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2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)最新文献

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Leukemia On Chip – Electrical Impedance Spectroscopy As An Online Readout To Investigate Drug-Cancer Interaction 芯片上的白血病-电阻抗谱作为在线读数来研究药物-癌症相互作用
Furkan Gökçe, Paolo S. Ravaynia, A. Kaestli, M. Modena, A. Hierlemann, K. Renggli
Based on recent advances in the field of microphysiological systems, we established a Leukemiaon-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) unit that enables to monitor the flowing cancer cells in real-time. The electric parameters, such as membrane conductivity and dielectric properties, alter upon the death of leukemia cells. Thus, drug-cancer interactions can be studied online and label-free by means of EIS. In this study, we present proof-of-concept experimental results that show the potential of EIS for real-time drug efficacy research.
基于微生理系统领域的最新进展,我们建立了一个白血病芯片的概念,通过在微流控系统中连续循环白血病细胞来模拟体外血癌。该平台由集成电阻抗光谱(EIS)单元补充,能够实时监测流动的癌细胞。在白血病细胞死亡后,膜的电导率和介电性质等电参数会发生改变。因此,通过EIS可以在线和无标签地研究药物-癌症相互作用。在这项研究中,我们提出了概念验证实验结果,显示了EIS在实时药物疗效研究中的潜力。
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引用次数: 0
Cmos Controlled Ghz Ultrasonic Impedance Imager Cmos控制的Ghz超声阻抗成像仪
M. Abdelmejeed, J. Kuo, Adarsh Ravi, A. Lal
This paper presents a demonstration of CMOS driven 1-2 GHz ultrasonic imager that can be monolithically integrated in a single-chip and operate at 1.5V battery voltages. The pulse transmit/receive operation of a single AlN transducer pixel driven by custom 180nm CMOS RF circuits is demonstrated. The pixel transducer is scanned in two dimensions to image fingerprints and leaves with 254 dpi resolution. Based on a single pixel imaging time, frame rate is estimated to be 500 fps at 13.6 μJ/frame. The contrast of returned signal between rubber and air is 3.3:1 for dry rubber and 1.5:1 for wet rubber. This work shows a pathway towards single chip GHz ultrasonic imager.
本文演示了一种CMOS驱动的1- 2ghz超声成像仪,该成像仪可以单片集成在单片机中,并在1.5V电池电压下工作。演示了由定制的180nm CMOS RF电路驱动的单个AlN换能器像素的脉冲发射/接收操作。像素传感器进行二维扫描,以254dpi的分辨率对指纹和树叶进行成像。基于单像素成像时间,估计帧率为500 fps,为13.6 μJ/帧。干橡胶与空气的回波信号比为3.3:1,湿橡胶为1.5:1。本工作为实现单芯片GHz超声成像仪提供了一条途径。
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引用次数: 5
A Fingertip-Shaped Tactile Sensor with Machine-Learning-Based Sensor-To-Information Processing 一种基于机器学习的指尖型触觉传感器
J. Kuehn, Y. Manoli
We present a fingertip-shaped tactile sensor system that can measure static forces and slip vibrations using the same sensor. A fully integrated stress sensor ASIC leads to a simple design and assembly of the tactile fingertip. Instead of calibrating the fingertip to quantitatively measure forces, we use machine learning to extract abstract information out of the raw sensor data. Avoiding complex signal processing, this sensor-to-information processing scheme is fast and can have a small footprint. The results show that the system can classify the direction of applied forces with 99.8% accuracy. The combination of the stress sensor array and the machine learning approach allows to detect slip and tangential force direction simultaneously. The combined classification achieves 99.6% accuracy.
我们提出了一个指尖形状的触觉传感器系统,可以测量静力和滑动振动使用相同的传感器。一个完全集成的应力传感器ASIC导致一个简单的设计和组装触觉指尖。我们不是通过校准指尖来定量测量力,而是使用机器学习从原始传感器数据中提取抽象信息。该方案避免了复杂的信号处理,速度快,占用空间小。结果表明,该系统能以99.8%的准确率对作用力方向进行分类。应力传感器阵列和机器学习方法的结合可以同时检测滑移和切向力方向。组合分类准确率达到99.6%。
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引用次数: 1
Electro-Hydrodynamic Droplet Generation, Manipulation, and Repulsion of Oxidized Gallium-Based Liquid Metal 氧化镓基液态金属的电流体动力液滴的产生、操纵和排斥
Jinwon Jeong, S. Chung, Jeong‐Bong Lee, Daeyoung Kim
This paper presents the electric field-based on-demand size controllable droplet generation, falling direction manipulation, and repulsion. We controlled the size of the generated gallium-based liquid metal droplets by adjusting the amplitude of the applied electric field. The volume and the number of the generated liquid metal droplet depending on flow rate and applied voltage were measured. We also studied time-dependent falling velocity of the generated liquid metal droplet according to various applied voltages. In addition, by changing the electric field which was achieved by controlling the position of the circular-shaped electrode, the falling direction of liquid metal droplet can be manipulated. Finally, the electro-hydrodynamic repulsion of the liquid metal was demonstrated.
本文介绍了基于电场的按需尺寸可控液滴生成、下落方向控制和排斥。我们通过调节外加电场的振幅来控制生成的镓基液态金属液滴的大小。测量了随流速和施加电压变化而产生的液态金属液滴的体积和数量。我们还研究了所产生的液态金属液滴在不同电压下随时间变化的下落速度。此外,通过控制圆形电极的位置来改变电场,可以控制液态金属液滴的下落方向。最后,证明了液态金属的电流体斥力。
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引用次数: 1
Shape Deformation Analysis of Single Cell in 3d Tissue Under Mechanical Stimuli 机械刺激下三维组织中单细胞的形状变形分析
Keitaro Kasahara, Yuta Kurashina, S. Miura, S. Miyata, H. Onoe
This paper describes an analytical platform to investigate the cell response against mechanical stimuli in in vitro 3D tissues. The system is capable of live-imaging cells in 3D tissues at a single cell level under mechanical stimuli, which makes this system similar to the in vivo environment and suitable for analysis of maturation mechanism. We succeeded in imaging various shapes of cells in 3D tissue under mechanical stimuli and observed that the stretch-induced deformation was distributed non-uniformly inside cells. We believe that our system could contribute to a further understanding of the tissue maturation mechanism induced by mechanical stimuli, which is highly useful for the development of tissue reconstruction.
本文描述了一个分析平台来研究细胞对体外3D组织机械刺激的反应。该系统能够在机械刺激下在单细胞水平上对三维组织中的细胞进行活体成像,这使得该系统与体内环境相似,适合于成熟机制的分析。我们成功地在机械刺激下成像三维组织中各种形状的细胞,并观察到拉伸引起的变形在细胞内分布不均匀。我们相信该系统有助于进一步了解机械刺激诱导的组织成熟机制,对组织重建的发展具有重要意义。
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引用次数: 1
Rapid Assembly of DNA Origami in Microfluidic Temperature Gradient 微流控温度梯度下DNA折纸的快速组装
K. Kawai, Harada Keita, Ryota Nakamura, Kenta Arima, K. Yamamura, O. Tabata
DNA nanostructures, called DNA origami, are self-assembled through DNA hybridization by annealing process. DNA origami consists of a long single-strand DNA, scaffold, and hundreds of complementary oligonucleotides, staple, and constructs various 2D or 3D nanostructures. For DNA origami folding, it is necessary to denature DNAs and annealed them slowly. Although in general annealing process using microtube and commercial thermal cycler, it takes a long time for DNA hybridization due to large scale reactor. Here, We present an effect of temperature distribution during a rapid folding of DNA nanostructures, called DNA origami. DNA origami can fabricate various designs and sizes of 2D/3D nanostructures by self-assembly of DNA hybridization. Based on results of computational fluid dynamics (CFD) simulation, time-dependent temperature distribution in microtube effects the yield of DNA origami. Triangle DNA origami can be folded at -30 °C/min in microfluidic channel whereas no DNA nanostructures were observed by general annealing process. We confirmed 20 times-faster self-assembly of DNA nanostructures in microfluidic channel, compared to general annealing process in microtube by thermal cycler.
DNA纳米结构,称为DNA折纸,是通过DNA杂交退火过程自组装的。DNA折纸由长单链DNA、支架和数百个互补的寡核苷酸、短钉组成,并构建各种2D或3D纳米结构。对于DNA折纸,需要对DNA进行变性和缓慢退火。虽然一般的退火工艺采用微管和商用热循环器,但由于反应器规模较大,DNA杂交耗时较长。在这里,我们提出了温度分布对DNA纳米结构快速折叠的影响,称为DNA折纸。DNA折纸技术通过DNA杂交的自组装可以制造出各种形状和尺寸的二维/三维纳米结构。计算流体动力学(CFD)模拟结果表明,微管温度随时间的变化对DNA折纸的产率有影响。在-30°C/min的温度下,在微流控通道中可以折叠出三角形DNA折纸,而一般的退火工艺没有观察到DNA纳米结构。我们证实了DNA纳米结构在微流控通道中的自组装速度比在微管中使用热循环器的一般退火过程快20倍。
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引用次数: 0
A Planar Single-Actuator Bi-Stable Switch Based on Latch-Lock Mechanism 基于闭锁机构的平面单动器双稳开关
Yang Gao, Toshiki Ema, Zeyuan Cao, Sheng Ni, Elena Chan, O. Tabata, T. Tsuchiya, X. Wang, M. Wong
Described presently is a micro-fabricated planar bi-stable mechanical switch driven using only one compliant electro-thermal actuator. The state-defining bi-stable mechanism is connected to the actuator via a displacement lever-amplifier and an electrically/thermally insulating linkage structure. More robust state-locking is achieved using a latch-lock rather than the commonly employed buckled-mode mechanism. Realized on a silicon-on-insulator substrate, the device could be switched between the "set" and the "reset" mechanical states with respective actuation-voltage of 11 and 6 V.
目前描述的是一种微加工平面双稳态机械开关,仅使用一个柔性电热致动器驱动。定义状态的双稳定机构通过位移杠杆放大器和电/热绝缘连杆结构连接到致动器。使用闩锁而不是通常使用的屈曲模式机制可以实现更健壮的状态锁定。在绝缘体上硅衬底上实现,该器件可以在分别为11 V和6 V的驱动电压下在“设置”和“复位”机械状态之间切换。
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引用次数: 4
Fabrication of Contact Lens Device with Integrated Microtubes for in Situ Extended Drug Delivery for Ocular Disease Treatment 集成微管隐形眼镜装置的研制用于眼部疾病治疗的原位扩展给药
Xiaoke Ding, Chao Song, L. Que
Drug delivery is a difficult task in ocular therapeutics due to the physiological and anatomical constraints of the eye. The correct therapeutic concentration of a drug at the required site of action is difficult to obtain. For instance, only <1% of a topically administered drug reaches the aqueous humor. Herein, we report a new type of contact lens device with integrated microtubes as drug containers, which can provide a simple, noninvasive, extended drug release up to 40 days with higher bioavailability and lower risk for adverse effects.
由于眼睛的生理和解剖限制,给药是眼科治疗中的一项艰巨任务。药物在所需作用部位的正确治疗浓度很难获得。例如,只有<1%的局部给药到达房水。本文报道了一种以集成微管作为药物容器的新型隐形眼镜装置,该装置可以提供长达40天的简单,无创,延长药物释放时间,具有较高的生物利用度和较低的不良反应风险。
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引用次数: 8
Design and Manufacture of A Silicone Pendulum for PTB’S Nanoforce Standard Facility PTB纳米力标准装置用硅酮摆的设计与制造
S. Bütefisch, T. Weimann, A. Vierheller, V. Nesterov, A. Dietzel
This article presents the design and micro manufacture of a novel silicon pendulum to be used at the German National Metrology Institute (PTB) for the measurement of ultra-small forces. The nanoforce standard facility with the previous pendulum, manufactured by precision engineering methods, together with the constructive requirements are described. The particularities of wetchemical anisotropic silicon etching and their benefits and challenges when used for the manufacturing of the new pendulum are discussed. Finally, two design variants that were realized are discussed. One of the variants proved to be more robust against variations in the silicon raw wafer material and promises to offer an advantageous replacement for the precision engineered pendulums.
本文介绍了德国国家计量研究所(PTB)用于测量超小型力的新型硅摆的设计和微制造。介绍了用精密工程方法制造的纳米力标准摆装置及其构造要求。讨论了湿化学各向异性硅蚀刻的特点及其在制造新型摆时的优势和挑战。最后,讨论了实现的两种设计变体。其中一种变体被证明对硅原料晶圆材料的变化更为坚固,并有望为精密工程钟摆提供有利的替代品。
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引用次数: 0
Piezoelectric Scanning Micromirror with Large Scan Angle Based on Thin Film Aluminum Nitride 基于氮化铝薄膜的大扫描角压电微镜
Katja Meinel, C. Stoeckel, M. Melzer, S. Zimmermann, R. Forke, K. Hiller, T. Otto
In this paper micromirrors based on piezoelectric thin film aluminum nitride (AlN) are presented. The microsystems with a 6 mm² footprint are fabricated successfully in 150 mm SOI technology. A large tilt angle is achieved by FEM-based optimization of the lever arm parameters. Three micromirror types with varied spring widths are characterized, achieving tilt angles up to 51.3° at 1.9 kHz, 31.6° at 4.6 kHz, and 16.5° at 12.5 kHz for an actuation voltage of less than 5 V. For higher actuation voltages up to 20 V, a maximum scan angle of 104.9° is reached, limited by the measurement setup.
本文提出了一种基于压电薄膜氮化铝(AlN)的微镜。采用150mm SOI技术成功制备了占地面积为6mm²的微系统。通过有限元法优化杆臂参数,实现了较大的倾斜角度。具有不同弹簧宽度的三种微镜类型的特征,在小于5 V的驱动电压下,在1.9 kHz时可达到51.3°,4.6 kHz时可达到31.6°,12.5 kHz时可达到16.5°。对于高达20 V的较高驱动电压,受测量设置的限制,最大扫描角达到104.9°。
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引用次数: 10
期刊
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
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