Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30627-7
Zhou Yunfeng , Li Lin , Sun Lan , Zhou Lidong , Xu Yang
OBJECTIVE
To assess the antioxidant capacity of aqueous extracts of buds and flowers of Lonicera japonica Thunb. (BLJ and FLJ) using in vitro assays.
METHODS
We assessed the in vitro antioxidant activities of aqueous extracts of BLJ and FLJ and compared with that of classical antioxidants vitamin C and butylated hydroxytoluene, using several well-established methods including the 1,1-diphenyl-2-picryl-hydrazyl assay, 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) assay, reducing power assay, fluorescence recovery after photo-bleaching assay, β-carotene bleaching assay, ferric thiocyanate assay, and thiobarbituric acid method.
RESULTS
The aqueous extracts of both BLJ and FLJ had similarly potent antioxidant capacity. There were no significance differences between BLJ and FLJ in all the assays.
CONCLUSION
The aqueous extracts of both BLJ and FLJ have antioxidant activity with comparable efficacy. These findings suggest that both BLJ and FLJ may have the potential as natural antioxidants.
{"title":"In comparison with vitamin C and butylated hydroxytoluene, the antioxidant capacity of aqueous extracts from buds and flowers of Lonicera japonica Thunb.","authors":"Zhou Yunfeng , Li Lin , Sun Lan , Zhou Lidong , Xu Yang","doi":"10.1016/S0254-6272(18)30627-7","DOIUrl":"10.1016/S0254-6272(18)30627-7","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To assess the antioxidant capacity of aqueous extracts of buds and flowers of Lonicera japonica Thunb. (BLJ and FLJ) using <em>in vitro</em> assays.</p></div><div><h3>METHODS</h3><p>We assessed the <em>in vitro</em> antioxidant activities of aqueous extracts of BLJ and FLJ and compared with that of classical antioxidants vitamin C and butylated hydroxytoluene, using several well-established methods including the 1,1-diphenyl-2-picryl-hydrazyl assay, 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) assay, reducing power assay, fluorescence recovery after photo-bleaching assay, β-carotene bleaching assay, ferric thiocyanate assay, and thiobarbituric acid method.</p></div><div><h3>RESULTS</h3><p>The aqueous extracts of both BLJ and FLJ had similarly potent antioxidant capacity. There were no significance differences between BLJ and FLJ in all the assays.</p></div><div><h3>CONCLUSION</h3><p>The aqueous extracts of both BLJ and FLJ have antioxidant activity with comparable efficacy. These findings suggest that both BLJ and FLJ may have the potential as natural antioxidants.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 373-379"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30627-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46602436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30628-9
Hou Yi , Wang Tieshan , Guo Xiangyu , Sun Wen , Guo Xuan , Wu Lili , Qin Lingling , Zhang Chengfei , Liu Tonghua
OBJECTIVE
To investigate the protective effects of Jiayan Kangtai (JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis (AIT), and the possible underlying mechanism.
METHODS
Female Lewis rats (6–8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin (IL)-6, IL23p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper (Th)17 cells and regulatory T cells (Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined via bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western blot.
RESULTS
Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg activity.
CONCLUSION
JYKT treatment appeared to be protective against AIT in rats, possibly via the regulation of the Th17 cell/Treg imbalance in AIT.
{"title":"Protective effects of Jiayan Kangtai granules on autoimmune thyroiditis in a rat model by modulating Th17/Treg cell balance","authors":"Hou Yi , Wang Tieshan , Guo Xiangyu , Sun Wen , Guo Xuan , Wu Lili , Qin Lingling , Zhang Chengfei , Liu Tonghua","doi":"10.1016/S0254-6272(18)30628-9","DOIUrl":"10.1016/S0254-6272(18)30628-9","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the protective effects of Jiayan Kangtai (JYKT) granules, consisting of 9 Chinese herbs, in a rat model of autoimmune thyroiditis (AIT), and the possible underlying mechanism.</p></div><div><h3>METHODS</h3><p>Female Lewis rats (6–8 weeks) were randomly apportioned to 5 groups of 10, including a normal control. AIT was induced in the untreated AIT-model group, and rats treated subsequently with daily low, medium, or high dose JYKT granules. After 12 weeks, plasma levels of thyroid autoantibodies and morphological changes in the thyroid were detected by enzyme-linked immunosorbent assay and histological examination, respectively. The presence of interleukin (IL)-6, IL23p19, and IL-2 in thyroid tissue was assessed by immunohistochemical staining. The percentages of T helper (Th)17 cells and regulatory T cells (Tregs) in the peripheral blood were analyzed by flow cytometry. Relevant levels of cytokines and proteins were examined <em>via</em> bead-based multiplex flow cytometry and ELISA, respectively. Expressions of genes and proteins regulated by Th17 cells and Tregs were shown by real-time PCR and Western blot.</p></div><div><h3>RESULTS</h3><p>Compared to the control, AIT-model rats had higher plasma concentrations of thyroid autoantibodies. The high-dose JYKT rats showed significantly lower levels of thyroid autoantibodies compared with the AIT model group. Rats in the AIT-JYKT groups also had fewer thyroid lesions and less lymphocytic infiltration, a lower percentage of Th17 cells, and a higher percentage of Tregs, compared with the AIT-model. Rats given high-dose JYKT had a significantly lower Th17/Treg ratio compared with the AIT model. Differences in plasma cytokine concentrations and relevant gene and protein expressions in the spleens of JYKT-treated rats and the AIT group suggested an association between JYKT treatment and lower Th17 cell percentage and higher Treg activity.</p></div><div><h3>CONCLUSION</h3><p>JYKT treatment appeared to be protective against AIT in rats, possibly <em>via</em> the regulation of the Th17 cell/Treg imbalance in AIT.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 380-390"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30628-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41717740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30631-9
Wu Haotian , Zhang Fengshun , Liu Jinyi , Li Xuezhao , Guo Fei , Wu Yiling
OBJECTIVE
To investigate the effects of Tongxinluo superfine powder on cardiac function, infarct size and the number of myocardial capillaries in a rabbit model of acute myocardial infarction.
METHODS
A total of 32 New Zealand white rabbits were randomly divided into four groups: sham operation group, model group, treatment group, and pre-treatment, the experiment of pre-treatment group was performed 6 weeks early than the treat) group, The four groups use a unified modeling technique. An acute myocardial infarction model was established through external application of 70% ferric chloride on the coronary artery. After 7 d, electrocardiogram, ultrasonography of cardiac function, micro-computed tomography, pathology and other data were collected.
RESULTS
In the treatment and pre-treatment groups, ejection fraction, left ventricular short axis shortening rate, left ventricular end-systolic diameter and cardiac output significantly improved, the number of capillaries significantly increased, and infarct size significantly decreased. In addition, the results suggest that the value of intra-ventricular pressure and the situation of electrocardiogram also changed to different degrees with the increasing of treatment of cycle.
CONCLUSION
Tongxinluo superfine powder can protect the myocardium, improve the blood supply of the myocardium and reduce the degree of myocardial injury, during acute stage of myocardial infarction.
{"title":"Observation of changes in the number of myocardial capillaries in rabbits after treatment of acute myocardial infarction by Tongxinluo superfine powder","authors":"Wu Haotian , Zhang Fengshun , Liu Jinyi , Li Xuezhao , Guo Fei , Wu Yiling","doi":"10.1016/S0254-6272(18)30631-9","DOIUrl":"10.1016/S0254-6272(18)30631-9","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effects of Tongxinluo superfine powder on cardiac function, infarct size and the number of myocardial capillaries in a rabbit model of acute myocardial infarction.</p></div><div><h3>METHODS</h3><p>A total of 32 New Zealand white rabbits were randomly divided into four groups: sham operation group, model group, treatment group, and pre-treatment, the experiment of pre-treatment group was performed 6 weeks early than the treat) group, The four groups use a unified modeling technique. An acute myocardial infarction model was established through external application of 70% ferric chloride on the coronary artery. After 7 d, electrocardiogram, ultrasonography of cardiac function, micro-computed tomography, pathology and other data were collected.</p></div><div><h3>RESULTS</h3><p>In the treatment and pre-treatment groups, ejection fraction, left ventricular short axis shortening rate, left ventricular end-systolic diameter and cardiac output significantly improved, the number of capillaries significantly increased, and infarct size significantly decreased. In addition, the results suggest that the value of intra-ventricular pressure and the situation of electrocardiogram also changed to different degrees with the increasing of treatment of cycle.</p></div><div><h3>CONCLUSION</h3><p>Tongxinluo superfine powder can protect the myocardium, improve the blood supply of the myocardium and reduce the degree of myocardial injury, during acute stage of myocardial infarction.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 406-411"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30631-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47199159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30624-1
Luo Hao , Li Hui , Wang Yangyang , Yao Sha , Xu Wenjie
OBJECTIVE
To critically appraise the methodological quality of clinical practice guidelines for headache produced over the last two decades, including those covering specific interventions using Traditional Chinese Medicine.
METHODS
The guidelines on headache disorders were obtained by searching a number of databases, including PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, and Wanfang database, three guideline-related databases [Guideline-International Network, National Guideline Clearinghouse, and Medlive], and the records of organizations that develop guidelines. The publication date was limited to the period from January 1996 to June 2015. The search terms “headache”, “headache disorders”, “cephalalgia”, “migraine”, “tension-type headache”, “practice guideline”, “consensus “, “statement”, “regulation”, and “recommendation” were used in the “MeSH” and “Free-text” fields. The guidelines were independently appraised by four researchers using the Appraisal of Guidelines for Research and Evaluation II instrument.
RESULTS
A total of 23 guidelines published between 1998 and 2014 were reviewed. The overall consistency of the four appraisers was good [interclass correlation coefficient 0.84; 95% confidence interval (CI) 0.82–0.86]. The mean (standard deviation) scores for scope and purpose, stakeholder involvement, rigor of development, clarity of presentation, applicability, and editorial independence were 52.1 (18.0), 39.5 (17.1), 33.4 (21.0), 49.8 (21.9), 23.8 (19.3), and 24.2 (23.7). Only two guidelines were recommended, 12 were recommended with modification, and nine were not recommended.
CONCLUSION
Physical Traditional Chinese Medicine therapies were recommended to treat headache. The overall quality of headache guidelines was low in China, but evidence-based guidelines are gradually becoming mainstream. Guideline developers should carefully consider, in particular, three domains: rigor of development, applicability, and editorial independence.
目的:批判性地评价过去二十年来制定的头痛临床实践指南的方法学质量，包括那些使用中医的特定干预措施。方法通过检索PubMed、EMBASE、Web of Science、中国生物医学文献数据库、中国国家知识基础数据库、中国科技期刊数据库、万方数据库、指南国际网、国家指南信息中心、Medlive等3个指南相关数据库以及指南制定机构的记录，获得头痛疾病指南。发布日期限于1996年1月至2015年6月期间。在“MeSH”和“Free-text”字段中使用的搜索词是“头痛”、“头痛失调”、“头痛”、“偏头痛”、“紧张性头痛”、“实践指南”、“共识”、“声明”、“规范”和“建议”。指南由四名研究人员使用研究和评估指南评估II工具进行独立评估。结果对1998 - 2014年间发表的23份指南进行了回顾。四个评价者的总体一致性较好[类间相关系数0.84;95%置信区间(CI) 0.82-0.86]。范围和目的、利益相关者参与、开发的严谨性、表述的清晰度、适用性和编辑独立性的平均(标准差)得分分别为52.1(18.0)、39.5(17.1)、33.4(21.0)、49.8(21.9)、23.8(19.3)和24.2(23.7)。只有两个指南被推荐，12个建议修改，9个不推荐。结论中药理疗是治疗头痛的有效方法。中国头痛指南的总体质量较低，但循证指南正逐渐成为主流。指南开发者应该仔细考虑，特别是三个领域:开发的严谨性、适用性和编辑独立性。
{"title":"Clinical practice guidelines for treating headache with Traditional Chinese Medicine: quality assessment with the appraisal of guidelines for research and evaluation II instrument","authors":"Luo Hao , Li Hui , Wang Yangyang , Yao Sha , Xu Wenjie","doi":"10.1016/S0254-6272(18)30624-1","DOIUrl":"https://doi.org/10.1016/S0254-6272(18)30624-1","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To critically appraise the methodological quality of clinical practice guidelines for headache produced over the last two decades, including those covering specific interventions using Traditional Chinese Medicine.</p></div><div><h3>METHODS</h3><p>The guidelines on headache disorders were obtained by searching a number of databases, including PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, and Wanfang database, three guideline-related databases [Guideline-International Network, National Guideline Clearinghouse, and Medlive], and the records of organizations that develop guidelines. The publication date was limited to the period from January 1996 to June 2015. The search terms “headache”, “headache disorders”, “cephalalgia”, “migraine”, “tension-type headache”, “practice guideline”, “consensus “, “statement”, “regulation”, and “recommendation” were used in the “MeSH” and “Free-text” fields. The guidelines were independently appraised by four researchers using the Appraisal of Guidelines for Research and Evaluation II instrument.</p></div><div><h3>RESULTS</h3><p>A total of 23 guidelines published between 1998 and 2014 were reviewed. The overall consistency of the four appraisers was good [interclass correlation coefficient 0.84; 95% confidence interval (<em>CI</em>) 0.82–0.86]. The mean (standard deviation) scores for scope and purpose, stakeholder involvement, rigor of development, clarity of presentation, applicability, and editorial independence were 52.1 (18.0), 39.5 (17.1), 33.4 (21.0), 49.8 (21.9), 23.8 (19.3), and 24.2 (23.7). Only two guidelines were recommended, 12 were recommended with modification, and nine were not recommended.</p></div><div><h3>CONCLUSION</h3><p>Physical Traditional Chinese Medicine therapies were recommended to treat headache. The overall quality of headache guidelines was low in China, but evidence-based guidelines are gradually becoming mainstream. Guideline developers should carefully consider, in particular, three domains: rigor of development, applicability, and editorial independence.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 339-350"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30624-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91615216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the effect of Banxia Xiexin decoction (BXD) on Helicobacter pylori (Hp)-related peptic ulcers (PUs) and the possible mechanism underlying BXD actions via the transforming growth factor-β/small mothers against decapentaplegic (TGF-β/Smad) signaling pathway.
METHODS
PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured in vitro and randomly divided into the following seven groups: control, model, healthy, Western Medicine, prior treatment, low dosage, and high dosage. After 72 h of treatment with the corresponding serum, the mRNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.
RESULTS
The mRNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells, and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.
CONCLUSION
BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7.
{"title":"Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway","authors":"Chen Shaofang , Liang Huiqing , Chen Shaodong , Huang Yanping , Wan Shichuan , Huang Yanxia","doi":"10.1016/S0254-6272(18)30633-2","DOIUrl":"10.1016/S0254-6272(18)30633-2","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the effect of Banxia Xiexin decoction (BXD) on Helicobacter pylori (Hp)-related peptic ulcers (PUs) and the possible mechanism underlying BXD actions <em>via</em> the transforming growth factor-β/small mothers against decapentaplegic (TGF-β/Smad) signaling pathway.</p></div><div><h3>METHODS</h3><p>PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured <em>in vitro</em> and randomly divided into the following seven groups: control, model, healthy, Western Medicine, prior treatment, low dosage, and high dosage. After 72 h of treatment with the corresponding serum, the mRNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.</p></div><div><h3>RESULTS</h3><p>The mRNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells, and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.</p></div><div><h3>CONCLUSION</h3><p>BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 419-426"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30633-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46113117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30638-1
Wang Xiaohong , Zhang Qi , Cui Baojuan , Sun Junhua , Ye Lan , Huang Laigang , Wang Daoqing
OBJECTIVE
To determine whether patients with post-stroke hemiplegia could benefit from long-term treatment with scalp cluster (SC) acupuncture combined with electrical stimulation (ES) and to evaluate the feasibility of this treatment to improve motor and living abilities.
METHODS
Twenty patients were enrolled and divided into two groups: SC acupuncture and SC acupuncture with ES (SC and SC + ES, respectively). All participants also received rehabilitation training. All participants were blindly evaluated using the Fugl-Meyer assessment scale for motor ability, the modified Barthel Index for living ability, and a scale for the degree of neurological deficits. Outcome was assessed at three points before randomized grouping, at the beginning or treatment, and after 4 weeks of treatment.
RESULTS
Following 4 weeks treatment, all the patients exhibited significant improvements in aspects of motor ability, living ability, and the severity of neurological deficits. The experimental group (SC + ES) scored higher on the Fugl-Meyer assessment scale (68 ± 12) and the modified Barthel Index (49 ± 9) than the control (SC) group (50 ± 13, 36 ± 13, respectively).
CONCLUSION
When patients with post-stroke hemiplegia are treated using SC acupuncture with ES, motor and living ability can improve more than if they were treated with SC acupuncture alone.
{"title":"Scalp-cluster acupuncture with electrical stimulation can improve motor and living ability in convalescent patients with post-stroke hemiplegia","authors":"Wang Xiaohong , Zhang Qi , Cui Baojuan , Sun Junhua , Ye Lan , Huang Laigang , Wang Daoqing","doi":"10.1016/S0254-6272(18)30638-1","DOIUrl":"10.1016/S0254-6272(18)30638-1","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To determine whether patients with post-stroke hemiplegia could benefit from long-term treatment with scalp cluster (SC) acupuncture combined with electrical stimulation (ES) and to evaluate the feasibility of this treatment to improve motor and living abilities.</p></div><div><h3>METHODS</h3><p>Twenty patients were enrolled and divided into two groups: SC acupuncture and SC acupuncture with ES (SC and SC + ES, respectively). All participants also received rehabilitation training. All participants were blindly evaluated using the Fugl-Meyer assessment scale for motor ability, the modified Barthel Index for living ability, and a scale for the degree of neurological deficits. Outcome was assessed at three points before randomized grouping, at the beginning or treatment, and after 4 weeks of treatment.</p></div><div><h3>RESULTS</h3><p>Following 4 weeks treatment, all the patients exhibited significant improvements in aspects of motor ability, living ability, and the severity of neurological deficits. The experimental group (SC + ES) scored higher on the Fugl-Meyer assessment scale (68 ± 12) and the modified Barthel Index (49 ± 9) than the control (SC) group (50 ± 13, 36 ± 13, respectively).</p></div><div><h3>CONCLUSION</h3><p>When patients with post-stroke hemiplegia are treated using SC acupuncture with ES, motor and living ability can improve more than if they were treated with SC acupuncture alone.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 452-456"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30638-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48655117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30623-X
Liu Shi , Wu Jiarui , Zhang Dan , Tan Di
OBJECTIVE
To undertake a systematic review and network meta-analysis (NMA) to compare the effectiveness among the different regimens of Salvia miltiorrhiza injection classes (SMICs) for unstable angina pectoris (UAP) treatment.
METHODS
A systematic retrieval was conducted in several literature databases to identify randomized controlled trials focusing on the different regimens of SMICs for UAP treatment until January 2016. The quality assessment was accomplished according to the Cochrane risk of bias tool. Pair-wise meta-analyses were carried out by RevMan 5.3. A random-effects model of NMA was used to compare the different regimens of SMICs with regard to efficacy by STATA 13.0.
RESULTS
A total of 111 studies involving 10 500 patients were included in the NMA. The methodological quality of included studies was not high. Current evidence shows that salvianolate (SI) is the optimal treatment for UAP in improving the total efficacy against UAP. Guanxingning (GXN) is the optimal treatment for UAP for improving the total effectiveness of electrocardiography.
CONCLUSION
SMICs have advantages in preventing cardiovascular events. GXN, SI, and Danhong had the greatest probability of being the best treatment in the total efficacy against UAP and for improving the total effectiveness of electrocardiography.
{"title":"What are the best Salvia miltiorrhiza injection classes for treatment of unstable angina pectoris? A systematic review and network Meta-analysis","authors":"Liu Shi , Wu Jiarui , Zhang Dan , Tan Di","doi":"10.1016/S0254-6272(18)30623-X","DOIUrl":"10.1016/S0254-6272(18)30623-X","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To undertake a systematic review and network meta-analysis (NMA) to compare the effectiveness among the different regimens of Salvia miltiorrhiza injection classes (SMICs) for unstable angina pectoris (UAP) treatment.</p></div><div><h3>METHODS</h3><p>A systematic retrieval was conducted in several literature databases to identify randomized controlled trials focusing on the different regimens of SMICs for UAP treatment until January 2016. The quality assessment was accomplished according to the Cochrane risk of bias tool. Pair-wise meta-analyses were carried out by RevMan 5.3. A random-effects model of NMA was used to compare the different regimens of SMICs with regard to efficacy by STATA 13.0.</p></div><div><h3>RESULTS</h3><p>A total of 111 studies involving 10 500 patients were included in the NMA. The methodological quality of included studies was not high. Current evidence shows that salvianolate (SI) is the optimal treatment for UAP in improving the total efficacy against UAP. Guanxingning (GXN) is the optimal treatment for UAP for improving the total effectiveness of electrocardiography.</p></div><div><h3>CONCLUSION</h3><p>SMICs have advantages in preventing cardiovascular events. GXN, SI, and Danhong had the greatest probability of being the best treatment in the total efficacy against UAP and for improving the total effectiveness of electrocardiography.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 321-338"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30623-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43079346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01Epub Date: 2018-08-17DOI: 10.1016/S0254-6272(18)30636-8
Zhang Mengxue, Guan Ling, Wang Lili, Li Ying
OBJECTIVE
To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) on the neutrophil-to-lymphocyte ratio (NLR) and quality of life in patients with non-small-cell lung cancer (NSCLC).
METHODS
Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) every day for 6 weeks, while group B received no intervention (control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.
RESULTS
Five participants dropped out, leaving a final total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B (P < 0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life (P < 0.001) and function (P < 0.05), and significantly lower in terms of symptoms (P < 0.05).
CONCLUSION
The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli (ST 36) and Feishu (BL 13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.
{"title":"Effect of scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) on neutrophil-to-lymphocyte ratio and quality of life in patients with non-small-cell lung cancer: A randomized, controlled trial","authors":"Zhang Mengxue, Guan Ling, Wang Lili, Li Ying","doi":"10.1016/S0254-6272(18)30636-8","DOIUrl":"10.1016/S0254-6272(18)30636-8","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the effect of heat stimulation <em>via</em> scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) on the neutrophil-to-lymphocyte ratio (NLR) and quality of life in patients with non-small-cell lung cancer (NSCLC).</p></div><div><h3>METHODS</h3><p>Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli (ST 36) and Feishu (BL 13) every day for 6 weeks, while group B received no intervention (control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.</p></div><div><h3>RESULTS</h3><p>Five participants dropped out, leaving a final total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B (<em>P</em> < 0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life (<em>P</em> < 0.001) and function (<em>P</em> < 0.05), and significantly lower in terms of symptoms (<em>P</em> < 0.05).</p></div><div><h3>CONCLUSION</h3><p>The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli (ST 36) and Feishu (BL 13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 3","pages":"Pages 439-446"},"PeriodicalIF":2.6,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30636-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45758900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-01Epub Date: 2018-04-21DOI: 10.1016/j.jtcm.2018.04.002
Yang Hongchang , Wu Xueping , Wang Min
OBJECTIVE
To systematically evaluate the effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus (T2DM) in Chinese patients.
METHODS
A literature search was conducted in PubMed, Medline, Embase, China National Knowledge Infrastructure Database, Wanfang and China Science and Technology Journal Database until on January 2017. In this Meta-analysis, enrolled were the studies, including experimental group (with conventional medical treatment plus Qigong therapy) and control group (with conventional medical treatment plus diet control or other exercises). Then, the standardized mean differences (SMDs) of fasting blood-glucose (FBG), 2-hplasmaglucose (2hPG), hemoglobinAlc (HbAlc), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low density lipoprotein (LDL), as well as their 95% confidence interval (CIs) were calculated to evaluate the effect of Qigong on patients with T2DM by RevMan 5.2 and Stata 11.0 software.
RESULTS
Totally 834 cases of T2DM from 11 studies were included in this review. The pooled SMDs with its 95% CIs of FBG, 2hPG, HbAlc, TG, TC, HDL and LDL were – 0.70 (– 0.93, – 0.47), – 0.66 (– 1.11, – 0.21), – 0.73 (– 0.96, – 0.50), – 1.05 (– 1.67, – 0.43), – 0.42 (– 1.12, 0.28), 0.69 (0.19, 1.19), and – 0.26 (– 0.69, 0.18), respectively. The pooled data showed significantly difference between Qigong and the levels of FBG, 2hPG, HbA1c, TG, and HDL in patients with T2DM (P < 0.05).
CONCLUSION
Combining with conventional medical treatment, Qigong exercise might have significant effect on T2DM in Chinese patients.
{"title":"Effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus in Chinese patients: A Meta-analysis","authors":"Yang Hongchang , Wu Xueping , Wang Min","doi":"10.1016/j.jtcm.2018.04.002","DOIUrl":"10.1016/j.jtcm.2018.04.002","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To systematically evaluate the effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus (T2DM) in Chinese patients.</p></div><div><h3>METHODS</h3><p>A literature search was conducted in PubMed, Medline, Embase, China National Knowledge Infrastructure Database, Wanfang and China Science and Technology Journal Database until on January 2017. In this Meta-analysis, enrolled were the studies, including experimental group (with conventional medical treatment plus Qigong therapy) and control group (with conventional medical treatment plus diet control or other exercises). Then, the standardized mean differences (SMDs) of fasting blood-glucose (FBG), 2-hplasmaglucose (2hPG), hemoglobinAlc (HbAlc), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low density lipoprotein (LDL), as well as their 95% confidence interval (<em>CIs</em>) were calculated to evaluate the effect of Qigong on patients with T2DM by RevMan 5.2 and Stata 11.0 software.</p></div><div><h3>RESULTS</h3><p>Totally 834 cases of T2DM from 11 studies were included in this review. The pooled SMDs with its 95% <em>CIs</em> of FBG, 2hPG, HbAlc, TG, TC, HDL and LDL were – 0.70 (– 0.93, – 0.47), – 0.66 (– 1.11, – 0.21), – 0.73 (– 0.96, – 0.50), – 1.05 (– 1.67, – 0.43), – 0.42 (– 1.12, 0.28), 0.69 (0.19, 1.19), and – 0.26 (– 0.69, 0.18), respectively. The pooled data showed significantly difference between Qigong and the levels of FBG, 2hPG, HbA1c, TG, and HDL in patients with T2DM (<em>P</em> < 0.05).</p></div><div><h3>CONCLUSION</h3><p>Combining with conventional medical treatment, Qigong exercise might have significant effect on T2DM in Chinese patients.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 167-174"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48556239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-01Epub Date: 2018-04-21DOI: 10.1016/j.jtcm.2018.04.007
Gong Zhenghua , Deng Chaowen , Xiang Tianxin , Tao Lili , Xiao Hongbo , Peng Yanzhong , Zheng Jie , Hu Guoxin
OBJECTIVE
To investigate the involvement of growth arrest specific 5 (GAS5), a long non-coding RNA, in the anti-hepatic fibrosis process induced by Dahuang Zhechong pill (DHZCP) in rats.
METHODS
Thirty adult rats were divided into three groups, including a control group, a CCl4-induced fibrosis group and a DHZCP-treated fibrosis group. Hematoxylin-eosin and Masson staining were used for histopathological study. Serum enzymes, cytokines and cell proliferation were assayed using commercially available kits. A GAS5 lenti-virus vector was constructed to further investigate the role of GAS5 in the anti-hepatic fibrosis effect of DHZCP in rats.
RESULTS
Our results revealed that the proliferation of hepatic stellate cells cultured in serum derived from rats treated with DHZCP was significantly decreased, compared with cells treated with serum from the untreated rats. DHZCP alleviated the CCl4-induced hepatic fibrosis. Additionally, DHZCP can restore the expression of GAS5, which was significantly decreased in the CCl4-induced group, and markedly suppress the expression of p-p38 and p-Erk induced by CCl4, but not p-Jnk. Cell proliferation was significantly arrested when cells overexpressed GAS5. Thus, DHZCP can inhibit the expression of p-p38 and p-Erk, while GAS5 can only inhibit the expression of p-Erk.
CONCLUSIONS
DHZCP can alleviate hepatic fibrosis by increasing the expression of GAS5 to suppress p-Erk and regulating other factors to inhibit p-p38.
{"title":"Effect of Dahuang Zhechong pills on long non-coding RNA growth arrest specific 5 in rat models of hepatic fibrosis","authors":"Gong Zhenghua , Deng Chaowen , Xiang Tianxin , Tao Lili , Xiao Hongbo , Peng Yanzhong , Zheng Jie , Hu Guoxin","doi":"10.1016/j.jtcm.2018.04.007","DOIUrl":"10.1016/j.jtcm.2018.04.007","url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the involvement of growth arrest specific 5 (GAS5), a long non-coding RNA, in the anti-hepatic fibrosis process induced by Dahuang Zhechong pill (DHZCP) in rats.</p></div><div><h3>METHODS</h3><p>Thirty adult rats were divided into three groups, including a control group, a CCl<sub>4</sub>-induced fibrosis group and a DHZCP-treated fibrosis group. Hematoxylin-eosin and Masson staining were used for histopathological study. Serum enzymes, cytokines and cell proliferation were assayed using commercially available kits. A GAS5 lenti-virus vector was constructed to further investigate the role of GAS5 in the anti-hepatic fibrosis effect of DHZCP in rats.</p></div><div><h3>RESULTS</h3><p>Our results revealed that the proliferation of hepatic stellate cells cultured in serum derived from rats treated with DHZCP was significantly decreased, compared with cells treated with serum from the untreated rats. DHZCP alleviated the CCl<sub>4</sub>-induced hepatic fibrosis. Additionally, DHZCP can restore the expression of GAS5, which was significantly decreased in the CCl<sub>4</sub>-induced group, and markedly suppress the expression of p-p38 and p-Erk induced by CCl<sub>4,</sub> but not p-Jnk. Cell proliferation was significantly arrested when cells overexpressed GAS5. Thus, DHZCP can inhibit the expression of p-p38 and p-Erk, while GAS5 can only inhibit the expression of p-Erk.</p></div><div><h3>CONCLUSIONS</h3><p>DHZCP can alleviate hepatic fibrosis by increasing the expression of GAS5 to suppress p-Erk and regulating other factors to inhibit p-p38.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 190-196"},"PeriodicalIF":2.6,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2018.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44625930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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