Wenhui Cui, Shuaitong Liang, Junping Miao, Wenli Li, Hanwen An, Rongrong Yu, Juan Zhou, Ruiqi Shao, Zhiwei Xu
Molecular engineering of cellulose is essential for improving ionic conductivity and mechanical stability in solid polymer electrolytes. This work presents the first utilization of apocynum venetum, a drought-resistant biomass, as a sustainable source of cellulose nanofibers (CNFs) to investigate lithium-ion (Li+) transport mechanisms in composite polymer electrolytes for lithium metal batteries (LMBs). The reconstructed type II cellulose disrupts the polymer chain order by reorganizing hydrogen bonds and expanding amorphous regions, leading to a high Li+ transference number of 0.67 and an extended electrochemical window of 5.5 V. Operando synchrotron SAXS/WAXS reveals that CNFs modulate the structural evolution of the electrolyte and facilitate the formation of continuous Li+ conduction pathways within the amorphous phase. Through ion–dipole interactions among CNFs hydroxyl groups, PEO ether oxygens, and Li+, dynamic Li+─O coordination structures are formed, enhancing Li+ mobility. This work demonstrates the critical role of apocynum venetum-derived nanocellulose in enhancing the performance of bio-based polymer electrolytes.
{"title":"Operando SAXS/WAXS Reveals the Formation of Li+ Conduction Pathways Enabled by Apocynum Venetum-Derived Nanocellulose","authors":"Wenhui Cui, Shuaitong Liang, Junping Miao, Wenli Li, Hanwen An, Rongrong Yu, Juan Zhou, Ruiqi Shao, Zhiwei Xu","doi":"10.1002/adfm.202523000","DOIUrl":"https://doi.org/10.1002/adfm.202523000","url":null,"abstract":"Molecular engineering of cellulose is essential for improving ionic conductivity and mechanical stability in solid polymer electrolytes. This work presents the first utilization of apocynum venetum, a drought-resistant biomass, as a sustainable source of cellulose nanofibers (CNFs) to investigate lithium-ion (Li<sup>+</sup>) transport mechanisms in composite polymer electrolytes for lithium metal batteries (LMBs). The reconstructed type II cellulose disrupts the polymer chain order by reorganizing hydrogen bonds and expanding amorphous regions, leading to a high Li<sup>+</sup> transference number of 0.67 and an extended electrochemical window of 5.5 V. Operando synchrotron SAXS/WAXS reveals that CNFs modulate the structural evolution of the electrolyte and facilitate the formation of continuous Li<sup>+</sup> conduction pathways within the amorphous phase. Through ion–dipole interactions among CNFs hydroxyl groups, PEO ether oxygens, and Li<sup>+</sup>, dynamic Li<sup>+</sup>─O coordination structures are formed, enhancing Li<sup>+</sup> mobility. This work demonstrates the critical role of apocynum venetum-derived nanocellulose in enhancing the performance of bio-based polymer electrolytes.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"23 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gout is a type of inflammatory arthritis resulting from abnormal uric acid (UA) metabolism. The core issue is elevated UA levels in the body, which cause the formation and accumulation of insoluble crystals in the joints or surrounding tissues, leading to a severe inflammatory response. Due to its complex causes, gout treatment faces challenges such as difficulty in achieving a complete cure and a high recurrence rate, which increases the risk of other systemic diseases. Functionalized biomaterials have been widely applied in the biomedical field and have demonstrated remarkable therapeutic potential, particularly for treating inflammatory diseases. Owing to their excellent biocompatibility and multiple bioactivities, these materials can effectively address multiple challenges faced in gout treatment. In this review, we categorize gout treatment into three aspects: UA degradation, inflammation reduction, and pain relief, and provide a systematic overview of the mechanisms and recent advancements in multifunctional biomaterials for managing gout from these three angles, emphasizing the importance of addressing gout-related pain and highlighting the current scarcity of research in this area. This review offers a novel perspective for optimizing the design and application of functionalized biomaterials, facilitating the development of more effective gout treatment strategies.
{"title":"Advanced Biomaterials Revolutionize Gout Therapy: From Uric Acid Degradation to Pain Alleviation","authors":"Jie Cao, Fei Gong, Zhihui Han, Xinyi Qiao, Xiang Cui, Liang Cheng","doi":"10.1002/adfm.202530174","DOIUrl":"https://doi.org/10.1002/adfm.202530174","url":null,"abstract":"Gout is a type of inflammatory arthritis resulting from abnormal uric acid (UA) metabolism. The core issue is elevated UA levels in the body, which cause the formation and accumulation of insoluble crystals in the joints or surrounding tissues, leading to a severe inflammatory response. Due to its complex causes, gout treatment faces challenges such as difficulty in achieving a complete cure and a high recurrence rate, which increases the risk of other systemic diseases. Functionalized biomaterials have been widely applied in the biomedical field and have demonstrated remarkable therapeutic potential, particularly for treating inflammatory diseases. Owing to their excellent biocompatibility and multiple bioactivities, these materials can effectively address multiple challenges faced in gout treatment. In this review, we categorize gout treatment into three aspects: UA degradation, inflammation reduction, and pain relief, and provide a systematic overview of the mechanisms and recent advancements in multifunctional biomaterials for managing gout from these three angles, emphasizing the importance of addressing gout-related pain and highlighting the current scarcity of research in this area. This review offers a novel perspective for optimizing the design and application of functionalized biomaterials, facilitating the development of more effective gout treatment strategies.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"32 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manali Nandy, Udit Ghosh, Ketan A. Ganar, Hans Ippel, Ingrid Dijkgraaf, Siddharth Deshpande
Bubbles within Protein Droplets
蛋白滴内的气泡
{"title":"pH-Tunable Material Properties of Glycine-Rich Condensates from Tick Bioadhesive (Adv. Funct. Mater. 10/2026)","authors":"Manali Nandy, Udit Ghosh, Ketan A. Ganar, Hans Ippel, Ingrid Dijkgraaf, Siddharth Deshpande","doi":"10.1002/adfm.73795","DOIUrl":"https://doi.org/10.1002/adfm.73795","url":null,"abstract":"<b>Bubbles within Protein Droplets</b>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"111 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
All-solid-state sodium-metal batteries (ASSSMBs) hold great promise for large-scale energy storage owing to their intrinsic safety, low cost, and high energy density, yet their practical deployment is hindered by poor cathode-electrolyte contact and unstable interphases. Herein, we propose a descriptor-guided strategy that integrates the minimum average local ionization energy (ALIEmin) with cation binding energy as dual screening criteria to establish a predictive solvent screening framework that enables high-voltage tolerance (high ALIEmin) while promoting weak solvation (low binding energy), thereby enhancing anion participation during interphase formation. Guided by this framework, succinonitrile (SN) was identified as the optimal solvent, uniquely combining a high ALIEmin with a low Na+ binding energy, thereby enabling both oxidative robustness and weak solvation. When SN-based electrolytes serve as the interlayer in the NVP@NZSP||NZSP||Na cell, they drive the in situ formation of a uniform thin-layer cathode-electrolyte interface (CEI) rich in sodium fluoride. As a result, the optimized ASSSMB achieves long-term cycling stability (97.7% capacity retention after 10,700 h at 0.1C) and high-rate durability (94.5% after 2,100 cycles at 1C), outperforming previously reported NASICON-based systems. This study positions physically interpretable molecular descriptors as a versatile approach for rational interphase design, advancing the development of stable interfaces in next-generation solid-state batteries.
{"title":"Data-Driven Ionization-Energy Descriptor Enables Stable Cathode-Electrolyte Interface in All-Solid-State Sodium-Metal Batteries","authors":"Ming Zhang, Yuan He, Zikai Li, Tingting Li, Jitao Li, Yang-Feng Cui, Zixuan Fang, Mengqiang Wu","doi":"10.1002/adfm.202527652","DOIUrl":"https://doi.org/10.1002/adfm.202527652","url":null,"abstract":"All-solid-state sodium-metal batteries (ASSSMBs) hold great promise for large-scale energy storage owing to their intrinsic safety, low cost, and high energy density, yet their practical deployment is hindered by poor cathode-electrolyte contact and unstable interphases. Herein, we propose a descriptor-guided strategy that integrates the minimum average local ionization energy (ALIEmin) with cation binding energy as dual screening criteria to establish a predictive solvent screening framework that enables high-voltage tolerance (high ALIEmin) while promoting weak solvation (low binding energy), thereby enhancing anion participation during interphase formation. Guided by this framework, succinonitrile (SN) was identified as the optimal solvent, uniquely combining a high ALIEmin with a low Na<sup>+</sup> binding energy, thereby enabling both oxidative robustness and weak solvation. When SN-based electrolytes serve as the interlayer in the NVP@NZSP||NZSP||Na cell, they drive the in situ formation of a uniform thin-layer cathode-electrolyte interface (CEI) rich in sodium fluoride. As a result, the optimized ASSSMB achieves long-term cycling stability (97.7% capacity retention after 10,700 h at 0.1C) and high-rate durability (94.5% after 2,100 cycles at 1C), outperforming previously reported NASICON-based systems. This study positions physically interpretable molecular descriptors as a versatile approach for rational interphase design, advancing the development of stable interfaces in next-generation solid-state batteries.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"292 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Efficient thermal management in stretchable electronics demands materials that seamlessly integrate high thermal conductivity, mechanical flexibility, and reliable interface stability. This paper presents a stretchable, thermally conductive, biphasic, liquid-metal sheet (LM sheet)—formed by dispersing copper particles in gallium-based liquid metal—encapsulated between nanoscale styrene–butadiene–styrene elastomer layers. This trilayer architecture establishes continuous thermal-conduction pathways while providing excellent electrical insulation and corrosion resistance. The LM sheet achieves impressive in-plane and through-plane thermal conductivities (40.4 and 16.7 W m−1 K−1, respectively), with an elongation at break >200%. Notably, it retains 96% of its thermal conductivity even under 100% tensile strain. It adheres strongly to various substrates without adhesives, excellently spreading heat in flexible heaters and stretchable LED devices under both static and stretched conditions. This paper presents a compelling strategy for developing next-generation thermal-interface materials for deformable and skin-integrated electronic systems.
可拉伸电子产品的高效热管理要求材料无缝集成高导热性，机械灵活性和可靠的界面稳定性。本文提出了一种可拉伸的、导热的、双相的液态金属片（LM片），它是由分散在镓基液态金属中的铜颗粒形成的，并被包裹在纳米级的苯乙烯-丁二烯-苯乙烯弹性体层之间。这种三层结构建立了连续的热传导途径，同时提供了出色的电绝缘和耐腐蚀性。LM薄片具有令人印象深刻的面内和透面导热系数（分别为40.4和16.7 W m−1 K−1），断裂伸长率为200%。值得注意的是，即使在100%拉伸应变下，它仍保持96%的导热系数。它可以在没有粘合剂的情况下牢固地粘附在各种基材上，在静态和拉伸条件下都可以在柔性加热器和可拉伸LED器件中出色地传播热量。本文提出了一种开发下一代可变形和皮肤集成电子系统的热界面材料的引人注目的策略。
{"title":"Nanolayer-Encapsulated Stretchable Liquid-Metal Sheets for Thermal Management","authors":"Daisuke Kuse, Yudai Kaneko, Ryohei Fujita, Tatsuhiro Horii, Daishi Shiojiri, Yuta Ozawa, Kyohei Nagatake, Tamami Takano, Yutaka Isoda, Aoi Koishikawa, Takashi Goto, Ai Ueno, Shoji Maruo, Kazuhide Ueno, Toshinori Fujie, Hosei Nagano, Hiroki Ota","doi":"10.1002/adfm.202527281","DOIUrl":"https://doi.org/10.1002/adfm.202527281","url":null,"abstract":"Efficient thermal management in stretchable electronics demands materials that seamlessly integrate high thermal conductivity, mechanical flexibility, and reliable interface stability. This paper presents a stretchable, thermally conductive, biphasic, liquid-metal sheet (LM sheet)—formed by dispersing copper particles in gallium-based liquid metal—encapsulated between nanoscale styrene–butadiene–styrene elastomer layers. This trilayer architecture establishes continuous thermal-conduction pathways while providing excellent electrical insulation and corrosion resistance. The LM sheet achieves impressive in-plane and through-plane thermal conductivities (40.4 and 16.7 W m<sup>−1 </sup>K<sup>−1</sup>, respectively), with an elongation at break >200%. Notably, it retains 96% of its thermal conductivity even under 100% tensile strain. It adheres strongly to various substrates without adhesives, excellently spreading heat in flexible heaters and stretchable LED devices under both static and stretched conditions. This paper presents a compelling strategy for developing next-generation thermal-interface materials for deformable and skin-integrated electronic systems.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"8 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jixue Shen, Xinyu Tian, Zhongxuan Li, Xiaoyu Zhao, Yulu Tian, Zeheng Li, Lei Cheng, Fuqiang Zhou, Jun Lu
High-capacity, low-cost ultra-high Ni (Ni ≥ 0.9, NCM9) single-crystal layered oxides have emerged as the most promising cathode materials for lithium-ion batteries. However, they undergo lattice distortion and severe structural degradation after high-temperature storage. In this study, a high-valence Nb gradient doping modification strategy is employed to achieve the fabrication of structurally stable ultra-high Ni single-crystal cathode materials (SNCM9-xNb) under high-temperature storage. The introduction of Nb inhibits harmful phase transitions, alleviates stress accumulation, reduces intracrystalline microcracks, and prolongs cycle life. Meanwhile, the formation of Nb─O bonds suppress lattice oxygen release and mitigates structural collapse caused by high-temperature storage. Consequently, SNCM9-0.02Nb (after 60°C storage for 90 days) exhibits a high discharge capacity of 6.82Ah and a high-retention of 82.1% following 600 cycles of the pouch-type full-cells. Despite undergoing 90 days of storage under elevated temperature conditions (60°C), the capacity retention and recovery rates exhibit minimal degradation, maintaining 90.87% and 93.28%, respectively, thus demonstrating remarkable stability and resilience. The high-valence Nb gradient doping modification strategy reported in this work has been shown to mitigate the high-temperature structural degradation of ultra-high Ni single-crystal cathode materials, thus offering a valuable insight into the development of cathode materials with stable performance at high temperatures.
{"title":"Enhancing High-Temperature Electrochemical Performance of Single-Crystal Ultra-High Nickel Cathodes via High-Valence Nb Gradient Doping","authors":"Jixue Shen, Xinyu Tian, Zhongxuan Li, Xiaoyu Zhao, Yulu Tian, Zeheng Li, Lei Cheng, Fuqiang Zhou, Jun Lu","doi":"10.1002/adfm.202525784","DOIUrl":"https://doi.org/10.1002/adfm.202525784","url":null,"abstract":"High-capacity, low-cost ultra-high Ni (Ni ≥ 0.9, NCM9) single-crystal layered oxides have emerged as the most promising cathode materials for lithium-ion batteries. However, they undergo lattice distortion and severe structural degradation after high-temperature storage. In this study, a high-valence Nb gradient doping modification strategy is employed to achieve the fabrication of structurally stable ultra-high Ni single-crystal cathode materials (SNCM9-xNb) under high-temperature storage. The introduction of Nb inhibits harmful phase transitions, alleviates stress accumulation, reduces intracrystalline microcracks, and prolongs cycle life. Meanwhile, the formation of Nb─O bonds suppress lattice oxygen release and mitigates structural collapse caused by high-temperature storage. Consequently, SNCM9-0.02Nb (after 60°C storage for 90 days) exhibits a high discharge capacity of 6.82Ah and a high-retention of 82.1% following 600 cycles of the pouch-type full-cells. Despite undergoing 90 days of storage under elevated temperature conditions (60°C), the capacity retention and recovery rates exhibit minimal degradation, maintaining 90.87% and 93.28%, respectively, thus demonstrating remarkable stability and resilience. The high-valence Nb gradient doping modification strategy reported in this work has been shown to mitigate the high-temperature structural degradation of ultra-high Ni single-crystal cathode materials, thus offering a valuable insight into the development of cathode materials with stable performance at high temperatures.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"80 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Graphene-based liquid crystals have ultra-high electric responsivity and hold great promise in fabricating light modulators with ultra-low-field driving and macroscopic centimeter-scale electrode spacing. However, their narrow bandgap and uncontrollable electroresponse severely restrict their modulated spectral region and performance, especially for the visible and ultraviolet regions. Here, we report a fluorographene liquid crystal, which has a wide bandgap of ∼5.5 eV and controllable electroresponse from modulation of fluorine doping ratio, and exceptional stability under deep-ultraviolet exposure. As a consequence, a fluorographene liquid crystal-based deep-ultraviolet electro-optic modulator is fabricated with negligible degradation after 5 h of ultraviolet irradiation under 0 and 12 V m−1 electric fields. The fluorographene liquid crystals expand the family of graphene liquid crystals and pave the way for broadening their applications in a variety of scenarios, as conceptually demonstrated with integrated sea-land-air solar-blind communication for smart port applications.
石墨烯基液晶具有超高的电响应性，在制造具有超低场驱动和宏观厘米级电极间距的光调制器方面具有很大的前景。然而，它们窄小的带隙和不可控的电响应严重限制了它们的调制光谱区域和性能，特别是在可见光和紫外线区域。在这里，我们报道了一种氟石墨烯液晶，它具有约5.5 eV的宽带隙和可控制的电响应，通过调制氟掺杂比，在深紫外照射下具有优异的稳定性。因此，在0和12 V m−1电场下，经过5小时的紫外照射后，制备了基于氟石墨烯液晶的深紫外电光调制器，其降解可以忽略不计。氟石墨烯液晶扩展了石墨烯液晶家族，并为拓宽其在各种场景中的应用铺平了道路，如概念上展示的用于智能端口应用的集成海陆空太阳盲通信。
{"title":"Deep-Ultraviolet Electro-optic Modulator Based on Fluorographene Liquid Crystal","authors":"Sheng Wei, Wenjun Kuang, Siyuan Tian, Feng Wang, Rui Gong, Fufang Xu, Baofu Ding","doi":"10.1002/adfm.202530639","DOIUrl":"https://doi.org/10.1002/adfm.202530639","url":null,"abstract":"Graphene-based liquid crystals have ultra-high electric responsivity and hold great promise in fabricating light modulators with ultra-low-field driving and macroscopic centimeter-scale electrode spacing. However, their narrow bandgap and uncontrollable electroresponse severely restrict their modulated spectral region and performance, especially for the visible and ultraviolet regions. Here, we report a fluorographene liquid crystal, which has a wide bandgap of ∼5.5 eV and controllable electroresponse from modulation of fluorine doping ratio, and exceptional stability under deep-ultraviolet exposure. As a consequence, a fluorographene liquid crystal-based deep-ultraviolet electro-optic modulator is fabricated with negligible degradation after 5 h of ultraviolet irradiation under 0 and 12 V m<sup>−1</sup> electric fields. The fluorographene liquid crystals expand the family of graphene liquid crystals and pave the way for broadening their applications in a variety of scenarios, as conceptually demonstrated with integrated sea-land-air solar-blind communication for smart port applications.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"58 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tao Lu, Ranhua Xiong, Chaobo Huang, David W. Grainger, Koen Raemdonck, Félix Sauvage, Kevin Braeckmans, Stefaan C. De Smedt
Having access to high-quality cell populations is essential for biomedical research, diagnosis, prognosis, and therapeutic applications. Traditional enzymatic methods, such as trypsinization, remain widely used to detach cells from supporting material surfaces, though they often compromise cell surface integrity, viability and functionality. To address these limitations, diverse strategies have emerged that enable a much gentler release of cells from material surfaces. The use of external physical stimuli (like shear stresses, light, temperature, magnetic fields), chemical stimuli (based on changes in pH or ligand-exchange based detachment) and biological stimuli (like aptamers and nucleic acid sequences) have been explored for the purpose of non-invasive cell detachment. This review discusses the principles, mechanisms, advantages, and limitations of these most diverse cell detachment technologies. By providing this comprehensive perspective, we hope to guide researchers in selecting the most suitable techniques for their specific needs and to inspire further innovation in this vital biomedical area.
{"title":"Detaching Cells From Materials: Techniques and Biomedical Applications","authors":"Tao Lu, Ranhua Xiong, Chaobo Huang, David W. Grainger, Koen Raemdonck, Félix Sauvage, Kevin Braeckmans, Stefaan C. De Smedt","doi":"10.1002/adfm.202531101","DOIUrl":"https://doi.org/10.1002/adfm.202531101","url":null,"abstract":"Having access to high-quality cell populations is essential for biomedical research, diagnosis, prognosis, and therapeutic applications. Traditional enzymatic methods, such as trypsinization, remain widely used to detach cells from supporting material surfaces, though they often compromise cell surface integrity, viability and functionality. To address these limitations, diverse strategies have emerged that enable a much gentler release of cells from material surfaces. The use of external physical stimuli (like shear stresses, light, temperature, magnetic fields), chemical stimuli (based on changes in pH or ligand-exchange based detachment) and biological stimuli (like aptamers and nucleic acid sequences) have been explored for the purpose of non-invasive cell detachment. This review discusses the principles, mechanisms, advantages, and limitations of these most diverse cell detachment technologies. By providing this comprehensive perspective, we hope to guide researchers in selecting the most suitable techniques for their specific needs and to inspire further innovation in this vital biomedical area.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"1100 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prem Singh, Constanze Raitmayr, Syed Zaki Husain Rizvi, Ammar Salem, Vladislav Grigoriev, Tetiana Korzun, Karthickraja Duraisamy, Akshay Vyawahare, Kongbrailatpam Shitaljit Sharma, Ana Paula Mesquita Souza, Yitayal Admassu Workie, Yoon Tae Goo, Manali P. Phawde, Chrissa Kioussi, Adam W.G. Alani, Oleh Taratula, Olena R. Taratula
Photothermal therapy (PTT) utilizes near-infrared (NIR) light to activate photothermal agents, enabling localized tumor ablation. However, conventional agents require high laser power densities to reach therapeutic temperatures, exceeding the skin safety limit of 0.33 W/cm2, thereby limiting their clinical translation. Presented herein is a nanoplatform that utilizes resonance energy transfer (RET) to boost photothermal performance under clinically acceptable irradiation. The nanoagent, PC-Fe/Co-AuNRs@SiNc, integrates gold nanorods (AuNRs) coated with an ∼3.5 nm bimetallic iron (Fe)–cobalt (Co) shell and the NIR dye silicon naphthalocyanine (SiNc), co-encapsulated within a polymeric carrier (PC). The Fe/Co shell functions as both a nanoscale spacer and a plasmonic modulator, red-shifting and amplifying the AuNR resonance, to enhance spectral overlap with SiNc and facilitate non-radiative energy transfer. Meanwhile, the polymer matrix ensures effective dye-plasmon coupling. Under low-power irradiation (0.25 W/cm2, 780 nm), PC-Fe/Co-AuNRs@SiNc exhibits photothermal conversion efficiencies 6.6- and 3.3-fold higher than SiNc and Fe/Co-AuNRs alone, respectively, and 2.3-fold higher than an agent containing SiNc and AuNRs without the Fe/Co shell. In an aggressive transgenic melanoma model, a single treatment with systemically delivered PC-Fe/Co-AuNRs@SiNc, under the same low-power parameters, achieves complete tumor ablation. This work establishes RET as a transformative strategy for designing next-generation PTT agents.
{"title":"Resonance Energy Transfer–Driven Photothermal Nanoagent Enables Melanoma Ablation Under Low-Power Near-Infrared Irradiation","authors":"Prem Singh, Constanze Raitmayr, Syed Zaki Husain Rizvi, Ammar Salem, Vladislav Grigoriev, Tetiana Korzun, Karthickraja Duraisamy, Akshay Vyawahare, Kongbrailatpam Shitaljit Sharma, Ana Paula Mesquita Souza, Yitayal Admassu Workie, Yoon Tae Goo, Manali P. Phawde, Chrissa Kioussi, Adam W.G. Alani, Oleh Taratula, Olena R. Taratula","doi":"10.1002/adfm.202522663","DOIUrl":"https://doi.org/10.1002/adfm.202522663","url":null,"abstract":"Photothermal therapy (PTT) utilizes near-infrared (NIR) light to activate photothermal agents, enabling localized tumor ablation. However, conventional agents require high laser power densities to reach therapeutic temperatures, exceeding the skin safety limit of 0.33 W/cm<sup>2</sup>, thereby limiting their clinical translation. Presented herein is a nanoplatform that utilizes resonance energy transfer (RET) to boost photothermal performance under clinically acceptable irradiation. The nanoagent, PC-Fe/Co-AuNRs@SiNc, integrates gold nanorods (AuNRs) coated with an ∼3.5 nm bimetallic iron (Fe)–cobalt (Co) shell and the NIR dye silicon naphthalocyanine (SiNc), co-encapsulated within a polymeric carrier (PC). The Fe/Co shell functions as both a nanoscale spacer and a plasmonic modulator, red-shifting and amplifying the AuNR resonance, to enhance spectral overlap with SiNc and facilitate non-radiative energy transfer. Meanwhile, the polymer matrix ensures effective dye-plasmon coupling. Under low-power irradiation (0.25 W/cm<sup>2</sup>, 780 nm), PC-Fe/Co-AuNRs@SiNc exhibits photothermal conversion efficiencies 6.6- and 3.3-fold higher than SiNc and Fe/Co-AuNRs alone, respectively, and 2.3-fold higher than an agent containing SiNc and AuNRs without the Fe/Co shell. In an aggressive transgenic melanoma model, a single treatment with systemically delivered PC-Fe/Co-AuNRs@SiNc, under the same low-power parameters, achieves complete tumor ablation. This work establishes RET as a transformative strategy for designing next-generation PTT agents.","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"41 1","pages":""},"PeriodicalIF":19.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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