magnetic microalgal biohybrids in constrained microenvironments. By leveraging the inherent propulsion of green microalgae and external steering capabilities acquired through the magnetization of microalgal cells, our biohybrids exhibit efficient navigation in viscous and confined microenvironments. Through high-yield fabrication and magnetic manipulation, we show precise control over their movement. Our findings reveal distinct navigation patterns influenced by magnetic guidance, namely backtracking and crossing, shedding light on the unexplored dynamics of confined locomotion assisted by magnetism. Our work highlights the significance of understanding microalgal biohybrid swimming behavior, offering crucial insights for future biotechnological and biomedical applications requiring precise navigation in confined environments.
{"title":"Navigating microalgal biohybrids through confinements with magnetic guidance","authors":"Mukrime Birgul Akolpoglu , Saadet Fatma Baltaci , Ugur Bozuyuk , Selcan Karaz , Metin Sitti","doi":"10.1016/j.matt.2025.102052","DOIUrl":"10.1016/j.matt.2025.102052","url":null,"abstract":"<div><div>In the natural world, microorganisms constantly navigate through confined spaces—such as those found in tissues, biological gels, and soil—yet their behavior in such environments remains poorly understood. Here, we explore this phenomenon by examining the navigation of magnetic microalgal biohybrids in constrained microenvironments. By leveraging the inherent propulsion of green microalgae and external steering capabilities acquired through the magnetization of microalgal cells, our biohybrids exhibit efficient navigation in viscous and confined microenvironments. Through high-yield fabrication and magnetic manipulation, we show precise control over their movement. Our findings reveal distinct navigation patterns influenced by magnetic guidance, namely backtracking and crossing, shedding light on the unexplored dynamics of confined locomotion assisted by magnetism. Our work highlights the significance of understanding microalgal biohybrid swimming behavior, offering crucial insights for future biotechnological and biomedical applications requiring precise navigation in confined environments.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102052"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102042
Punit Kumar , David H. Cook , Wenqing Wang , Madelyn Payne , Pedro P.P.O. Borges , Andrew M. Minor , Mark Asta , Robert O. Ritchie
Atomic structure and electronic state influence deformation mechanisms in traditional and high-entropy alloys (HEAs). In HEAs, nature and scale differ from those of traditional alloys due to lattice distortion and variations in local chemistry resulting from large concentrations of multiple principal elements. In CrCoNi, a face-centered cubic (fcc) HEA, dislocation dissociation, nanotwinning, and transformation-induced plasticity are promoted at cryogenic temperatures (<77 K). In Nb45Ta25Ti15Hf15, a body-centered cubic (bcc) HEA, screw dislocations, twinning, and kink band formation are activated at temperatures ranging from 77 to 1,473 K. These deformation mechanisms impart exceptionally high fracture resistance in CrCoNi and Nb45Ta25Ti15Hf15. However, their tensile stress-strain curves differ significantly at these temperatures; while CrCoNi exhibits extensive strain hardening, Nb45Ta25Ti15Hf15 demonstrates nearly elastic, perfectly plastic stress-strain behavior. Understanding the origin of the high fracture resistance of these alloys, despite their contrasting stress-strain behavior, would enable the discovery of HEAs suitable for applications in extreme environments.
原子结构和电子状态会影响传统合金和高熵合金（HEAs）的变形机制。在高熵合金中，由于晶格畸变和多种主要元素大量聚集导致的局部化学变化，其性质和规模与传统合金不同。铬钴镍是一种面心立方（fcc）HEA，在低温（77 K）条件下会产生位错解离、纳米孪晶和转化诱导塑性。在 Nb45Ta25Ti15Hf15（体心立方（bcc）HEA）中，螺位错、孪晶和扭结带的形成在 77 至 1,473 K 的温度范围内被激活。然而，它们在这些温度下的拉伸应力-应变曲线却有很大不同；铬钴镍表现出广泛的应变硬化，而铌45Ta25Ti15Hf15则表现出近乎弹性的完全塑性应力-应变行为。尽管这些合金的应力应变行为截然不同，但了解它们具有高抗断裂性的原因将有助于发现适合极端环境应用的 HEA。
{"title":"Fracture behavior of high-entropy alloys: Resistance to fracture from strain hardening and softening","authors":"Punit Kumar , David H. Cook , Wenqing Wang , Madelyn Payne , Pedro P.P.O. Borges , Andrew M. Minor , Mark Asta , Robert O. Ritchie","doi":"10.1016/j.matt.2025.102042","DOIUrl":"10.1016/j.matt.2025.102042","url":null,"abstract":"<div><div>Atomic structure and electronic state influence deformation mechanisms in traditional and high-entropy alloys (HEAs). In HEAs, nature and scale differ from those of traditional alloys due to lattice distortion and variations in local chemistry resulting from large concentrations of multiple principal elements. In CrCoNi, a face-centered cubic (<em>fcc</em>) HEA, dislocation dissociation, nanotwinning, and transformation-induced plasticity are promoted at cryogenic temperatures (<77 K). In Nb<sub>45</sub>Ta<sub>25</sub>Ti<sub>15</sub>Hf<sub>15</sub>, a body-centered cubic (<em>bcc</em>) HEA, screw dislocations, twinning, and kink band formation are activated at temperatures ranging from 77 to 1,473 K. These deformation mechanisms impart exceptionally high fracture resistance in CrCoNi and Nb<sub>45</sub>Ta<sub>25</sub>Ti<sub>15</sub>Hf<sub>15</sub>. However, their tensile stress-strain curves differ significantly at these temperatures; while CrCoNi exhibits extensive strain hardening, Nb<sub>45</sub>Ta<sub>25</sub>Ti<sub>15</sub>Hf<sub>15</sub> demonstrates nearly elastic, perfectly plastic stress-strain behavior. Understanding the origin of the high fracture resistance of these alloys, despite their contrasting stress-strain behavior, would enable the discovery of HEAs suitable for applications in extreme environments.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102042"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102010
Il Woo Ock , Zhaoqi Duan , Jing Xu , Xun Zhao , Jun Chen
The direction and frequency drift of ocean waves presents considerable challenges to existing platform technologies to utilize such energy. Here, we present a starfish-inspired magnetoelastic generator (MEG) array floating on the ocean surface, efficiently converting irregular ocean wave fluctuations into electricity for sustainable water splitting and hydrogen (H2) fuel production. Within the starfish-inspired MEG array system, each MEG unit that harnesses the magnetoelastic effect to efficiently convert local ocean wave energy into electricity with a voltage of 12.52 mV cm⁻2 and a current of 0.24 mA cm⁻2 at 2 Hz. By integrating eight such units onto the tube feet, the starfish-inspired system achieved a maximum peak voltage of 4.33 V, charged a capacitor to 2.42 V within 80 s and electrolyzed the water to continuously produce H2 at a rate of 1.18 μL min⁻1. The starfish-inspired MEG array is a milestone for ocean wave energy harvesting, promoting H2 economics and carbon neutrality.
海洋波浪的方向和频率漂移给利用这种能量的现有平台技术带来了巨大挑战。在这里，我们展示了一种受海星启发的磁弹性发电机（MEG）阵列，它漂浮在海面上，能有效地将不规则的海浪波动转化为电能，用于可持续的水分离和氢（H2）燃料生产。在受海星启发的 MEG 阵列系统中，每个 MEG 单元都能利用磁弹性效应有效地将局部海浪能量转化为电能，电压为 12.52 mV cm-2，电流为 0.24 mA cm-2，频率为 2 Hz。通过在管脚上集成八个这样的单元，受海星启发的系统获得了 4.33 V 的最大峰值电压，在 80 秒内将电容器充电至 2.42 V，并以 1.18 μL min-1 的速率连续电解水以产生 H2。受海星启发的 MEG 阵列是海洋波浪能收集的一个里程碑，促进了 H2 经济性和碳中和。
{"title":"Starfish-inspired magnetoelastic generator array for ocean wave energy harvesting","authors":"Il Woo Ock , Zhaoqi Duan , Jing Xu , Xun Zhao , Jun Chen","doi":"10.1016/j.matt.2025.102010","DOIUrl":"10.1016/j.matt.2025.102010","url":null,"abstract":"<div><div>The direction and frequency drift of ocean waves presents considerable challenges to existing platform technologies to utilize such energy. Here, we present a starfish-inspired magnetoelastic generator (MEG) array floating on the ocean surface, efficiently converting irregular ocean wave fluctuations into electricity for sustainable water splitting and hydrogen (H<sub>2</sub>) fuel production. Within the starfish-inspired MEG array system, each MEG unit that harnesses the magnetoelastic effect to efficiently convert local ocean wave energy into electricity with a voltage of 12.52 mV cm⁻<sup>2</sup> and a current of 0.24 mA cm⁻<sup>2</sup> at 2 Hz. By integrating eight such units onto the tube feet, the starfish-inspired system achieved a maximum peak voltage of 4.33 V, charged a capacitor to 2.42 V within 80 s and electrolyzed the water to continuously produce H<sub>2</sub> at a rate of 1.18 μL min⁻<sup>1</sup>. The starfish-inspired MEG array is a milestone for ocean wave energy harvesting, promoting H<sub>2</sub> economics and carbon neutrality.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102010"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102003
Samuel W. Ong , Simon A. Agnew , Md Saifur Rahman , William J. Scheideler
Two-dimensional (2D) metal oxide semiconductors offer a superlative combination of high electron mobility and visible-range transparency uniquely suitable for flexible transparent electronics. Synthesis of these ultrathin (<3 nm) semiconductors by Cabrera-Mott oxidation of liquid metals could enable emerging device applications but requires the precise design of their electrostatics at the nanoscale. This study demonstrates sub-nanometer-level control over the thickness of semiconducting 2D antimony-doped indium oxide (AIO) by manipulating the kinetics of Cabrera-Mott oxidation through variable-speed liquid metal printing at plastic-compatible temperatures (175°C). By modulating both the growth kinetics and doping, we engineer the conductivity and crystallinity of AIO for integration in ultrathin channel transistors exhibiting exceptional steep turn-on, on-off ratios > 106 and an outstanding average mobility of 34.7 ± 12.9 cm2/Vs. This result shows the potential for kinetically controlling 2D oxide synthesis for various high-performance optoelectronic device applications.
{"title":"Sub-nm kinetically controlled liquid metal printing of ternary antimony indium oxide transistors","authors":"Samuel W. Ong , Simon A. Agnew , Md Saifur Rahman , William J. Scheideler","doi":"10.1016/j.matt.2025.102003","DOIUrl":"10.1016/j.matt.2025.102003","url":null,"abstract":"<div><div>Two-dimensional (2D) metal oxide semiconductors offer a superlative combination of high electron mobility and visible-range transparency uniquely suitable for flexible transparent electronics. Synthesis of these ultrathin (<3 nm) semiconductors by Cabrera-Mott oxidation of liquid metals could enable emerging device applications but requires the precise design of their electrostatics at the nanoscale. This study demonstrates sub-nanometer-level control over the thickness of semiconducting 2D antimony-doped indium oxide (AIO) by manipulating the kinetics of Cabrera-Mott oxidation through variable-speed liquid metal printing at plastic-compatible temperatures (175°C). By modulating both the growth kinetics and doping, we engineer the conductivity and crystallinity of AIO for integration in ultrathin channel transistors exhibiting exceptional steep turn-on, on-off ratios > 10<sup>6</sup> and an outstanding average mobility of 34.7 ± 12.9 cm<sup>2</sup>/Vs. This result shows the potential for <em>kinetically</em> controlling 2D oxide synthesis for various high-performance optoelectronic device applications.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102003"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102061
Shixing Yuan , Lei Wei
To address the challenges of scalability and customization in manufacturing textile electronics, recent innovations have introduced a patterned graphene fabrication approach combining transfer printing and laser engraving. This technique demonstrates broad fabric compatibility and low device resistance, providing suitable paradigms for developing integrated fabric-based electronics.
{"title":"Engraving patterned graphene for fabric-integrated electronics","authors":"Shixing Yuan , Lei Wei","doi":"10.1016/j.matt.2025.102061","DOIUrl":"10.1016/j.matt.2025.102061","url":null,"abstract":"<div><div>To address the challenges of scalability and customization in manufacturing textile electronics, recent innovations have introduced a patterned graphene fabrication approach combining transfer printing and laser engraving. This technique demonstrates broad fabric compatibility and low device resistance, providing suitable paradigms for developing integrated fabric-based electronics.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102061"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102062
Saimeng Li , Junwei Liu , Vakhobjon Kuvondikov , Jinyue Yan , Long Ye
Intrinsically stretchable organic photovoltaics (IS-OPVs) are poised to revolutionize wearable and flexible electronics by combining mechanical robustness with high power conversion efficiency. Writing in Joule, researchers introduced new IS-OPVs that retain over 80% of their initial efficiency under 50% strain and exhibit an increase in power output when strained to 40%, marking a remarkable improvement over conventional photovoltaic cells, which typically experience efficiency degradation and failure when stretched. This approach could inspire the next wave of stretchable electronics.
{"title":"Organic photovoltaics generate more power under stretching","authors":"Saimeng Li , Junwei Liu , Vakhobjon Kuvondikov , Jinyue Yan , Long Ye","doi":"10.1016/j.matt.2025.102062","DOIUrl":"10.1016/j.matt.2025.102062","url":null,"abstract":"<div><div>Intrinsically stretchable organic photovoltaics (IS-OPVs) are poised to revolutionize wearable and flexible electronics by combining mechanical robustness with high power conversion efficiency. Writing in <em>Joule</em>, researchers introduced new IS-OPVs that retain over 80% of their initial efficiency under 50% strain and exhibit an increase in power output when strained to 40%, marking a remarkable improvement over conventional photovoltaic cells, which typically experience efficiency degradation and failure when stretched. This approach could inspire the next wave of stretchable electronics.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102062"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The adoption of a circular economy model for biopolymers necessitates new technologies for valorizing keratin-rich wastes, particularly from wool. This study presents an approach to convert hard keratin proteins into flexible, moldable, and freestanding bioplastics. This method relies on reprogramming the keratin’s structure by grafting building blocks on fully unfolded keratin via the thiol-based Michael-type addition between double bonds of the building blocks and thiols of keratin. The engineered protein showed new functionalities, resulting in: thermoplastic keratin after grafting with poly(ethylene glycol) methyl ether methacrylate; and increased toughness with poly(ethylene glycol) dimethacrylate, a fully bio-based, flexible, and tough material (that outperformed every other regenerated keratin material) from epoxidized soybean oil acrylate. This efficient reaction occurs at room temperature in the same aqueous solution used for the extraction, without the need for additional steps. This approach emphasizes the potential of proteins as sustainable plastic alternatives.
{"title":"Upgrading keratin into a moldable bioplastic","authors":"Dagmara J. Trojanowska , Arkadiusz Zych , Stefania Sganga , Nicola Tirelli , Matteo Boventi , Camilla Rinaldi , Roberto Simonutti , Athanassia Athanassiou , Giovanni Perotto","doi":"10.1016/j.matt.2025.102039","DOIUrl":"10.1016/j.matt.2025.102039","url":null,"abstract":"<div><div>The adoption of a circular economy model for biopolymers necessitates new technologies for valorizing keratin-rich wastes, particularly from wool. This study presents an approach to convert hard keratin proteins into flexible, moldable, and freestanding bioplastics. This method relies on reprogramming the keratin’s structure by grafting building blocks on fully unfolded keratin via the thiol-based Michael-type addition between double bonds of the building blocks and thiols of keratin. The engineered protein showed new functionalities, resulting in: thermoplastic keratin after grafting with poly(ethylene glycol) methyl ether methacrylate; and increased toughness with poly(ethylene glycol) dimethacrylate, a fully bio-based, flexible, and tough material (that outperformed every other regenerated keratin material) from epoxidized soybean oil acrylate. This efficient reaction occurs at room temperature in the same aqueous solution used for the extraction, without the need for additional steps. This approach emphasizes the potential of proteins as sustainable plastic alternatives.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102039"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102040
Hao Wang , Ruisi Cai , Shenqiang Wang , Yinxian Yang , Tao Sheng , Wentao Zhang , Shiqi Wang , Jiahuan You , Ziyi Lu , Kangfan Ji , Yunlong Jiao , Mengyuan Ma , Nianou Wang , Ke Li , Wenjin Chu , Zhixi Yang , Jicheng Yu , Yuqi Zhang , Zhen Gu
Microneedle (MN) patches have shown great potential in biomedical applications because of their minimal invasiveness and efficient drug delivery. However, challenges remain, such as restricted penetration depth, limited drug loading capacity, and the complexity of controlled release formulations. Here, we present a wearable transdermal device (WTD) system composed of a portable iontophoresis device with an electroresponsive hydrogel (electrogel) and polymeric MN patches. When activated by a programmed current of the WTD, the macroporous electrogel shrinks to control drug solution release and further transport into the skin via MN-generated microchannels, providing efficient, on-demand transdermal drug administration. In vivo experiments in a diabetic model demonstrated that the WTD system rescued mice from hyperglycemia or hypoglycemia by transdermally delivering insulin or glucagon, respectively. It enabled programmed delivery based on blood glucose levels to avoid multiple injections. Moreover, the WTD system could deliver high-dosing required chemo drug and effectively inhibited tumor growth in 4T1 tumor-bearing mice.
{"title":"A wearable transdermal device for on-demand drug delivery","authors":"Hao Wang , Ruisi Cai , Shenqiang Wang , Yinxian Yang , Tao Sheng , Wentao Zhang , Shiqi Wang , Jiahuan You , Ziyi Lu , Kangfan Ji , Yunlong Jiao , Mengyuan Ma , Nianou Wang , Ke Li , Wenjin Chu , Zhixi Yang , Jicheng Yu , Yuqi Zhang , Zhen Gu","doi":"10.1016/j.matt.2025.102040","DOIUrl":"10.1016/j.matt.2025.102040","url":null,"abstract":"<div><div>Microneedle (MN) patches have shown great potential in biomedical applications because of their minimal invasiveness and efficient drug delivery. However, challenges remain, such as restricted penetration depth, limited drug loading capacity, and the complexity of controlled release formulations. Here, we present a wearable transdermal device (WTD) system composed of a portable iontophoresis device with an electroresponsive hydrogel (electrogel) and polymeric MN patches. When activated by a programmed current of the WTD, the macroporous electrogel shrinks to control drug solution release and further transport into the skin via MN-generated microchannels, providing efficient, on-demand transdermal drug administration. <em>In vivo</em> experiments in a diabetic model demonstrated that the WTD system rescued mice from hyperglycemia or hypoglycemia by transdermally delivering insulin or glucagon, respectively. It enabled programmed delivery based on blood glucose levels to avoid multiple injections. Moreover, the WTD system could deliver high-dosing required chemo drug and effectively inhibited tumor growth in 4T1 tumor-bearing mice.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102040"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.matt.2025.102049
Dylan M. Barber , Michael D. Nelwood , Jennifer A. Lewis
Zwitterions (ZIs) are emerging candidates for soft dielectrics but are limited by high melting points (Tm), glass transition temperatures (Tg), and viscosities (η) dramatically exceeding those of ionic liquids. To overcome these limitations, we synthesized 18 imidazolium-derived zwitterions with systematically varied composition at the (1) imidazolium tail (Rt), (2) imidazolium 2 position (R2), (3) inter-charge spacer (Rs), and (4) anion (Ra). We found that long, flexible spacers yield stable zwitterionic liquids (ZILs), which we attribute to amplified entropy of fusion. Remarkably, stable ZILs with an elongated (6–16 atom length) inter-charge spacer, flexible tail, and a CF3-sulfonimide anion are 100- to 500-fold less viscous at room temperature than a benchmark supercooled ZI with a 4-atom spacer and a sulfonate anion. Moreover, these previously unreported ZILs exhibit high permittivities ranging from εr,s = 290 (6-atom spacers) to εr,s = 404 (16-atom spacers), highlighting the promise of this class of polarizable soft matter.
{"title":"Rational design and synthesis of zwitterionic liquid dielectrics","authors":"Dylan M. Barber , Michael D. Nelwood , Jennifer A. Lewis","doi":"10.1016/j.matt.2025.102049","DOIUrl":"10.1016/j.matt.2025.102049","url":null,"abstract":"<div><div>Zwitterions (ZIs) are emerging candidates for soft dielectrics but are limited by high melting points (<em>T</em><sub><em>m</em></sub>), glass transition temperatures (<em>T</em><sub><em>g</em></sub>), and viscosities (<em>η</em>) dramatically exceeding those of ionic liquids. To overcome these limitations, we synthesized 18 imidazolium-derived zwitterions with systematically varied composition at the (1) imidazolium tail (R<sub>t</sub>), (2) imidazolium 2 position (R<sub>2</sub>), (3) inter-charge spacer (R<sub>s</sub>), and (4) anion (R<sub>a</sub>). We found that long, flexible spacers yield stable zwitterionic liquids (ZILs), which we attribute to amplified entropy of fusion. Remarkably, stable ZILs with an elongated (6–16 atom length) inter-charge spacer, flexible tail, and a CF<sub>3</sub>-sulfonimide anion are 100- to 500-fold less viscous at room temperature than a benchmark supercooled ZI with a 4-atom spacer and a sulfonate anion. Moreover, these previously unreported ZILs exhibit high permittivities ranging from <em>ε</em><sub><em>r,s</em></sub> = 290 (6-atom spacers) to <em>ε</em><sub><em>r,s</em></sub> = 404 (16-atom spacers), highlighting the promise of this class of polarizable soft matter.</div></div>","PeriodicalId":388,"journal":{"name":"Matter","volume":"8 4","pages":"Article 102049"},"PeriodicalIF":17.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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