Pub Date : 2025-12-01Epub Date: 2025-11-15DOI: 10.1016/j.molp.2025.11.004
Xiaosong Yu, Jiuer Liu, Wei Wang, Jinbo Shen, Kai Shi, Jian-Feng Li, Jian Ye, Jack Rhodes, Cyril Zipfel, Chuanyou Li, Jia Li, Jianbing Yan, Yanli Lu, Yi Cai
Global agriculture faces critical challenges due to the overreliance on chemical pesticides, driving an urgent need for eco-friendly biopesticides and biostimulants (BioP&S). Plant-derived peptides, evolved as natural regulators of growth, development, and stress adaptation, offer immense potential as biodegradable and biocompatible alternatives. However, their commercialization remains constrained by limited exploration of the diversity and activity, high production costs, incomplete ecological risk evaluations, and undefined application scenarios. This Perspective overviews emerging discoveries and proposes integrated frameworks for plant peptide identification, molecular design, biomanufacturing, and ecological impact assessments integrated with germplasm development and field application systems. To overcome existing bottlenecks, we discuss the integrative potential of emerging technologies that synergistically combine artificial intelligence for high-throughput peptide discovery and de novo structural refinement, nanotechnology for enhancing environmental resilience and targeted delivery, and synthetic biology for developing industrial biomanufacturing platforms. We emphasize the need to align phytopeptide BioP&S with compatible germplasm resources, stage-specific crop requirements, and complementary chemical pesticides to maximize their efficacy, cost-effectiveness, and trait-specific agronomic performance by integrating with precision agriculture systems. Future advancements will rely on interdisciplinary innovations and policy support to unlock their full potential in enhancing crop resilience, productivity, and quality while ensuring ecological sustainability.
{"title":"Plant-derived peptides: From identification to agronomic applications.","authors":"Xiaosong Yu, Jiuer Liu, Wei Wang, Jinbo Shen, Kai Shi, Jian-Feng Li, Jian Ye, Jack Rhodes, Cyril Zipfel, Chuanyou Li, Jia Li, Jianbing Yan, Yanli Lu, Yi Cai","doi":"10.1016/j.molp.2025.11.004","DOIUrl":"10.1016/j.molp.2025.11.004","url":null,"abstract":"<p><p>Global agriculture faces critical challenges due to the overreliance on chemical pesticides, driving an urgent need for eco-friendly biopesticides and biostimulants (BioP&S). Plant-derived peptides, evolved as natural regulators of growth, development, and stress adaptation, offer immense potential as biodegradable and biocompatible alternatives. However, their commercialization remains constrained by limited exploration of the diversity and activity, high production costs, incomplete ecological risk evaluations, and undefined application scenarios. This Perspective overviews emerging discoveries and proposes integrated frameworks for plant peptide identification, molecular design, biomanufacturing, and ecological impact assessments integrated with germplasm development and field application systems. To overcome existing bottlenecks, we discuss the integrative potential of emerging technologies that synergistically combine artificial intelligence for high-throughput peptide discovery and de novo structural refinement, nanotechnology for enhancing environmental resilience and targeted delivery, and synthetic biology for developing industrial biomanufacturing platforms. We emphasize the need to align phytopeptide BioP&S with compatible germplasm resources, stage-specific crop requirements, and complementary chemical pesticides to maximize their efficacy, cost-effectiveness, and trait-specific agronomic performance by integrating with precision agriculture systems. Future advancements will rely on interdisciplinary innovations and policy support to unlock their full potential in enhancing crop resilience, productivity, and quality while ensuring ecological sustainability.</p>","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1963-1982"},"PeriodicalIF":24.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The recognition of plant-derived immunogenic peptides, known as phytocytokines (PCKs), by cell surface receptors triggers immune signaling pathways that bolster basal plant defense against pathogens. However, little is known about the molecular mechanisms that underlie PCK-mediated immune regulation in wheat. In this study, we identified a wheat PCK, delta-like PCK (DEP), that robustly activates immune responses and confers multi-pathogen resistance. DEP is perceived by the leucine-rich repeat (LRR) receptor kinases (RKs) DEP RECEPTOR 1 (DEPR1) and SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 2 (SERK2) and triggers DEPR1- and SERK2-dependent immune signaling. Cryogenic electron microscopy structural analysis revealed that DEP2 binds to the extracellular LRR domain of DEPR1 and recruits SERK2 through a disulfide-bond-stabilized loop to promote DEPR1-SERK2 heterodimerization. Furthermore, we showed that the DEP2-DEPR1-SERK2 module confers wheat resistance to Xanthomonas translucens, Fusarium graminearum, and Fusarium pseudograminearum. We also demonstrated that this module enhances wheat resistance to X. translucens by antagonizing abscisic acid signaling. Collectively, our study reveals a novel PCK-mediated immune signaling pathway and suggests a promising strategy for engineering multi-pathogen resistance in wheat.
{"title":"Recognition of a phytocytokine by the DEPR1-SERK2 receptor complex confers multi-pathogen resistance in wheat.","authors":"Lijun Wang, Jun Zhao, Chuanchun Yin, Hongxu Li, Yanan Xiao, Cuicui Du, Zhaoxi Lu, Yongjian Zhang, Fangshuai Jia, Jiaxin Hao, Jinghui Yan, Yi Zhang, Jian Li, Xinhua Ding, Zhifu Han, Haitao Cui, Jijie Chai, Xingwang Deng, Cheng Chi, Shuguo Hou","doi":"10.1016/j.molp.2025.10.005","DOIUrl":"10.1016/j.molp.2025.10.005","url":null,"abstract":"<p><p>The recognition of plant-derived immunogenic peptides, known as phytocytokines (PCKs), by cell surface receptors triggers immune signaling pathways that bolster basal plant defense against pathogens. However, little is known about the molecular mechanisms that underlie PCK-mediated immune regulation in wheat. In this study, we identified a wheat PCK, delta-like PCK (DEP), that robustly activates immune responses and confers multi-pathogen resistance. DEP is perceived by the leucine-rich repeat (LRR) receptor kinases (RKs) DEP RECEPTOR 1 (DEPR1) and SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 2 (SERK2) and triggers DEPR1- and SERK2-dependent immune signaling. Cryogenic electron microscopy structural analysis revealed that DEP2 binds to the extracellular LRR domain of DEPR1 and recruits SERK2 through a disulfide-bond-stabilized loop to promote DEPR1-SERK2 heterodimerization. Furthermore, we showed that the DEP2-DEPR1-SERK2 module confers wheat resistance to Xanthomonas translucens, Fusarium graminearum, and Fusarium pseudograminearum. We also demonstrated that this module enhances wheat resistance to X. translucens by antagonizing abscisic acid signaling. Collectively, our study reveals a novel PCK-mediated immune signaling pathway and suggests a promising strategy for engineering multi-pathogen resistance in wheat.</p>","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":" ","pages":"1999-2017"},"PeriodicalIF":24.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1016/j.molp.2025.11.009
Jeky Chanwala, Peter Kindgren
{"title":"The tug-of-war between growth and cold tolerance in plants: how to create resilient crops with maintained biomass","authors":"Jeky Chanwala, Peter Kindgren","doi":"10.1016/j.molp.2025.11.009","DOIUrl":"https://doi.org/10.1016/j.molp.2025.11.009","url":null,"abstract":"","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"5 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.molp.2025.11.008
Alessandro Tondelli, Andreas Maurer, Tsu-Wei Chen, Luigi Cattivelli
{"title":"Cultivars and variety mixtures in small grain cereals: to mix or not to mix?","authors":"Alessandro Tondelli, Andreas Maurer, Tsu-Wei Chen, Luigi Cattivelli","doi":"10.1016/j.molp.2025.11.008","DOIUrl":"https://doi.org/10.1016/j.molp.2025.11.008","url":null,"abstract":"","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"96 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.molp.2025.11.005
Jiazong Liu, Qiyue Xu, Wendi Li, Xinhua Ding
{"title":"Equilibrium in the Apoplast: The Molecular Tug-of-War Between Plant and Pathogen","authors":"Jiazong Liu, Qiyue Xu, Wendi Li, Xinhua Ding","doi":"10.1016/j.molp.2025.11.005","DOIUrl":"https://doi.org/10.1016/j.molp.2025.11.005","url":null,"abstract":"","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"1 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.molp.2025.11.002
Michelle Widlyne, Xueru Liu, Edan Jackson, Xin Li
{"title":"Fine-tuning of calcium channel homeostasis and activity through balanced phosphorylation and ubiquitination during immune activation","authors":"Michelle Widlyne, Xueru Liu, Edan Jackson, Xin Li","doi":"10.1016/j.molp.2025.11.002","DOIUrl":"https://doi.org/10.1016/j.molp.2025.11.002","url":null,"abstract":"","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"182 1","pages":""},"PeriodicalIF":27.5,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号