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Comprehensive characterization of nonlinear viscoelastic properties of arterial tissues using guided-wave optical coherence elastography. 用导波光学相干弹性成像综合表征动脉组织的非线性粘弹性特性。
IF 5.8 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1038/s42005-026-02502-0
Yuxuan Jiang, Guo-Yang Li, Ruizhi Wang, Xu Feng, Yanhang Zhang, Seok-Hyun Yun

The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography, comprehensive characterization of the complex mechanical behavior of arterial tissues remains challenging. Here, we present a broadband guided-wave optical coherence elastography (OCE) technique, grounded in viscoelasto-acoustic theory, for quantifying the nonlinear viscoelastic, anisotropic, and layer-specific properties of arterial walls with high spatial and temporal resolution. Our results reveal a strong stretch dependence of arterial viscoelasticity, with increasing prestress leading to a reduction in tissue viscosity. Under mechanical loading, the adventitia becomes significantly stiffer than the media, attributable to engagement of collagen fibers. Chemical degradation of collagen fibers highlighted their role in nonlinear viscoelasticity. This study demonstrates the potential of OCE as a powerful tool for detailed profiling of vascular biomechanics, with applications in basic research and future clinical diagnosis.

动脉壁的力学特性对于维持搏动压力下的血管功能至关重要,并且与心血管疾病的发生密切相关。尽管成像和弹性成像技术取得了进步,但动脉组织复杂力学行为的综合表征仍然具有挑战性。在这里,我们提出了一种基于粘弹性声学理论的宽带导波光学相干弹性成像(OCE)技术,用于量化动脉壁的非线性粘弹性、各向异性和层特异性,具有高空间和时间分辨率。我们的研究结果揭示了动脉粘弹性的强拉伸依赖性,随着预应力的增加导致组织粘度的降低。在机械载荷下,由于胶原纤维的参与,外膜变得明显比介质更硬。胶原纤维的化学降解突出了其在非线性粘弹性中的作用。这项研究证明了OCE作为血管生物力学详细分析的有力工具的潜力,在基础研究和未来临床诊断中具有应用价值。
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引用次数: 0
Disentangling autoencoders and spherical harmonics for efficient shape classification in crystal growth simulations. 解缠自编码器和球面谐波在晶体生长模拟中的有效形状分类。
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-07-02 DOI: 10.1038/s42005-025-02129-7
Jaehoon Cha, Steven Tendyra, Alvin J Walisinghe, Adam R Hill, Susmita Basak, Peter R Spackman, Michael W Anderson, Jeyan Thiyagalingam

Controlling crystal growth is a challenge across numerous industries, as the functional properties of crystalline materials are determined during formation and often depend on particle shape. Current approaches rely on expensive, time-consuming experimental studies complemented by exhaustive parameter space simulations, creating significant computational and analytical burdens. Despite machine learning advances in crystal growth for structure-property relationships, applications targeting morphological control remain underdeveloped. Here, we demonstrate how disentangling autoencoders combined with particle aspect ratio and spherical harmonics descriptors can enhance simulation workflows for crystal growth. This approach reveals continuous transformation pathways between different crystal morphologies whilst preserving underlying crystallographic principles. Our method significantly reduces data analytics burdens, shortens design study timelines, and deepens understanding of crystal shape control. This framework enables more efficient exploration of possible crystal morphologies, facilitating the targeted design of crystalline materials with specific functional properties.

控制晶体生长是许多行业面临的挑战,因为晶体材料的功能特性是在形成过程中决定的,通常取决于颗粒形状。目前的方法依赖于昂贵、耗时的实验研究,辅以详尽的参数空间模拟,造成了巨大的计算和分析负担。尽管机器学习在晶体生长的结构-性质关系方面取得了进展,但针对形态控制的应用仍然不发达。在这里,我们展示了解缠自编码器如何结合粒子长宽比和球面谐波描述符来增强晶体生长的模拟工作流程。这种方法揭示了不同晶体形态之间的连续转化途径,同时保留了潜在的晶体学原理。我们的方法大大减少了数据分析的负担,缩短了设计研究的时间,加深了对晶体形状控制的理解。该框架能够更有效地探索可能的晶体形态,促进具有特定功能特性的晶体材料的针对性设计。
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引用次数: 0
Speeding up adiabatic ion transport in macroscopic multi-Penning-trap stacks for high-precision experiments. 加速宏观多彭宁阱堆中绝热离子输运的高精度实验。
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1038/s42005-025-02031-2
Moritz von Boehn, Jan Schaper, Julia A Coenders, Johannes Brombacher, Teresa Meiners, Malte Niemann, Juan M Cornejo, Stefan Ulmer, Christian Ospelkaus

Multi-Penning traps are an excellent tool for high-precision tests of fundamental physics in a variety of applications, ranging from atomic mass measurements to symmetry tests. In such experiments, single ions are transferred between distinct trap regions as part of the experimental sequence, resulting in measurement dead time and heating of the ion motions. Here, we report a procedure to reduce the duration of adiabatic single-ion transport in macroscopic multi-Penning-trap stacks by using ion-transport waveforms and electronic filter predistortion. For this purpose, transport adiabaticity of a single laser-cooled 9Be+is analyzed via Doppler-broadened sideband spectra obtained by stimulated Raman spectroscopy, yielding an average heating per transport of 2.6 ± 4.0 quanta for transport times between 7 and 15 ms. Applying these techniques to current multi-Penning trap experiments could reduce ion transport times by up to three orders of magnitude. Furthermore, these results are a key requisite for implementing quantum logic spectroscopy in Penning trap experiments.

从原子质量测量到对称性测试,多潘宁陷阱是各种应用中高精度基础物理测试的绝佳工具。在这种实验中,作为实验序列的一部分,单个离子在不同的陷阱区域之间转移,导致测量死区时间和离子运动的加热。在这里,我们报告了一种利用离子输运波形和电子滤波器预失真来减少宏观多潘宁阱堆中绝热单离子输运持续时间的方法。为此,通过受激拉曼光谱获得的多普勒加宽边带光谱分析了单激光冷却9Be+的输运绝热性,得出输运时间在7到15 ms之间,每次输运的平均加热为2.6±4.0量子。将这些技术应用于当前的多潘宁阱实验,可以将离子传输时间减少多达三个数量级。此外,这些结果是在Penning陷阱实验中实现量子逻辑光谱的关键条件。
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引用次数: 0
Universality in multispecies urban traffic. 多物种城市交通的普遍性。
IF 5.8 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-11-20 DOI: 10.1038/s42005-025-02326-4
Georg Anagnostopoulos, Nikolas Geroliminis

Collective phenomena involving motorcycles in mixed traffic, and more generally bicycles and other new micromobilities in cities, are of great interest, as the behavior of these vulnerable road users raises major safety concerns. This is especially true when the limited urban infrastructure is shared with conventional vehicles, such as cars. However, this topic is severely understudied from a physics point of view and a solid theoretical foundation of multispecies traffic does not exist. By studying the pNEUMA dataset, we first establish a nonlinear relationship between maneuverability and speed, which maps to the nonequilibrium concept of a sample space reducing process (SSR). Coupling SSR with Newell's nonlinear traffic model, we identify a power-law relationship between the average maneuverability (interpreted as temperature) and the mean speed difference between motorcycle and car populations. Simulation results allow us to recover a nonequilibrium phase transition from an ordered state of lane formation to a disordered state of cluster formation governed by a universal scaling exponent that is robust to traffic conditions and model variants. Our contribution creates a link between microscopic behaviors and the macroscopic theory of percolation.

人们对混合交通中的摩托车以及城市中更普遍的自行车和其他新型微型交通工具的集体现象非常感兴趣,因为这些脆弱的道路使用者的行为引起了重大的安全问题。当有限的城市基础设施与汽车等传统交通工具共享时,情况尤其如此。然而,从物理学的角度来看,这一主题的研究严重不足,并且缺乏坚实的多物种交通理论基础。通过研究气动数据集,我们首先建立了机动性和速度之间的非线性关系,映射到样本空间缩减过程(SSR)的非平衡概念。将SSR与Newell的非线性交通模型相结合,我们确定了摩托车和汽车群体之间的平均机动性(解释为温度)与平均速度差之间的幂律关系。仿真结果使我们能够恢复非平衡相变,从有序车道形成状态到无序簇形成状态,由一个对交通条件和模型变量具有鲁棒性的通用缩放指数控制。我们的贡献在微观行为和宏观渗透理论之间建立了联系。
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引用次数: 0
Monolithic silicon nitride electro-optic modulator enabled by optically-assisted poling. 光辅助极化实现的单片氮化硅电光调制器。
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-04-08 DOI: 10.1038/s42005-025-02071-8
Christian Lafforgue, Boris Zabelich, Camille-Sophie Brès

Electro-optic (EO) modulation is a key functionality to have on-chip. However, achieving a notable linear EO effect in stoichiometric silicon nitride has been a persistent challenge due to the material's intrinsic properties. Recent advancements revealed that the displacement of thermally excited charge carriers under a high electric field induces a second-order nonlinearity in silicon nitride, thus enabling the linear EO effect in this platform regardless of the material's inversion symmetry. In this work, we introduce optically-assisted poling of a silicon nitride microring resonator, removing the need for high-temperature processing of the device. The optical stimulation of charges avoids the technical constraints due to elevated temperature. By optimizing the poling process, we experimentally obtain a long-term effective second-order nonlinearity χ eff ( 2 ) of 1.218 pm/V. Additionally, we measure the high-speed EO response of the modulator, showing a bandwidth of 4 GHz, only limited by the quality factor of the microring resonator. This work goes towards the implementation of monolithic, compact silicon nitride EO modulators, a necessary component for high-density integrated optical signal processing.

电光(EO)调制是芯片上的一个关键功能。然而,由于材料的固有特性,在化学计量氮化硅中实现显着的线性EO效应一直是一个持续的挑战。最近的进展表明,在高电场下,热激发载流子的位移在氮化硅中引起二阶非线性,从而使该平台中的线性EO效应与材料的反演对称性无关。在这项工作中,我们介绍了氮化硅微环谐振器的光学辅助极化,消除了对器件高温加工的需要。电荷的光学刺激避免了由于温度升高而造成的技术限制。通过优化极化过程,我们实验获得了长期有效的二阶非线性χ eff(2)为1.218 pm/V。此外,我们测量了调制器的高速EO响应,显示带宽为4 GHz,仅受微环谐振器质量因素的限制。这项工作是为了实现单片紧凑的氮化硅EO调制器,这是高密度集成光信号处理的必要组件。
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引用次数: 0
Fast high-resolution lifetime image reconstruction for positron lifetime tomography. 快速高分辨率寿命图像重建正电子寿命断层扫描。
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-04-26 DOI: 10.1038/s42005-025-02100-6
Bangyan Huang, Zipai Wang, Xinjie Zeng, Amir H Goldan, Jinyi Qi

Due to the ortho-positronium formed prior to the annihilation, the lifetime of a positron is sensitive to the tissue microenvironment and can potentially provide valuable information for monitoring disease progression and treatment response. However, the lifetime of positrons before annihilation has long been overlooked in current positron emission tomography (PET). Here we develop a positron lifetime image reconstruction method called SIMPLE (Statistical IMage reconstruction of Positron Lifetime via time-wEighting) and demonstrate its performance using a real scan on a time-of-flight PET scanner. The SIMPLE method achieves high-resolution positron lifetime imaging of extended heterogeneous tissue illuminated by a 22Na point source, successfully resolving the boundary between muscle and fat. It delivers spatial resolution comparable to that of conventional PET activity images while maintaining a computational cost equivalent to reconstructing two PET images. This work paves the way for clinical translation of high-resolution positron lifetime imaging.

由于正电子在湮灭之前形成,正电子的寿命对组织微环境敏感,可以潜在地为监测疾病进展和治疗反应提供有价值的信息。然而,在目前的正电子发射断层扫描(PET)中,正电子湮灭前的寿命一直被忽视。在这里,我们开发了一种称为SIMPLE(通过时间加权的正电子寿命的统计图像重建)的正电子寿命图像重建方法,并通过在飞行时间PET扫描仪上的真实扫描验证了其性能。SIMPLE方法在22Na点源照射下实现了扩展异质组织的高分辨率正电子寿命成像,成功地解决了肌肉和脂肪之间的边界。它提供与传统PET活动图像相当的空间分辨率,同时保持相当于重建两张PET图像的计算成本。这项工作为高分辨率正电子寿命成像的临床翻译铺平了道路。
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引用次数: 0
Dissipative realization of Kondo models. 近藤模型的耗散实现。
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-05-22 DOI: 10.1038/s42005-025-02141-x
Martino Stefanini, Yi-Fan Qu, Tilman Esslinger, Sarang Gopalakrishnan, Eugene Demler, Jamir Marino

The Kondo effect is a prototypical strongly correlated phenomenon, and it is usually discussed in the context of unitary dynamics. Here, we demonstrate that the Kondo effect can be induced through non-linear dissipative channels, without requiring any coherent interaction on the impurity site. Specifically, we consider a reservoir of noninteracting fermions that can hop on a few impurity sites that are subjected to strong two-body losses. In the simplest case of a single lossy site, we recover the Anderson impurity model in the regime of infinite repulsion, with a small residual dissipation as a perturbation. While the Anderson model gives rise to the Kondo effect, this residual dissipation competes with it, offering an instance of a nonlinear dissipative impurity where the interplay between coherent and incoherent dynamics emerges from the same underlying physical process. We further outline how this dissipative engineering scheme can be extended to two or more lossy sites, realizing generalizations of the Kondo model with spin 1 or higher. Our results suggest alternative implementations of Kondo models using ultracold atoms in transport experiments, where localized dissipation can be naturally introduced, and the Kondo effect observed through conductance measurements.

近藤效应是一种典型的强相关现象,通常在统一动力学的背景下讨论。在这里,我们证明了近藤效应可以通过非线性耗散通道诱导,而不需要在杂质位点上进行任何相干相互作用。具体地说,我们考虑了一个非相互作用费米子的储存库,它可以跳到一些遭受强双体损失的杂质位点上。在最简单的单损点情况下,我们恢复了无限排斥状态下的安德森杂质模型,并以小的残余耗散作为扰动。虽然安德森模型产生了近藤效应,但这种残余耗散与它竞争,提供了一个非线性耗散杂质的实例,其中相干和非相干动力学之间的相互作用来自相同的潜在物理过程。我们进一步概述了如何将这种耗散工程方案扩展到两个或更多的有耗点,实现自旋为1或更高的近藤模型的推广。我们的结果提出了在输运实验中使用超冷原子的近藤模型的替代实现,其中局部耗散可以自然引入,并且通过电导测量观察到近藤效应。
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引用次数: 0
Suppressing nonperturbative gauge errors in the thermodynamic limit using local pseudogenerators. 利用局部伪发电机抑制热力学极限中的非微扰规整误差
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1038/s42005-025-02035-y
Maarten Van Damme, Julius Mildenberger, Fabian Grusdt, Philipp Hauke, Jad C Halimeh

With recent progress in quantum simulations of lattice-gauge theories, it is becoming a pressing question how to reliably protect the gauge symmetry that defines such models. Recently, an experimentally feasible gauge-protection scheme has been proposed that is based on the concept of a local pseudogenerator, which is required to act identically to the full gauge-symmetry generator in the target gauge sector, but not necessarily outside of it. The scheme has been analytically and numerically shown to reliably stabilize lattice gauge theories in the presence of perturbative errors on finite-size analog quantum-simulation devices. In this work, through uniform matrix product state calculations, we demonstrate the efficacy of this scheme for nonperturbative errors in analog quantum simulators up to all accessible evolution times in the thermodynamic limit, where it is a priori neither established nor expected that this scheme will succeed. Our results indicate the presence of an emergent gauge symmetry in an adjusted gauge theory even in the thermodynamic limit, which is beyond our analytic predictions. Additionally, we show through quantum circuit model calculations that gauge protection with local pseudogenerators also successfully suppresses gauge violations on finite quantum computers that discretize time through Trotterization. Our results firm up the robustness and feasibility of the local pseudogenerator as a viable tool for enforcing gauge invariance in modern quantum simulators and noisy intermediate-scale quantum devices.

随着晶格规范理论的量子模拟的最新进展,如何可靠地保护定义这些模型的规范对称性成为一个紧迫的问题。最近,基于局部伪发生器的概念,提出了一种实验上可行的量规保护方案,该方案要求在目标量规扇区内与全量规对称发生器工作相同,但不一定在目标量规扇区外。在有限尺寸模拟量子模拟器件上,该方案在存在微扰误差的情况下可靠地稳定了晶格规范理论。在这项工作中,通过均匀矩阵积状态计算,我们证明了该方案在模拟量子模拟器中的非摄动误差的有效性,直到热力学极限下所有可访问的进化时间,其中先验地既不建立也不期望该方案会成功。我们的结果表明,即使在热力学极限下,在调整规范理论中也存在紧急规范对称,这超出了我们的分析预测。此外,我们通过量子电路模型计算表明,局部伪发生器的规范保护也成功地抑制了通过Trotterization离散时间的有限量子计算机上的规范违规。我们的结果证实了局部伪发生器作为现代量子模拟器和有噪声的中等规模量子器件中强制规范不变性的可行工具的鲁棒性和可行性。
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引用次数: 0
Aerosol size determination via light scattering of viruses and protein complexes. 通过病毒和蛋白质复合物的光散射测定气溶胶大小。
IF 5.4 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-04-12 DOI: 10.1038/s42005-025-02076-3
Lena Worbs, Tej Varma Yenupuri, Tong You, Filipe R N C Maia

The study of ultrafine particle aerosols, those with particle diameters of 100 nm or less, is important due to their impact on our health and environment. However, given their small sizes, such particles can be difficult to measure and trace. Most common optical methods are unable to reach this size range. Other methods exist but incur other limitations, such as the need for electrically charged particles. Here we show how light scattering can be used to detect and measure the size and location of single viruses and protein complexes forming an aerosol beam, as well as trace their path. We were able to detect individual particles down to 16 nm in diameter. The primary purpose of our instrument is to monitor the delivery of single bioparticles to the focus of an X-ray laser to image those particles, but it has the potential to study any other aerosols such as those resulting from ultrafine sea spray, with important consequences for cloud formation and climate modeling, or from combustion, responsible for most air pollution and resulting health impacts.

超细颗粒气溶胶,即粒径小于等于100纳米的气溶胶,对我们的健康和环境有重要影响。然而,考虑到它们的小尺寸,这种粒子很难测量和追踪。大多数常用的光学方法都无法达到这个尺寸范围。其他方法也存在,但会产生其他限制,例如需要带电粒子。在这里,我们展示了如何使用光散射来检测和测量单个病毒和蛋白质复合物形成气溶胶束的大小和位置,以及追踪它们的路径。我们能够探测到直径小至16纳米的单个粒子。我们的仪器的主要目的是监测单个生物颗粒在x射线激光焦点上的传递,以对这些颗粒进行成像,但它也有可能研究任何其他气溶胶,例如由超细海洋喷雾产生的气溶胶,对云的形成和气候建模有重要影响,或者由燃烧产生的气溶胶,造成大多数空气污染和由此产生的健康影响。
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引用次数: 0
Chaotic and quantum dynamics in driven-dissipative bosonic chains. 驱动耗散玻色子链中的混沌和量子动力学。
IF 5.8 1区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2025-01-01 Epub Date: 2025-10-16 DOI: 10.1038/s42005-025-02314-8
Filippo Ferrari, Fabrizio Minganti, Camille Aron, Vincenzo Savona

Thermalization in quantum many-body systems typically unfolds over timescales governed by intrinsic relaxation mechanisms. Yet, its spatial aspect is less understood. We investigate this phenomenon in the nonequilibrium steady state (NESS) of a Bose-Hubbard chain subject to coherent driving and dissipation at its boundaries, a setup inspired by current designs in circuit quantum electrodynamics. The dynamical fingerprints of chaos in this NESS are probed using semiclassical out-of-time-order correlators within the truncated Wigner approximation. At intermediate drive strengths, we uncover a two-stage thermalization along the spatial dimension: phase coherence is rapidly lost near the drive, while amplitude relaxation occurs over much longer distances. This separation of scales gives rise to an extended hydrodynamic regime exhibiting anomalous temperature profiles, which we designate as a "prethermal" domain. At stronger drives, the system enters a nonthermal, non-chaotic finite-momentum condensate characterized by sub-Poissonian photon statistics and a spatially modulated phase profile, whose stability is undermined by quantum fluctuations. We explore the conditions underlying this protracted thermalization in space and argue that similar mechanisms are likely to emerge in a broad class of extended driven-dissipative systems.

量子多体系统中的热化通常在由内在松弛机制控制的时间尺度上展开。然而,人们对其空间方面的了解较少。我们研究了受当前电路量子电动力学设计启发的波色-哈伯德链的非平衡稳态(NESS)中受相干驱动和边界耗散影响的这一现象。利用截断维格纳近似内的半经典非时序相关器探测混沌的动态指纹。在中等驱动强度下,我们发现了沿空间维度的两阶段热化:相位相干性在驱动附近迅速丧失,而振幅松弛发生在更长的距离上。这种尺度的分离产生了一个扩展的流体动力区,显示出异常的温度分布,我们将其称为“预热”域。在较强的驱动下,系统进入以亚泊松光子统计和空间调制相位轮廓为特征的非热、非混沌有限动量凝聚体,其稳定性受到量子涨落的破坏。我们探索了空间中这种持久热化的条件,并认为类似的机制可能出现在广泛的一类扩展驱动耗散系统中。
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引用次数: 0
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Communications Physics
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