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Temperature-mediated structural evolution of vapor–phase deposited cyclosiloxane polymer thin films for enhanced mechanical properties and thermal conductivity 气相沉积环硅氧烷聚合物薄膜增强机械性能和导热性能的温度介导结构演化
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-03-20 DOI: 10.1088/2631-7990/acc5c1
W. Du, J. Tu, Mingjun Qiu, S. Zhou, Yingwu Luo, W. Ong, Junjie Zhao
Polymer-derived ceramic (PDC) thin films are promising wear-resistant coatings for protecting metals and carbon–carbon composites from corrosion and oxidation. However, the high pyrolysis temperature hinders the applications on substrate materials with low melting points. We report a new synthesis route for PDC coatings using initiated chemical vapor deposited poly(1,3,5-trivinyl-1,3,5-trimethylcyclotrisiloxane) (pV3D3) as the precursor. We investigated the changes in siloxane moieties and the network topology, and proposed a three-stage mechanism for the thermal annealing process. The rise of the connectivity number for the structures obtained at increased annealing temperatures was found with strong correlation to the enhanced mechanical properties and thermal conductivity. Our PDC films obtained via annealing at 850 °C exhibit at least 14.6% higher hardness than prior reports for PDCs synthesized below 1100 °C. Furthermore, thermal conductivity up to 1.02 W (mK)−1 was achieved at the annealing temperature as low as 700 °C, which is on the same order of magnitude as PDCs obtained above 1100 °C. Using minimum thermal conductivity models, we found that the thermal transport is dominated by diffusons in the films below the percolation of rigidity, while ultra-short mean-free path phonons contribute to the thermal conductivity of the films above the percolation threshold. The findings of this work provide new insights for the development of wear-resistant and thermally conductive PDC thin films for durable protection coatings.
聚合物衍生陶瓷(PDC)薄膜是一种很有前途的耐磨涂层,可以保护金属和碳-碳复合材料免受腐蚀和氧化。然而,高热解温度阻碍了在低熔点基材上的应用。本文报道了以化学气相沉积聚(1,3,5-三乙烯基-1,3,5-三甲基环三硅氧烷)(pV3D3)为前驱体合成PDC涂料的新路线。我们研究了硅氧烷基团和网络拓扑结构的变化,并提出了热退火过程的三阶段机制。在提高退火温度下获得的结构的连通性数的增加与力学性能和导热性的增强有很强的相关性。我们在850°C下退火得到的PDC薄膜的硬度比之前报道的在1100°C下合成的PDC至少高14.6%。此外,在低至700℃的退火温度下,热导率高达1.02 W (mK)−1,这与在1100℃以上获得的PDCs在同一数量级上。利用最小热导率模型,我们发现热输运主要由薄膜中的扩散主导,而超短平均自由程声子则有助于薄膜的热导率高于渗透阈值。研究结果为开发耐磨性、导热性强的PDC薄膜提供了新的思路。
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引用次数: 1
Morphological characteristics and atomic evolution behavior of nanojoints in Ag nanowire interconnect network 银纳米线互连网络中纳米接头的形态特征及原子演化行为
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-03-14 DOI: 10.1088/2631-7990/acc434
Jianlei Cui, Xiaoying Ren, X. Mei, Z. Fan, Chenchen Huang, Zhijun Wang, Xiaofei Sun, Wenjun Wang
Ag nanowires (AgNWs) have shown great application value in the field of flexible electronics due to their excellent optical and electrical properties, and the quality of its joints of AgNWs in the thin film network directly plays a key role in its performance. In order to further improve the joint quality of AgNWs under thermal excitation, the thermal welding process and atomic evolution behavior of AgNWs were investigated through a combination of in situ experimental and molecular dynamics simulations. The influence of processing time, temperature, and stress distribution due to spatial arrangement on nanojoints was systematically explored. What is more, the failure mechanisms and their atomic interface behavior of the nanojoints were also investigated.
银纳米线以其优异的光学和电学性能在柔性电子领域显示出巨大的应用价值,而银纳米线在薄膜网络中的接头质量直接影响其性能。为了进一步提高AgNWs在热激发下的接头质量,采用原位实验和分子动力学模拟相结合的方法研究了AgNWs的热焊接过程和原子演化行为。系统地探讨了加工时间、温度和空间排列引起的应力分布对纳米接头的影响。此外,还研究了纳米接头的破坏机制及其原子界面行为。
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引用次数: 1
Progresses on cryo-tribology: lubrication mechanisms, detection methods and applications 低温摩擦学研究进展:润滑机理、检测方法及应用
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-03-09 DOI: 10.1088/2631-7990/acc2fa
Wenyan Cui, Hongzhan Chen, Jianxun Zhao, Quan-sheng Ma, Qiang Xu, T. Ma
Tribology at cryogenic temperatures has attracted much attention since the 1950s with the acceleration of its applications in high-tech equipment such as cryogenic wind tunnels, liquid fuel rockets, space infrared telescopes, superconducting devices, and planetary exploration, which require solid lubrication for moving parts at low temperatures down to 4 K in cryogenic liquid, gaseous, or vacuum environments. Herein, the research progress regarding cryo-tribology is reviewed. The tribological properties and mechanisms of solid lubricants listed as carbon materials, molybdenum disulfide, polymers, and polymer-based composites with decreasing temperature are summarized. The friction coefficient increases with decreasing temperature induced by thermally activated processes. The mechanism of transfer film formation should be considered as a significant way to enhance the tribological properties of solid lubricants. In addition, applications of solid lubrication on moving parts under cryogenic conditions, such as spherical plain bearings and roller bearings, are introduced. The technology for tribological testing of materials and bearings at cryogenic temperatures is summarized, where the environmental control, motion and loading realization, as well as friction and wear measurement together in a low-temperature environment, result in the difficulties and challenges of the low-temperature tribotester. In particular, novel technologies and tribotesters have been developed for tribotests and tribological studies of solid lubricants, spherical plain bearings, and roller bearings, overcoming limitations regarding cooling in vacuum and resolution of friction measurement, among others, and concentrating on in-situ observation of friction interface. These not only promote a deep understanding of friction and wear mechanism at low temperatures, but also provide insights into the performance of moving parts or components in cryogenic applications.
自20世纪50年代以来,低温摩擦学在低温风洞、液体燃料火箭、空间红外望远镜、超导装置和行星探测等高科技设备中的应用加速,引起了人们的广泛关注。这些设备需要在低温液体、气体或真空环境中对低至4 K的运动部件进行固体润滑。本文对低温摩擦学的研究进展进行了综述。综述了碳材料、二硫化钼、聚合物和聚合物基复合材料等固体润滑剂的摩擦学性能及其降温机理。热活化过程引起的摩擦系数随温度的降低而增大。研究转移膜形成机理是提高固体润滑剂摩擦学性能的重要途径。此外,还介绍了在低温条件下运动部件(如球面滑动轴承和滚子轴承)上固体润滑的应用。总结了低温下材料和轴承的摩擦学测试技术,其中低温环境下的环境控制、运动和载荷的实现以及摩擦和磨损的测量是低温摩擦学测试的难点和挑战。特别是,针对固体润滑剂、球面滑动轴承和滚子轴承的摩擦试验和摩擦学研究开发了新的技术和摩擦测试仪,克服了真空冷却和摩擦测量分辨率等方面的限制,集中于摩擦界面的原位观察。这些不仅促进了对低温下摩擦和磨损机制的深入理解,而且还提供了对低温应用中运动部件或组件性能的见解。
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引用次数: 3
Meta-silencer with designable timbre 具有可设计音色的元消声器
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-03-06 DOI: 10.1088/2631-7990/acbd6d
Nengyin Wang, Chengcheng Zhou, Sheng Qiu, Sibo Huang, Bin Jia, Shanshan Liu, Junmei Cao, Zhiling Zhou, Hua Ding, Jie Zhu, Yong Li
Timbre, as one of the essential elements of sound, plays an important role in determining sound properties, whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances. Here, we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband. Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model, which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning. As proof-of-concept demonstrations for our design concepts, we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation, efficiency-controlled sound attenuation and designable timbre, respectively. The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm. Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering, impedance engineering, and architectural acoustics.
音色作为声音的基本元素之一,在决定声音特性方面起着重要作用,然而由于共振固有的色散性质,对被动机械系统来说,音色的操纵仍然具有挑战性。在这里,我们提出了一种支持密集模式密度和高度可调的固有损耗的元消声器,并为宽带中可设计的音色提供了新的途径。强全局耦合是由强模密度引起的,并在理论模型的指导下进行精细调制,有效地抑制了共振色散,并为音色调谐提供了理想的频率选择性波操纵能力。作为我们设计概念的概念验证,我们提出了三种元消声器,其设计目标分别是高效宽带声衰减、效率控制声衰减和可设计音色。所提出的元消声器都在500至3200hz的宽带频率范围内工作,其深亚波长尺寸约为50mm。我们的工作开辟了一条利用被动共振控制声学超材料来操纵音色的基本途径,并可能激发在噪声控制工程、阻抗工程和建筑声学中新型多功能设备的发展。
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引用次数: 6
Failure mode change and material damage with varied machining speeds: a review 不同加工速度下的失效模式变化和材料损伤:综述
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-02-20 DOI: 10.1088/2631-7990/acbd6f
Jianqiu Zhang, Binbin He, Bi Zhang
High-speed machining (HSM) has been studied for several decades and has potential application in various industries, including the automobile and aerospace industries. However, the underlying mechanisms of HSM have not been formally reviewed thus far. This article focuses on the solid mechanics framework of adiabatic shear band (ASB) onset and material metallurgical microstructural evolutions in HSM. The ASB onset is described using partial differential systems. Several factors in HSM were considered in the systems, and the ASB onset conditions were obtained by solving these systems or applying the perturbation method to the systems. With increasing machining speed, an ASB can be depressed and further eliminated by shock pressure. The damage observed in HSM exhibits common features. Equiaxed fine grains produced by dynamic recrystallization widely cause damage to ductile materials, and amorphization is the common microstructural evolution in brittle materials. Based on previous studies, potential mechanisms for the phenomena in HSM are proposed. These include the thickness variation of the white layer of ductile materials. These proposed mechanisms would be beneficial to deeply understanding the various phenomena in HSM.
高速加工(HSM)已经研究了几十年,在包括汽车和航空航天工业在内的各个行业都有潜在的应用。然而,迄今为止,高速切削的潜在机制尚未得到正式审查。本文重点研究了高速切削过程中绝热剪切带(ASB)起始的固体力学框架和材料的金相组织演变。ASB的发病是用偏微分系统描述的。在系统中考虑了高速切削过程中的多个影响因素,通过求解这些系统或对系统应用摄动法得到了ASB的发生条件。随着加工速度的提高,ASB可以被压缩,并进一步被冲击压力消除。在HSM中观察到的损伤表现出共同的特征。动态再结晶产生的等轴细晶粒广泛地对韧性材料造成损伤,非晶化是脆性材料中常见的显微组织演变过程。在前人研究的基础上,提出了这种现象的潜在机制。其中包括延性材料白层厚度的变化。这些机制的提出将有助于深入理解高速切削中的各种现象。
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引用次数: 2
Will high-entropy carbides and borides be enabling materials for extreme environments? 高熵碳化物和硼化物会成为极端环境下的有利材料吗?
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-02-20 DOI: 10.1088/2631-7990/acbd6e
Fei Wang, F. Monteverde, B. Cui
The concept of multi-principal component has created promising opportunities for the development of novel high-entropy ceramics for extreme environments encountered in advanced turbine engines, nuclear reactors, and hypersonic vehicles, as it expands the compositional space of ceramic materials with tailored properties within a single-phase solid solution. The unique physical properties of some high-entropy carbides and borides, such as higher hardness, high-temperature strength, lower thermal conductivity, and improved irradiation resistance than the constitute ceramics, have been observed. These promising properties may be attributed to the compositional complexity, atomic-level disorder, lattice distortion, and other fundamental processes related to defect formation and phonon scattering. This manuscript serves as a critical review of the recent progress in high-entropy carbides and borides, focusing on synthesis and evaluations of their performance in extreme high-temperature, irradiation, and gaseous environments.
多主成分的概念为先进涡轮发动机、核反应堆和高超音速飞行器等极端环境中新型高熵陶瓷的开发创造了有希望的机会,因为它扩大了单相固溶体中具有定制性能的陶瓷材料的成分空间。一些高熵碳化物和硼化物具有比构成陶瓷更高的硬度、高温强度、更低的热导率和更好的耐辐照性等独特的物理性质。这些有希望的性质可能归因于组成的复杂性、原子水平的无序性、晶格畸变以及与缺陷形成和声子散射相关的其他基本过程。这份手稿作为一个重要的审查,在高熵碳化物和硼化物的最新进展,集中在合成和评估其性能在极端高温,辐射和气体环境。
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引用次数: 2
Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for directed cellular infiltration and tissue regeneration 在3d打印聚己内酯支架中嵌入对齐的纳米纤维结构,用于定向细胞浸润和组织再生
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-02-20 DOI: 10.1088/2631-7990/acbd6c
Zijie Meng, Xingdou Mu, Jiankang He, Juliang Zhang, Rui Ling, Dichen Li
Three-dimensional (3D) printing provides a promising way to fabricate biodegradable scaffolds with designer architectures for the regeneration of various tissues. However, the existing 3D-printed scaffolds commonly suffer from weak cell-scaffold interactions and insufficient cell organizations due to the limited resolution of the 3D-printed features. Here, composite scaffolds with mechanically-robust frameworks and aligned nanofibrous architectures are presented and hybrid manufactured by combining techniques of 3D printing, electrospinning, and unidirectional freeze-casting. It was found that the composite scaffolds provided volume-stable environments and enabled directed cellular infiltration for tissue regeneration. In particular, the nanofibrous architectures with aligned micropores served as artificial extracellular matrix materials and improved the attachment, proliferation, and infiltration of cells. The proposed scaffolds can also support the adipogenic maturation of adipose-derived stem cells (ADSCs) in vitro. Moreover, the composite scaffolds were found to guide directed tissue infiltration and promote nearby neovascularization when implanted into a subcutaneous model of rats, and the addition of ADSCs further enhanced their adipogenic potential. The presented hybrid manufacturing strategy might provide a promising way to produce additional topological cues within 3D-printed scaffolds for better tissue regeneration.
三维(3D)打印为制造具有设计结构的生物可降解支架提供了一种很有前途的方法,用于各种组织的再生。然而,由于3d打印特征的分辨率有限,现有的3d打印支架普遍存在细胞-支架相互作用弱和细胞组织不足的问题。本文通过3D打印、静电纺丝和单向冷冻铸造技术的结合,提出了具有机械坚固框架和排列纳米纤维结构的复合支架。结果表明,复合支架为组织再生提供了体积稳定的环境和定向细胞浸润。特别是,具有排列微孔的纳米纤维结构作为人工细胞外基质材料,改善了细胞的附着、增殖和浸润。所提出的支架也可以在体外支持脂肪源性干细胞(ADSCs)的成脂成熟。此外,复合支架植入大鼠皮下模型后,发现其具有引导组织定向浸润和促进附近新生血管形成的作用,并且ADSCs的加入进一步增强了其成脂潜能。所提出的混合制造策略可能为在3d打印支架内产生额外的拓扑线索提供了一种有希望的方法,以实现更好的组织再生。
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引用次数: 1
Bionic microchannels for step lifting transpiration 台阶提升蒸腾仿生微通道
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-02-17 DOI: 10.1088/2631-7990/acbcff
Zhaolong Wang, Qiu Yin, Ziheng Zhan, Wenhao Li, Mingzhu Xie, H. Duan, P. Cheng, Ce Zhang, Yongping Chen, Zhichao Dong
Those various cross-sectional vessels in trees transfer water to as high as 100 meters, but the traditional fabrication methods limit the manufacturing of those vessels, resulting in the non-availability of those bionic microchannels. Herein, we fabricate those bionic microchannels with various cross-sections by employing projection micro-stereolithography (PµSL) based 3D printing technique. The circumradius of bionic microchannels (pentagonal, square, triangle, and five-pointed star) can be as small as 100 μm with precisely fabricated sharp corners. What’s more, those bionic microchannels demonstrate marvelous microfluidic performance with strong precursor effects enabled by their sharp corners. Most significantly, those special properties of our bionic microchannels enable them outstanding step lifting performance to transport water to tens of millimeters, though the water can only be transported to at most 20 mm for a single bionic microchannel. The mimicked transpiration based on the step lifting of water from bionic microchannels is also achieved. Those precisely fabricated, low-cost, various cross-sectional bionic microchannels promise applications as microfluidic chips, long-distance unpowered water transportation, step lifting, mimicked transpiration, and so on.
树木中的各种横截面容器可以将水输送到100米高的地方,但传统的制造方法限制了这些容器的制造,导致这些仿生微通道的不可用性。在此,我们采用基于投影微立体光刻(PµSL)的3D打印技术制造了具有不同横截面的仿生微通道。仿生微通道(五角形、正方形、三角形和五角星形)的周长可小至100 μm,并具有精确制造的尖角。此外,这些仿生微通道的尖角使其具有强大的前驱效应,表现出优异的微流控性能。最重要的是,我们的仿生微通道的这些特殊性能使它们具有出色的台阶提升性能,可以将水输送到几十毫米的高度,尽管单个仿生微通道最多只能将水输送到20毫米的高度。在模拟蒸腾的基础上,实现了水从仿生微通道的阶梯提升。这些精确制造、低成本、不同截面的仿生微通道有望应用于微流控芯片、长距离无动力水运、台阶提升、模拟蒸腾等领域。
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引用次数: 8
Numerical simulation of materials-oriented ultra-precision diamond cutting: review and outlook 面向材料的超精密金刚石切削数值模拟:回顾与展望
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-02-10 DOI: 10.1088/2631-7990/acbb42
Liang Zhao, Junjie Zhang, Jianguo Zhang, Houfu Dai, A. Hartmaier, Tao Sun
Ultra-precision diamond cutting is a promising machining technique for realizing ultra-smooth surface of different kinds of materials. While fundamental understanding of the impact of workpiece material properties on cutting mechanisms is crucial for promoting the capability of the machining technique, numerical simulation methods at different length and time scales act as important supplements to experimental investigations. In this work, we present a compact review on recent advancements in the numerical simulations of material-oriented diamond cutting, in which representative machining phenomena are systematically summarized and discussed by multiscale simulations such as molecular dynamics simulation and finite element simulation: the anisotropy cutting behavior of polycrystalline material, the thermo-mechanical coupling tool-chip friction states, the synergetic cutting responses of individual phase in composite materials, and the impact of various external energetic fields on cutting processes. In particular, the novel physics-based numerical models, which involve the high precision constitutive law associated with heterogeneous deformation behavior, the thermo-mechanical coupling algorithm associated with tool-chip friction, the configurations of individual phases in line with real microstructural characteristics of composite materials, and the integration of external energetic fields into cutting models, are highlighted. Finally, insights into the future development of advanced numerical simulation techniques for diamond cutting of advanced structured materials are also provided. The aspects reported in this review present guidelines for the numerical simulations of ultra-precision mechanical machining responses for a variety of materials.
超精密金刚石切削是实现各种材料表面超光滑加工的一种很有前途的加工技术。虽然对工件材料特性对切削机制影响的基本理解对于提高加工技术的能力至关重要,但不同长度和时间尺度的数值模拟方法是实验研究的重要补充。在这项工作中,我们对材料取向金刚石切削数值模拟的最新进展进行了简要回顾,其中通过分子动力学模拟和有限元模拟等多尺度模拟系统地总结和讨论了具有代表性的加工现象:研究了多晶材料的各向异性切削行为,刀具-切屑摩擦状态的热-机械耦合,复合材料中单个相的协同切削响应,以及各种外部能场对切削过程的影响。特别强调了基于物理的新型数值模型,包括与非均质变形行为相关的高精度本构律,与刀具-切屑摩擦相关的热-力耦合算法,符合复合材料真实微观结构特征的单个相配置,以及将外部能场集成到切削模型中。最后,对先进结构材料的金刚石切削的先进数值模拟技术的未来发展也提供了见解。这篇综述中所报道的方面为各种材料的超精密机械加工响应的数值模拟提供了指导。
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引用次数: 7
3D printed fiber-optic nanomechanical bioprobe 3D打印光纤纳米机械生物探针
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-01-30 DOI: 10.1088/2631-7990/acb741
Mengqiang Zou, C. Liao, Yanping Chen, Lei Xu, Shuo Tang, Gaixia Xu, Ke Ma, Jiangtao Zhou, Zhihao Cai, Bozhe Li, Cong Zhao, Zhourui Xu, Yuanyuan Shen, Shen Liu, Y. Wang, Zongsong Gan, Hao Wang, Xuming Zhang, S. Kasas, Yiping Wang
Ultrasensitive nanomechanical instruments, e.g. atomic force microscopy (AFM), can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes. However, these instruments are limited because of their size and complex feedback system. In this study, we demonstrate a miniature fiber optical nanomechanical probe (FONP) that can be used to detect the mechanical properties of single cells and in vivo tissue measurements. A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization nanolithography. To realize stiffness matching of the FONP and sample, a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated mechanics. As a proof-of concept, three FONPs with spring constants varying from 0.421 N m−1 to 52.6 N m−1 by more than two orders of magnitude were prepared. The highest microforce sensitivity was 54.5 nm μN−1 and the detection limit was 2.1 nN. The Young’s modulus of heterogeneous soft materials, such as polydimethylsiloxane, muscle tissue of living mice, onion cells, and MCF-7 cells, were successfully measured, which validating the broad applicability of this method. Our strategy provides a universal protocol for directly programming fiber-optic AFMs. Moreover, this method has no special requirements for the size and shape of living biological samples, which is infeasible when using commercial AFMs. FONP has made substantial progress in realizing basic biological discoveries, which may create new biomedical applications that cannot be realized by current AFMs.
超灵敏的纳米机械仪器,如原子力显微镜(AFM),可用于进行精密的生物力学测量,揭示生物过程的复杂机械环境。然而,这些仪器由于其尺寸和复杂的反馈系统而受到限制。在这项研究中,我们展示了一种微型光纤纳米机械探针(FONP),可用于检测单细胞的机械特性和体内组织测量。利用飞秒激光双光子聚合纳米光刻技术,在单模光纤的端面设计了微悬臂探针,开发了一种可在空气和液体中工作的光纤激光器。为了实现微悬臂梁与试样的刚度匹配,基于结构相关力学,提出了一种根据试样定制微悬臂梁弹簧常数的策略。作为概念验证,制备了三个弹簧常数在0.421 N m−1至52.6 N m−1之间变化超过两个数量级的fonp。微力灵敏度最高为54.5 nm μN−1,检出限为2.1 nN。异质软质材料(如聚二甲基硅氧烷、活小鼠肌肉组织、洋葱细胞和MCF-7细胞)的杨氏模量成功测量,验证了该方法的广泛适用性。我们的策略为直接编程光纤afm提供了一个通用协议。此外,该方法对活体生物样品的大小和形状没有特殊要求,这在使用商用AFMs时是不可行的。FONP在实现基础生物学发现方面取得了实质性进展,这可能会创造出当前afm无法实现的新的生物医学应用。
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引用次数: 4
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International Journal of Extreme Manufacturing
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