The COVID-19 pandemic posed a significant impact on employees' work outcomes worldwide. However, it remains unclear whether some employees fared worse than others when facing work-related health threats and what role individual differences in vulnerability to disease played in shaping their work experiences. Integrating the evolutionary psychology perspective of the behavioral immune system with Job Demands-Resources Theory, we argue that a fundamental factor in how employees dealt with these threats was the extent to which they perceived themselves as vulnerable to infectious diseases. Employees with higher susceptibility to infectious diseases were predicted to experience heightened workplace safety concerns and engage less with their work. In addition, a health-oriented leadership style was expected to decrease employees' safety concerns and increase their work engagement, especially for the more vulnerable employees. To test hypotheses, we conducted a three-wave field survey and two vignette-based experiments on working adults in the United Kingdom at different stages of the pandemic. Results largely supported our predictions, revealing that employees who felt more vulnerable to infectious diseases were more concerned about their workplace safety, inhibiting their work engagement. We discuss these findings' theoretical and practical implications for promoting a safe and healthy post-pandemic workplace, especially for vulnerable employees.