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The relation between bimanual coordination, lesion timing, and corticospinal tract wiring pattern in children with unilateral cerebral palsy 单侧脑瘫患儿双手协调性、病变时间与皮质脊髓束布线模式的关系
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.138
Charlotte Lambrechts, Alexandra Kalkantzi, Lisa Decraene, Lize Kleeren, Monica Crotti, Katrijn Klingels, Els Ortibus, Hilde Feys, Lisa Mailleux
In children with unilateral cerebral palsy (uCP), it is well-described that the corticospinal tract (CST) wiring pattern and lesion timing are strongly related to unimanual upper limb function.1 Remarkably, the relation between those neurological factors and bimanual coordination is not yet thoroughly examined, while most daily life activities require the integrated use of both hands. Does bimanual coordination differ depending on the CST-wiring pattern and lesion timing in children with uCP? Bimanual coordination was assessed in 29 children with uCP (12.1 y±2.7 y) using the ball-on-bar task on the Kinarm robotic exoskeleton.2 This task consists of two levels of increasing difficulty, during which participants move a ball to a target while balancing it on a bar through two-dimensional virtual reality visual guidance. Eight parameters of each level were included. Using transcranial magnetic stimulation, the participants were classified into two groups according to their CST-wring pattern: the contralateral (N=10) versus the reorganized ipsilateral or bilateral (N=3/7) CST-wiring. In 9 children, this assessment was not feasible. Based on magnetic resonance imaging, the participants were classified according to their lesion timing in predominant white matter (PWM) lesions (N=16) versus predominant grey matter (PGM) lesions (N=5). In 8 children, brain imaging was missing. Between-group comparisons were calculated with ANCOVA or the non-parametric Quade’s Rank (p<0.05), with age as covariate. Effect sizes were calculated using partial eta squared (np2) and interpreted as: ηp2=0.01 small effect, ηp2=0.06 medium effect, ηp2=0.14 large effect Between the CST-wiring groups, a significant difference was found for hand speed difference in level 2 (F=4.876, p=0.04, ηp2=0.22), indicating a better hand synchrony in children with a contralateral CST-wiring compared to children with a reorganized CST-wiring. Between the lesion timing groups, a significant difference was found for bar tilt standard deviation (SD) in level 1 (F=7.679, p=0.01, ηp2=0.29), reflecting a more stable maintenance of the bar by the PGM-group compared to the PWM-group. Interestingly, a significant group*age interaction was found for level 2 of this parameter (p=0.03), revealing more variability of the bar tilt in the PGM-group with increasing age, in contrast to the PWM-group, which had less variability (Fig. 1).Download : Download high-res image (49KB)Download : Download full-size image Our findings are partially in line with current literature suggesting that children with a contralateral wiring have a better motor function. However, in contrast to previous studies, our results suggest worse bimanual coordination in children with PWM-lesions, which could be explained by the higher incidence of bilateral lesions in PWM-lesions compared to PGM-lesions.3 Nevertheless, future research with larger samples accounting for age interactions is warranted.
在单侧脑瘫(uCP)患儿中,皮质脊髓束(CST)接线模式和病变时间与单侧上肢功能密切相关值得注意的是,这些神经因素与双手协调之间的关系尚未得到彻底的研究,而大多数日常生活活动都需要综合使用双手。uCP患儿的双手协调能力是否因cst连线模式和病变时间的不同而不同?使用Kinarm机器人外骨骼上的球-棒任务评估29例uCP患儿(12.1 y±2.7 y)的双手协调能力这项任务包括两个难度递增的关卡,在此期间,参与者通过二维虚拟现实视觉引导将球移动到目标,同时在杆上保持平衡。每个水平包括8个参数。使用经颅磁刺激,参与者根据他们的cst连接模式被分为两组:对侧(N=10)与重组的同侧或双侧(N=3/7) cst连接。在9名儿童中,这种评估是不可行的。基于磁共振成像,参与者根据主要白质(PWM)病变(N=16)和主要灰质(PGM)病变(N=5)的病变时间进行分类。8例患儿脑显像缺失。以年龄为协变量,采用ANCOVA或非参数Quade’s Rank计算组间比较(p<0.05)。效应量采用偏eta平方(np2)计算,解释为:ηp2=0.01小效应,ηp2=0.06中效应,ηp2=0.14大效应。在cst连线组之间,手速度差异在2水平上有显著性差异(F=4.876, p=0.04, ηp2=0.22),表明对侧cst连线组的手同步性优于重组cst连线组。在病变时间组之间,1级棒倾斜标准差(SD)有显著差异(F=7.679, p=0.01, ηp2=0.29),反映pgm组比pwm组对棒的维护更稳定。有趣的是,在该参数的水平2中发现了显著的组与年龄之间的相互作用(p=0.03),揭示了pdm组随着年龄的增长柱倾斜的变异性更多,而pwm组变异性较少(图1)。我们的研究结果部分符合当前文献的建议,即具有对侧连线的儿童具有更好的运动功能。然而,与以往的研究相比,我们的研究结果表明,患有pwm病变的儿童双手协调能力较差,这可以解释为pwm病变中双侧病变的发生率高于pgm病变然而,未来的研究需要更大的样本来解释年龄的相互作用。
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引用次数: 0
Knee flexion while walking versus knee contractures in children with bilateral spastic cerebral palsy 行走时膝关节屈曲与双侧痉挛性脑瘫患儿膝关节挛缩的比较
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.141
Cecilia Lidbeck, Bartonek Åsa
Flexed knee is a multidimensional kinematic walking pattern in children with bilateral spastic CP that has been described to develop as gait matures, particularly at higher GMFCS levels (1). One cause might be limited knee extension that have been described to lead to significant disability with a flexed knee gait posture during walking (2). The aim of this study was to compare knee position during walking with passive knee extension in an unloaded body position, and with respect to functional mobility during walking. Gait in 30 children with bilateral spastic CP (13 females) median [min, max] age 11.3 [7.6, 17.1] years and 22 typical developing (TD) children (11 females) median [min-max] age 8.9 [6.5-16.9], was assessed with 3D-motion analysis (Vicon MX40®). Joint contractures in ankle, knee and hip, defined from a neutral joint position, were assessed through goniometric measurement of passive hip extension, knee extension, and ankle dorsiflexion with extended knee in supine position. Orthopaedic lower limb surgeries were documented. Functional mobility was measured with the time up and go test (TUG). Non-parametric statistics were used (p<0.05). Knee contractures were greater at GMFCS III than at GMFCS I and in the TD group (p=0.046 and p= 0.002). During walking, knee angle at initial contact (KneeAngleIC) was greater than peak knee extension in stance (MinKneeFlexSt) in the TD group and at GMFCS I, II, and III (p=0.008, p=0.043, 0.005, and p=0.002) respectively. MinKneeFlexSt exceeded maximum passive knee extension at GMFCS levels II (p=0.004), and III (p=0.002). Both KneeAngleIC and MinKneeFlexSt were greater at GMFCS II and III, than at GMFCS I and the TD group (Fig. 1). TUG took longer for GMFCS II and GMFCS III compared to TD (p<.001 and p<.001) and GMFCS I (p= 0.001 and p<0.001), and longer for GMFCS III compared to GMFCS II (p<0.001). Fig. 1 Light bars represent KneeAngleIC and dark bars MinKneeFlexSt. (+) indicates knee flexion, brackets above the boxes: differences at KneeAngleIC, and below: differences at MinKneeFlexSt.Download : Download high-res image (58KB)Download : Download full-size image This study found that knee flexion in stance was significantly greater than knee contractures at GMFCS levels II and III with no difference in occurrence of orthopaedic surgery. Furthermore, walking ability took longer at GMFCS level III compared to at level II at similar knee flexion contracture. The discrepancy in knee position in weight-bearing versus passive knee extension in the unloaded position at GMFCS II and III, and the large difference in TUG between children at GMFCS level III and those in the other groups, are likely explained by the effort to overcome motor disorders such as spasticity, however, may also be explained by the commonly occurring sensorimotor disorders (4).
膝关节屈曲是双侧痉挛性CP患儿的一种多维运动步行模式,随着步态的成熟而发展,特别是在GMFCS水平较高时(1)。其中一个原因可能是膝关节伸展受限,这被描述为导致行走时膝关节屈曲步态姿势的严重残疾(2)。本研究的目的是比较行走时膝关节位置与无负荷体位时被动膝关节伸展。以及行走时的功能性活动能力。采用3d运动分析(Vicon MX40®)对30名双侧痉挛性CP患儿(13名女性)的步态进行评估,其中中位[最小,最大]年龄为11.3[7.6,17.1]岁,22名典型发育(TD)患儿(11名女性)的中位[最小,最大]年龄为8.9[6.5-16.9]岁。踝关节、膝关节和髋关节的关节挛缩,从关节的中性位置定义,通过测量被动髋关节伸展、膝关节伸展和仰卧位时踝关节背屈的角度来评估。记录了骨科下肢手术。功能活动度采用起走时间(time up and go test, TUG)测试。采用非参数统计(p<0.05)。GMFCS III组的膝关节收缩大于GMFCS I组和TD组(p=0.046和p= 0.002)。行走时,TD组和GMFCS I、II、III组初始接触膝关节角度(knee angleic)分别大于站立时膝关节伸展峰值(MinKneeFlexSt) (p=0.008、p=0.043、0.005和p=0.002)。MinKneeFlexSt超过GMFCS II级(p=0.004)和III级(p=0.002)的最大被动膝关节伸展。GMFCS II组和GMFCS III组的kneangleic和MinKneeFlexSt均高于GMFCS I组和TD组(图1)。与TD组相比,GMFCS II组和GMFCS III组的TUG所需时间更长(p<。(p<0.001)和GMFCS I (p= 0.001和p<0.001), GMFCS III比GMFCS II的治疗时间更长(p<0.001)。图1亮条代表kneangleic,暗条代表MinKneeFlexSt。(+)表示膝关节屈曲,方框上方括号为膝关节角的差异,方框下方括号为膝关节角的差异。本研究发现,GMFCS II级和III级患者站立时膝关节屈曲明显大于膝关节挛缩,在骨科手术发生率上无差异。此外,在类似膝关节屈曲挛缩的情况下,GMFCS III级患者的行走能力比II级患者需要更长的时间。GMFCS II和III级负重时膝关节位置与无负重时被动膝关节伸展位置的差异,以及GMFCS III级儿童与其他组儿童之间TUG的巨大差异,可能是由于克服痉挛等运动障碍的努力所致,然而,也可能是由于常见的感觉运动障碍所致(4)。
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引用次数: 0
Comparison of spine structure, mobility, and competency in dentists with and without low back pain 有和没有腰痛的牙医脊柱结构、活动性和能力的比较
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.120
Merve Keskin, Mehmet Irfan Karadede, Derya Ozer Kaya
Dental practices can cause musculoskeletal pain and dysfunction due to cumulative microtrauma and inappropriate working positions (1). The prevalence of musculoskeletal pain in dentists was declared between 64% and 93% (2). The prevalence of low back pain in dentists was reported as 47.6% as the most common musculoskeletal dysfunction (3,4). Is there a difference in spine structure, mobility, and competency of dentists with low back pain compared to those without low back pain? In the study, 65 dentists with low back pain (40 females, 25 males, age: 25.57±2.83 years, weight: 67.64±13.20 kg, height: 171.72±8.46 cm, BMI, 22.75±3.25 kg/m2) and 57 pain-free matched control group (30 females, 27 males, age: 26.36±3.94 years, weight: 69.05±13.00 kg, height: 170.53±7.78 cm, BMI, 23.64±3.52 kg/m2) were included. Spine structure, mobility, and competency in the sagittal and frontal planes were evaluated with the Valedo®Shape device (Idiag, Fehraltorf, Switzerland). Parameters were obtained in degrees: thoracic, lumbar, sacral/hip angle, and trunk inclination angle (angle between straight line from T1 to S1 and vertical line). After the spinous processes of the spine were marked as reference points, the Valedo®Shape device was moved down by the evaluator over all the spinous processes starting from the C7 spinous process to approximately the S3 spinous process. The response of the spine to loading was evaluated using weight for competency measurement. After measuring before the weight, the participant was asked to wait for 30 seconds with the weights in hand, and the measurement was repeated (6). The normality distributions of the data were determined by the Shapiro-Wilk test. In the comparison of the data, the independent sample t-test was used in those with normal distribution, and the Mann-Whitney U test was used for those that were not normally distributed. In patients with low back pain, in the sagittal plane, the inclination angle decreased (p=0.045), there was a shift in the sacral angle with loading (p=0.037). In the sagittal and frontal planes, there was no significant difference in thoracic region angles (p=0.292;0.074) and in the lumbar region angles (p=0.369; p=0.781). In participants with low back pain, the angle of inclination decreased in the sagittal plane and a lateral shift response occurred in the sacrum with loading. It is known that the angles of the lumbopelvic region are directly related to the curvature of the spine and compensatory mechanisms against spinal deformities in the sagittal plane in this region (7). In a previous study, a shift in the inclination angle was reported by dentists with low back pain (8). The changes in the spine in dentists may be seen in the occurrence of low back pain. This should be considered for the assessment and treatment of low back pain.
由于累积的微创伤和不适当的工作位置,牙科治疗会导致肌肉骨骼疼痛和功能障碍(1)。牙医肌肉骨骼疼痛的患病率在64%到93%之间(2)。据报道,牙医腰痛的患病率为47.6%,是最常见的肌肉骨骼功能障碍(3,4)。与没有腰痛的牙医相比,腰痛牙医的脊柱结构、活动性和能力有什么不同吗?本研究纳入65例腰痛牙医师(女性40例,男性25例,年龄25.57±2.83岁,体重67.64±13.20 kg,身高171.72±8.46 cm, BMI 22.75±3.25 kg/m2)和57例无痛匹配对照组(女性30例,男性27例,年龄26.36±3.94岁,体重69.05±13.00 kg,身高170.53±7.78 cm, BMI 23.64±3.52 kg/m2)。采用Valedo®Shape器械(Idiag, Fehraltorf,瑞士)评估脊柱结构、活动能力和矢状面和额面能力。以度为单位获取参数:胸椎角、腰椎角、骶髋角、躯干倾角(T1 - S1直线与垂直线之间的夹角)。将脊柱棘突标记为参考点后,评估者将Valedo®Shape装置移至从C7棘突开始的所有棘突至大约S3棘突。脊柱对负荷的反应是用体重来评估能力的。称重前测量结束后,要求被测者手拿砝码等待30秒,并重复测量(6)。数据的正态分布通过Shapiro-Wilk检验确定。在数据比较中,正态分布采用独立样本t检验,非正态分布采用Mann-Whitney U检验。腰痛患者矢状面倾斜角减小(p=0.045),骶骨角随负重而移位(p=0.037)。在矢状面和额状面,胸椎区角(p=0.292;0.074)和腰椎区角(p=0.369;p = 0.781)。在患有腰痛的参与者中,随着负荷的增加,矢状面倾斜角度减小,骶骨发生侧向移位反应。众所周知,腰骨盆区域的角度与脊柱的曲度以及该区域矢状面脊柱畸形的代偿机制直接相关(7)。在先前的研究中,下腰痛的牙医报告了倾斜角度的变化(8)。牙医脊柱的变化可能出现在下腰痛的发生中。在评估和治疗腰痛时应考虑到这一点。
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引用次数: 0
The use of a novel assessment protocol for the knee joint velocity proprioceptive sense to investigate motor learning abilities 使用一种新的评估方案膝关节速度本体感觉来调查运动学习能力
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.118
Anthi Kellari, Eumorphia Papapostolou, Euaggelia Papadimou, Zacharias Dimitriadis, Eleni Kapreli, George Koumantakis, Nikolaos Strimpakos, Asimakis Kanellopoulos
Proprioception is a significant factor in balance, coordination, joint stability and movement acuity (1). Among proprioception’s components, joint position sense (JPS) and movement detection have been mostly assessed whereas little is known about the joint velocity proprioceptive sense (2). Finding the joint angular velocity(-ies) that is more comprehensible by the human’s brain, and therefore more accurately reproduced, could be used, among others, in motor learning rehabilitation protocols. To investigate the knee angular velocities envelope inside which the joint can be moved with the most accuracy, depending on the task. 48 subjects (23 men and 25 women) without knee pathology participated in the study (age 21.4 ±3.85). Velocity replication (VR) was assessed in a spectrum of 5 different and randomly chosen low velocities (2°/s, 5°/s, 10°/s, 20°/s and 30°/s) by using concentric quadriceps contraction in an Isokinetic Dynamometer (Biodex System3 Pro). During the procedure the subjects were blindfolded, and the examiners were blind regarding the results.The passive demonstrations of each joint angular velocity were followed by active velocity replications. The number of passive demonstrations and active replications were adapted for each velocity in such a way, that each subject would stay almost the same amount of time, and therefore having the same effect or effort, in all of them. The knee angular velocities of 2°/s and 5°/s had the bigger mean percentage replication errors (68.2% and 29.0%) but the smallest mean errors in absolute value (1.4°/s for both the velocities). In the velocities of 10°/s, 20°/s and 30°/s the mean percentage replication errors were 26.3%, 26.1% and 29.0% respectively, while the mean errors in absolute value were 2.6°/s, 5.5°/s and 8.6°/s respectively. According to the present research, the knee joint can achieve a maximal precision of 1.4°/s angular velocity error, appear in joint velocities below 5°/s. Rehabilitation protocols require precision should focus is this kinematic envelope as, above this threshold, the angular velocity error increases gradually, as the joint velocity increases. For gross motor activities, where percentage joint angular velocity errors are more meaningful than the absolute error values, the kinematic envelope between 10°/s - 20°/s seem to be the ideal for motor learning tasks. According to our knowledge, this is the first attempt in the literature to investigate the knee angular velocity proprioception, and further investigation is needed on the velocity proprioceptive behavior of other joints, as well as any deviations in pathologies or trauma.
本体感觉是平衡、协调、关节稳定性和运动灵敏度的重要因素(1)。在本体感觉的组成部分中,关节位置感(JPS)和运动检测被评估得最多,而对关节速度本体感觉知之甚少(2)。寻找更容易被人脑理解的关节角速度(-ies),因此更准确地再现,可以用于运动学习康复方案等。为了研究膝关节角速度包络,其中关节可以最准确地移动,这取决于任务。48名无膝关节病理的受试者(男23名,女25名)参加了研究(年龄21.4±3.85岁)。在等速动力测力仪(Biodex System3 Pro)中,利用股四头肌同心收缩,在5种不同且随机选择的低速(2°/s、5°/s、10°/s、20°/s和30°/s)谱中评估速度复制(VR)。在测试过程中,受试者被蒙住眼睛,考官对测试结果一无所知。每个关节角速度的被动演示之后是主动速度复制。被动演示和主动复制的数量以这样一种方式适应每种速度,即每个受试者将保持几乎相同的时间,因此在所有过程中具有相同的效果或努力。膝关节角速度为2°/s和5°/s时,平均百分比复制误差较大(68.2%和29.0%),但绝对值平均误差最小(1.4°/s)。在10°/s、20°/s和30°/s速度下,复制误差的平均百分比分别为26.3%、26.1%和29.0%,绝对值的平均误差分别为2.6°/s、5.5°/s和8.6°/s。根据目前的研究,膝关节可以实现最大精度1.4°/s的角速度误差,出现在关节速度低于5°/s时。康复方案要求的精度应该集中在这个运动包络线上,因为在这个阈值以上,角速度误差随着关节速度的增加而逐渐增加。对于大运动活动,关节角速度误差百分比比绝对误差值更有意义,运动包络在10°/s - 20°/s之间似乎是运动学习任务的理想选择。据我们所知,这是文献中首次尝试研究膝关节角速度本体感觉,其他关节的速度本体感觉行为,以及病理或创伤的偏差,还需要进一步研究。
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引用次数: 0
Does using the hip joint distance (x-ray) as an input change the kinematic, kinetic output and is this clinically relevant? 使用髋关节距离(x光片)作为输入是否会改变运动学和动力学输出,这是否与临床相关?
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.130
Andreas Kranzl, Groblschegg Leonore, Attwenger Bernhard, Durstberger Sebastian, Koppenwallner Laurin Xaver, Unglaube Fabian
There are a number of methods for determining the centre of the hip joint (HJ). The most common are regression equations or functional methods. In individual cases, however, we do not know how well the HJ centre is actually determined. Several papers present Harrington's regression formula as the best choice (Harrington et al., 2007; Kainz et al., 2015; Peters et al., 2012). If an image of the pelvis is available, the HJCD can be determined from it, and this can be used to optimise the determination of the joint centre in the regression formula. Does using the hip joint distance (x-ray) as an input change the joint parameters? A retrospective analysis of the gait laboratory database identified patients who had a calibrated radiograph and a 3D gait analysis. The calculated HJCD from the gait data was compared with that from the radiograph. In addition, the ASIS distance was calculated using the hip joint distance from the radiograph, and again the HJ position was determined using the newly obtained ASIS distance in the Harrington formula. The gait data were statistically compared using SPM analysis and the maximum distance between the two methods was determined over all curves. This was compared with the minimal detectable changes (MDC) (Wilken et al., 2012). Data from 349 patients (legs n=698, age: 4-22 years) with anterior knee malalignment without neuromuscular disease were analysed. HJCD correlations between radiographs and 3DGA values were 0.662 (p<0.001) using the Harrington method. The Bland-Altman plots for HJCD showed minimal differences using the Harrington regression formula. However, there were differences of up to 40 mm between the two methods of determining the HJCD. A comparison of the gait results with the two calculated equations shows significant differences (SPM). In most cases the differences between the two methods were negligible, but in some patients (legs) they were above the MDC value.Download : Download high-res image (85KB)Download : Download full-size image On average, the HJ distance from the radiograph and the gait analysis data were in good agreement, but not in every patient (up to 40 mm). The gait curves show significantly different results according to SPM analysis. In most cases the differences are below the MDC, but in individual patients there may well be clinically relevant differences in the results. Therefore, if pelvic imaging is available, we recommend using it to calculate the HJ centre.
有许多确定髋关节中心(HJ)的方法。最常见的是回归方程或泛函方法。然而,在个别情况下,我们不知道HJ中心实际上是如何确定的。有几篇论文将Harrington的回归公式作为最佳选择(Harrington et al., 2007;Kainz et al., 2015;Peters et al., 2012)。如果骨盆的图像是可用的,HJCD可以从中确定,这可以用来优化回归公式中的关节中心的确定。使用髋关节距离(x线)作为输入是否会改变关节参数?步态实验室数据库的回顾性分析确定了有校准的x光片和3D步态分析的患者。将步态数据计算的HJCD与x线片的HJCD进行比较。此外,根据髋关节与x线片的距离计算出ASIS距离,再根据哈林顿公式中新获得的ASIS距离确定HJ位置。采用SPM分析对步态数据进行统计比较,并确定两种方法在所有曲线上的最大距离。这与最小可检测变化(MDC)进行了比较(Wilken et al., 2012)。分析了349例无神经肌肉疾病的膝关节前位失调患者(腿数698,年龄4-22岁)的数据。采用Harrington方法,x线片与3DGA值的HJCD相关性为0.662 (p<0.001)。使用哈林顿回归公式,HJCD的Bland-Altman图显示最小的差异。然而,有差异高达40毫米之间的两种方法确定HJCD。步态结果与两种计算方程的比较显示出显著差异(SPM)。在大多数情况下,两种方法之间的差异可以忽略不计,但在一些患者(腿部),它们高于MDC值。平均而言,与x线片的HJ距离和步态分析数据符合得很好,但并非每个患者(高达40 mm)。根据SPM分析,步态曲线有明显差异。在大多数情况下,差异低于MDC,但在个别患者中,结果可能存在临床相关差异。因此,如果盆腔成像可用,我们建议使用它来计算HJ中心。
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引用次数: 0
Backward and forward walking and its association with falls and fear of falling in people with multiple sclerosis 多发性硬化症患者的前后行走及其与跌倒和害怕跌倒的关系
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.238
Heidi Stölzer-Hutsch, Dirk Schriefer, Katrin Trentzsch, Tjalf Ziemssen
Common symptoms in people with multiple sclerosis (pwMS) are walking limitations that can reduce the quality of life and lead to an increased risk of falling and fear of falling [1,2]. Instrumented gait analysis on a walkway with integrated pressure sensors can be used for assessment of both forward and backward walking. Walking backwards has been established as a more sensitive parameter to detect fallers, compared to walking forwards [3]. It is unknown whether fear of falling can be already detected by walking backwards. For possible interventions, it is important to identify patients with falls resp. fear of falling as early as possible. Is there an association between forward and backward walking and falls resp. fear of falling in pwMS? 705 pwMS (71.6% female, 82.1% with relapsing remitting MS) completed three test conditions on an eight-meter pressor sensor walking way (GAITRite® System) without shoes: (i) walking forwards at a self-selected normal speed, (ii) walking forwards at fast speed and (iii) walking backwards at the highest possible speed. In addition, fall history and fear of falling in the previous month were assessed. Velocity, step length and stance phase of gait cycle were determined in all test conditions. In walking backwards condition, time for 3-meter backward walking test (3MBWT) was additionally included in the analysis. Multiple logistic regressions adjusted for age, gender, body mass index (BMI) and Expanded Disability Status Scale (EDSS) were applied. Of 705 pwMS, 10.6% were fallers (n=75; age: 46.52 ±10.79; BMI: 26.05 ±5.66; EDSS median: 3.5), while 31.9% presented with fear of falling (n=225; age: 47.58 ±11,29; BMI: 25.73 ±5.01; EDSS median: 3.5). Step length during fast walking (odds ratio (OR) 0.982; CI 0.966-0.998) and velocity during walking backwards proved to be significant indicators of falls with an OR of 0.982 (CI 0.970-0.995). All parameters of walking backwards (velocity, step length, stance of cycle and 3MBWT) and stance of cycle in normal walking could be proven as an indicator of fear of falling (see Fig. 1). In addition to identifying patients at risk of falling [3], the results suggest that walking backwards also can identify pwMS presenting with fear of falling. Longitudinal analyses will be performed to validate the clinical utility of walking backwards. Fig. 1.Download : Download high-res image (111KB)Download : Download full-size image
多发性硬化症(pwMS)患者的常见症状是行走受限,这会降低生活质量,并导致跌倒风险增加和对跌倒的恐惧[1,2]。在集成压力传感器的人行道上进行仪器步态分析,可用于评估向前和向后行走。与向前行走相比,向后行走被认为是检测坠落者的更敏感的参数[3]。目前尚不清楚是否可以通过后退来检测出对摔倒的恐惧。对于可能的干预措施,识别有跌倒倾向的患者是很重要的。怕摔倒的趁早。向前和向后走路和跌倒有关系吗?害怕掉进pwMS?705名pwMS(71.6%为女性,82.1%为复发缓解型MS)在不穿鞋的8米压力传感器行走方式(GAITRite®系统)上完成了三个测试条件:(i)以自己选择的正常速度向前行走,(ii)以快速向前行走,(iii)以尽可能快的速度向后行走。此外,还评估了上个月的跌倒史和对跌倒的恐惧。在所有测试条件下测定步态周期的速度、步长和站立相位。在倒走条件下,3米倒走测试时间(3MBWT)也被纳入分析。采用校正年龄、性别、体重指数(BMI)和扩展残疾状态量表(EDSS)的多元logistic回归。705名pwMS患者中,10.6%为跌倒患者(n=75;年龄:46.52±10.79;Bmi: 26.05±5.66;EDSS中位数:3.5),而31.9%表现为害怕跌倒(n=225;年龄:47.58±11.29岁;Bmi: 25.73±5.01;EDSS中位数:3.5)。快速步行时的步长(比值比(OR) 0.982;CI 0.966 ~ 0.998)和倒走速度是跌倒的显著指标,OR为0.982 (CI 0.970 ~ 0.995)。正常行走时倒走的所有参数(速度、步长、步数、3MBWT)和步数都可以被证明是害怕跌倒的指标(见图1)。结果表明,倒走除了可以识别有跌倒风险的患者[3]外,还可以识别有跌倒恐惧的pwMS。将进行纵向分析以验证向后行走的临床效用。图1所示。下载:下载高分辨率图片(111KB)下载:下载全尺寸图片
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引用次数: 0
Individuals with pre-obesity exhibit a more asymmetrical gait pattern 肥胖前期的个体表现出更不对称的步态模式
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.223
Halit Selçuk, Hilal Keklicek
Previous studies have shown that obesity impairs body biomechanics (1-3). However, no study has been found examining the gait of individuals who are not obese but have an above-normal BMI and were considered pre-obese. Does pre-obesity affect the symmetry of the angular values of the lower extremity during walking? Thirteen individuals with normal body mass index (BMI) (21.53±2.05 kg/m) and eight individuals with pre-obesity (28.52±2.21 kg/m) were recruited for the study. Participants walked at their self-paced speed for 4-5 minutes (4) on a motorized treadmill and the data of lower limb angles were collected with inertial measurement units (Xsens Technologies B.V.). Minimum, maximum, and average values of stance and swing phase of the participants for the whole series of the ankle, knee, and hip angles, as well as; the series at heel strike and foot release phase were recorded. Differences between right and left joints were calculated to examine gait symmetry. Symmetry in ankle angles was similar between groups (p>0.05). In the pre-obese group; minimum(p=0.011) and maximum (p=0.007) knee angles were more asymmetrical in the stance phase than in the normal-weight group. Also, the minimum knee angle in the swing phase was more asymmetrical (p=0.043) in the pre-obese group. In addition, it was determined that the pre-obese group exhibited more asymmetrical knee angles at heel strike (p=0.032) and foot release (p=0.017). The maximum hip angle of the pre-obese group was more asymmetrical in the stance phase (p=0.003) and swing phase (p= 0.006). Also, in the heel strike, the hip angle (p=0.009) was found to be more asymmetrical than the normal-weight group. No difference was observed between the groups for all other measurements (p>0.05). The results of the study showed that individuals with pre-obesity level BMI exhibited a more asymmetrical gait pattern in the proximal joints during walking. It was observed that the increase in BMI negatively affected gait even if below the level of obesity.
先前的研究表明,肥胖会损害身体的生物力学(1-3)。然而,目前还没有研究发现对体重指数高于正常水平的非肥胖者的步态进行调查。肥胖前期是否影响行走时下肢角值的对称性?研究对象为体重指数(BMI)正常的13例(21.53±2.05 kg/m)和肥胖前期的8例(28.52±2.21 kg/m)。参与者在电动跑步机上以自己的速度步行4-5分钟(4),下肢角度数据由惯性测量装置(Xsens Technologies B.V.)收集。参与者在脚踝、膝盖和臀部角度的整个系列中,站姿和摇摆阶段的最小值、最大值和平均值,以及;记录了足跟撞击和足部释放阶段的一系列动作。计算左右关节之间的差异以检查步态对称性。两组间踝关节角度对称性比较,差异无统计学意义(p < 0.05)。在肥胖前组;站立阶段最小(p=0.011)和最大(p=0.007)膝关节角度比正常体重组更不对称。此外,肥胖前组在摇摆阶段的最小膝关节角度更不对称(p=0.043)。此外,确定肥胖前组在脚跟撞击(p=0.032)和足部释放(p=0.017)时表现出更多的不对称膝关节角度。肥胖前组髋部最大角度在站立阶段(p=0.003)和摇摆阶段(p= 0.006)更为不对称。此外,在脚跟撞击时,发现臀部角度(p=0.009)比正常体重组更不对称。各组间其他指标均无差异(p < 0.05)。研究结果表明,肥胖前BMI水平的个体在行走时近端关节表现出更不对称的步态模式。据观察,即使低于肥胖水平,BMI的增加也会对步态产生负面影响。
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引用次数: 0
Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm 用超声扫描和一种新的直方图匹配算法量化中斜方肌的形态学变化
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.197
Fraser Philp, Erik Meilak, Tracey Willis, Naomi Winn, Anand Pandyan
Facioscapulohumeral dystrophy (FSHD) can affect upper-limb function through muscle degeneration, fatty infiltration and oedema. Muscle echogenicity, measured using ultrasound, could be used as a biomarker for muscular changes and disease progression [1–3]. Histogram-matching may be instrumental in overcoming existing shortcomings that prevent us from using such images to extract clinically useful information [4,5]. Can histogram-matching of muscle ultrasound images be used to extract clinically relevant measures to quantify the muscle morphological changes in people with FSHD (pwFSHD)? Participants attended a single motion analysis session for upper-limb 2D-ultrasound imaging and 3D-movement analysis. Stratified sampling by arm function was used for pwFSHD. Controls were age and sex matched. Middle trapezius measurement was taken at the midpoint of a line between C7 and ACJ. Six total measurements were taken (3-longitudinal and 3-transverse views) using an Esoate MyLab-Gamma device and linear probe (3-13 MHz). Muscle thickness measurements were carried using ImageJ 1.53t. Histogram-matching was carried out as described by Bottenus et al. [4]. All images were matched to a single reference image from a control group participant. Manual segmentation of the subcutaneous fat layer was carried out and used as the region-of-interest for histogram-matching across all images. Using full histogram-matching, the monotonic transformation was applied across the entire image. The trapezius muscle was segmented to determine mean grayscale values (echogenicity). The student t-test was used for evaluating between group differences and the relationship between echogenicity values and muscle thickness was investigated. Data was collected for 14 participants (7 pwFSHD (2 F:5 M) and 7 sex- and age-matched controls (2 F:5 M). PwFSHD had mean (SD) age, height and weight values of 41.9-years (17.1), 176 cm (8.8) and 90.6 kg (24.8) respectively. The control group had age, height and weight values of 41.4-years (15.5), 176.4 cm (5.7) and 77.1 kg (11.2) respectively. Group echogenicity values are presented in Fig. 1. Download : Download high-res image (106KB)Download : Download full-size image Mean (SD) echogenicity values for pwFSHD were higher than the control group (96.5 (30.3) vs 32.2 (11.2) respectively) with statistically significant differences (p<0.001). Mean (SD) trapezius muscle thickness was higher in the control group 1.48 cm (0.27) vs 0.74 cm (0.45) respectively. Mean echogenicity scores accounted for 82% of the variance in mean muscle thickness values (R2=0.824). PwFSHD demonstrated higher echogenicity values and smaller muscle thicknesses indicative of degenerative muscle structure changes associated with the disease. Preliminary results suggest that post capture processing of ultrasound images using histogram matching can provide quantifiable differences in people with and without FSHD. This could facilitate clinically feasible bedside methods for assessing
面肩肱骨营养不良(FSHD)可通过肌肉变性、脂肪浸润和水肿影响上肢功能。超声测量的肌肉回声性可作为肌肉变化和疾病进展的生物标志物[1-3]。直方图匹配可能有助于克服现有的缺陷,使我们无法使用此类图像提取临床有用的信息[4,5]。肌肉超声图像的直方图匹配能否用于提取临床相关措施,以量化FSHD (pwFSHD)患者的肌肉形态学变化?参与者参加了上肢2d超声成像和3d运动分析的单一运动分析会议。pwFSHD采用臂函数分层抽样。对照组年龄和性别匹配。在C7和ACJ之间的中点处测量中斜方肌。使用Esoate MyLab-Gamma设备和线性探头(3-13 MHz)进行了6次测量(3-纵向和3-横向视图)。使用ImageJ 1.53t进行肌肉厚度测量。按照Bottenus等人[4]的描述进行直方图匹配。所有图像都与来自对照组参与者的单个参考图像相匹配。对皮下脂肪层进行人工分割,并将其作为所有图像的直方图匹配的兴趣区域。采用全直方图匹配,对整个图像进行单调变换。对斜方肌进行分割,确定平均灰度值(回声性)。采用学生t检验评价组间差异,探讨回声度值与肌肉厚度的关系。收集了14名参与者(7名pwFSHD (2 F:5 M)和7名性别和年龄匹配的对照组(2 F:5 M)的数据。pwFSHD的平均年龄(SD)分别为41.9岁(17.1),176厘米(8.8)和90.6公斤(24.8)。对照组年龄41.4岁(15.5岁),身高176.4 cm(5.7岁),体重77.1 kg(11.2岁)。群回声度值如图1所示。pwFSHD的平均(SD)回声度值高于对照组(分别为96.5(30.3)和32.2(11.2)),差异有统计学意义(p<0.001)。对照组斜方肌平均(SD)厚度分别为1.48 cm(0.27)和0.74 cm(0.45)。平均回声性评分占平均肌肉厚度值方差的82% (R2=0.824)。PwFSHD显示较高的回声值和较小的肌肉厚度,表明与疾病相关的退行性肌肉结构改变。初步结果表明,使用直方图匹配的超声图像捕获后处理可以提供FSHD患者和非FSHD患者的可量化差异。这可以促进临床可行的床边方法来评估和监测pwFSHD的疾病进展。需要进一步的工作来招募更大的pwFSHD样本和不同水平的臂功能,进行纵向测量,并在可变参考图像的基础上评估这些测量的灵敏度。
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引用次数: 0
Articular ankle joint loading during dynamic activities 关节踝关节负荷在动态活动
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.202
Barbara Postolka, Bryce A. Killen, Hannelore Boey, Jos Vander Sloten, Ilse Jonkers
Increased joint contact stress can lead to cartilage degeneration and thus the development of osteoarthritis. While articular knee joint loading is well studied [1], less is known about other joints despite them being at risk of the disease as well. In particular, structural deformities of the foot-ankle complex such as flat feet are known to increase the risk for developing osteoarthritis at the hind- and midfoot joints [2]. The aim of this project was to combine state of the art in vivo kinematics with dynamic musculoskeletal simulations using an extended foot-ankle model including contact modelling to estimate ankle articular joint loading in healthy subjects during different gait activities. 6 healthy subjects (4 female, 2 male; 23.8±3.0 years; BMI 23.2±2.4 kg/m²) with no history of foot-ankle injuries participated in this study. Whole body kinematics were measured for each subject during three gait cycles of walking and running using a full body and extended foot skin marker system [3]. Cartilage contact between the tibia and talus were added to a foot-ankle model [4] to allow estimation of articular joint mechanics using an elastic foundation model based on cartilage stiffness and mesh penetration [1]. Generic models were scaled for each individual and kinematics calculated for every trial. Based on subject-specific kinematics, articular joint mechanics were estimated using the OpenSim joint and articular mechanics (JAM) tool [1]. To investigate articular joint loading, contact area as well as mean and peak pressure at the ankle joint were analysed during the stance phase. Mean and peak cartilage contact pressure were comparable at heel strike and toe off, but substantially differed throughout the stance phases of walking and running (Fig. 1A). During walking, cartilage contact pressure showed a double peak with the higher peak around contralateral heel strike (peak pressure: 5.96±1.66 MPa) whereas during running cartilage contact pressure showed a single peak during mid-stance (peak pressure: 9.61±2.41 MPa) (Fig. 1A&B). Although similar cartilage contact locations were found for walking and running, contact area was considerably larger during running (1.39±0.15 cm²) then walking (0.96±0.19 cm²) (Fig. 1B).Download : Download high-res image (119KB)Download : Download full-size image This study showed a first analysis of ankle mechanics during multiple gait cycles of walking and running. Using a detailed musculoskeletal foot-ankle model combined with recently developed methods to estimate cartilage contact mechanics, this study allowed novel insights on the location and magnitude of articular joint loading. While this study provided important findings on the ankle joint, further developments are needed to also estimate cartilage contact mechanics at the subtalar joint. In addition, analysis of pathological cohorts such as subjects with chronic ankle instability or flat feet, will help to understand changes in articular mechanics and how they
关节接触应力的增加会导致软骨变性,从而发展成骨关节炎。虽然膝关节负荷的研究很好[1],但对其他关节的了解较少,尽管它们也有疾病的风险。特别是足-踝综合体的结构性畸形,如扁平足,已知会增加后肢和中足关节发生骨关节炎的风险[2]。该项目的目的是结合最先进的体内运动学与动态肌肉骨骼模拟,使用扩展的脚-踝关节模型,包括接触建模,以估计健康受试者在不同步态活动时的踝关节负荷。健康受试者6例(女性4例,男性2例;23.8±3.0年;BMI为23.2±2.4 kg/m²),无足踝损伤史。在行走和跑步的三个步态周期中,使用全身和延伸足部皮肤标记系统测量每个受试者的全身运动学[3]。在足踝模型中加入胫骨和距骨之间的软骨接触[4],以便使用基于软骨刚度和网格穿透性的弹性基础模型来估计关节力学[1]。为每个个体缩放通用模型,并为每次试验计算运动学。基于受试者特定的运动学,使用OpenSim关节和关节力学(JAM)工具估计关节关节力学[1]。为了研究关节负荷,分析了站立阶段踝关节的接触面积以及平均和峰值压力。在脚跟撞击和脚趾脱落时,软骨接触压力的平均值和峰值是相当的,但在步行和跑步的整个站立阶段存在显著差异(图1A)。行走时,软骨接触压力呈现双峰,对侧足跟撞击处峰值较高(峰值:5.96±1.66 MPa),而跑步时,软骨接触压力在站立中呈现单峰(峰值:9.61±2.41 MPa)(图1a和图b)。虽然步行和跑步时的软骨接触位置相似,但跑步时的接触面积(1.39±0.15 cm²)明显大于步行时的接触面积(0.96±0.19 cm²)(图1B)。这项研究首次分析了在步行和跑步的多个步态周期中的脚踝力学。使用详细的肌肉骨骼脚-踝关节模型,结合最近开发的方法来估计软骨接触力学,本研究对关节负载的位置和大小提供了新的见解。虽然这项研究提供了关于踝关节的重要发现,但还需要进一步发展来估计距下关节的软骨接触力学。此外,对病理队列的分析,如慢性踝关节不稳定或平底足的受试者,将有助于了解关节力学的变化及其与软骨退变的关系。
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引用次数: 0
Investigation of the relationship between measurement of scapular asymmetry and working posture in dentists 牙医师肩胛骨不对称测量与工作姿势关系的研究
Pub Date : 2023-09-01 DOI: 10.1016/j.gaitpost.2023.07.121
Merve Keskin, Derya Ozer Kaya
Dentists are at risk due to adverse conditions they are exposed to, such as improper working posture, repetitive movements, long-term static positions, excessive effort with frequent use of small muscles, tight grip of materials, using vibrating instruments, and holding their arms high for long periods of time (1). Does the scapular asymmetry distance increase as the working posture of dentists worsens? In the study, 122 volunteers (52 males, 70 females, age: 25.94±3.40 years) from dentists who have been active in the clinic for at least 6 months were included. The Lateral Scapular Slide Test was used to measure scapular asymmetry. Measurement was performed in 4 positions: in a neutral position of the glenohumeral joint with arms at both sides in a free-standing position, shoulders at 45° abduction and 90° abduction (2), and the arms were in 90° abduction holding 2.3 kg (5 lb) for those with a body weight of 68.1 kg and above, and 1.4 kg (3 lb) for those with a body weight of less than 68.1 kg. The distance between the inferior end of the scapula and the spinous process of the nearest thoracic vertebra was measured in all four positions. Working posture was evaluated during the study by observation with the REBA whole-body assessment method. The risk levels of the scoring results were made according to the REBA method; 1 point was classified as “negligible, 2-3 points as “low”, 4-7 points as “moderate”, 8-10 as “high” and 11-15 as “very high” (3,4). According to the REBA score risk classification, 36.1% of the participants were included between 4-7 “medium risk”, 56.6% 8-10 “high risk”, and 7.4% 11-15 “very high risk” group. The mean REBA score was found to be 6.48±0.73 in the intermediate-risk group, 8.72±0.73 in the high-risk group, and 11.00±0.00 in the very high-risk group. A positive correlation was found between the REBA score and dominant side lateral scapular slide test with neutral, 45°, 90° and weights (r=0.325, p<0.001; r=0.268, p=0.003; r=0.267, p=0.003; r=0.265, p=0.003). In the results, it was seen that the working posture of the dentists was risky and there was no participant in the risk-free group. The scapular asymmetry distance increased as the risk in the working posture of the dentists increased. In a previous study, interns and 1-year dentists were compared for the lateral scapular slide test, and, scapular asymmetry distance was found to be higher in 1-year dentists. (5). It has been observed that the exposure may increase as the exposure to the working posture increases. Risky postures may be related to scapular asymmetry those may further develop dysfunctions.
由于牙医所处的不利环境,例如不适当的工作姿势、重复的动作、长期静止的姿势、频繁使用小肌肉的过度用力、紧握材料、使用振动仪器、长时间高举手臂等,牙医会面临风险(1)。随着牙医工作姿势的恶化,肩胛骨不对称距离是否会增加?本研究纳入了122名志愿者,其中男性52名,女性70名,年龄25.94±3.40岁,均为在临床活动至少6个月的牙医。肩胛骨外侧滑动试验用于测量肩胛骨不对称。测量采用4种体位:肩关节中立位,两侧手臂独立站立,肩膀45°外展和90°外展(2),手臂90°外展,体重在68.1 kg及以上的人保持2.3 kg (5 lb),体重在68.1 kg以下的人保持1.4 kg (3 lb)。在所有四个位置测量肩胛骨下端与最近的胸椎棘突之间的距离。采用REBA全身评估法观察研究期间的工作姿势。采用REBA法对评分结果进行风险等级评定;1分为“可忽略”,2-3分为“低”,4-7分为“中等”,8-10分为“高”,11-15分为“非常高”(3,4)。根据REBA评分风险分类,36.1%的参与者处于4-7“中等风险”组,56.6%的参与者处于8-10“高风险”组,7.4%的参与者处于11-15“非常高风险”组。中危组REBA平均评分为6.48±0.73,高危组为8.72±0.73,极高危组为11.00±0.00。REBA评分与优势侧肩胛骨外侧滑动试验中性、45°、90°和体重呈正相关(r=0.325, p<0.001;r = 0.268, p = 0.003;r = 0.267, p = 0.003;r = 0.265, p = 0.003)。结果显示,牙医的工作姿势是有风险的,无风险组没有参与者。肩胛骨不对称距离随着牙医工作姿势风险的增加而增加。在之前的研究中,我们比较了实习生和1年牙医肩胛骨外侧滑动试验,发现1年牙医肩胛骨不对称距离更高。(5).据观察,暴露量可能随着工作姿势暴露量的增加而增加。危险的姿势可能与肩胛骨不对称有关,这些不对称可能进一步发展为功能障碍。
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Gait & posture
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