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Longitudinal sleep multi-trajectories from age 1 to 5.5 years and their early correlates: results from the Étude Longitudinale Française depuis l'Enfance birth cohort study. 1岁至5.5岁的纵向睡眠多轨迹及其早期相关性:Étude纵向法国儿童出生队列研究的结果
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-11-08 DOI: 10.1093/sleep/zsad236
Mihyeon Kim, Danielle Saade, Marie-Noëlle Dufourg, Marie-Aline Charles, Sabine Plancoulaine

Study objectives: To identify sleep multi-trajectories in children from age 1 to 5.5 years and their early correlates.

Methods: We collected early family, maternal, and child characteristics, including children's nighttime sleep duration (NSD) and daytime sleep duration (DSD), night waking (NW), and sleep-onset difficulties (SOD), by parental phone interviews at age 2 months and 1-, 2-, 3.5-, and 5.5 years. Group-based multi-trajectory modeling identified sleep multi-trajectory groups. Multinomial logistic regression assessed associations with early factors.

Results: We identified five distinct sleep multi-trajectory groups for NSD, DSD, NW, and SOD in 9273 included children. The "Good sleepers" (31.6%) and "Long sleepers" (31.0%) groups had low NW and SOD prevalence and shorter NSD but longer DSD in "Good sleepers" than in "Long sleepers." The "Good sleepers but few SOD" group (10.3%) had long NSD and DSD but a SOD peak at age 3.5 years; the "Improving NW and SOD" group (9.6%) showed short but rapidly increasing NSD to a plateau and high but decreasing NW and SOD; the "Persistent NW and SOD" group (17.5%) had persistent high NW and SOD. Maternal depression during pregnancy and sleep habits at age 1 (e.g. parental presence or feeding to fall asleep, sleeping at least part of the night away from own bed) were common risk factors associated with the most disordered sleep multi-trajectory groups.

Conclusions: We identified distinct sleep multi-trajectory groups and early life-associated factors in preschoolers. Most of the factors associated with the most sleep-disordered multi-trajectory groups are likely modifiable and provide clues for early prevention interventions.

研究目的:确定1 - 5.5岁儿童的睡眠多轨迹及其早期相关因素。方法:通过2个月大、1岁、2岁、3.5岁和5.5岁的父母电话访谈,收集早期家庭、母亲和儿童的特征,包括儿童夜间睡眠时间(NSD)和日间睡眠时间(DSD)、夜间清醒时间(NW)和睡眠发作困难(SOD)。基于组的多轨迹建模确定了睡眠多轨迹组。多项逻辑回归评估与早期因素的关联。结果:我们在9273名纳入的儿童中确定了NSD、DSD、NW和SOD五个不同的睡眠多轨迹组。“好睡眠者”(31.6%)和“长睡眠者”(31.0%)组NW和SOD患病率较低,“好睡眠者”的NSD较短,而“长睡眠者”的DSD较长。“睡眠好但SOD少”组(10.3%)的NSD和DSD较长,但在3.5岁时出现SOD高峰;“改善NW和SOD”组(9.6%)NSD短而迅速上升至平台,NW和SOD高但下降;“持续NW和SOD”组(17.5%)持续高NW和SOD。怀孕期间的母亲抑郁和1岁时的睡眠习惯(例如,父母在场或喂食入睡,晚上至少有一部分时间不在自己的床上睡觉)是与睡眠最紊乱的多轨迹组相关的常见风险因素。结论:我们在学龄前儿童中发现了不同的睡眠多轨迹组和早期生活相关因素。与大多数睡眠紊乱多轨迹组相关的大多数因素可能是可以改变的,并为早期预防干预提供线索。
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引用次数: 0
Symptom-specific effects of zolpidem and behavioral treatment for insomnia: a network intervention analysis. 唑吡坦与行为治疗失眠症的症状特异性效果:网络干预分析。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-11-08 DOI: 10.1093/sleep/zsad240
Jaap Lancee, Charles M Morin, Jack D Edinger, Hans Ivers, Tanja van der Zweerde, Tessa F Blanken
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引用次数: 0
Phase-amplitude coupling of Go/Nogo task-related neuronal oscillation decreases for humans with insufficient sleep. 睡眠不足的人Go/Nogo任务相关的神经元振荡的相幅耦合减少。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-11-08 DOI: 10.1093/sleep/zsad243
Peng Zhang, Chuancai Sun, Zhongqi Liu, Qianxiang Zhou

Phase-amplitude coupling (PAC) across frequency might be associated with the long-range synchronization of brain networks, facilitating the spatiotemporal integration of multiple cell assemblies for information transmission during inhibitory control. However, sleep problems may affect these cortical information transmissions based on cross-frequency PAC, especially when humans work in environments of social isolation. This study aimed to evaluate changes in the theta-beta/gamma PAC of task-related electroencephalography (EEG) for humans with insufficient sleep. Here, we monitored the EEG signals of 60 healthy volunteers and 18 soldiers in the normal environment, performing a Go/Nogo task. Soldiers also participated in the same test in isolated cabins. These measures demonstrated theta-beta PACs between the frontal and central-parietal, and robust theta-gamma PACs between the frontal and occipital cortex. Unfortunately, these PACs significantly decreased when humans experienced insufficient sleep, which was positively correlated with the behavioral performance of inhibitory control. The evaluation of theta-beta/gamma PAC of Go/Nogo task-related EEG is necessary to help understand the different influences of sleep problems in humans.

跨频率的相位振幅耦合(PAC)可能与大脑网络的远程同步有关,促进了抑制控制过程中多个细胞组件的时空整合以传递信息。然而,睡眠问题可能会影响这些基于交叉频率PAC的皮质信息传输,特别是当人们在社会隔离的环境中工作时。本研究旨在评估睡眠不足的人在任务相关脑电图(EEG)中β - β / γ PAC的变化。在这里,我们监测了60名健康志愿者和18名在正常环境下执行Go/Nogo任务的士兵的脑电图信号。士兵们也在孤立的小木屋里参加了同样的测试。这些测量表明前额和中央顶叶皮层之间有β - PACs,前额和枕叶皮层之间有强大的β - PACs。不幸的是,当人类睡眠不足时,这些pac显著减少,这与抑制控制的行为表现呈正相关。评估Go/Nogo任务相关脑电图的theta-beta/gamma PAC对于帮助理解人类睡眠问题的不同影响是必要的。
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引用次数: 0
Phase advance of bedtimes in Alzheimer's disease. 阿尔茨海默病的就寝时间提前。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-11-08 DOI: 10.1093/sleep/zsad191
Donald L Bliwise, Ting-Chuan Wang, Vladimir Svetnik, Gary Zammit, Peining Tao, Christopher Lines, W Joseph Herring
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引用次数: 0
What's in a name? delayed by any other name is still a circadian disorder: a call for improved nomenclature for delayed sleep-wake phase disorder subtypes. 名字里有什么?延迟的任何其他名称仍然是一种昼夜节律障碍:呼吁改进延迟睡眠-觉醒阶段障碍亚型的命名。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-11-08 DOI: 10.1093/sleep/zsad222
Sabra M Abbott, Andrew J Phillips, Kathryn J Reid, Sean W Cain, Phyllis C Zee
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引用次数: 0
Where does inflammation in insomnia come from? and does it matter for comorbidity? 失眠的炎症是从哪里来的?这对共病有关系吗?
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-10-11 DOI: 10.1093/sleep/zsad223
Andrea Ballesio
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引用次数: 0
Disseminating sleep education to graduate psychology programs online: a knowledge translation study to improve the management of insomnia. 在线向研究生心理学项目传播睡眠教育:一项改善失眠管理的知识翻译研究。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-10-11 DOI: 10.1093/sleep/zsad169
Hailey Meaklim, Lisa J Meltzer, Imogen C Rehm, Moira F Junge, Melissa Monfries, Gerard A Kennedy, Romola S Bucks, Marnie Graco, Melinda L Jackson

Study objectives: Despite the negative impact of poor sleep on mental health, evidence-based insomnia management guidelines have not been translated into routine mental healthcare. Here, we evaluate a state-wide knowledge translation effort to disseminate sleep and insomnia education to graduate psychology programs online using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) evaluation framework.

Methods: Using a non-randomized waitlist control design, graduate psychology students attended a validated 6-hour online sleep education workshop delivered live as part of their graduate psychology program in Victoria, Australia. Sleep knowledge, attitudes, and practice assessments were conducted pre- and post-program, with long-term feedback collected at 12 months.

Results: Seven out of ten graduate psychology programs adopted the workshop (adoption rate = 70%). The workshop reached 313 graduate students, with a research participation rate of 81%. The workshop was effective at improving students' sleep knowledge and self-efficacy to manage sleep disturbances using cognitive behavioral therapy for insomnia (CBT-I), compared to the waitlist control with medium-to-large effect sizes (all p < .001). Implementation feedback was positive, with 96% of students rating the workshop as very good-to-excellent. Twelve-month maintenance data demonstrated that 83% of students had used the sleep knowledge/skills learned in the workshop in their clinical practice. However, more practical training is required to achieve CBT-I competency.

Conclusions: Online sleep education workshops can be scaled to deliver cost-effective foundational sleep training to graduate psychology students. This workshop will accelerate the translation of insomnia management guidelines into psychology practice to improve sleep and mental health outcomes nationwide.

研究目标:尽管睡眠不足对心理健康有负面影响,但循证失眠管理指南尚未转化为常规心理健康。在这里,我们使用RE-AIM(覆盖范围、有效性、采用、实施和维护)评估框架,评估了全州范围内的知识翻译工作,以在线向研究生心理学项目传播睡眠和失眠教育。方法:采用非随机等待名单对照设计,心理学研究生参加了一个经过验证的6小时在线睡眠教育研讨会,该研讨会是他们在澳大利亚维多利亚州的研究生心理学项目的一部分。睡眠知识、态度和实践评估在项目前后进行,并在12个月时收集长期反馈。结果:十分之七的心理学研究生课程采用了研讨会(采用率=70%)。研讨会有313名研究生参加,研究参与率为81%。与中等至较大效果的等待名单对照组相比,该研讨会有效地提高了学生的睡眠知识和自我效能,以使用失眠认知行为疗法(CBT-I)来管理睡眠障碍(均p<0.001)。实施反馈是积极的,96%的学生将该研讨会评为非常好至优秀。12个月的维护数据表明,83%的学生在临床实践中使用了在研讨会上学到的睡眠知识/技能。然而,要获得CBT-I能力,还需要更多的实践培训。结论:在线睡眠教育研讨会可以扩大规模,为心理学研究生提供具有成本效益的基础睡眠培训。该研讨会将加速将失眠管理指南转化为心理学实践,以改善全国范围内的睡眠和心理健康状况。
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引用次数: 1
Adverse effects of 21 antidepressants on sleep during acute-phase treatment in major depressive disorder: a systemic review and dose-effect network meta-analysis. 21种抗抑郁药在重度抑郁症急性期治疗期间对睡眠的不良影响:一项系统综述和量效网络荟萃分析。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-10-11 DOI: 10.1093/sleep/zsad177
Shuzhe Zhou, Pei Li, Xiaozhen Lv, Xuefeng Lai, Zuoxiang Liu, Junwen Zhou, Fengqi Liu, Yiming Tao, Meng Zhang, Xin Yu, Jingwei Tian, Feng Sun

Study objectives: Sleep-related adverse effects during acute treatment with antidepressants undermine adherence and impede remission. We aimed to address subtypes of sleep-related adverse effects and depict the relationship between dose and sleep-related adverse events.

Methods: We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science for double-blind randomized controlled trials of depression published before April 30th, 2023. Eligible studies reporting sleep-related adverse effects during short-term monotherapy were included. The odds ratios (ORs) for sleep-related adverse effects were addressed with network meta-analysis. A Bayesian approach was used to depict the dose-effect relationship. Heterogeneity among studies was assessed using the τ2 and I2 statistics. Sensitivity analyses were performed without studies featuring high risk of bias.

Results: Studies with 64 696 patients were examined from 216 trials. Compared to placebo, 13 antidepressants showed higher ORs for somnolence, of which fluvoxamine (OR = 6.32; 95% CI: 3.56 to 11.21) ranked the top. Eleven had higher risks for insomnia, reboxetine ranked the top (OR = 3.47; 95% CI: 2.77 to 4.36). The dose-effect relationships curves between somnolence or insomnia and dose included linear shape, inverted U-shape, and other shapes. There was no significant heterogeneity among individual studies. The quality of evidence for results in network meta-analyses was rated as very low to moderate by Grading of Recommendations Assessment, Development, and Evaluation.

Conclusions: Most antidepressants had higher risks for insomnia or somnolence than placebo. The diverse relationship curves between somnolence or insomnia and dose of antidepressants can guide clinicians to adjust the doses. These findings suggest clinicians pay more attention to sleep-related adverse effects during acute treatment with antidepressants.

研究目的:抗抑郁药急性治疗期间与睡眠相关的不良反应会破坏依从性并阻碍病情缓解。我们旨在解决睡眠相关不良反应的亚型,并描述剂量与睡眠相关不良事件之间的关系。方法:我们检索了PubMed、Embase、Cochrane Central Register of Controlled Trials和Web of Science在2023年4月30日之前发表的抑郁症双盲随机对照试验。纳入了报告短期单药治疗期间睡眠相关不良反应的合格研究。睡眠相关不良反应的比值比(OR)通过网络荟萃分析进行处理。使用贝叶斯方法来描述剂量-效应关系。使用τ2和I2统计来评估研究之间的异质性。进行敏感性分析时没有进行具有高偏倚风险的研究。结果:对216项试验中的64696名患者进行了研究。与安慰剂相比,13种抗抑郁药表现出更高的嗜睡ORs,其中氟伏沙明(OR=6.32;95%CI:3.56至11.21)位居榜首。11人失眠风险较高,瑞波西汀排在首位(OR=3.47;95%CI:2.77~4.36)。嗜睡或失眠与剂量之间的量效关系曲线包括线性、倒U形和其他形状。个体研究之间没有显著的异质性。网络荟萃分析结果的证据质量被建议评估、发展和评估分级评定为极低至中等。结论:大多数抗抑郁药比安慰剂有更高的失眠或嗜睡风险。嗜睡或失眠与抗抑郁药剂量之间的不同关系曲线可以指导临床医生调整剂量。这些发现表明临床医生在抗抑郁药的急性治疗过程中更加关注睡眠相关的不良反应。
{"title":"Adverse effects of 21 antidepressants on sleep during acute-phase treatment in major depressive disorder: a systemic review and dose-effect network meta-analysis.","authors":"Shuzhe Zhou,&nbsp;Pei Li,&nbsp;Xiaozhen Lv,&nbsp;Xuefeng Lai,&nbsp;Zuoxiang Liu,&nbsp;Junwen Zhou,&nbsp;Fengqi Liu,&nbsp;Yiming Tao,&nbsp;Meng Zhang,&nbsp;Xin Yu,&nbsp;Jingwei Tian,&nbsp;Feng Sun","doi":"10.1093/sleep/zsad177","DOIUrl":"10.1093/sleep/zsad177","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep-related adverse effects during acute treatment with antidepressants undermine adherence and impede remission. We aimed to address subtypes of sleep-related adverse effects and depict the relationship between dose and sleep-related adverse events.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science for double-blind randomized controlled trials of depression published before April 30th, 2023. Eligible studies reporting sleep-related adverse effects during short-term monotherapy were included. The odds ratios (ORs) for sleep-related adverse effects were addressed with network meta-analysis. A Bayesian approach was used to depict the dose-effect relationship. Heterogeneity among studies was assessed using the τ2 and I2 statistics. Sensitivity analyses were performed without studies featuring high risk of bias.</p><p><strong>Results: </strong>Studies with 64 696 patients were examined from 216 trials. Compared to placebo, 13 antidepressants showed higher ORs for somnolence, of which fluvoxamine (OR = 6.32; 95% CI: 3.56 to 11.21) ranked the top. Eleven had higher risks for insomnia, reboxetine ranked the top (OR = 3.47; 95% CI: 2.77 to 4.36). The dose-effect relationships curves between somnolence or insomnia and dose included linear shape, inverted U-shape, and other shapes. There was no significant heterogeneity among individual studies. The quality of evidence for results in network meta-analyses was rated as very low to moderate by Grading of Recommendations Assessment, Development, and Evaluation.</p><p><strong>Conclusions: </strong>Most antidepressants had higher risks for insomnia or somnolence than placebo. The diverse relationship curves between somnolence or insomnia and dose of antidepressants can guide clinicians to adjust the doses. These findings suggest clinicians pay more attention to sleep-related adverse effects during acute treatment with antidepressants.</p>","PeriodicalId":49514,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10120161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Contactless and longitudinal monitoring of nocturnal sleep and daytime naps in older men and women: a digital health technology evaluation study. 老年男性和女性夜间睡眠和日间小睡的非接触式和纵向监测:一项数字健康技术评估研究。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-10-11 DOI: 10.1093/sleep/zsad194
Kiran K G Ravindran, Ciro Della Monica, Giuseppe Atzori, Damion Lambert, Hana Hassanin, Victoria Revell, Derk-Jan Dijk

Study objectives: To compare the 24-hour sleep assessment capabilities of two contactless sleep technologies (CSTs) to actigraphy in community-dwelling older adults.

Methods: We collected 7-14 days of data at home from 35 older adults (age: 65-83), some with medical conditions, using Withings Sleep Analyser (WSA, n = 29), Emfit QS (Emfit, n = 17), a standard actigraphy device (Actiwatch Spectrum [AWS, n = 34]), and a sleep diary (n = 35). We compared nocturnal and daytime sleep measures estimated by the CSTs and actigraphy without sleep diary information (AWS-A) against sleep-diary-assisted actigraphy (AWS|SD).

Results: Compared to sleep diary, both CSTs accurately determined the timing of nocturnal sleep (intraclass correlation [ICC]: going to bed, getting out of bed, time in bed >0.75), whereas the accuracy of AWS-A was much lower. Compared to AWS|SD, the CSTs overestimated nocturnal total sleep time (WSA: +92.71 ± 81.16 minutes; Emfit: +101.47 ± 75.95 minutes) as did AWS-A (+46.95 ± 67.26 minutes). The CSTs overestimated sleep efficiency (WSA: +9.19% ± 14.26%; Emfit: +9.41% ± 11.05%), whereas AWS-A estimate (-2.38% ± 10.06%) was accurate. About 65% (n = 23) of participants reported daytime naps either in bed or elsewhere. About 90% in-bed nap periods were accurately determined by WSA while Emfit was less accurate. All three devices estimated 24-hour sleep duration with an error of ≈10% compared to the sleep diary.

Conclusions: CSTs accurately capture the timing of in-bed nocturnal sleep periods without the need for sleep diary information. However, improvements are needed in assessing parameters such as total sleep time, sleep efficiency, and naps before these CSTs can be fully utilized in field settings.

研究目的:比较两种非接触式睡眠技术(CST)与活动描记术在社区老年人中的24小时睡眠评估能力。方法:我们在家中收集了35名老年人(年龄:65-83岁)7-14天的数据,其中一些人患有疾病,使用Withings睡眠分析仪(WSA,n=29)、Emfit QS(Emfit,n=17)、标准活动描记设备(Actiwatch Spectrum[AWS,n=34])和睡眠日记(n=35)。我们将CST和无睡眠日记信息的活动描记术(AWS-A)估计的夜间和日间睡眠测量值与睡眠日记辅助活动描记法(AWS|SD)进行了比较。结果:与睡眠日记相比,两种CST都准确地确定了夜间睡眠的时间(组内相关性[ICC]:上床、起床、上床时间>0.75),而AWS-A的准确性要低得多。与AWS|SD相比,CST高估了夜间总睡眠时间(WSA:+92.71±81.16分钟;Emfit:+101.47±75.95分钟),AWS-A(+46.95±67.26分钟)也是如此。CST高估了睡眠效率(WSA:+9.19%±14.26%;Emfit:+9.41%±11.05%),而AWS-A估计值(-2.38%±10.06%)是准确的。大约65%(n=23)的参与者报告白天在床上或其他地方小睡。大约90%的床上小睡时间是由WSA准确确定的,而Emfit则不那么准确。这三种设备都估计了24小时的睡眠时间,与睡眠日记相比,误差约为10%。结论:CST可以准确地捕捉床上夜间睡眠时间,而无需睡眠日记信息。然而,在现场设置中充分利用CST之前,需要改进评估参数,如总睡眠时间、睡眠效率和小睡。
{"title":"Contactless and longitudinal monitoring of nocturnal sleep and daytime naps in older men and women: a digital health technology evaluation study.","authors":"Kiran K G Ravindran,&nbsp;Ciro Della Monica,&nbsp;Giuseppe Atzori,&nbsp;Damion Lambert,&nbsp;Hana Hassanin,&nbsp;Victoria Revell,&nbsp;Derk-Jan Dijk","doi":"10.1093/sleep/zsad194","DOIUrl":"10.1093/sleep/zsad194","url":null,"abstract":"<p><strong>Study objectives: </strong>To compare the 24-hour sleep assessment capabilities of two contactless sleep technologies (CSTs) to actigraphy in community-dwelling older adults.</p><p><strong>Methods: </strong>We collected 7-14 days of data at home from 35 older adults (age: 65-83), some with medical conditions, using Withings Sleep Analyser (WSA, n = 29), Emfit QS (Emfit, n = 17), a standard actigraphy device (Actiwatch Spectrum [AWS, n = 34]), and a sleep diary (n = 35). We compared nocturnal and daytime sleep measures estimated by the CSTs and actigraphy without sleep diary information (AWS-A) against sleep-diary-assisted actigraphy (AWS|SD).</p><p><strong>Results: </strong>Compared to sleep diary, both CSTs accurately determined the timing of nocturnal sleep (intraclass correlation [ICC]: going to bed, getting out of bed, time in bed >0.75), whereas the accuracy of AWS-A was much lower. Compared to AWS|SD, the CSTs overestimated nocturnal total sleep time (WSA: +92.71 ± 81.16 minutes; Emfit: +101.47 ± 75.95 minutes) as did AWS-A (+46.95 ± 67.26 minutes). The CSTs overestimated sleep efficiency (WSA: +9.19% ± 14.26%; Emfit: +9.41% ± 11.05%), whereas AWS-A estimate (-2.38% ± 10.06%) was accurate. About 65% (n = 23) of participants reported daytime naps either in bed or elsewhere. About 90% in-bed nap periods were accurately determined by WSA while Emfit was less accurate. All three devices estimated 24-hour sleep duration with an error of ≈10% compared to the sleep diary.</p><p><strong>Conclusions: </strong>CSTs accurately capture the timing of in-bed nocturnal sleep periods without the need for sleep diary information. However, improvements are needed in assessing parameters such as total sleep time, sleep efficiency, and naps before these CSTs can be fully utilized in field settings.</p>","PeriodicalId":49514,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10135038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Amygdala resting-state functional connectivity alterations in patients with chronic insomnia disorder: correlation with electroencephalography beta power during sleep. 慢性失眠患者杏仁核静息状态功能连接的改变:与睡眠期间脑电图β功率的相关性。
IF 5.6 2区 医学 Q1 Medicine Pub Date : 2023-10-11 DOI: 10.1093/sleep/zsad205
Woojin Kweon, Kyung Hwa Lee, Sang Ho Choi, Jiyoon Shin, Mincheol Seo, Jeong Eun Jeon, Ha Young Lee, Chowon Park, Sun-Young Kim, Jong Won Kim, Jun Hyuk Chang, Yu Jin Lee

Study objectives: This study investigated alterations in resting-state functional connectivity (RSFC) and hyperarousal biomarkers in patients with chronic insomnia disorder (CID), compared with good sleepers (GS). We also examined the relationships between altered RSFC and hyperarousal biomarkers.

Methods: Fifty patients with CID and 52 GS completed self-reporting questionnaires, and then underwent polysomnography and resting-state functional magnetic resonance imaging. We analyzed RSFC in the amygdala (AMG) and anterior insula (aINS), which are core regions of the salience network that are likely to be involved in hyperarousal. We also analyzed electroencephalography (EEG) relative beta power and heart rate variability (HRV) parameters (e.g. low and high frequency) during sleep. We then tested between-group differences in the RSFC and hyperarousal biomarkers; we examined correlations of RSFC with EEG beta power and HRV.

Results: Compared with GS, patients with CID showed more negative RSFC between the right amygdala (R.AMG) and left supramarginal gyrus (L.SMG), but less positive RSFC between the left aINS and bilateral lateral prefrontal cortex. The R.AMG-L.SMG RSFC was negatively correlated with EEG beta power in central regions (C3: r = -0.336, p = 0.012; C4: r = -0.314, p = 0.024).

Conclusions: Decreased RSFC between the R.AMG and L.SMG in patients with insomnia may reflect the difficulty in cortical top-down regulation of the AMG, indicating daytime hyperarousal. Individuals who experience hyperarousal during the daytime may also exhibit cortical hyperarousal during sleep, as indicated by increased EEG beta power.

研究目的:本研究调查了与良好睡眠者(GS)相比,慢性失眠障碍(CID)患者静息状态功能连接(RSFC)和超兴奋生物标志物的变化。我们还研究了RSFC改变与超兴奋生物标志物之间的关系。方法:50例CID患者和52例GS患者完成自我报告问卷,然后进行多导睡眠图和静息状态功能磁共振成像。我们分析了杏仁核(AMG)和前脑岛(aINS)中的RSFC,这两个区域是显著性网络的核心区域,可能与过度兴奋有关。我们还分析了睡眠期间的脑电图(EEG)相对β功率和心率变异性(HRV)参数(例如低频和高频)。然后,我们测试了RSFC和超兴奋生物标志物的组间差异;结果:与GS相比,CID患者右侧杏仁核(R.AMG)和左侧缘上回(L.SMG)的RSFC呈阴性,而左侧aINS和双侧外侧前额叶皮层的RSFC阳性较少。R.AMG-L.SMG-RSFC与中心区域的EEGβ功率呈负相关(C3:R = -0.336,p = 0.012;C4:r = -0.314,p = 0.024)。结论:失眠患者R.AMG和L.SMG之间的RSFC降低可能反映了AMG的皮质自上而下调节的困难,表明白天过度兴奋。白天经历过度兴奋的个体在睡眠期间也可能表现出皮层过度兴奋,如脑电图β功率增加所示。
{"title":"Amygdala resting-state functional connectivity alterations in patients with chronic insomnia disorder: correlation with electroencephalography beta power during sleep.","authors":"Woojin Kweon,&nbsp;Kyung Hwa Lee,&nbsp;Sang Ho Choi,&nbsp;Jiyoon Shin,&nbsp;Mincheol Seo,&nbsp;Jeong Eun Jeon,&nbsp;Ha Young Lee,&nbsp;Chowon Park,&nbsp;Sun-Young Kim,&nbsp;Jong Won Kim,&nbsp;Jun Hyuk Chang,&nbsp;Yu Jin Lee","doi":"10.1093/sleep/zsad205","DOIUrl":"10.1093/sleep/zsad205","url":null,"abstract":"<p><strong>Study objectives: </strong>This study investigated alterations in resting-state functional connectivity (RSFC) and hyperarousal biomarkers in patients with chronic insomnia disorder (CID), compared with good sleepers (GS). We also examined the relationships between altered RSFC and hyperarousal biomarkers.</p><p><strong>Methods: </strong>Fifty patients with CID and 52 GS completed self-reporting questionnaires, and then underwent polysomnography and resting-state functional magnetic resonance imaging. We analyzed RSFC in the amygdala (AMG) and anterior insula (aINS), which are core regions of the salience network that are likely to be involved in hyperarousal. We also analyzed electroencephalography (EEG) relative beta power and heart rate variability (HRV) parameters (e.g. low and high frequency) during sleep. We then tested between-group differences in the RSFC and hyperarousal biomarkers; we examined correlations of RSFC with EEG beta power and HRV.</p><p><strong>Results: </strong>Compared with GS, patients with CID showed more negative RSFC between the right amygdala (R.AMG) and left supramarginal gyrus (L.SMG), but less positive RSFC between the left aINS and bilateral lateral prefrontal cortex. The R.AMG-L.SMG RSFC was negatively correlated with EEG beta power in central regions (C3: r = -0.336, p = 0.012; C4: r = -0.314, p = 0.024).</p><p><strong>Conclusions: </strong>Decreased RSFC between the R.AMG and L.SMG in patients with insomnia may reflect the difficulty in cortical top-down regulation of the AMG, indicating daytime hyperarousal. Individuals who experience hyperarousal during the daytime may also exhibit cortical hyperarousal during sleep, as indicated by increased EEG beta power.</p>","PeriodicalId":49514,"journal":{"name":"Sleep","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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