In this study, the Delphi method was used to construct the evaluation index system of the specific physical fitness of Chinese wheelchair badminton players. The Delphi method was used in the first two rounds to determine sport-specific strength and conditioning evaluation indexes for wheelchair badminton athletes. The Analytic Hierarchy Process was used in the third round to determine the weighting of each index. The results indicate that the recovery rate of questionnaires in the first two rounds was higher than 90%, the degree of expert authority was >80%, the degree of expert coordination in the second round was 0.350 and was greater than that in the first round (0.298), and significance testing of the coordination coefficient was significant (p < 0.001), thus indicating that expert opinions were consistent. Results during construction of the evaluation system were credible. Ultimately, we identified four primary indicators, 12 secondary indicators, and 30 tertiary indicators. The order of the four primary indices in terms of weighting was as follows: sport-specific skills (0.4406), sports qualities (0.2928), cardiorespiratory function (0.1828), and body shape (0.0838). We used the Delphi method to construct an evaluation index system for the sport-specific physical ability of elite male wheelchair badminton athletes. The index system exhibited high credibility and specificity for wheelchair badminton.
{"title":"Construction of a sport-specific strength and conditioning evaluation index system for elite male wheelchair badminton athletes by the Delphi method","authors":"","doi":"10.22514/jomh.2023.087","DOIUrl":"https://doi.org/10.22514/jomh.2023.087","url":null,"abstract":"In this study, the Delphi method was used to construct the evaluation index system of the specific physical fitness of Chinese wheelchair badminton players. The Delphi method was used in the first two rounds to determine sport-specific strength and conditioning evaluation indexes for wheelchair badminton athletes. The Analytic Hierarchy Process was used in the third round to determine the weighting of each index. The results indicate that the recovery rate of questionnaires in the first two rounds was higher than 90%, the degree of expert authority was >80%, the degree of expert coordination in the second round was 0.350 and was greater than that in the first round (0.298), and significance testing of the coordination coefficient was significant (p < 0.001), thus indicating that expert opinions were consistent. Results during construction of the evaluation system were credible. Ultimately, we identified four primary indicators, 12 secondary indicators, and 30 tertiary indicators. The order of the four primary indices in terms of weighting was as follows: sport-specific skills (0.4406), sports qualities (0.2928), cardiorespiratory function (0.1828), and body shape (0.0838). We used the Delphi method to construct an evaluation index system for the sport-specific physical ability of elite male wheelchair badminton athletes. The index system exhibited high credibility and specificity for wheelchair badminton.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem. To address this condition, there is a need for the development of more drugs. Wedelolactone, the main active chemical component extracted from dried lotus leaves, exhibits a wide range of pharmacological effects. Here we constructed an oxygen-glucose deprivation/reperfusion (OGD/R) model. Cell counting kit-8 (CCK-8) assays evaluated the impact of Wedelolactone on cell growth. Real-time quantitative polymerase chain reaction (RT-qPCR) assessed its effects on inflammation. We employed 2′,7′-Dichlorofluorescein (DCF) staining and an iron detection kit to measure ferroptosis. Flow cytometry (FCM) and immunoblot assays were utilized to investigate cell apoptosis. The results showed that Wedelactone promoted OGD-induced HT-22 cell viability and alleviated OGD/R-induced cellular inflammation, OGD/R-stimulated ferroptosis and OGD/R-induced apoptosis. Mechanically, Wedelactone inhibited OGD/R-stimulated ferroptosis via mediating glutathione peroxidase 4 (GPX4) expression. In conclusion, Wedelolactone may attenuate cerebral ischemia-reperfusion (CIR)/I by blocking GPX4-mediated ferroptosis.
{"title":"Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis","authors":"","doi":"10.22514/jomh.2023.106","DOIUrl":"https://doi.org/10.22514/jomh.2023.106","url":null,"abstract":"Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem. To address this condition, there is a need for the development of more drugs. Wedelolactone, the main active chemical component extracted from dried lotus leaves, exhibits a wide range of pharmacological effects. Here we constructed an oxygen-glucose deprivation/reperfusion (OGD/R) model. Cell counting kit-8 (CCK-8) assays evaluated the impact of Wedelolactone on cell growth. Real-time quantitative polymerase chain reaction (RT-qPCR) assessed its effects on inflammation. We employed 2′,7′-Dichlorofluorescein (DCF) staining and an iron detection kit to measure ferroptosis. Flow cytometry (FCM) and immunoblot assays were utilized to investigate cell apoptosis. The results showed that Wedelactone promoted OGD-induced HT-22 cell viability and alleviated OGD/R-induced cellular inflammation, OGD/R-stimulated ferroptosis and OGD/R-induced apoptosis. Mechanically, Wedelactone inhibited OGD/R-stimulated ferroptosis via mediating glutathione peroxidase 4 (GPX4) expression. In conclusion, Wedelolactone may attenuate cerebral ischemia-reperfusion (CIR)/I by blocking GPX4-mediated ferroptosis.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135261899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prostate health is related to the frequency of ejaculation and prostate drainage. Frequent, repetitive ejaculations theoretically may pose a prostate cancer risk due to ensuing high testosterone levels and loss of zinc. In line with this, the proximity of the human rectum and prostate is of diagnostic and therapeutic importance. We provide evidence to support the view that the proximity of the rectum and prostate in men enables lower bowel distention to compress the prostate’s lateral side to facilitate drainage, which might lower cancer risk. This drainage mechanism is likely on-going and gradual, compared to rapid drainage following ejaculation. The physiological context suggests that these mechanisms of prostate drainage are complementary. Dietary content containing polyphenol- and fiber-rich meals, along with voluminous stool formation and increased gastrointestinal transit may all help improve prostate drainage. This may be important in voluntary abstinent men or other categories of sexually limited men. Recognizing that the anatomic relationship between the rectal area and prostate may facilitate prostate drainage, because of diet and gastro-intestinal activity, could be important to prostate health maintenance.
{"title":"The close proximity between the human rectum and prostate: a functional-anatomic arrangement favoring prostate health","authors":"","doi":"10.22514/jomh.2023.094","DOIUrl":"https://doi.org/10.22514/jomh.2023.094","url":null,"abstract":"Prostate health is related to the frequency of ejaculation and prostate drainage. Frequent, repetitive ejaculations theoretically may pose a prostate cancer risk due to ensuing high testosterone levels and loss of zinc. In line with this, the proximity of the human rectum and prostate is of diagnostic and therapeutic importance. We provide evidence to support the view that the proximity of the rectum and prostate in men enables lower bowel distention to compress the prostate’s lateral side to facilitate drainage, which might lower cancer risk. This drainage mechanism is likely on-going and gradual, compared to rapid drainage following ejaculation. The physiological context suggests that these mechanisms of prostate drainage are complementary. Dietary content containing polyphenol- and fiber-rich meals, along with voluminous stool formation and increased gastrointestinal transit may all help improve prostate drainage. This may be important in voluntary abstinent men or other categories of sexually limited men. Recognizing that the anatomic relationship between the rectal area and prostate may facilitate prostate drainage, because of diet and gastro-intestinal activity, could be important to prostate health maintenance.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135262422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FOXD2 Adjacent Opposite Strand RNA 1 (FOXD2-AS1), a long noncoding RNA (lncRNA), exhibits specifically elevated in numerous cancerous cells. Numerous studies have shown that FOXD2-AS1 encourages cellular proliferation, migration and invasion. Nevertheless, the exact mechanism through which FOXD2-AS1 contributes to prostate cancer (PCa) remains unclear. Consequently, we aimed to explore the implications of FOXD2-AS1 on the growth of PCa. Initially, an elevation of FOXD2-AS1 observed in PCa cells (PC-3, DU145 and Lncap) than the prostate normal cell line RWPE2. Then, PC-3 cells were tranafected with shFOXD2-AS1, sh-Numerical Control (shNC) or FOXD2-AS1 to assess the implications of FOXD2-AS. Cell growth was measured with cell counting kit-8 (CCK8) and 5-ethynyl-2′-deoxyuridine (EDU) assays, and cell invasion and migration were assessed by Transwell assays, which demonstrated that FOXD2-AS1 silence impeded proliferation, migration and invasion of PC-3 cells. Additionally, we discovered that FOXD2-AS1 bonded with miR-206/programmed cell death protein 10 (PDCD10) trough analyzing the interaction sites of lncRNA, miRNA and protein. Then, these interaction abilities were confirmed by dual-luciferase reporter assays and RT-qPCR, suggesting FOXD2-AS1 could upregulate the amount of PDCD10 through suppressing miR-206. Furthermore, the role of FOXD2-AS1 silencing on PCa carcinogenesis were assessed. In vivo experiment, shFOXD2-AS1 led to a notable reduction in both the size and weight of PCa. These findings indicated that FOXD2-AS1 silencing effectively hindered the progression of prostate cancer. In conclusion, the upregulation of FOXD2-AS1 was observed in PCa, and the knockdown of FOXD2-AS1 could alleviated tumor development by targeting miR-206 to upregulate PDCD10 expression.
FOXD2相邻对链RNA 1 (FOXD2- as1)是一种长链非编码RNA (lncRNA)，在许多癌细胞中表现出特异性升高。大量研究表明FOXD2-AS1促进细胞增殖、迁移和侵袭。然而，FOXD2-AS1导致前列腺癌(PCa)的确切机制尚不清楚。因此，我们旨在探讨FOXD2-AS1对PCa生长的影响。最初，在前列腺癌细胞(PC-3、DU145和Lncap)中，FOXD2-AS1的表达高于前列腺正常细胞系RWPE2。然后，用shFOXD2-AS1、sh-Numerical Control (shNC)或FOXD2-AS1转染PC-3细胞，以评估FOXD2-AS的影响。采用细胞计数试剂盒-8 (CCK8)和5-乙基-2′-脱氧尿苷(EDU)检测细胞生长，Transwell检测细胞侵袭和迁移，结果表明FOXD2-AS1沉默可抑制PC-3细胞的增殖、迁移和侵袭。此外，我们通过分析lncRNA、miRNA和蛋白的相互作用位点，发现FOXD2-AS1与miR-206/程序性细胞死亡蛋白10 (PDCD10)结合。然后，通过双荧光素酶报告基因检测和RT-qPCR证实了这些相互作用能力，提示FOXD2-AS1可以通过抑制miR-206上调PDCD10的量。此外，我们还评估了FOXD2-AS1沉默在PCa癌变中的作用。体内实验中，shFOXD2-AS1能显著降低PCa的体积和重量。这些发现表明FOXD2-AS1沉默有效地阻碍了前列腺癌的进展。综上所述，在PCa中观察到FOXD2-AS1的上调，FOXD2-AS1的下调可以通过靶向miR-206上调PDCD10的表达来缓解肿瘤的发展。
{"title":"FOXD2-AS1 inhibits the proliferation and migration in prostate cancer: an in vitro and in vivo study","authors":"","doi":"10.22514/jomh.2023.092","DOIUrl":"https://doi.org/10.22514/jomh.2023.092","url":null,"abstract":"FOXD2 Adjacent Opposite Strand RNA 1 (FOXD2-AS1), a long noncoding RNA (lncRNA), exhibits specifically elevated in numerous cancerous cells. Numerous studies have shown that FOXD2-AS1 encourages cellular proliferation, migration and invasion. Nevertheless, the exact mechanism through which FOXD2-AS1 contributes to prostate cancer (PCa) remains unclear. Consequently, we aimed to explore the implications of FOXD2-AS1 on the growth of PCa. Initially, an elevation of FOXD2-AS1 observed in PCa cells (PC-3, DU145 and Lncap) than the prostate normal cell line RWPE2. Then, PC-3 cells were tranafected with shFOXD2-AS1, sh-Numerical Control (shNC) or FOXD2-AS1 to assess the implications of FOXD2-AS. Cell growth was measured with cell counting kit-8 (CCK8) and 5-ethynyl-2′-deoxyuridine (EDU) assays, and cell invasion and migration were assessed by Transwell assays, which demonstrated that FOXD2-AS1 silence impeded proliferation, migration and invasion of PC-3 cells. Additionally, we discovered that FOXD2-AS1 bonded with miR-206/programmed cell death protein 10 (PDCD10) trough analyzing the interaction sites of lncRNA, miRNA and protein. Then, these interaction abilities were confirmed by dual-luciferase reporter assays and RT-qPCR, suggesting FOXD2-AS1 could upregulate the amount of PDCD10 through suppressing miR-206. Furthermore, the role of FOXD2-AS1 silencing on PCa carcinogenesis were assessed. In vivo experiment, shFOXD2-AS1 led to a notable reduction in both the size and weight of PCa. These findings indicated that FOXD2-AS1 silencing effectively hindered the progression of prostate cancer. In conclusion, the upregulation of FOXD2-AS1 was observed in PCa, and the knockdown of FOXD2-AS1 could alleviated tumor development by targeting miR-206 to upregulate PDCD10 expression.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigated whether the prehospital shock index (SI) could predict clinical outcomes in trauma patients, with or without pre-injury alcohol consumption, and whether this predictive capacity varied by age. We conducted a retrospective study on severe trauma patients transported to a level-1 trauma center by emergency medical services from 2015 to 2021. Our primary exposure was abnormal SI, defined as an SI ≥0.9, with in-hospital mortality and poor functional outcomes as study outcomes of interest. Multivariable logistic regression analysis estimated the effect of SI on clinical outcomes. Our findings indicated a significant association between abnormal SI and poor functional outcomes in all trauma patients (adjusted odds ratio: 2.15; 95%confidence interval: 1.41–3.28), notably pronounced in the older age group (adjusted odds ratio: 3.56; 95% confidence interval: 1.55–8.30). However, no association was found with in-hospital mortality. Importantly, among severe trauma patients who did not consume alcohol, abnormal SI was significantly associated with poor functional outcomes, irrespective of age, and with increased in-hospital mortality exclusively in the older age group. Thus, abnormal SI significantly predicted clinical outcomes in non-alcohol-consuming severe trauma patients, with the predictive power for in-hospital mortality being specifically significant in older, non-alcohol-consuming patients.
{"title":"Modifying effects of alcohol use and age on the predictive performance of prehospital shock index for functional and survival outcomes in severe trauma patients","authors":"","doi":"10.22514/jomh.2023.088","DOIUrl":"https://doi.org/10.22514/jomh.2023.088","url":null,"abstract":"This study investigated whether the prehospital shock index (SI) could predict clinical outcomes in trauma patients, with or without pre-injury alcohol consumption, and whether this predictive capacity varied by age. We conducted a retrospective study on severe trauma patients transported to a level-1 trauma center by emergency medical services from 2015 to 2021. Our primary exposure was abnormal SI, defined as an SI ≥0.9, with in-hospital mortality and poor functional outcomes as study outcomes of interest. Multivariable logistic regression analysis estimated the effect of SI on clinical outcomes. Our findings indicated a significant association between abnormal SI and poor functional outcomes in all trauma patients (adjusted odds ratio: 2.15; 95%confidence interval: 1.41–3.28), notably pronounced in the older age group (adjusted odds ratio: 3.56; 95% confidence interval: 1.55–8.30). However, no association was found with in-hospital mortality. Importantly, among severe trauma patients who did not consume alcohol, abnormal SI was significantly associated with poor functional outcomes, irrespective of age, and with increased in-hospital mortality exclusively in the older age group. Thus, abnormal SI significantly predicted clinical outcomes in non-alcohol-consuming severe trauma patients, with the predictive power for in-hospital mortality being specifically significant in older, non-alcohol-consuming patients.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To analyze the contrast-enhanced ultrasound (CEUS) features of livers in male patients under 50 years-of-age with liver cancer and unhealthy life habits. A total of 89 male patients with liver cancer and unhealthy life habits were included in the observation group (all of these patients were first diagnosed with liver cancer when they were <50 years-of-age) and 60 male patients of the same age with benign liver lesions admitted during the same period were included in the control group. All patients had undergone CEUS examination. We summarized and compared the features of liver CEUS from patients in the two groups and analyzed the relationship between liver CEUS results and pathological features. The time to enhancement, enhancement duration and the clearance time of cancer tissues were all significantly shorter in patients from the observation group than those in the control group (p < 0.05). Enhancement patterns of cancer tissues and benign lesion tissues in patients in the observation group were significantly higher than those in the control group (p < 0.05). Cancerous tissues had fast wash-in and fast wash-out features (93.2%), while benign lesions had slow wash-in and slow wash-out features (60.00%). The proportion of patients with microvascular invasion (MVI)-positive lesions showing more than a 15% increase in maximum diameter was significantly larger than those with MVI-negative lesions (p < 0.05). The differences in enhancement features between liver cancer lesions with various differentiation grades in the portal phase and the delayed phase were statistically significant (p < 0.05). Our findings show that CEUS has high clinical value for diagnosing liver cancer and can be used to judge the MVI status and differentiation grade of liver cancer lesions, thus providing a reference for diagnosing liver cancer and its severity.
{"title":"The analysis of contrast-enhanced ultrasound features of the liver in male patients with liver cancer and unhealthy life habits under 50 years-of-age","authors":"","doi":"10.22514/jomh.2023.073","DOIUrl":"https://doi.org/10.22514/jomh.2023.073","url":null,"abstract":"To analyze the contrast-enhanced ultrasound (CEUS) features of livers in male patients under 50 years-of-age with liver cancer and unhealthy life habits. A total of 89 male patients with liver cancer and unhealthy life habits were included in the observation group (all of these patients were first diagnosed with liver cancer when they were <50 years-of-age) and 60 male patients of the same age with benign liver lesions admitted during the same period were included in the control group. All patients had undergone CEUS examination. We summarized and compared the features of liver CEUS from patients in the two groups and analyzed the relationship between liver CEUS results and pathological features. The time to enhancement, enhancement duration and the clearance time of cancer tissues were all significantly shorter in patients from the observation group than those in the control group (p < 0.05). Enhancement patterns of cancer tissues and benign lesion tissues in patients in the observation group were significantly higher than those in the control group (p < 0.05). Cancerous tissues had fast wash-in and fast wash-out features (93.2%), while benign lesions had slow wash-in and slow wash-out features (60.00%). The proportion of patients with microvascular invasion (MVI)-positive lesions showing more than a 15% increase in maximum diameter was significantly larger than those with MVI-negative lesions (p < 0.05). The differences in enhancement features between liver cancer lesions with various differentiation grades in the portal phase and the delayed phase were statistically significant (p < 0.05). Our findings show that CEUS has high clinical value for diagnosing liver cancer and can be used to judge the MVI status and differentiation grade of liver cancer lesions, thus providing a reference for diagnosing liver cancer and its severity.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135058504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study aims to investigate the effect of ERAS (Enhanced Recovery After Surgery) management mode on functional exercise compliance and functional recovery after ACL (anterior cruciate ligament) reconstruction in males. Patients were admitted between June 2021 and December 2021 as the control group, and patients were admitted between January 2022 and June 2022 as the observation group. Routine nursing was adopted in the control group, while ERAS management mode was applied in the observation group for nursing. The clinical nursing efficacy, knee joint function (Lysholm score) and VAS (Visual analogue scale) score, patients’ functional training compliance and complications were compared. After intervention, the swelling disappearance time, pain disappearance time, hospital stay and other indicators of clinical nursing effect in the observation group were better (p < 0.05); the preoperative Lysholm score and VAS score showed no statistical significance (p > 0.05). The Lysholm score and VAS score at each time point after operation were markedly higher, and repeated measures analysis of variance manifested that the Lysholm score, VAS score, intergroup effect, time effect and interaction effect in both groups had statistical significance (p < 0.05). The total compliance rate of functional training in the observation group was conspicuously higher (p < 0.05); the overall incidence of complications in the observation group (13.3%) was evidently lower (28.7%) (p < 0.05). ERAS management mode can improve the functional training compliance, accelerate the recovery of joint function, reduce the incidence of complications and promote the quality of life of patients with ACL injury.
本研究旨在探讨ERAS (Enhanced Recovery After Surgery)管理模式对男性前交叉韧带(ACL)重建术后功能运动依从性和功能恢复的影响。患者于2021年6月至2021年12月入院作为对照组，患者于2022年1月至2022年6月入院作为观察组。对照组采用常规护理，观察组采用ERAS管理模式进行护理。比较两组患者的临床护理效果、膝关节功能(Lysholm评分)和视觉模拟评分(VAS)、功能训练依从性及并发症发生情况。干预后，观察组患者在肿胀消失时间、疼痛消失时间、住院时间等临床护理效果指标均优于对照组(p <术前Lysholm评分和VAS评分差异均无统计学意义(p >0.05)。术后各时间点Lysholm评分和VAS评分均显著升高，重复测量方差分析显示，两组患者Lysholm评分、VAS评分、组间效应、时间效应、交互效应均有统计学意义(p <0.05)。观察组功能训练总依从率显著高于对照组(p <观察组总并发症发生率(13.3%)明显低于对照组(28.7%)(p <0.05)。ERAS管理模式可以提高ACL损伤患者的功能训练依从性，加速关节功能恢复，减少并发症的发生，提高患者的生活质量。
{"title":"Effect of ERAS management mode on postoperative functional exercise compliance and functional recovery in male anterior cruciate ligament injury","authors":"","doi":"10.22514/jomh.2023.103","DOIUrl":"https://doi.org/10.22514/jomh.2023.103","url":null,"abstract":"The study aims to investigate the effect of ERAS (Enhanced Recovery After Surgery) management mode on functional exercise compliance and functional recovery after ACL (anterior cruciate ligament) reconstruction in males. Patients were admitted between June 2021 and December 2021 as the control group, and patients were admitted between January 2022 and June 2022 as the observation group. Routine nursing was adopted in the control group, while ERAS management mode was applied in the observation group for nursing. The clinical nursing efficacy, knee joint function (Lysholm score) and VAS (Visual analogue scale) score, patients’ functional training compliance and complications were compared. After intervention, the swelling disappearance time, pain disappearance time, hospital stay and other indicators of clinical nursing effect in the observation group were better (p < 0.05); the preoperative Lysholm score and VAS score showed no statistical significance (p > 0.05). The Lysholm score and VAS score at each time point after operation were markedly higher, and repeated measures analysis of variance manifested that the Lysholm score, VAS score, intergroup effect, time effect and interaction effect in both groups had statistical significance (p < 0.05). The total compliance rate of functional training in the observation group was conspicuously higher (p < 0.05); the overall incidence of complications in the observation group (13.3%) was evidently lower (28.7%) (p < 0.05). ERAS management mode can improve the functional training compliance, accelerate the recovery of joint function, reduce the incidence of complications and promote the quality of life of patients with ACL injury.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"1176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High handgrip strength in men’s artistic gymnastics is crucial, mainly for improving performance and to potentially prevent injuries, as well as for the fact that gymnasts body movements are around immovable apparatuses (pommel horse, rings, parallel bars and high bar) for the extended period of time. Since there are not so many studies that have dealt with this topic and on actual competition, we have aimed to examine the handgrip strength influence on the competition result in elite male artistic gymnasts. The sample of participants were conducted of 37 elite male artistic gymnasts (8–21 years old), from 8 different countries as national team competitors at the International Competition “Laza Krstić and Marica Dželatović” held in Novi Sad, Serbia. Basic anthropometric measurements were included (body height, body weight and Body Mass Index (BMI)), along with training experience and handgrip strength measurement (both dominant and nondominant hand). Kolmogorov-Smirnov Z test (p < 0.05) was used for distribution normality, along with regression analysis with Model 1 (participants age, training experience, body height, body weight and BMI), Model 2 (Model 1 + dominant handgrip strength) and Model 3 (Model 1 + nondominant handgrip strength). SPSS v.20 was used for all statistical analysis. Our study have revealed that there is significant influence of all 3 Models on the parallel bars final result (p = 0.33; p = 0.49; p = 0.31, respectively), in terms of all set of variables, whereas body weight Beta scores (28.6%; 30.3%; 32.7%, respectively) moslty explains the results. Both dominant and nondominant handgrip strength are influential factors only on the parallel bars final result. Since both hands are contributing equally, bilateral training is necessary. In order to expand the knowledge on this topic and completely understand the influential factors, future studies are needed on this sample. Regardless of our main findings, our results should be taken with caution.
在男子艺术体操中，高握力是至关重要的，主要是为了提高成绩和潜在地防止受伤，同时也是因为体操运动员的身体运动是在固定的器械(鞍马、吊环、双杠和高杠)周围长时间进行的。由于涉及这一主题和实际比赛的研究并不多，我们的目的是研究握力对优秀男子艺术体操运动员比赛结果的影响。参与者的样本是来自8个不同国家的37名优秀男子艺术体操运动员(8 - 21岁)，作为国家队选手参加了在塞尔维亚诺维萨德举行的“拉扎·克斯蒂奇和玛丽卡Dželatović”国际比赛。包括基本的人体测量(身高、体重和身体质量指数(BMI))，以及训练经验和握力测量(包括惯用手和非惯用手)。Kolmogorov-Smirnov Z检验(p <采用0.05)为分布正态性，并对模型1(参与者年龄、训练经验、身高、体重、BMI)、模型2(模型1 +优势握力)、模型3(模型1 +非优势握力)进行回归分析。采用SPSS v.20进行统计分析。我们的研究发现，在所有变量集上，3种模型对双杠最终成绩的影响都是显著的(p = 0.33; p = 0.49; p = 0.31)，而体重Beta分数(分别为28.6%;30.3%;32.7%)可以解释这一结果。优势握力和非优势握力都是影响双杠最终成绩的因素。由于两只手的贡献是相等的，因此双边培训是必要的。为了扩大对这一课题的认识，全面了解影响因素，还需要对这一样本进行进一步的研究。不管我们的主要发现是什么，我们的结果都应该谨慎对待。
{"title":"Is the handgrip strength influential factor on the competition result in elite male artistic gymnasts?","authors":"","doi":"10.22514/jomh.2023.081","DOIUrl":"https://doi.org/10.22514/jomh.2023.081","url":null,"abstract":"High handgrip strength in men’s artistic gymnastics is crucial, mainly for improving performance and to potentially prevent injuries, as well as for the fact that gymnasts body movements are around immovable apparatuses (pommel horse, rings, parallel bars and high bar) for the extended period of time. Since there are not so many studies that have dealt with this topic and on actual competition, we have aimed to examine the handgrip strength influence on the competition result in elite male artistic gymnasts. The sample of participants were conducted of 37 elite male artistic gymnasts (8–21 years old), from 8 different countries as national team competitors at the International Competition “Laza Krstić and Marica Dželatović” held in Novi Sad, Serbia. Basic anthropometric measurements were included (body height, body weight and Body Mass Index (BMI)), along with training experience and handgrip strength measurement (both dominant and nondominant hand). Kolmogorov-Smirnov Z test (p < 0.05) was used for distribution normality, along with regression analysis with Model 1 (participants age, training experience, body height, body weight and BMI), Model 2 (Model 1 + dominant handgrip strength) and Model 3 (Model 1 + nondominant handgrip strength). SPSS v.20 was used for all statistical analysis. Our study have revealed that there is significant influence of all 3 Models on the parallel bars final result (p = 0.33; p = 0.49; p = 0.31, respectively), in terms of all set of variables, whereas body weight Beta scores (28.6%; 30.3%; 32.7%, respectively) moslty explains the results. Both dominant and nondominant handgrip strength are influential factors only on the parallel bars final result. Since both hands are contributing equally, bilateral training is necessary. In order to expand the knowledge on this topic and completely understand the influential factors, future studies are needed on this sample. Regardless of our main findings, our results should be taken with caution.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current study aimed to evaluate the efficacy of simultaneous administration of Zingiber officinale (ginger) and Cinnamomum cassia (cinnamon) extracts in mitigating testicular changes associated with diabetes mellitus in rats and to investigate its molecular mode of action. After induction of diabetes using streptozotocin, 36 male rats were divided to six groups namely control, diabetic, metformin-treated, cinnamon-treated, ginger-treated and combined, each group having 6 rats. Fasting blood glucose, serum insulin, testosterone was measured. Expression of inflammatory mediators; tumor necrosis factor-alpha (TNF-α), Nuclear factor kappa B (NF-κB) and Sirtuin 1 (SIRT1) was assessed in the testicular tissue. Histopathological changes in the testis were observed and spermatogenesis and apoptosis were assessed immunohistochemically. The histological and biochemical studies of the untreated group confirmed structural changes in testes induced by diabetes. Oral administration of ginger and cinnamon increased insulin level significantly increased while the blood glucose level significantly decreased in diabetic rats, improving structural testicular changes considerably. Joint intake of ginger and cinnamon increased antihyperglycemic, antioxidant and anti-inflammatory effects markedly improving the testicular injury compared to the administration of either of them. SIRT1 expression in the testis significantly increased in ginger plus cinnamon-treated rats. These results indicate that when administrated together, ginger and cinnamon synergistically enhanced antioxidant, antiapoptotic and anti-inflammatory effects and induced antihyperglycemic effect comparable to metformin. The combination of ginger and cinnamon also upregulated SIRT1 in the testis.
{"title":"Cinnamon and ginger extracts attenuate diabetes-induced inflammatory testicular injury in rats and modulating SIRT1 expression","authors":"","doi":"10.22514/jomh.2023.067","DOIUrl":"https://doi.org/10.22514/jomh.2023.067","url":null,"abstract":"The current study aimed to evaluate the efficacy of simultaneous administration of Zingiber officinale (ginger) and Cinnamomum cassia (cinnamon) extracts in mitigating testicular changes associated with diabetes mellitus in rats and to investigate its molecular mode of action. After induction of diabetes using streptozotocin, 36 male rats were divided to six groups namely control, diabetic, metformin-treated, cinnamon-treated, ginger-treated and combined, each group having 6 rats. Fasting blood glucose, serum insulin, testosterone was measured. Expression of inflammatory mediators; tumor necrosis factor-alpha (TNF-α), Nuclear factor kappa B (NF-κB) and Sirtuin 1 (SIRT1) was assessed in the testicular tissue. Histopathological changes in the testis were observed and spermatogenesis and apoptosis were assessed immunohistochemically. The histological and biochemical studies of the untreated group confirmed structural changes in testes induced by diabetes. Oral administration of ginger and cinnamon increased insulin level significantly increased while the blood glucose level significantly decreased in diabetic rats, improving structural testicular changes considerably. Joint intake of ginger and cinnamon increased antihyperglycemic, antioxidant and anti-inflammatory effects markedly improving the testicular injury compared to the administration of either of them. SIRT1 expression in the testis significantly increased in ginger plus cinnamon-treated rats. These results indicate that when administrated together, ginger and cinnamon synergistically enhanced antioxidant, antiapoptotic and anti-inflammatory effects and induced antihyperglycemic effect comparable to metformin. The combination of ginger and cinnamon also upregulated SIRT1 in the testis.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135058501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anejaculation is the inability to ejaculate during sexual activity, either in an antegrade or retrograde fashion. Both anejaculation following an iatrogenic injury of the abdominal aorta and the efficacy of low-frequency neuromuscular electrical stimulation (NMES) in treating anejaculation have been reported rarely. In this case report, we describe a patient who experienced anejaculation following an iatrogenic injury to the abdominal aorta and eventually regained normal ejaculation ability following treatment with NMES. The patient, a 23-year-old Chinese man, underwent laparoscopic varicocele ligation on both sides, during which he sustained a ruptured wound in the abdominal aorta from a 10-mm trocar. To stop the bleeding, he underwent abdominal aortic balloon catheter dilatation combined with covered stent implantation. However, 10 days after the endovascular interventions, the patient developed hemorrhagic shock and underwent emergency exploratory laparotomy and adventitial suture of the abdominal aorta. Despite normal erectile function since a week after the last surgery, the patient complained of aejaculation for a year during intercourse or masturbation. After receiving NMES treatment for over two months, the patient reported successful intravaginal ejaculation during intercourse, and the improvement persisted for a month after treatment. Altogether, these findings suggest that NMES could be a feasible, safe, and cost-effective treatment method for improving anejaculation and provides a novel option for patients with this condition.
{"title":"Low-frequency neuromuscular electrical stimulation as a treatment for anejaculation caused by iatrogenic injury of the abdominal aorta: a case study","authors":"","doi":"10.22514/jomh.2023.107","DOIUrl":"https://doi.org/10.22514/jomh.2023.107","url":null,"abstract":"Anejaculation is the inability to ejaculate during sexual activity, either in an antegrade or retrograde fashion. Both anejaculation following an iatrogenic injury of the abdominal aorta and the efficacy of low-frequency neuromuscular electrical stimulation (NMES) in treating anejaculation have been reported rarely. In this case report, we describe a patient who experienced anejaculation following an iatrogenic injury to the abdominal aorta and eventually regained normal ejaculation ability following treatment with NMES. The patient, a 23-year-old Chinese man, underwent laparoscopic varicocele ligation on both sides, during which he sustained a ruptured wound in the abdominal aorta from a 10-mm trocar. To stop the bleeding, he underwent abdominal aortic balloon catheter dilatation combined with covered stent implantation. However, 10 days after the endovascular interventions, the patient developed hemorrhagic shock and underwent emergency exploratory laparotomy and adventitial suture of the abdominal aorta. Despite normal erectile function since a week after the last surgery, the patient complained of aejaculation for a year during intercourse or masturbation. After receiving NMES treatment for over two months, the patient reported successful intravaginal ejaculation during intercourse, and the improvement persisted for a month after treatment. Altogether, these findings suggest that NMES could be a feasible, safe, and cost-effective treatment method for improving anejaculation and provides a novel option for patients with this condition.","PeriodicalId":16360,"journal":{"name":"Journal of Men's Health","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135260982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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