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Электрокинетические свойства, растворение in vitro, потенциальная биосовместимость оксидных и оксинитридных пленок титана для сердечно-сосудистых стентов 电动势特性,体外溶解度,氧化物和氧化氮的潜在生物相容性
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-04-28 DOI: 10.20538/1682-0363-2015-2-55-66
I. A. Khlusov, V. Pichugin, A. A. Pustovalova, M. E. Konischev, A. N. Dzyuman, Matthias Epple, Mathias Ulbricht, E. Cicinskas, V. S. Gulaya, V. V. Vikhareva
A state of titanium oxide and oxynitride coatings on L316 steel has been studied before and after their contact with model biological fluids. Electrokinetic investigation in 1 mmol potassium chloride showed significant (more than 10 times) fall of magnitude of electrostatic potential of thin (200–300 nm) titanium films at pH changing in the range of 5–9 units during 2 h. Nevertheless, zeta-potential of all samples had negative charge under pH > 6.5. Long-term (5 weeks) contact of samples with simulated body fluid (SBF) promoted steel corrosion and titanium oxide and oxynitride films dissolution. On the other hand, sodium and chloride ions precipitation and sodium chloride crystals formation occurred on the samples. Of positive fact is an absence of calcification of tested artificial surfaces in conditions of long-term being in SBF solution. It is supposed decreasing hazard of fast thrombosis and loss of materials functional properties. According to in vitro experiment conducted, prospective biocompatibility of materials tested before and after their contact with SBF lines up following manner: Ti–O–N (1/3) > Ti–O–N (1/1), TiO2 > Steel. It may be explained by: 1) the corrosion-preventive properties of thin titanium oxide and oxynitride films; 2) a store of surface negative charge for Ti–O–N (1/3) film; 3) minor augmentation of mass and thickness of titanium films connected with speed of mineralization processes on the interface of solution/solid body. At the same time, initial (before SBF contact) differences of samples wettability became equal. Modifying effect of model biological fluids on physicochemical characteristics of materials tested (roughness enhancement, a reduction or reversion of surface negative potential, sharp augmentation of surface hydrofilicity) should took into account under titanium oxide and oxynitride films formation and a forecast of their optimal biological properties as the materials for cardiovascular stents.
研究了L316钢表面氧化钛和氮化氧涂层与模型生物流体接触前后的状态。在1 mmol氯化钾溶液中,当pH值在5-9单位范围内变化时,2 h内钛薄膜(200-300 nm)的静电电位显著下降(降幅超过10倍),但在pH值为bbb6.5时,所有样品的ζ电位均带负电荷。样品与模拟体液(SBF)长期(5周)接触促进了钢的腐蚀和氧化钛和氮化氧膜的溶解。另一方面,钠离子和氯离子在样品上析出并形成氯化钠晶体。一个积极的事实是,在SBF溶液中长期存在的条件下,所测试的人造表面没有钙化。它可以减少快速血栓形成的危险和材料功能特性的损失。根据体外实验,材料与SBF接触前后的前瞻性生物相容性排列如下:Ti-O-N (1/3) > Ti-O-N (1/1), TiO2 > Steel。这可以解释为:1)氧化钛和氮化氧薄膜的防腐蚀性能;2) Ti-O-N薄膜的表面负电荷储存(1/3);3)钛膜的质量和厚度的增加与固液界面上矿化过程的速度有关。同时,试样润湿性的初始差值(在SBF接触前)趋于相等。在氧化钛和氮化氧薄膜形成过程中,模型生物流体对被测材料的物理化学特性(粗糙度增强、表面负电位的降低或逆转、表面亲水性的急剧增强)的修饰作用应被考虑在内,并预测其作为心血管支架材料的最佳生物学特性。
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引用次数: 3
OPTIMIZATION OF DIAGNOSTIC IMAGING IN BREAST CANCER 乳腺癌诊断影像学的优化
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-01-01 DOI: 10.20538/1682-0363-2015-4-12-16
S. Velichko, Yury Tyukalov, I. Frolova, D. G. Bukharin, Ye. Ye. Bober
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引用次数: 0
CLINICAL AND SOCIAL RISK FACTORS OF TARDIVE DYSKINESIA IN PATIENTS WITH SCHIZOPHRENIA DURING ANTIPSYCHOTIC TREATMENT 抗精神病药物治疗期间精神分裂症患者迟发性运动障碍的临床及社会危险因素
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-01-01 DOI: 10.20538/1682-0363-2015-1-32-39
Ye. G. Kornetova, A. Semke, Ye. G. Dmitrieva, Y. Borodyuk, A. Boyko
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引用次数: 2
INTERNATIONAL ASPECTS OF EDUCATION AND TRAINING IN TELEMEDICINE 远程医疗教育和培训的国际方面
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-01-01 DOI: 10.20538/1682-0363-2015-3-63-67
R. Engelbrecht, A. Hasman, J. Mantas, L. Nicholson
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引用次数: 3
THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO 体外氧化应激条件下蛋白氧化修饰在血液淋巴细胞氧化还原-调节caspase-3活性中的作用
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-01-01 DOI: 10.20538/1682-0363-2015-14-6-61-67
O. L. Nosareva, Y. A. Stepovaya, N. Ryazantseva, Ye. V. Shakhristova, O. Vesnina, V. V. Novitsky
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引用次数: 1
THE METHODS OF CHOLEDOCHOLITHIASIS TREATMENT 胆总管结石的治疗方法
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2015-01-01 DOI: 10.20538/1682-0363-2015-4-99-109
N. V. Merzlikin, V. F. Podgornov, Ye. V. Semichev, P. Bushlanov, V. D. Talacheva
The methods of choledocholithiasis treatment, which are currently used in clinics of the Russian Federation, has been presented. The problems of diagnosis and treatment of gallstones (GSD) in individuals of different age groups are spotlighted. In the study of treatment of cholelithiasis and choledocholithiasis, including arising complications, it can be concluded that so far the ideal method of treatment of this pa-thology has not been found. Up to now, the majority of doctor’s main treatment is surgical removal of gall stones by some method or other. This article also considers a conservative approach (drug: antispasmodics (selective and nonselective), and non-pharmacological: treatment, diet), describes the criteria and assessment of the effectiveness of therapeutic interventions that help in the question of further treatment: the continuation of drug therapy or assignment of surgical treatment. Invasive techniques that are covered in the article, namely, a tech-nique of remote and endoscopic lithotripsy, are high-tech and in demand at the moment, which, along with high efficiency removal of a stone, reduced the number and severity of postoperative complications. Additionally, in the analysis of the features of a particular method of treatment, advantages and disadvantages of different treatment methods are described, indications and contraindications (absolute and relative) together with complications, possible outcomes, and further prognosis are high-lighted .
介绍了目前在俄罗斯联邦诊所使用的治疗胆总管结石的方法。胆囊结石(GSD)在不同年龄组个体的诊断和治疗问题是突出的。在胆石症和胆总管结石的治疗研究中,包括所引起的并发症,可以得出结论,迄今为止还没有找到治疗这种病理的理想方法。到目前为止,大多数医生的主要治疗方法是通过某种方法手术切除胆结石。本文还考虑了一种保守方法(药物:抗痉挛药(选择性和非选择性),非药物:治疗,饮食),描述了治疗干预措施有效性的标准和评估,有助于进一步治疗的问题:继续药物治疗或手术治疗的分配。本文所涉及的侵入性技术,即远程内镜碎石技术,是目前急需的高科技技术,它与高效率的结石取出一起,减少了术后并发症的数量和严重程度。此外,在分析特定治疗方法的特点时,描述了不同治疗方法的优缺点,强调了适应症和禁忌症(绝对和相对),以及并发症、可能的结局和进一步的预后。
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引用次数: 3
THE IMPACT OF A SINGLE AND CONTINUOUS AUDIOVISUAL STIMULATION ON HEART RATE VARIABILITY AND MECHANISMS OF AUTONOMIC REGULATION IN ATHLETES-CYCLICS 单次和连续的视听刺激对运动员的心率变异性和自主调节机制的影响
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2014-12-28 DOI: 10.20538/1682-0363-2014-6-113-120
R. Aizman, M. Golovin
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引用次数: 2
БИОМЕХАНИКА ФАЗЫ ПОЛЕТА ПРИ ВЫПОЛНЕНИИ ПРЫЖКА В ДЛИНУ С МЕСТА У СПОРТСМЕНОВ РАЗЛИЧНОЙ КВАЛИФИКАЦИИ 飞行阶段生物力学
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2014-12-28 DOI: 10.20538/1682-0363-2014-6-174-179
A. V. Razuvanova, Ye. V. Koshelskaya, V. I. Andreyev, I. V. Kapilevich
Biomechanical features of flight phase when running long jump from place of different qualification sportsmen were investigated by method of Motion Tracking. The obtained results showed that the effective control of body position during the phase of flight can improve the effectiveness of jump actions.. This control is performed by moving parts of the body – bending legs at the knee, extension in the hip joints, the joints of the spine, shoulder joints and, as a consequence, any additional torque, contributing to increase the range of the jumping. In untrained persons the effectiveness of the management body in flight is reduced due to weak coordination and a predominance of actions aimed at safe. All the patterns can be viewed as the result of formation of a particular movement pattern, based on the interaction of vestibular and statokinetic reflexes.
采用运动跟踪的方法,研究了不同资格的跳远运动员在场地起跑时飞行阶段的生物力学特征。结果表明,在飞行阶段对身体位置的有效控制可以提高跳跃动作的有效性。这种控制是通过身体的活动部分来完成的——膝盖处的腿弯曲,髋关节的伸展,脊柱的关节,肩关节,以及由此产生的任何额外的扭矩,有助于增加跳跃的范围。在未经训练的人员中,由于协调不力和以安全为目的的行动占主导地位,管理机构在飞行中的有效性降低。所有这些模式都可以看作是基于前庭反射和静动反射的相互作用而形成的特定运动模式的结果。
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引用次数: 1
Пальмитиновая, олеиновая кислоты и их роль в патогенезе атеросклероза palmitine, oleno酸及其在动脉粥样硬化病原体中的作用
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2014-10-28 DOI: 10.20538/1682-0363-2014-5-149-159
V. N. Titov, A. M. Dygai, M. Y. Kotlovskiy, Ye. V. Kurdoyak, A. V. Yakimenko, I. Y. Yakimovich, N. Aksyutina, Y. V. Kotlovskiy
On the basis of phylogenetic theory of general pathology, the cause of a noninfectious disease whose occurrence in a population is more than 5–7% is an impaired biological function or reaction to the environment. From the general biology viewpoint, high mortality rate related to cardio-vascular diseases and atherosclerosis (intercellular deficiency of polyenic fatty acids (PFA)) is just extinction of the  Homo sapiens  population upon adaptation to new environmental factors. The biological function of throphology (feeding) and biological reaction of exotrophy (external feeding) are impaired in several aspects, the major of which is nonphysiologically high dietary content of saturated fatty acids, primarily, of palmitic fatty acid (FA). The lipoprotein system formed at early stages of phylogenesis cannot transport and provide physiological deposition of great amounts of palmitic FA, which leads to the development of an adaption (compensatory) and accumulation disease. This results in hypermipidemia, impaired bioavailability of PFA to cells, compesatory production of humoral mediators from ω-9 eicosatrienoic mead FA, disorders in physiological parameters of cell plasma membrane and integral proteins, nonphysiological conformation of apoВ-100 in lipoproteins, formation of ligandless lipoproteins (biological litter) and impairments in the biological function of endoecology, utilization of ligandless lipoproteins in arterial intima by phylogenetically early macrophages that do not hydrolyze polyenic cholesterol esters, increase in the intensity of the biological reaction of inflammation, and destructive and inflammatory lesions in arterial intima of an atheromatosis or atherothrombosis type. Atheromatous masses are catabolites of PFA which were not internalized by phylogenetically late cells via receptor-mediated pathway.
根据一般病理学的系统发育理论,在人群中发病率超过5-7%的非传染性疾病的原因是生物功能受损或对环境的反应。从一般生物学的观点来看,与心血管疾病和动脉粥样硬化相关的高死亡率(细胞间多烯脂肪酸缺乏)只是智人群体在适应新的环境因素后的灭绝。体外摄食的生物学功能和生物反应在几个方面受到损害,主要是非生理性的高饱和脂肪酸,主要是棕榈脂肪酸(FA)。在系统发育早期形成的脂蛋白系统不能运输和提供大量棕榈质FA的生理沉积,从而导致适应性(代偿)和蓄积性疾病的发展。这导致高脂血症、PFA对细胞的生物利用度受损、ω-9二十碳三烯酸mead FA的体液介质代偿性产生、细胞膜和整体蛋白的生理参数紊乱、脂蛋白中apoВ-100的非生理构象、无配体脂蛋白(生物垃圾)的形成和内生态生物学功能的损害。系统发育早期巨噬细胞对动脉内膜无配体脂蛋白的利用,这些细胞不水解多enic胆固醇酯,炎症生物反应的强度增加,动脉粥样硬化或动脉粥样硬化型动脉内膜的破坏性和炎症性病变。动脉粥样硬化团块是PFA的分解产物,它没有通过受体介导途径被系统发育晚期细胞内化。
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引用次数: 4
MOODLE – СИСТЕМА КОМПЬЮТЕРНОЙ ПОДДЕРЖКИ ДИСТАНТНОГО ОБУЧЕНИЯ MOODLE是一种远程计算机辅助教学系统。
IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2014-08-28 DOI: 10.20538/1682-0363-2014-4-123-128
V. A. Tunda, E. A. Tunda
Moodle (Modular Object-Oriented Dynamic Learning Environment) is the system developed by the English-speaking community around the world for more than 10 years, supports both, offline and online training. In most cases, Moodle is used to support and connect learning face-to-face with online training, as well as with other types of learning. Moodle allows you to ask all sorts of questions and assess responses in a variety of ways. The central concept of Moodle is a course in which one or more teachers offer students resources (such as files, folders, Web pages) and participate in interactive activities (such as forums, wikis, blogging, lessons, seminars, assignments, examinations). Students and teachers can change roles, mutually assess each other, share knowledge on the topics of study in the glossary and database system. In the English-speaking world, there are public sites with detailed documentation on Moodle, which is constantly verified and modified in accordance with emerging new versions of the system; Russian versions do not have public sites with detailed translation of the English-language documentation. On what and to whom you want to perform actions in the daily practice of the modern versions, only the barest of outlines on paid seminars and presentations to those who started the implementation of Moodle in your organization are given. And this despite the fact that the system has a great variety of Moodle (over 500) settings with different levels of functionality to be performed, to maintain and develop specially organized by the team of specialists. The question is not only about creating a training course in Moodle. It's about maintaining the health of the system within the institution, such as a University. Under the "health maintenance" means: availability and preservation of up-to-date documentation on system and manuals on Moodle separately for administrators, managers, teachers and students at their level, training consultants for each level and help Moodle users to carry out their work in an ever-growing versions of this system. The second important feature of the group is to perform administrative work on authentication of users and transfer/expulsion from the course assignment and modification of the roles, responsibilities and opportunities of users of Moodle, backing up, and take the necessary measures to ensure the confidentiality and security, implement the necessary measures for transfer students with the course on the course, at the end of the semester or school year, maintaining the required accounting and reporting documents, and so on. This article tries to understand the enormous potential of Moodle in transposition on the duties of the officers of the ad hoc group support this system within the University as a whole. Only competent and timely response to the needs of the teachers involved in the conduct of training courses in Moodle environment can allow to achieve a high level of educational services.
Moodle(模块化面向对象动态学习环境)是由世界各地的英语社区开发了十多年的系统,支持离线和在线培训。在大多数情况下,Moodle用于支持和连接面对面的学习与在线培训,以及与其他类型的学习。Moodle允许你提出各种各样的问题,并以各种方式评估答案。Moodle的核心概念是,在一门课程中,一位或多位教师为学生提供资源(如文件、文件夹、网页),并参与互动活动(如论坛、维基、博客、课程、研讨会、作业、考试)。学生和教师可以在词汇表和数据库系统中转换角色,相互评估,分享学习主题的知识。在英语世界,Moodle上有一些公共网站,上面有详细的文档,这些文档会根据系统的新版本不断得到验证和修改;俄文版本没有提供英文文件详细翻译的公共网站。在现代版本的日常实践中,您希望对谁执行什么操作,对于那些开始在您的组织中实现Moodle的人,只提供了付费研讨会和演示文稿的最简单的概述。尽管该系统有各种各样的Moodle(超过500)设置,具有不同级别的功能,需要由专家团队专门组织维护和开发。这个问题不仅仅是关于在Moodle上创建一个培训课程。它是关于维持机构内系统的健康,比如大学。“健康维护”系指:提供和保存最新的系统文档和Moodle上的手册,分别供相应级别的管理员、经理、教师和学生使用,为每个级别的培训顾问使用,并帮助Moodle用户在不断增长的系统版本中开展工作。小组的第二个重要特征是对Moodle用户的角色、职责和机会的分配和修改、备份,以及采取必要的措施确保保密和安全,在学期或学年结束时,对与课程在一起的转学生实施必要的措施。维护所需的会计和报告文件等。本文试图了解Moodle在整个大学内支持该系统的特设小组官员职责转换方面的巨大潜力。在Moodle环境中,只有称职且及时地响应参与培训课程的教师的需求,才能实现高水平的教育服务。
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引用次数: 0
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Byulleten Sibirskoy Meditsiny
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