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A 96 dB Input Dynamic Range Galvanic Skin Response Readout IC With 3.5 pArms Input-Referred Noise for Mental Stress Monitoring 一种96 dB输入动态范围皮肤电响应读出IC, 3.5 pArms输入参考噪声,用于精神压力监测。
IF 4.9 Pub Date : 2025-03-26 DOI: 10.1109/TBCAS.2025.3573614
Yi-Jie Lin;Lin Chou;Kun-Ju Tsai;Yu-Te Liao
This paper presents a low-noise, low-power galvanic skin response (GSR) sensing circuit capable of simultaneously measuring skin conductance level (SCL) and skin conductance response (SCR) for psychological stress monitoring. The circuit incorporates second-order sub-ten-hertz filters that suppresses out-of-band interference and a programmable gain amplifier (PGA) to accommodate signals of varying magnitudes. Additionally, a dynamic range adjustment mechanism optimizes the primary amplifier’s operating range based on real-time SCL readings. The design achieves a 96.4 dB dynamic range with an input-referred noise of only 3.47 pArms within 0.5–5 Hz under optimal conditions. These advancements significantly enhance measurement accuracy and robustness for wearable stress monitoring and real-time biofeedback applications.
提出了一种低噪声、低功耗皮肤电反应(GSR)传感电路,可同时测量皮肤电导水平(SCL)和皮肤电导反应(SCR),用于心理应激监测。该电路包含抑制带外干扰的二阶次十赫兹滤波器和可编程增益放大器(PGA),以容纳不同幅度的信号。此外,基于实时SCL读数的动态范围调节机制优化了主放大器的工作范围。在最佳条件下,该设计在0.5-5 Hz范围内实现了96.4 dB的动态范围,输入参考噪声仅为3.47 pArms。这些进步显著提高了可穿戴应力监测和实时生物反馈应用的测量精度和稳健性。
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引用次数: 0
A Wearable Ultra-Low-Power System for EEG-Based Speech-Imagery Interfaces 基于脑电图语音图像接口的可穿戴超低功耗系统。
IF 4.9 Pub Date : 2025-03-23 DOI: 10.1109/TBCAS.2025.3573027
Thorir Mar Ingolfsson;Victor Kartsch;Luca Benini;Andrea Cossettini
Speech imagery—the process of mentally simulating speech without vocalization—is a promising approach for brain-computer interfaces (BCIs), enabling assistive communication for individuals with speech impairments or to enhance privacy. However, existing EEG-based speech imagery systems remain impractical for use outside specialized laboratories due to their reliance on high-channel-count and resource-intensive machine learning models running on external computing platforms. In this work, we present the first end-to-end demonstration of EEG-based speech imagery decoding on a low-channel, ultra-low-power wearable device. Building on our previous work on vowel imagery, we introduce an extended framework leveraging the BioGAP platform and VowelNet, a lightweight neural network optimized for embedded speech imagery classification. In particular, we demonstrate state-of-the-art accuracy in the classification of an expanded vocabulary comprising vowels, commands, and rest states (13 classes) with a subject-specific training approach, achieving up to 50.0% for one subject (42.8% average) in multi-class classification. We deploy our model on an embedded biosignal acquisition and processing platform (BioGAP), based on the GAP9 processor, for real-time inference with minimal power consumption (25.93 mW). Our system achieves continuous execution for more than 21 hours on a small LiPo battery while maintaining classification latencies of 40.9 ms. Finally, we also explore the benefits of applying Continual Learning techniques to progressively improve the system’s performance throughout its operational lifetime, and we demonstrate that electrodes located on the temporal area contribute the most to the overall accuracy. This work marks a significant step toward practical, real-time, and unobtrusive speech imagery BCIs, unlocking new opportunities for covert communication and assistive technologies.
语音图像——一种不发声的心理模拟语音的过程——是一种很有前途的脑机接口(bci)方法,可以为有语言障碍的个体提供辅助交流或增强隐私。然而,现有的基于脑电图的语音图像系统仍然不适合在专业实验室之外使用,因为它们依赖于运行在外部计算平台上的高通道计数和资源密集型机器学习模型。在这项工作中,我们在低信道、超低功耗可穿戴设备上首次展示了基于脑电图的语音图像解码的端到端演示。基于我们之前在元音图像方面的工作,我们引入了一个扩展框架,利用BioGAP平台和VOWELNET,这是一个针对嵌入式语音图像分类进行优化的轻量级神经网络。特别是,我们通过特定学科的训练方法,在包含元音、命令和休息状态(13个类)的扩展词汇的分类中展示了最先进的准确性,在多类分类中,一个学科的分类准确率高达50.0%(平均42.8%)。我们将我们的模型部署在基于GAP9处理器的嵌入式生物信号采集和处理平台(BioGAP)上,以最小的功耗(25.93 mW)进行实时推断。我们的系统在一个小的LiPo电池上实现了超过21小时的连续执行,同时保持了40.9 ms的分类延迟。最后,我们还探讨了应用持续学习技术在整个操作寿命期间逐步提高系统性能的好处,并且我们证明了位于颞区的电极对整体准确性的贡献最大。这项工作标志着向实用、实时和不显眼的语音图像bci迈出了重要的一步,为隐蔽通信和辅助技术打开了新的机会。
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引用次数: 0
A 0.48$^{circ}$ Phase Error 91.1 dB SNR Bioimpedance Measurement IC for Monitoring Cardiopulmonary Diseases 用于心肺疾病监测的0.48°相位误差91.1dB信噪比生物阻抗测量芯片。
IF 4.9 Pub Date : 2025-03-21 DOI: 10.1109/TBCAS.2025.3572374
Jiarun Yuan;Yanxing Suo;Qiao Cai;Hui Wang;Yongfu Li;Yong Lian;Yang Zhao
This article presents a low-power and low phase error bioimpedance (BioZ) measurement IC designed for monitoring cardiopulmonary diseases. To compensate for the phase shift introduced along the signal path by current generator (CG), electrodes and sensor analog front-end (AFE), a novel phase shift calibration logic is proposed. Utilizing this calibration logic, a single-channel in-phase demodulation-based impedance measurement scheme is developed. A noise shaping pseudo-sine wave CG with data-weighted averaging (DWA) is used to minimize modulation harmonics. Fabricated in a 0.18µm CMOS process, the chip occupies 0.73 mm2 and consumes between 52.7 to 97.5 µA current from a 1.8V supply. The CG achieves 74.1 dB SFDR and −70dB THD at 15.5 kHz with a 50µApk stimulation current. The chip achieves 2mΩ/√Hz input-referred impedance noise at 1Hz, 91.1 dB SNR (BW = 4 Hz), 36 kΩ input range and less than 0.48$^{circ}$ phase error (0 − 90$^{circ}$, 1 – 20 kHz). On-body BioZ experiments using a 4-electrode configuration demonstrate clear recordings of Impedance Cardiography (ICG) and respiration signals.
本文介绍了一种用于监测心肺疾病的低功耗、低相位误差生物阻抗(BioZ)测量集成电路。为了补偿电流发生器(CG)、电极和传感器模拟前端(AFE)在信号路径上引入的相移,提出了一种新的相移校准逻辑。利用这种校准逻辑,开发了一种基于单相解调的阻抗测量方案。采用数据加权平均(DWA)的噪声整形伪正弦波CG来最小化调制谐波。该芯片采用0.18μm CMOS工艺制造,占地0.73mm2,从1.8V电源消耗52.7至97.5μA电流。在15.5kHz时,CG在50μApk的激励电流下实现了74.1dB的SFDR和-70dB的THD。该芯片实现了$2 text{m} Omega / sqrt{} Hz$输入参考阻抗噪声为1Hz,信噪比为91.1dB (BW=4Hz), $36 text{k} Omega$输入范围和小于0.48°相位误差(0-90°,1-20kHz)。使用4电极配置的人体BioZ实验显示阻抗心电图(ICG)和呼吸信号的清晰记录。
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引用次数: 0
Energy-Efficient Adaptive Neural Stimulator With Waveform Prediction by Sub-Threshold Interrogation of the Electrode-Tissue Interface 基于电极-组织界面亚阈值查询的高能效自适应神经刺激器。
IF 4.9 Pub Date : 2025-03-21 DOI: 10.1109/TBCAS.2025.3570264
Sudip Nag;Aryasree Remadevi;Jin Che;Matvii Prytula;Hanzhang Xing;Hanrui Xing;Xiaoxuan Xiao;Andreas Constas-Malvanets;Hengjia Zhang;Yinghe Sun;Joshua Olorocisimo;Jose Zariffa;Roman Genov
This paper presents an implantable low-power neural stimulator that generates electrical stimulation pulses based on subject-specific edge-learning of electrode-tissue voltage profiles. The system deploys a low-magnitude constant-current stimulation pulse to create a training dataset, which is subsequently utilized to predict the desired electrode voltage waveforms for higher magnitudes of constant-current stimulation. The predicted waveform dataset has been used to control a custom switched-capacitor output stage, thereby avoiding Vdriver_transistor · Istimulation power loss as in the conventional neural stimulator drivers. The proposed system incorporates on-chip learning and prediction implemented within an ultra-low-power microcontroller, which has been optimized for memory and power-constrained implantable environments. The stimulator output stage reduces power loss by up to 20% as compared to dynamic power supply scaling method, and consumes up to 3.63× lower as compared to conventional constant-current output stages. The intelligent neural interface system has been powered by a wireless inductive energy transfer link and is remotely controlled through a WiFi-based internet network. A custom-developed application interface, compatible with both mobile devices and personal computers, facilitates secure remote adjustments of stimulation parameters. The proposed system has been validated through a combination of in vivo rat peripheral nerve stimulation, in vitro saline tests, and benchtop experiments. These results collectively demonstrate the potential to advance future neural implant technologies by enabling intelligence, safety, energy efficiency, and remotely controllable neural organ modulation.
本文提出了一种植入式低功率神经刺激器,它基于电极组织电压分布的受试者边缘学习产生电刺激脉冲。该系统部署一个低强度恒流刺激脉冲来创建一个训练数据集,随后利用该数据集来预测更高强度恒流刺激所需的电极电压波形。预测的波形数据集已用于控制自定义开关电容输出级,从而避免了传统神经刺激器驱动器中Vdriver_transistor·stimulation的功率损耗。该系统集成了在超低功耗微控制器内实现的片上学习和预测,该微控制器已针对内存和功耗受限的可植入环境进行了优化。与动态电源缩放方法相比,刺激器输出级可减少高达20%的功率损耗,与传统恒流输出级相比,功耗降低高达3.63倍。智能神经接口系统由无线感应能量传输链路供电,并通过基于wifi的互联网网络进行远程控制。定制开发的应用程序界面,兼容移动设备和个人电脑,便于安全远程调整增产参数。该系统已通过体内大鼠周围神经刺激、体外生理盐水测试和台式实验的组合进行了验证。这些结果共同展示了通过实现智能、安全、节能和远程控制神经器官调节来推进未来神经植入技术的潜力。
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引用次数: 0
From Wearables to Implantables: Harnessing Sensor Technologies for Continuous Health Monitoring 从可穿戴设备到植入式设备:利用传感器技术进行持续健康监测。
IF 4.9 Pub Date : 2025-03-09 DOI: 10.1109/TBCAS.2025.3568754
Asish Koruprolu;Tyler Hack;Omid Ghadami;Aditi Jain;Drew A. Hall
Continuous health monitoring by placing sensors onto and into the human body has emerged as a pivotal approach in healthcare. This paper delves into the vast array of opportunities presented by instrumenting the body using wearable, ingestible, injectable, and implantable sensors. These sensors enable the continuous monitoring of vital signs, biomarkers, and other crucial health metrics, thus assessing an individual’s physiological state. This comprehensive health data empowers healthcare providers and individuals alike to make informed decisions and take timely action. Moreover, integrating sensors into the human body enables personalized medicine, enhances disease detection and management, and offers possibilities for proactive health interventions and preventive care to improve overall well-being.
通过将传感器放置在人体上和体内进行持续健康监测已经成为医疗保健领域的一种关键方法。本文深入研究了通过使用可穿戴、可摄取、可注射和可植入的传感器来测量身体所带来的大量机会。这些传感器能够持续监测生命体征、生物标志物和其他关键的健康指标,从而评估个人的生理状态。这些全面的健康数据使医疗保健提供者和个人能够做出明智的决定并及时采取行动。此外,将传感器集成到人体中可以实现个性化医疗,增强疾病检测和管理,并为主动健康干预和预防性护理提供可能性,以改善整体福祉。
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引用次数: 0
Artifact-Tolerant Electrophysiological Sensor Interface With 3.6V/1.8V DM/CM Input Range and 52.3mVpp/${mu}$s Recovery Using Asynchronous Signal Folding 具有3.6V/1.8V DM/CM输入范围和52.3mVpp/μs异步信号折叠恢复的伪影容电生理传感器接口。
IF 4.9 Pub Date : 2025-03-06 DOI: 10.1109/TBCAS.2025.3567524
Qiao Cai;Xinzi Xu;Yanxing Suo;Guanghua Qian;Yongfu Li;Guoxing Wang;Yong Lian;Yang Zhao
In the practical implementations of wearable sensors, motion artifacts with large amplitudes often cause signal chain saturation, significantly degrading biopotential signal integrity. Similarly, rapid stimulation artifacts are inevitable during closed-loop brain stimulation therapy, posing additional challenges for real-time signal acquisition. To address motion and stimulation artifacts with amplitudes reaching hundreds of mV while minimizing information loss, a sensor interface with high input range and fast artifacts recovery capability is essential. This paper presents a continuous-time track-and-zoom (CT-TAZ) technique designed to handle large artifacts events without saturation. The proposed system achieves a 3.6V/1.8V differential-mode/common-mode full-scale input range. Fabricated in a 180nm CMOS process, the prototype chip occupies an area of 0.694mm2 and consumes 12/32.6/51.6$mu$W for recordings without/with single-end/with differential rail-to-rail artifacts. The system demonstrates an average artifacts recovery time of 65.3 $mu$s under 3.6V stimulation artifacts, achieving an average artifacts recovery speed of 52.3mVpp/μs, which is 2.25× larger input range and 3× faster recovery compared to the state-of-the-art.
在可穿戴传感器的实际实现中,大幅度的运动伪影往往会导致信号链饱和,严重降低生物电位信号的完整性。同样,在闭环脑刺激治疗中,快速刺激伪影是不可避免的,这给实时信号采集带来了额外的挑战。为了解决振幅达到数百mV的运动和刺激伪影,同时最大限度地减少信息损失,具有高输入范围和快速伪影恢复能力的传感器接口是必不可少的。本文提出了一种连续时间跟踪和缩放(CT-TAZ)技术,用于处理无饱和的大型伪影事件。该系统实现了3.6V/1.8V差模/共模全量程输入。该原型芯片采用180nm CMOS工艺制造,面积为0.694mm2,功耗为12/32.6/51.6μW,用于无/带单端/带差动轨到轨伪影的记录。该系统在3.6V刺激下的平均伪影恢复时间为65.3 μs,平均伪影恢复速度为52.3mVpp/μs,比现有系统的输入范围大2.25倍,恢复速度快3倍。
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引用次数: 0
IEEE Circuits and Systems Society Information IEEE电路与系统学会信息
Pub Date : 2025-02-11 DOI: 10.1109/TBCAS.2025.3538049
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引用次数: 0
Guest Editorial: Ultralow-Power Technologies for Edge Computing in Human-Machine Interface Applications 嘉宾评论:人机界面应用中的边缘计算超低功耗技术
Pub Date : 2025-02-11 DOI: 10.1109/TBCAS.2025.3533805
Elisa Donati;Bo Zhao;Simone Benatti;Andrea Cossettini
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引用次数: 0
IEEE Transactions on Biomedical Circuits and Systems Publication Information IEEE生物医学电路和系统汇刊信息
Pub Date : 2025-02-11 DOI: 10.1109/TBCAS.2025.3538047
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引用次数: 0
Erratum to “Design of an Extreme Low Cutoff Frequency Highpass Frontend for CMOS ISFET via Direct Tunneling Principle” “利用直接隧道原理设计CMOS ISFET的极低截止频率高通前端”的勘误
Pub Date : 2025-02-11 DOI: 10.1109/TBCAS.2024.3411913
Jing Liang;Yuanqi Hu
In [1], in section III.E of the article, we calculate the equivalent tunnelling current according to equation (4) by using the value of Cg, eff as 1.679 fF, which is about 4.6 times smaller than the correct value. This leads to the wrong equivalent impedance value obtained in the final Fig. 10 is about 4.6 times larger than the correct value, and the equivalent impedance should be about 2.2 PΩ at this size, so according to the basis of the above, the article should be corrected as follows:
b[1],第三节。在本文E中,我们利用Cg, eff的值为1.679 fF,比正确值小约4.6倍,根据式(4)计算等效隧穿电流。这导致最终图10中得到的错误等效阻抗值比正确值大4.6倍左右,在此尺寸下的等效阻抗应该在2.2 PΩ左右,因此根据以上,本文应进行如下修正:
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引用次数: 0
期刊
IEEE transactions on biomedical circuits and systems
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