Alkaloids are a group of secondary metabolites that generate great interest since ancient times. Numerous Solanaceae plants are rich sources of tropane alkaloids as hyoscyamine and scopolamine which are obtained mainly from Hyoscyamus niger, Datura stramonium, Atropa belladonna, Mandragora officinarum. In the present study it was developed an HPLC-DAD using an XBridge Phenyl column for the quantification of scopolamine and hyoscyamine, molecules used in pharmaceutical industry to treat stomach or intestinal disorders. A. belladonna presented hyoscyamine and scopolamine, the first one ranged from 1466 to 5117 mg/Kg DW while the second one ranged from 140 to 1743 mg/Kg DW. In D. stramonium, hyoscyamine was not found while scopolamine ranged from 430 to 8980 mg/Kg DW. On the contrary H. niger and M. officinarum did not contain any trace of these alkaloids. This is the first work in which different parts of four Solanaceae were analysed for their hyoscyamine and scopolamine content.
{"title":"Simultaneous quantification of hyoscyamine and scopolamine using HPLC-DAD in four Solanaceae: Hyoscyamus niger, Datura stramonium, Atropa belladonna and Mandragora officinarum","authors":"Diletta Piatti , Riccardo Marconi , Simone Angeloni , Giovanni Caprioli , Filippo Maggi , Emanuele Ribatti , Vittorio Cattaneo , Gianni Sagratini","doi":"10.1080/14786419.2023.2269595","DOIUrl":"10.1080/14786419.2023.2269595","url":null,"abstract":"<div><div>Alkaloids are a group of secondary metabolites that generate great interest since ancient times. Numerous Solanaceae plants are rich sources of tropane alkaloids as hyoscyamine and scopolamine which are obtained mainly from <em>Hyoscyamus niger, Datura stramonium, Atropa belladonna, Mandragora officinarum</em>. In the present study it was developed an HPLC-DAD using an XBridge Phenyl column for the quantification of scopolamine and hyoscyamine, molecules used in pharmaceutical industry to treat stomach or intestinal disorders. <em>A. belladonna</em> presented hyoscyamine and scopolamine, the first one ranged from 1466 to 5117 mg/Kg DW while the second one ranged from 140 to 1743 mg/Kg DW. In <em>D. stramonium</em>, hyoscyamine was not found while scopolamine ranged from 430 to 8980 mg/Kg DW. On the contrary <em>H. niger</em> and <em>M. officinarum</em> did not contain any trace of these alkaloids. This is the first work in which different parts of four Solanaceae were analysed for their hyoscyamine and scopolamine content.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 438-443"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41205976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2272282
Weirong Bai , Tuanjie Wang , Xiaoming Yang , Zhenzhong Wang , Haibo Li , Jianliang Geng
Two undescribed sesquiterpenoids, including one nor-eudesmane type (1) and one guaiane type (2), together with two known analogues (3-4) have been isolated and identified from the fruits of Alpinia oxyphylla. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1D-, 2D-NMR, HRESIMS, IR, UV) and NMR calculations with DP4+ analysis. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE2 production in LPS stimulated RAW 264.7 macrophages.
{"title":"Two new sesquiterpenoids from the fruits of Alpinia oxyphylla","authors":"Weirong Bai , Tuanjie Wang , Xiaoming Yang , Zhenzhong Wang , Haibo Li , Jianliang Geng","doi":"10.1080/14786419.2023.2272282","DOIUrl":"10.1080/14786419.2023.2272282","url":null,"abstract":"<div><div>Two undescribed sesquiterpenoids, including one nor-eudesmane type (<strong>1</strong>) and one guaiane type (<strong>2</strong>), together with two known analogues (<strong>3</strong>-<strong>4</strong>) have been isolated and identified from the fruits of <em>Alpinia oxyphylla</em>. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1D-, 2D-NMR, HRESIMS, IR, UV) and NMR calculations with DP4+ analysis. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE<sub>2</sub> production in LPS stimulated RAW 264.7 macrophages.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 468-474"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2275265
Han-tao Zhao , Jun Yang , Qian-feng Chen
A new coumarin glucoside named angelol A-3'-β-D-glucoside and four known compounds (2–5) were isolated from the root of Angelica pubescens. Their chemical structures were elucidated by extensive spectroscopic methods involving HR-ESI-MS, 1D and 2D NMR. The absolute configuration of compound 1 was confirmed by the CD experiment. All compounds were tested for nitric oxide (NO) inhibitory activity in vitro. The results showed that all compounds exhibited weak to moderate inhibition activities of NO production except compound 5.
{"title":"A new coumarin glucoside from Angelica pubescens","authors":"Han-tao Zhao , Jun Yang , Qian-feng Chen","doi":"10.1080/14786419.2023.2275265","DOIUrl":"10.1080/14786419.2023.2275265","url":null,"abstract":"<div><div>A new coumarin glucoside named angelol A-3'-<em>β</em>-D-glucoside and four known compounds (<strong>2–5</strong>) were isolated from the root of <em>Angelica pubescens</em>. Their chemical structures were elucidated by extensive spectroscopic methods involving HR-ESI-MS, 1D and 2D NMR. The absolute configuration of compound <strong>1</strong> was confirmed by the CD experiment. All compounds were tested for nitric oxide (NO) inhibitory activity <em>in vitro</em>. The results showed that all compounds exhibited weak to moderate inhibition activities of NO production except compound <strong>5</strong>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 526-530"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71425214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2269466
Han Lin , Weiwei Dong , Changkuo Zhao , Xianheng Wang
Using molecular hybridisation to develop conjugates of natural antitumor drugs is one of the research hotspots in recent drug development. In this study, β-anhydroicaritine with anticancer activity was conjugated to norcantharidine selectively to develop new antitumor lead candidates. In the condition of EDCI/DMAP/DCM, the C-3 and C-5 hydroxyl groups of β-anhydroicaritine was coupled with norcantharidin monoacid ester respectively, and the inhibitory activity of the synthesised conjugates against HepG2, MCF-7 and L-02 cells were tested by CCK-8 method. Most of these conjugates showed a better activity against HepG2 and MCF-7 cell lines compared to parent compound icaritin, but weaker than another parent compound norcantharidin.
{"title":"Synthesis of 3- and 5-β-anhydroicaritine norcantharidin conjugates","authors":"Han Lin , Weiwei Dong , Changkuo Zhao , Xianheng Wang","doi":"10.1080/14786419.2023.2269466","DOIUrl":"10.1080/14786419.2023.2269466","url":null,"abstract":"<div><div>Using molecular hybridisation to develop conjugates of natural antitumor drugs is one of the research hotspots in recent drug development. In this study, <em>β</em>-anhydroicaritine with anticancer activity was conjugated to norcantharidine selectively to develop new antitumor lead candidates. In the condition of EDCI/DMAP/DCM, the C-3 and C-5 hydroxyl groups of <em>β</em>-anhydroicaritine was coupled with norcantharidin monoacid ester respectively, and the inhibitory activity of the synthesised conjugates against HepG2, MCF-7 and L-02 cells were tested by CCK-8 method. Most of these conjugates showed a better activity against HepG2 and MCF-7 cell lines compared to parent compound icaritin, but weaker than another parent compound norcantharidin.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 415-422"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2024.2449510
Julio Cesar Maceda Santivañez, Célio Fernando Figueiredo Angolini
The genus Palicourea Aubl. belong to the Rubiaceae family, which is distributed in Tropical America. A compressive bibliographic survey was carried out on the uses in traditional medicine, bioactive properties, and secondary metabolites isolated from the genus. The Web of Science, Science Direct, Pubmed, Scopus and Google Scholar databases were utilised between the years 1990 -2024. The genus is used in traditional medicine for purposes such as antimalarial, haemostatic, dewormer, hypertension, hepatitis, antiulcerogenic, and so on. Bioactivities have been reported for the extracts and isolated compounds such as anti-plasmodial activity, antiprotozoal, antioxidant, anti-inflammatory, antimycobacterial, toxicity, and so on. As well as, anticancer activity, nitric oxide, acetylcholinesterase, and monoamine oxidase inhibitory activity, anthelmintic and others, respectively. Approximately 106 metabolites were isolated from the genus, including iridoids, flavonoids, triterpenes, coumarins, phytosterols, phenolic acids, and alkaloids. The analysis of the collected information shows that the genus is an important source of bioactive compounds. The monoterpene indole alkaloids class represents the largest number of isolated compounds. This review provides a foundation on the phytochemical components, uses in traditional medicine, and biological activities of extracts and isolated compounds of the genus Palicourea Aubl., thereby contributing to future studies in the search for discoveries and potential applications.
{"title":"The genus <i>Palicourea</i> Aubl. (Rubiaceae): source of bioactive compounds.","authors":"Julio Cesar Maceda Santivañez, Célio Fernando Figueiredo Angolini","doi":"10.1080/14786419.2024.2449510","DOIUrl":"https://doi.org/10.1080/14786419.2024.2449510","url":null,"abstract":"<p><p>The genus <i>Palicourea</i> Aubl. belong to the Rubiaceae family, which is distributed in Tropical America. A compressive bibliographic survey was carried out on the uses in traditional medicine, bioactive properties, and secondary metabolites isolated from the genus. The Web of Science, Science Direct, Pubmed, Scopus and Google Scholar databases were utilised between the years 1990 -2024. The genus is used in traditional medicine for purposes such as antimalarial, haemostatic, dewormer, hypertension, hepatitis, antiulcerogenic, and so on. Bioactivities have been reported for the extracts and isolated compounds such as anti-plasmodial activity, antiprotozoal, antioxidant, anti-inflammatory, antimycobacterial, toxicity, and so on. As well as, anticancer activity, nitric oxide, acetylcholinesterase, and monoamine oxidase inhibitory activity, anthelmintic and others, respectively. Approximately 106 metabolites were isolated from the genus, including iridoids, flavonoids, triterpenes, coumarins, phytosterols, phenolic acids, and alkaloids. The analysis of the collected information shows that the genus is an important source of bioactive compounds. The monoterpene indole alkaloids class represents the largest number of isolated compounds. This review provides a foundation on the phytochemical components, uses in traditional medicine, and biological activities of extracts and isolated compounds of the genus <i>Palicourea</i> Aubl., thereby contributing to future studies in the search for discoveries and potential applications.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2260067
Jitendra D. Salunkhe , Satish V. Patil
Naringinase is an important enzyme for commercial purposes due to its dual activity as both α-l-rhamnosidase and β-d-glucosidase. The traditional method for screening microbes that produce naringinase involves growing them on naringin agar, but this method has limitations and result in false positive results. This is because the growth on the naringin agar plate could be due to the presence of other organisms that produce rhamnosidase or other glucosidases, or those that use agar as a carbon source, rather than actual naringinase producers. To address these limitations, a double screen plate assay was developed using synthetic substrates, to separately test for β-d-glucosidase and α-l-rhamnosidase activity. The presence of a yellow zone of p-nitrophenol indicates the action of these enzymes, and the intensity of the yellow colour zone indicates the potential for naringinase production. This new screening method is a significant improvement in identifying real naringinase producers and represents progress towards a more reliable screening assay.
{"title":"Improved naringinase double screen plate assay: progress towards the perfect screening","authors":"Jitendra D. Salunkhe , Satish V. Patil","doi":"10.1080/14786419.2023.2260067","DOIUrl":"10.1080/14786419.2023.2260067","url":null,"abstract":"<div><div>Naringinase is an important enzyme for commercial purposes due to its dual activity as both α-<span>l</span>-rhamnosidase and β-<span>d</span>-glucosidase. The traditional method for screening microbes that produce naringinase involves growing them on naringin agar, but this method has limitations and result in false positive results. This is because the growth on the naringin agar plate could be due to the presence of other organisms that produce rhamnosidase or other glucosidases, or those that use agar as a carbon source, rather than actual naringinase producers. To address these limitations, a double screen plate assay was developed using synthetic substrates, to separately test for β-d-glucosidase and α-l-rhamnosidase activity. The presence of a yellow zone of p-nitrophenol indicates the action of these enzymes, and the intensity of the yellow colour zone indicates the potential for naringinase production. This new screening method is a significant improvement in identifying real naringinase producers and represents progress towards a more reliable screening assay.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 609-612"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2269464
Salman Jameel , Loveleena Kaur , Henna Amin , Showkat Ahmad Bhat , Fayaz A. Malik , Khursheed Ahmad Bhat
Novel sarracinic acid derivatives bearing triazole or N-heterocyclic moiety were prepared via two separate reaction schemes. The triazoles and the N-heterocyclic derivatives were synthesised using standard click chemistry approach and amination of 2-bromoethyl ester of sarracinic acid respectively. All the synthesised derivatives were screened for in vitro neuroprotective activity against corticosterone induced impairment in neuroblastoma cell line SH-SY5Y. Two analogs SA-2 and SA-12 exhibited strong neuroprotective activity. The cell viability, after high dose corticosterone induced cell death, increased remarkably with the pre treatment of SA-2 and SA-12. The in vitro biological activity of SA-2 and SA-12 was verified through docking studies. The docking studies were in good agreement with the biological results. SA-2 and SA-12 showed strong binding affinities with the target protein having ΔGb = −8.88 and −7.52; inhibition constant (ki) = 3.08 nM and 30.9 nM respectively.
{"title":"Design, synthesis and neuroprotective evaluation of nitrogen heterocyclic and triazole derivatives of sarracinic acid","authors":"Salman Jameel , Loveleena Kaur , Henna Amin , Showkat Ahmad Bhat , Fayaz A. Malik , Khursheed Ahmad Bhat","doi":"10.1080/14786419.2023.2269464","DOIUrl":"10.1080/14786419.2023.2269464","url":null,"abstract":"<div><div>Novel sarracinic acid derivatives bearing triazole or N-heterocyclic moiety were prepared <em>via</em> two separate reaction schemes. The triazoles and the N-heterocyclic derivatives were synthesised using standard click chemistry approach and amination of 2-bromoethyl ester of sarracinic acid respectively. All the synthesised derivatives were screened for <em>in vitro</em> neuroprotective activity against corticosterone induced impairment in neuroblastoma cell line SH-SY5Y. Two analogs SA-2 and SA-12 exhibited strong neuroprotective activity. The cell viability, after high dose corticosterone induced cell death, increased remarkably with the pre treatment of SA-2 and SA-12. The <em>in vitro</em> biological activity of SA-2 and SA-12 was verified through docking studies. The docking studies were in good agreement with the biological results. SA-2 and SA-12 showed strong binding affinities with the target protein having ΔG<sub>b</sub> = −8.88 and −7.52; inhibition constant (k<sub>i</sub>) = 3.08 nM and 30.9 nM respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 405-414"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guggulsterone plays a significant role in cholesterol-lowering by inhibiting Farnesoid X Receptor. The present study aims to identify the isomers of Guggulsterone with high binding affinity and good binding interaction with targeted protein and positive control atorvastatin. The pharmacokinetic parameters of Guggulsterone isomers were estimated from P.K.C.S.M. online server, and molecular docking analysis was performed from Autodock V.® 4.2.6 Program. From the computer-aided drug designing, we have confirmed that guggulsterone isomers are inhibitors of the CYP3A4 enzyme and hepatotoxic. Guggulsterone isomer showed a stronger binding affinity when compared with atorvastatin. The docking score for Guggulsterone was −9.28 kcal/mol, E-Guggulsterone −9.56 kcal/mol, Z-Guggulsterone −9.79 kcal/mol, M-Guggulsterone −9.45 kcal/mol, and positive control atorvastatin −8.26 kcal/mol. The present study revealed that the isomers of Guggulsterone have high binding affinity and good binding interaction with targeted proteins.
{"title":"Physicochemical investigation and molecular docking analysis of Maha yogaraj Guggulu tablet and virtual screening of its major bioactive compound","authors":"Sarvesh Sabarathinam , Sanjana Satheesh , Rajappan Chandra Satish Kumar","doi":"10.1080/14786419.2023.2261071","DOIUrl":"10.1080/14786419.2023.2261071","url":null,"abstract":"<div><div>Guggulsterone plays a significant role in cholesterol-lowering by inhibiting Farnesoid X Receptor. The present study aims to identify the isomers of Guggulsterone with high binding affinity and good binding interaction with targeted protein and positive control atorvastatin. The pharmacokinetic parameters of Guggulsterone isomers were estimated from P.K.C.S.M. online server, and molecular docking analysis was performed from Autodock V.<sup>®</sup> 4.2.6 Program. From the computer-aided drug designing, we have confirmed that guggulsterone isomers are inhibitors of the CYP3A4 enzyme and hepatotoxic. Guggulsterone isomer showed a stronger binding affinity when compared with atorvastatin. The docking score for Guggulsterone was −9.28 kcal/mol, E-Guggulsterone −9.56 kcal/mol, Z-Guggulsterone −9.79 kcal/mol, M-Guggulsterone −9.45 kcal/mol, and positive control atorvastatin −8.26 kcal/mol. The present study revealed that the isomers of Guggulsterone have high binding affinity and good binding interaction with targeted proteins.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 618-624"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2272030
Hao Cheng , Yan-Lei Su , Meng-Tong Liu , Shi-Nong Yuan , Shao-Nan Wang , Fang-Jie Hou , Ma Dong-Lai , Duan Xu-Hong
Seven flavanones, including two new compounds coupled with styryl units, communins C (1) and D (2), as well as five known compounds, were isolated from Polytrichum commune Hedw. The planar structures of all compounds were determined using extensive spectroscopic analysis. The absolute configurations of two new compounds were assigned by comparing experimental ECD with calculated ECD. The cytotoxicity of all isolates against HCT-116, BGC803, MCF7 and PANC-1 cell lines was evaluated. Communin D exhibited significant cytotoxic activity on BGC803 cells with an IC50 value of 9.3 μM.
从Polytrichum community Hedw中分离到7种黄烷酮，包括两种与苯乙烯单元偶联的新化合物，公报子C（1）和D（2），以及5种已知化合物。使用广泛的光谱分析确定了所有化合物的平面结构。通过比较实验ECD和计算ECD，确定了两种新化合物的绝对构型。评价了所有分离株对HCT-116、BGC803、MCF7和PANC-1细胞系的细胞毒性。Communin D对BGC803细胞表现出显著的细胞毒性活性，IC50值为9.3 μM。
{"title":"Two new flavanones from Polytrichum commune Hedw","authors":"Hao Cheng , Yan-Lei Su , Meng-Tong Liu , Shi-Nong Yuan , Shao-Nan Wang , Fang-Jie Hou , Ma Dong-Lai , Duan Xu-Hong","doi":"10.1080/14786419.2023.2272030","DOIUrl":"10.1080/14786419.2023.2272030","url":null,"abstract":"<div><div>Seven flavanones, including two new compounds coupled with styryl units, communins C (<strong>1</strong>) and D (<strong>2</strong>), as well as five known compounds, were isolated from <em>Polytrichum commune</em> Hedw. The planar structures of all compounds were determined using extensive spectroscopic analysis. The absolute configurations of two new compounds were assigned by comparing experimental ECD with calculated ECD. The cytotoxicity of all isolates against HCT-116, BGC803, MCF7 and PANC-1 cell lines was evaluated. Communin D exhibited significant cytotoxic activity on BGC803 cells with an IC<sub>50</sub> value of 9.3 μM.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 453-459"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1080/14786419.2023.2275266
G. Sundarapandian , Arunachalam K
This article aims to assess the suitability of natural neem gum in various composite material applications in place of epoxy resin. The assessment was done by thermal characterisation, experimental study and comparative analysis of thermal behaviour, Fourier transform IR spectroscopy (FTIR) characterisation and comparison of functional groups and mechanical properties of neat epoxy and neat neem resins. To study and compare thermal behaviour differential scanning calorimetry (DSC), thermogravimetric (TG) and relative derivative TG (DTG) analysis were conducted. The glass transition temperatures, exothermic and endothermic peaks, curing of thermosetting epoxy and crystallisation of polymeric neem, value of % cure and mass change or mass loss concerning temperature of both the resins were experimentally determined and comparative analysis was conducted to find the suitability of neem resin in composite material applications in place of epoxy resin. Functional groups of neem gum were identified and mechanical properties such as bond strength, toughness, rigidity and ductility were characterised and compared with that of epoxy resin by conducting FTIR.
{"title":"Experimental studies on thermal and FTIR characterisation of bio-degradable neat neem gum and epoxy resin for composite material applications","authors":"G. Sundarapandian , Arunachalam K","doi":"10.1080/14786419.2023.2275266","DOIUrl":"10.1080/14786419.2023.2275266","url":null,"abstract":"<div><div>This article aims to assess the suitability of natural neem gum in various composite material applications in place of epoxy resin. The assessment was done by thermal characterisation, experimental study and comparative analysis of thermal behaviour, Fourier transform IR spectroscopy (FTIR) characterisation and comparison of functional groups and mechanical properties of neat epoxy and neat neem resins. To study and compare thermal behaviour differential scanning calorimetry (DSC), thermogravimetric (TG) and relative derivative TG (DTG) analysis were conducted. The glass transition temperatures, exothermic and endothermic peaks, curing of thermosetting epoxy and crystallisation of polymeric neem, value of % cure and mass change or mass loss concerning temperature of both the resins were experimentally determined and comparative analysis was conducted to find the suitability of neem resin in composite material applications in place of epoxy resin. Functional groups of neem gum were identified and mechanical properties such as bond strength, toughness, rigidity and ductility were characterised and compared with that of epoxy resin by conducting FTIR.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 531-540"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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