Natural Product Research最新文献

Two new C-glucofuranosyl flavones apigenin 6-C-β-glucofuranoside (1) and apigenin 6-C-α-glucofuranoside (2) together with four known compounds (3-6) were isolated from the flowers of Gypsophila oldhamiana. Their structures were elucidated on the basis of extensive spectroscopic analyses. These compounds were evaluated for the cytotoxic activities against four human cancer cell lines and did not exhibit any significant bioactivities (IC₅₀ values > 10 μM).

Bio-oil from Hibiscus cannabinus seeds was extracted with four solvents: acetone, benzene, isopropanol, and hexane. Solvent extraction techniques have less oil residue than other methods. The primary factors that influence the extraction processes such as extraction time, particle size, seed ageing, and solvent suitability were optimised to enhance the bio-oil yield. The extracted bio-oil was tested by GC-MS, FTIR, and ¹H-NMR. Physicochemical properties (free fatty acid, specific gravity, acid value, calorific value, saponification number, iodine number, etc.) of hibiscus cannabinus oil were also analysed on a dry weight basis. The hexane solvent gave the highest yield (25.37%) followed by acetone (21.32%), Benzene (16.98%), and Isopropanol (14.20%) over 3.5 h. It is also predicted that the cost of Hibiscus cannabinus seed bio-oil per litre is Rs. 230 which is moderately economical Hibiscus cannabinus oil has a calorific value of 39,895 kJ/kg, making it a better fuel choice.

Aralia elata (A. elata), a perennial woody plant of the Araliaceae family, is extensive in Northeast China. Esteemed for both its medicinal and edible qualities in the Changbai Mountain region, its primary components include polysaccharides, saponins, and flavonoids. A. elata displays numerous pharmacological effects, such as cardiovascular protection, anti-tumour, anti-fatigue, and hypoglycaemic properties. Through the extraction, purification and pharmacological evaluation of A. elata, it is expected to discover more biologically active components and provide scientific basis for their development as a clinical candidate drugs. This review consolidates recent research on extraction, separation, purification, and the biological efficacy of A. elata polysaccharides and saponins, which will provide the oretical basis and technical support for the further development and utilisation of A. elata resources and related by-products, and providing a foundation for the application of A. elata in functional foods and medicines.

For the first time, critical review on E. acuminata R. Br. (Boraginaceae) is established. A glance over its botanical description, geographic distribution, subspecies classification and traditional uses revealed its application in medical and non-medical purposes by ethnic communities in Asia and Australia. Numerous classes of phytoconstituents have been screened and isolated from E. acuminata parts, including phenolics, alkaloids, terpenoids, glycosides, saponins, tannins, lignans, steroids, volatile oils, and fatty acid esters. Crude extracts prepared from different parts were acclaimed with considerable to significant performance in anti-oxidant, anti-inflammatory, anti-diabetic, antimicrobial, antiviral, analgesic effect, muscle relaxant, antispasmodic effects, hepatoprotective, wound healing, and photoprotective activities. However, no report linking these pharmacological activities with their isolated phytochemicals can be found which is required to authenticate its role in traditional medicine. Accordingly, the review provides a comprehensive and categorised overview towards current research of E. acuminata R. Br., their limitations, and possible perspectives for future research.

Terminalia bellirica and Glycyrrhiza glabra are renowned for their medicinal properties and rich antioxidant content. These plants have been integral to Ayurvedic medicine, treating various ailments for centuries. The present study investigated the nephroprotective effects of aqueous methanolic extracts of Terminalia bellirica and Glycyrrhiza glabra in a Cisplatin-induced rodent model. Both in vitro and in vivo analyses were conducted using established biomarkers of renal function, such as serum creatinine, serum urea, blood urea nitrogen, and glomerular filtration rate, to evaluate the nephroprotective effects. In addition to biochemical parameters, renal histopathology was examined through H&E staining, revealing a significant reduction in tubular and glomerular injury following the administration of the plant extracts.

Inhibiting angiogenesis with plant-derived bioactive compounds can inhibit tumour progression. Antiangiogenic potential of Senegalia modesta was analysed by preparing and analysing ethanolic extracts of S.modesta by GC-MS and HPLC to identify bioactive components. In-vivo blood vessel formation assays in mice and chorioallantoic membrane assays (CAM) in eggs were employed to assess the antiangiogenic effects. qPCR was performed to elucidate mRNA expression of proangiogenic genes in MDA-MB-231 cells after exposure to S.modesta and thymol. Molecular docking analysis highlighted the interaction of thymol with VEGF receptors. S.modesta treatment significantly delayed wound healing in mice compared to control group. GC-MS and HPLC analyses thymol as a bioactive compound in S.modesta extract. CAM assay indicated reduced angiogenesis in thymol-treated groups, further confirmed by downregulation of proangiogenic genes. Molecular docking of thymol with VEGFR1/VEGFR2 revealed strong binding affinity, suggesting thymol-mediated receptor blocking. Thymol exhibits antiangiogenic potential and may serve as a promising therapeutic agent against cancer.

Acorus calamus L (A. calamus), known for its aromatic leaves and rhizomes, is extensively used in traditional medicine to treat digestive issues, inflammation, pain, anxiety, and stress. The petroleum ether extract of A. calamus isolates specific bioactive compounds using petroleum ether, a nonpolar solvent effective in dissolving nonpolar plant compounds. This extract potentially offers antimicrobial, anti-inflammatory, and analgesic benefits. However, research on this extract is limited, necessitating further investigation to determine its safety, efficacy, and medical applications. This study aims to develop more efficient extraction methods for the petroleum ether extract, focusing on sesquiterpenes and isocalamendiol from A. calamus. Additionally, the study will evaluate the extract's safety for topical use, providing insights into potential side effects and contraindications. This information is crucial for assessing the extract's suitability for topical treatments and guiding the development of new therapies and products.

Himalaflavones F (1) and G (2), two new flavonoids, along with eight known ones (3-10)were isolated from the roots of Oxybaphus himalaicus Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method. Among them 10 μM of compounds 1, 2, 8 and 10 could decrease the NO release against LPS-induced RAW264.7 macrophages. The results suggested that these compounds have the potential to be developed as anti-inflammatory drugs.