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Synthesis and Study Biological Activities of Sulfur - Containing Drugs 含硫药物的合成及生物活性研究
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178632
Zainab Saeed, M. Saleh, Ghufran T Sadeek
The importance of developing sulfur therapy is crucial to achieving the progress of pharmaceutical works - functional groups produced from sulfur can be found in a wide range of medicines due to the components of various biological and pharmaceutical effects. Sulfur compounds are an important class of chemical molecules. It can be used in various areas of chemistry. As a result of the widespread of pharmaceutical compounds containing sulfur, it gave great importance, as there are many drugs that have been developed, such as mafenide, sulfacetamide, Sulfadiazine, sulfamethazine, Sulfasalazine, sulfisoxazole. The study dealt with collecting the most important methods of preparing organic sulfur compounds. The focus was on thiols, thiones and sulfones, and a comparison was made between the pharmaceutical compounds that are included in their compositions in terms of synthesis and medical uses as antibacterial, antifungal and anticancer cells.
硫疗法的发展对药学工作的进展至关重要,硫所产生的官能团由于其各种生物和药物作用的组成而广泛存在于各种药物中。含硫化合物是一类重要的化学分子。它可用于化学的各个领域。由于含有硫的药物化合物广泛存在,因此它具有很大的重要性,因为已经开发了许多药物,如马菲尼德,磺胺乙酰胺,磺胺嘧啶,磺胺乙嘧啶,磺胺嘧啶,磺胺嘧啶,磺胺恶唑。本研究收集了制备有机硫化合物的最重要方法。重点是硫醇、硫酮和砜,并就其组合物中所含的药物化合物的合成和抗菌、抗真菌和抗癌细胞的医疗用途进行了比较。
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引用次数: 0
Detection of Parasitic Contamination of Cress Crop Irrigated with Two Types of Water in Jumka Village, Erbil – Iraq 伊拉克埃尔比勒Jumka村两种水灌溉的水芹作物寄生污染检测
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178570
Halwest Hassan, Y. Shekha
This study aims to evaluate the risk of using untreated wastewater for vegetable contamination. Water samples and vegetables cress and scientific name ( Lepidium sativum ) were collected from farms using wastewater and well water for irrigation for three seasons (Autumn, Winter, and Spring). Results show that untreated wastewater is characterized by an alkaline side of neutrality and has a high content of the Biochemical Oxygen Demand BOD 5 value of 124 mg. l -1 . The Biochemical Oxygen Demand (BOD 5 ) values variations coincided with water temperature variations and no Dissolved Oxygen (DO) detection during the study periods. Cryptosporidium spp. and other intestinal parasites were observed in wastewater in nearly all studied seasons. Wastewater-contaminated vegetables irrigated by it. Well, water is characterized by the highest EC value of 1119 µS.cm -1 during Winter and the highest pH value of 8.1 during the Spring season. Generally, well water is contaminated with parasitic organisms. Cryptosporidium spp. was detected in well water but no detection was found in cress irrigated by it.
本研究旨在评价利用未经处理的废水处理蔬菜污染的风险。从使用废水和井水灌溉的农场收集了三个季节(秋、冬、春)的水样和蔬菜苗和学名(Lepidium sativum)。结果表明,未经处理的废水具有中性碱性的特点,生化需氧量bod5含量较高,为124 mg。L -1。在研究期间,生化需氧量(BOD 5)值的变化与水温变化一致,且未检测到溶解氧(DO)。在几乎所有的研究季节,废水中都有隐孢子虫和其他肠道寄生虫。用它灌溉被污水污染的蔬菜。水的EC值最高,为1119µS。春季pH值最高,为8.1。一般来说,井水被寄生生物污染了。在井水中检出隐孢子虫,而在其灌溉的地衣中未检出。
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引用次数: 0
Investigation of the Acceleration and Deceleration Performance of the New Geometrical Shapes of the Three Electrode 新型三电极几何形状加减速性能研究
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178573
Mohammed idrees kanaan albayati, Abdullah I. M. Alabdullah, Alaa Alahmad
Electrostatic lenses are established using billed electrodes with cylinder bores which are exactly organized on a line of symmetry. In this paper, four designs of three-element cylindrical electrostatic lenses in the acceleration and deceleration mode with different geometrical shapes were created to prove how the operational characteristics of the lenses are affected by the electrode geometry according to potentials, the electron beam diameter in the image plane, kinetic energy, velocity, and acceleration before and after the electron beam passes through each of the four lenses. The best lens is chosen from the four lenses based on its optical performance. It has been found that the lens with the concave outer electrode surface has the best optical performance as an accelerating lens, and the lens with the concave inner electrode surface has the best optical performance as a decelerating lens. It was discovered that the geometry of the electrodes plays a major role in minimizing the beam electron diameter at the image plane and in accelerating and decelerating the electron beam. The calculations are carried out by using the SIMION8.0 and SL Tools Programs package.
静电透镜是用带有圆柱孔的电极建立的,圆柱孔精确地排列在一条对称线上。本文设计了四种不同几何形状的加速和减速模式的三元圆柱静电透镜,从电子束穿过四种透镜前后的电势、像面内电子束直径、动能、速度和加速度等方面证明了电极几何形状对三元圆柱静电透镜工作特性的影响。根据镜片的光学性能,从四个镜片中选出最佳镜片。研究发现,外电极面凹的透镜作为加速透镜光学性能最好,内电极面凹的透镜作为减速透镜光学性能最好。研究发现,电极的几何形状对电子束在像面上的电子束直径的最小化和电子束的加速和减速起着重要的作用。使用SIMION8.0和SL Tools程序包进行计算。
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引用次数: 0
A review: Determination of Diclofenac Sodium in Certain Pharmaceutical Preparations by Spectrophotometric and Chromatographic Methods 分光光度法和色谱法测定某些制剂中双氯芬酸钠的研究进展
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178578
N. Khalil, H. Mahmood
Diclofenac is act as analgesic and antipyretic drug, known as voltarol, voltarine, dicloflex, and many other known brand names, formulated mainly as capsules and tablets, or as gel and suppositories. Spectrophotometric methods for determination of diclofenac were based on oxidation-reduction reaction or on complex -formation reactions, as well as determination based on UV - derivatives detection, first or second order. Many HPLC-methods for determination of DFC have been published, these methods use different dimensions C 18 columns and different compositions of mobile phases, acetonitrile is one of the major components of mobile phase because it offers a suitable polarity and viscosity, few procedures use the internal standard, while many of the selected review articles involve detection by UV-detector. Many other determination methods have been published, this review concern on the spectrophotometric and chromatographic methods. The aim of the review is to offer these reported methods to analysts to be in use for quality control of the dosage forms, and to use the selected procedures for new work to determine other related compounds.
双氯芬酸是一种镇痛和解热药物,被称为伏他罗、伏他林、双氯福和许多其他已知的品牌,主要制成胶囊和片剂,或凝胶和栓剂。分光光度法测定双氯芬酸的方法主要是基于氧化还原反应或络合生成反应,以及基于一阶或二阶紫外衍生物检测的测定方法。许多hplc测定DFC的方法已经发表,这些方法使用不同尺寸的c18柱和不同的流动相组成,乙腈是流动相的主要成分之一,因为它提供了合适的极性和粘度,很少使用内标,而许多选择的综述文章涉及到紫外检测器的检测。许多其他的测定方法已经发表,本文综述了分光光度法和色谱法。本综述的目的是将这些方法提供给分析人员用于剂型的质量控制,并将选定的方法用于新的工作,以确定其他相关化合物。
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引用次数: 0
The Protective Effect of Grape Seed Oil on some Fertility Parameters in Male White Rats (Rattus norvegicus) Treated with Tamsulosin 葡萄籽油对坦索罗辛处理的褐家鼠(Rattus norvegicus)若干生育指标的保护作用
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178580
Yazdan Qaro, Waad S. Shaher
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引用次数: 0
Modified Optical Properties of Arsenic Selenide Thin Film at Low Temperatures 硒化砷薄膜在低温下的光学性质
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178576
Maher Abdullah
With the simultaneous thermal spraying of glassy arsenic selenide (As 2 Se 3 ), a significant influence of the introduced Indium (In) and Selenium (Se) on the films' structural and photovoltaic properties was established. The glassy As 2 Se 3 and In or Se were deposited simultaneously at up to 60 nm/s on cooled substrates at different temperatures ranging from 70 to -50 °C, layers with a thickness of 0.5 to 1 m in a vacuum 10-3 Pa. Films produced on low-temperature substrates result in structural modifications that can be utilized for lithography and electrically active defects. The energy necessary for the As 2 Se 3 annealing technique, according to the results, is equal to 0.57 eV of high-temperature energy. When Se is supplied at a temperature of -50 °C, we saw that the photocurrent increases at low temperatures. The image is minimally affected by Se increases greater than 7%. The solubility time of the non-irradiated segment is 5 seconds, the rest layer dissolves in 12 seconds, and the thickness of the rest layer is above 75%.
通过同时热喷涂玻璃化硒化砷(As 2 Se 3),确定了引入铟(In)和硒(Se)对薄膜结构和光伏性能的显著影响。在10-3 Pa的真空条件下,在70 ~ -50°C的不同温度下,以高达60 nm/s的速度同时沉积了As 2 Se 3和In或Se,层厚为0.5 ~ 1 m。在低温衬底上生产的薄膜导致结构修改,可用于光刻和电活性缺陷。结果表明,as2se3退火技术所需的能量为0.57 eV的高温能量。当Se在-50°C的温度下供电时,我们看到光电流在低温时增加。Se增加大于7%对图像影响最小。未辐照段溶解度时间为5秒,休息层溶解度为12秒,休息层厚度在75%以上。
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引用次数: 0
Assessment Biochemical Parameters Role in Women with Polycystic Ovary Syndrome (PCOS) in Nineveh Governorate 评价生化指标在尼尼微省多囊卵巢综合征(PCOS)妇女中的作用
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178579
K. Aldulaimy, M. Jankeer
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in female reproductive age, it is associated with metabolic disorder, oxidative stress and infertility. This study amid to show the effect of PCOS and obesity on a number of biochemical parameters in serum of 70 patients which age ranged (15-45) years attending Al-khansa hospital and private laboratories in Nineveh governorate They were diagnosed as PCOS by gynecologists, obstetricians and infertility doctors, 50 of healthy female with the same ages of patient were used as a control group for comparison. The results showed significant increase (P≤0.01) in concentration of Glucose, Insulin, Insulin resistance HOMA-IR, Triglyceride, Cholesterol, Low density lipoprotein LDL, very low-density lipoprotein VLDL, with non-significant decrease in High density lipoprotein HDL compared to control group. When comparing the previously mentioned parameters in serum of obese PCOS (BMI>30) with non-obese PCOS (BMI<30) we found significant increase (P≤0.05) in these parameters in obese more than in non-obese patient.
多囊卵巢综合征(PCOS)是育龄女性最常见的内分泌疾病之一,与代谢紊乱、氧化应激和不孕症有关。本研究旨在探讨在尼尼微省Al-khansa医院和私人实验室就诊的70例(15-45岁)经妇科、产科和不孕不育医生诊断为多囊卵巢综合征(PCOS)的患者和肥胖对血清多项生化指标的影响,并选取50例与患者年龄相同的健康女性作为对照组。结果显示,与对照组相比,葡萄糖、胰岛素、胰岛素抵抗HOMA-IR、甘油三酯、胆固醇、低密度脂蛋白LDL、极低密度脂蛋白VLDL浓度显著升高(P≤0.01),高密度脂蛋白HDL浓度无显著降低。肥胖型PCOS (BMI>30)患者与非肥胖型PCOS (BMI<30)患者的血清上述参数比较,肥胖患者上述参数明显高于非肥胖患者(P≤0.05)。
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引用次数: 0
Detection of Heat Resulting from Determining the Concentrations of some Radionuclides for Different Samples of Natural Water in Nineveh Governorate, Iraq 对伊拉克尼尼微省不同天然水样品中某些放射性核素浓度测定所产生的热的探测
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178581
Danya al sofy, F. Al-jomaily, A. El-Taher
The current study included the determination of the Heat Production Rate (HPR) resulting from the decay of radioactive elements ( 238 U, 232 Th, and 40 k) after determining their concentrations using the technique of collecting gamma ray’s spectrum by means of the sodium iodide detector NaI (TI). The importance of determining the heat production rate, because it has a profound effect on the surface of the earth’s crust, especially in the conditions of desertification that have swept the globe in the last two decades. To achieve the objective of the study, 30 samples of natural water were collected. These samples varied between rainwater, dams, groundwater and pure tap water to natural spring water. The results showed that the concentrations of uranium ( 238 U) ranged between 0.161-0.006 ppm and thorium ( 232 Th) concentrations between (0.462-0.110 ppm), in addition to the potassium ( 40 k) concentration between (0.23-0.023%). These values showed radioactivity levels below the safe and standard limits set by the UNSCEAR Committee. While the results showed for the heat production rate values ranged between (0.0223-0.0091), which indicates a low heat production rate that does not affect the temperature of the earth's crust within the limits of the sample sites that this study included. The results of the current study can be used to provide basic data for future epidemiological investigations and monitoring programs. In the areas under study
目前的研究包括利用碘化钠探测器NaI (TI)收集伽马射线能谱的技术确定放射性元素(238 U, 232 Th和40 k)的浓度后,确定其衰变产生的产热率(HPR)。确定产热率的重要性,因为它对地壳表面有深远的影响,特别是在过去二十年席卷全球的沙漠化情况下。为了达到研究目的,采集了30个天然水体样本。这些样本从雨水、水坝、地下水、纯自来水到天然泉水不等。结果表明,铀(238 U)浓度在0.161 ~ 0.006 ppm之间,钍(232 Th)浓度在0.462 ~ 0.110 ppm之间,钾(40 k)浓度在0.23 ~ 0.023%之间。这些数值表明放射性水平低于辐射科委会规定的安全和标准限度。而结果显示,产热率值在(0.0223-0.0091)之间,这表明在本研究所包括的样品点范围内,低产热率不影响地壳温度。本研究结果可为今后的流行病学调查和监测提供基础数据。在研究的领域
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引用次数: 0
An Active Inductor Based Transimpedance Amplifier with Two Local Feedbacks as a Fiber Optic Application 基于有源电感的双局部反馈跨阻放大器在光纤中的应用
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178574
Ruwaida Al-Berwari, Muhammed Hameed Alsheikhjader
An important use of active inductor feedback is reported. It was evident that a frequency dependent impedance of an active inductor is similar to that of an ordinary spiral inductor which is a key advantage in integrated circuit design given the fact that Mosfet-based active inductor circuit occupies less volume on board a chip. In this work, a 42 dBΩ transimpedance (TIA) gain at 1 GHz is obtained with 33 𝑝𝐴 ⁄√ 𝐻𝑧 of input referred noise with a very low power consumption of 0.605 mW. The Common-Gate Common-Source input stage with an active inductor feedback is reported in this work for the first-time long side a second stage current mirror with additional local active inductor feedback. The extremely low level of power consumption is considered to be another key advantage for that matter despite the moderate levels of TIA gain, bandwidth and input-referred noise current spectral density with 1V DC supply voltage. The LTspice software was used for simulation.
报道了有源电感反馈的一个重要用途。很明显,有源电感的频率依赖阻抗类似于普通螺旋电感,这是集成电路设计中的一个关键优势,因为基于mosfet的有源电感电路在芯片上占用的体积较小。在这项工作中,在1 GHz时获得42 dBΩ跨阻(TIA)增益,输入参考噪声为33𝑝/ / /𝐻/ /,功耗极低,为0.605 mW。在本工作中,报告了具有有源电感反馈的共门共源输入级,用于具有附加本地有源电感反馈的第二级电流镜的第一次长侧。极低的功耗水平被认为是另一个关键优势,尽管在1V直流电源电压下,TIA增益、带宽和输入参考噪声电流谱密度水平适中。采用LTspice软件进行仿真。
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引用次数: 0
Effect of Diffuseness Parameter on the Fusion Cross-Section of Closed-Shell Nuclei 扩散参数对闭壳核聚变截面的影响
Pub Date : 2023-06-01 DOI: 10.33899/rjs.2023.178575
Bilal Othman, Adil Hussein, A. Taqi
Heavy-ion fusion reactions are important and essential to express the dynamical properties of colliding nuclei, and to address the tunneling effect in quantum mechanics. In the fusion process, the ion-ion potential plays an important role in approaching the measured cross section with the experimental value by influencing the tunneling probability of interacting nuclei. In this work, the fusion cross-sections of closed-shell heavy-ion fusion systems have been calculated and analyzed in the framework of coupled channel theory, using the code CCFULL, by fixing the potential depth value = 102.9 MeV and the fusion radius = 1.096 , while, the diffuseness parameter of Wood--Saxon potential is varied from 0.6 to 1.1 to fitting the fusion cross-section data at energies near and below the Coulomb barrier. It was observed that our approach is able to estimating the experimentally observed cross-sections of closed-shell colliding nuclei.
在量子力学中,重离子聚变反应对于表达碰撞核的动力学性质和解决隧道效应是至关重要的。在聚变过程中,离子-离子势通过影响相互作用核的隧穿概率,使测量截面与实验值接近。本文在耦合通道理论的框架下,利用CCFULL程序,将势深定为102.9 MeV,聚变半径为1.096,Wood—Saxon势的扩散参数在0.6 ~ 1.1之间变化,计算和分析了闭壳重离子聚变系统的聚变截面,以拟合库仑势垒附近和以下能量处的聚变截面数据。结果表明,我们的方法能够估计实验观察到的闭壳核碰撞截面。
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引用次数: 0
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Rafidain journal of science
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