Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300118
Y. Nara, H. Sugino, T. Arakawa, Y. Shirasaki, T. Funatsu, S. Shoji
High through-put parallel biomolecules sorter was fabricated with the three dimensional PDMS stack structure. Three dimensional channel structure was realized by using PDMS dry etching. High speed switching of 10 ms order in each channel was realized with four and eight parallel type sorter. Sorting rate is about 20 samples/sec in the case of the four parallel type sorter. High through-put sorting of about 20 times higher than that of the previous single channel sorter was obtained in actual E. coli cells separation.
{"title":"High Through-Put Parallel Biomolecules Sorting Microsystem with Three Dimensional PDMS Stack","authors":"Y. Nara, H. Sugino, T. Arakawa, Y. Shirasaki, T. Funatsu, S. Shoji","doi":"10.1109/SENSOR.2007.4300118","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300118","url":null,"abstract":"High through-put parallel biomolecules sorter was fabricated with the three dimensional PDMS stack structure. Three dimensional channel structure was realized by using PDMS dry etching. High speed switching of 10 ms order in each channel was realized with four and eight parallel type sorter. Sorting rate is about 20 samples/sec in the case of the four parallel type sorter. High through-put sorting of about 20 times higher than that of the previous single channel sorter was obtained in actual E. coli cells separation.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"46 1","pages":"257-260"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91366034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300168
D. Chiu
This paper highlights some of the recent developments in our lab, where we are developing microfluidic and optical methods for the generation and manipulation of single picoliter and femtoliter- volume aqueous droplets. These droplets can be used for a wide range of applications, such as to confine spatially single-molecule reactions for single-organelle and single-cell studies.
{"title":"Aqueous Droplets as Single-Molecule Reaction Containers","authors":"D. Chiu","doi":"10.1109/SENSOR.2007.4300168","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300168","url":null,"abstract":"This paper highlights some of the recent developments in our lab, where we are developing microfluidic and optical methods for the generation and manipulation of single picoliter and femtoliter- volume aqueous droplets. These droplets can be used for a wide range of applications, such as to confine spatially single-molecule reactions for single-organelle and single-cell studies.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"2010 1","pages":"465-468"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89875833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300496
Sungyoung Choi, J. Park
We report a new separation method of microscopic particles with hydrophoresis - the movement of suspended particles under the influence of a microstructure-induced pressure field. By exploiting slanted obstacles in a microchannel, we can generate a lateral pressure gradient so that microparticles can be deflected and arranged along the pressure gradient. The hydrophoretic method for high-resolution particle separation was successfully applied to discriminate microbeads with a diameter difference of- 7.3% and to separate blood plasma.
{"title":"Hydrophoresis: A New -Phoretic Method for High-Resolution Particle Separation","authors":"Sungyoung Choi, J. Park","doi":"10.1109/SENSOR.2007.4300496","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300496","url":null,"abstract":"We report a new separation method of microscopic particles with hydrophoresis - the movement of suspended particles under the influence of a microstructure-induced pressure field. By exploiting slanted obstacles in a microchannel, we can generate a lateral pressure gradient so that microparticles can be deflected and arranged along the pressure gradient. The hydrophoretic method for high-resolution particle separation was successfully applied to discriminate microbeads with a diameter difference of- 7.3% and to separate blood plasma.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"93 1","pages":"1769-1772"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73553767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300228
G. J. Shah, E. Pierstorff, D. Ho, C. Kim
This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demonstrate the technique on an EWOD device. We also show specific, localized concentration of a target protein over antibody- conjugated MBs ("MB-Abs") as proof of concept.
{"title":"Meniscus-Assisted Magnetic Bead Trapping on Ewod-Based Digital Microfluidics for Specific Protein Localization","authors":"G. J. Shah, E. Pierstorff, D. Ho, C. Kim","doi":"10.1109/SENSOR.2007.4300228","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300228","url":null,"abstract":"This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demonstrate the technique on an EWOD device. We also show specific, localized concentration of a target protein over antibody- conjugated MBs (\"MB-Abs\") as proof of concept.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"22 1","pages":"707-710"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75038937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300226
K. Kwon, Sang Ho Lee, Byungkyu Kim, Min Cheol Park, P. Kim, K. Suh
A simple, label-free microfluidic separation of cancer cells by exploiting difference in cell adhesion. To maximize the adhesion difference, three types of polymeric nanostructures (50 nm pillars, 50 nm perpendicular and parallel lines with respect to the direction of flow) were fabricated using UV- assisted capillary moulding onto glass substrate of PDMS microfluidic channel. The adhesion force of human breast epithelial cells (MCF10A) and human breast carcinoma (MCF7) was measured independently by injecting each cell line into the microfluidic device followed by culture for a period of time (e.g., one, two, and three hours). Then, the cells bound to the floor of a microfluidic channel were detached by increasing the flow rate of medium in a stepwise fashion. The adhesion force of MCF10A was always higher than that of MCF cells regardless of culture time and surface nanotopography at all flow rates, resulting in a label-free separation of cancer cells. For the cell types used in our study, the optimum separation was found for 2 hours culture on 50 nm parallel line pattern followed by flow-induced detachment at a flow rate of 300 mul/min
{"title":"Label-Free, Microfluidic Separation of Human Breast Carcinoma and Epithelial Cells by Adhesion Difference","authors":"K. Kwon, Sang Ho Lee, Byungkyu Kim, Min Cheol Park, P. Kim, K. Suh","doi":"10.1109/SENSOR.2007.4300226","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300226","url":null,"abstract":"A simple, label-free microfluidic separation of cancer cells by exploiting difference in cell adhesion. To maximize the adhesion difference, three types of polymeric nanostructures (50 nm pillars, 50 nm perpendicular and parallel lines with respect to the direction of flow) were fabricated using UV- assisted capillary moulding onto glass substrate of PDMS microfluidic channel. The adhesion force of human breast epithelial cells (MCF10A) and human breast carcinoma (MCF7) was measured independently by injecting each cell line into the microfluidic device followed by culture for a period of time (e.g., one, two, and three hours). Then, the cells bound to the floor of a microfluidic channel were detached by increasing the flow rate of medium in a stepwise fashion. The adhesion force of MCF10A was always higher than that of MCF cells regardless of culture time and surface nanotopography at all flow rates, resulting in a label-free separation of cancer cells. For the cell types used in our study, the optimum separation was found for 2 hours culture on 50 nm parallel line pattern followed by flow-induced detachment at a flow rate of 300 mul/min","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"148 1","pages":"699-702"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77918462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300265
Seung-Ro Lee, T. Hizawa, K. Sawada, H. Takao, M. Ishida
The charge transfer type blood glucose sensor (CTTGS) has been proposed. The CTTGS is an accumulation method H+ ion (gluconic acid) perception system. As compared to cyclic-voltammetry and ISFET, the performance was found to be excellent with span and range of 1445 mV and 200 mmol/L respectively. The sensitivity obtained for blood glucose level of the person was 29.06 mV/mmol with a non-linear error of 1%, which is acceptable for clinical application.
{"title":"High Performance Blood Glucose Sensor using Charge Transfer Technique","authors":"Seung-Ro Lee, T. Hizawa, K. Sawada, H. Takao, M. Ishida","doi":"10.1109/SENSOR.2007.4300265","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300265","url":null,"abstract":"The charge transfer type blood glucose sensor (CTTGS) has been proposed. The CTTGS is an accumulation method H+ ion (gluconic acid) perception system. As compared to cyclic-voltammetry and ISFET, the performance was found to be excellent with span and range of 1445 mV and 200 mmol/L respectively. The sensitivity obtained for blood glucose level of the person was 29.06 mV/mmol with a non-linear error of 1%, which is acceptable for clinical application.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"3 1","pages":"855-858"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78295991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300451
Kai-Uwe Roscher, W. Fischer, J. Landgraf, G. Pfeifer, E. Starke
The integration of sensor networks into textile-reinforced composites enables monitoring of different physical values like strain, acceleration and temperature in a component. This paper presents a system concept of a modular sensor network supporting different sensor types and the wireless transmission of stored measurements. Sensor and transponder ASICs have been developed for realizing first demonstration examples. The feasibility of integration of discrete components and silicon chips was successfully verified in experiments with a composite made of glass fibers and polypropylene. Two demonstrators with fully functional integrated modules were fabricated in order to show the possibility of integrated strain monitoring and recording of impact events with wireless data transmission.
{"title":"Sensor Networks for Integration into Textile-Reinforced Composites","authors":"Kai-Uwe Roscher, W. Fischer, J. Landgraf, G. Pfeifer, E. Starke","doi":"10.1109/SENSOR.2007.4300451","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300451","url":null,"abstract":"The integration of sensor networks into textile-reinforced composites enables monitoring of different physical values like strain, acceleration and temperature in a component. This paper presents a system concept of a modular sensor network supporting different sensor types and the wireless transmission of stored measurements. Sensor and transponder ASICs have been developed for realizing first demonstration examples. The feasibility of integration of discrete components and silicon chips was successfully verified in experiments with a composite made of glass fibers and polypropylene. Two demonstrators with fully functional integrated modules were fabricated in order to show the possibility of integrated strain monitoring and recording of impact events with wireless data transmission.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"62 1","pages":"1589-1592"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78319091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300073
A. M. Sodagar, G. E. Perlin, Ying Yao, K. Wise, K. Najafi
This paper reports a 64-channel microsystem for chronic neural recording. The system scans all the channels simultaneously, detects any neural spikes, and reports their occurrence wirelessly to the external world. Any one of the selected channels can also be digitized and read out wirelessly to allow inspection of the full analog waveform. The neural signals are amplified with 60 dB of gain, a programmable bandwidth, and an 8 muVrms input-referred noise level before being processed digitally. For a 2 MHz clock, the channel scan rate for spike detection is 62.5 kS/Sec and the total system power dissipation at 1.8 V is 14.4 mW. The implantable version of the microsystem weighs 275 mg and measures 1.4 cm times 1.55 cm.
{"title":"An Implantable Microsystem for Wireless Multi-Channel Cortical Recording","authors":"A. M. Sodagar, G. E. Perlin, Ying Yao, K. Wise, K. Najafi","doi":"10.1109/SENSOR.2007.4300073","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300073","url":null,"abstract":"This paper reports a 64-channel microsystem for chronic neural recording. The system scans all the channels simultaneously, detects any neural spikes, and reports their occurrence wirelessly to the external world. Any one of the selected channels can also be digitized and read out wirelessly to allow inspection of the full analog waveform. The neural signals are amplified with 60 dB of gain, a programmable bandwidth, and an 8 muVrms input-referred noise level before being processed digitally. For a 2 MHz clock, the channel scan rate for spike detection is 62.5 kS/Sec and the total system power dissipation at 1.8 V is 14.4 mW. The implantable version of the microsystem weighs 275 mg and measures 1.4 cm times 1.55 cm.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"12 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76329797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300578
Yen-Wen Lu, Po-Ting Lin, C. Pai
A methodology characterizing the strength of PDMS bonding has been proposed. This method employs a blister test to measure and a line force model to describe the bonding strength. The blister test provides us a close approximation to the bonding failure modes under field-used situations. The line force model is a general means to study the bonding strength. A series of the blister tests on PDMS samples have been conducted. The effects of sample size and structured surface on the bonding strength have been examined.
{"title":"Polydimethylsiloxane (PDMS) Bonding Strength Characterization by a Line Force Model in Blister Tests","authors":"Yen-Wen Lu, Po-Ting Lin, C. Pai","doi":"10.1109/SENSOR.2007.4300578","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300578","url":null,"abstract":"A methodology characterizing the strength of PDMS bonding has been proposed. This method employs a blister test to measure and a line force model to describe the bonding strength. The blister test provides us a close approximation to the bonding failure modes under field-used situations. The line force model is a general means to study the bonding strength. A series of the blister tests on PDMS samples have been conducted. The effects of sample size and structured surface on the bonding strength have been examined.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"349 1","pages":"2095-2098"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74832295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-06-10DOI: 10.1109/SENSOR.2007.4300161
H. Mizuno, H. Nagai, K. Sasaki, H. Hosaka, C. Sugimoto, K. Khalil, S. Tatsuta
We developed a wearable sensor system for human behavior recognition. It can distinguish users' behaviors such as walking, running, standing, eating, talking, and desk working. The system consists of foot pressure sensing shoes, motion sensing watch, Sound sensing glasses, pen-shaped ceiling sensor and Indoor/outdoor positioning mobile phones. These sensors are all connected by wireless communication.
{"title":"Wearable Sensor System for Human Behavior Recognition (First Report: Basic Architecture and Behavior Prediction Method)","authors":"H. Mizuno, H. Nagai, K. Sasaki, H. Hosaka, C. Sugimoto, K. Khalil, S. Tatsuta","doi":"10.1109/SENSOR.2007.4300161","DOIUrl":"https://doi.org/10.1109/SENSOR.2007.4300161","url":null,"abstract":"We developed a wearable sensor system for human behavior recognition. It can distinguish users' behaviors such as walking, running, standing, eating, talking, and desk working. The system consists of foot pressure sensing shoes, motion sensing watch, Sound sensing glasses, pen-shaped ceiling sensor and Indoor/outdoor positioning mobile phones. These sensors are all connected by wireless communication.","PeriodicalId":23295,"journal":{"name":"TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference","volume":"22 1","pages":"435-438"},"PeriodicalIF":0.0,"publicationDate":"2007-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74606371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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