NK911 is the first successful polymeric micelle system directed to remarkable accumulation in solid tumor through 5PR affect. The micelle consists of block copolymer of polyethylene glycol (PEG) and poly (aspartic acid) partially conjugated doxorubicin. The main objectives of this phase I study were to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and the recommended dose (RD) for phase II given every 3 weeks as a 10 mg DXR equivalent/min iv infusion to patients with solid tumors. Dose escalation is based on the accelerated titration method followed by a modified Fibonacci method. The starting dose was 6.0 mg/m2 (1/10 of rat LD10). No intrapatient dose escalation was allowed.
{"title":"Basic Aspects and Clinical Trials of Micelle Carrier System","authors":"Y. Matsumura","doi":"10.1109/ICMENS.2004.38","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.38","url":null,"abstract":"NK911 is the first successful polymeric micelle system directed to remarkable accumulation in solid tumor through 5PR affect. The micelle consists of block copolymer of polyethylene glycol (PEG) and poly (aspartic acid) partially conjugated doxorubicin. The main objectives of this phase I study were to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and the recommended dose (RD) for phase II given every 3 weeks as a 10 mg DXR equivalent/min iv infusion to patients with solid tumors. Dose escalation is based on the accelerated titration method followed by a modified Fibonacci method. The starting dose was 6.0 mg/m2 (1/10 of rat LD10). No intrapatient dose escalation was allowed.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132653795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We study the effect of functionalization of Carbon Nanotubes (CNTs) with a primary monoclonal mouse immunoglobin G (IgG) specific to the cell-surface receptors of breast cancer cells, and secondary polyclonal goat ant- mouse IgG. The CNTs, in solution with a surfactant (sodium dodecyl benzene sulfonate) were labeled with dihexyloxacarbocyanine iodide (DiOC6), a fluorescent dye, in order to view them with fluorescently labeled antibodies through confocal microscopy. Co-localization for CNTs in combination with the primary antibody conjugated to the secondary was determined to be 90%, whereas CNTs in combination with the secondary antibody and polyethylene glycol (PEG), a polymer used to block CNTs from proteins binding to their surface, was found to be very minimal (0.5%). Preliminary studies on the electrical measurements of the primary mouse IgG incubated with CNTs show a decrease in conductance compared to that of bare CNT field effect transistors (CNTFETs). This observed change in conductance, can eventually be amplified and utilized in applications leading to a full-fledged breast cancer detection system in the future.
{"title":"Functionalization of Carbon Nanotubes with Antibodies for Breast Cancer Detection Applications","authors":"R. Sirdeshmukh, K. Teker, B. Panchapakesan","doi":"10.1109/ICMENS.2004.74","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.74","url":null,"abstract":"We study the effect of functionalization of Carbon Nanotubes (CNTs) with a primary monoclonal mouse immunoglobin G (IgG) specific to the cell-surface receptors of breast cancer cells, and secondary polyclonal goat ant- mouse IgG. The CNTs, in solution with a surfactant (sodium dodecyl benzene sulfonate) were labeled with dihexyloxacarbocyanine iodide (DiOC6), a fluorescent dye, in order to view them with fluorescently labeled antibodies through confocal microscopy. Co-localization for CNTs in combination with the primary antibody conjugated to the secondary was determined to be 90%, whereas CNTs in combination with the secondary antibody and polyethylene glycol (PEG), a polymer used to block CNTs from proteins binding to their surface, was found to be very minimal (0.5%). Preliminary studies on the electrical measurements of the primary mouse IgG incubated with CNTs show a decrease in conductance compared to that of bare CNT field effect transistors (CNTFETs). This observed change in conductance, can eventually be amplified and utilized in applications leading to a full-fledged breast cancer detection system in the future.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134533172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The interaction of nanosecond laser pulses in the ultraviolet wavelength range with the semiconductor SiC was investigated. Under low energy fluence, an array of highly orientated nanoparticles on the surface of SiC was formed via defect activation and coulomb explosion using 355 nm UV laser irradiation. Under high energy fluence, surface modification and ablation could occur.
{"title":"Nanopillar Formation via Defect Activation and Coulomb Explosion Initiated by a 355 nm Nd:YAG Laser Beam","authors":"Yujie Han, Y. Furukawa","doi":"10.1109/ICMENS.2004.110","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.110","url":null,"abstract":"The interaction of nanosecond laser pulses in the ultraviolet wavelength range with the semiconductor SiC was investigated. Under low energy fluence, an array of highly orientated nanoparticles on the surface of SiC was formed via defect activation and coulomb explosion using 355 nm UV laser irradiation. Under high energy fluence, surface modification and ablation could occur.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133510983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
After the September 11 events, both the governments and industries have illustrated the importance of transportation security as well as cargo security. The September 11 terrorists hijacked the commercial passenger aircrafts to attack to World Trade Center Towers in New York City and Pentagon Building near Washington D.C. These attacks remind the public of how transportation security establishments directly affect the national security. Today more than 85% of cargo entering the United States is coming in the standard ocean containers. It is now essential to ensure these containers are well monitored and inspected along the way as they arrive in the U.S. ports so no mass destruction materials are smuggling into this country. In the wake of the container security initiative (CSI), the Electronic Container Seal (E-Seal) and Radio Frequency Identification (RFID) technology are introduced. In this paper, the basic technical features of RFID systems are described and linked to the practical applications. This paper will also determine how the technologies perform in the real-world operational environments and evaluate the various trade-offs that exist with e-seal design and the potential impact of those trade-offs on functionality, reliability, utility, and cost.
{"title":"The Role of Electronic Container Seal (E-Seal) with RFID Technology in the Container Security Initiatives","authors":"Le-Pong Chin, Chia-Lin Wu","doi":"10.1109/ICMENS.2004.142","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.142","url":null,"abstract":"After the September 11 events, both the governments and industries have illustrated the importance of transportation security as well as cargo security. The September 11 terrorists hijacked the commercial passenger aircrafts to attack to World Trade Center Towers in New York City and Pentagon Building near Washington D.C. These attacks remind the public of how transportation security establishments directly affect the national security. Today more than 85% of cargo entering the United States is coming in the standard ocean containers. It is now essential to ensure these containers are well monitored and inspected along the way as they arrive in the U.S. ports so no mass destruction materials are smuggling into this country. In the wake of the container security initiative (CSI), the Electronic Container Seal (E-Seal) and Radio Frequency Identification (RFID) technology are introduced. In this paper, the basic technical features of RFID systems are described and linked to the practical applications. This paper will also determine how the technologies perform in the real-world operational environments and evaluate the various trade-offs that exist with e-seal design and the potential impact of those trade-offs on functionality, reliability, utility, and cost.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129467377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper defines a finite element modeling protocol developed on a reported fabricated hydrogel structures inside a microfluidic channel for the purpose of fluid control. The modeling was done using ANSYS 8.0 Multiphysics software. A reported convergence of polymerization time to Young’s modulus E was used. The modeling was done to verify the reported convergence.
{"title":"Finite Element Modeling of a Hydrogel Micro-Valve for Fluid Control inside Microfluidic Channels","authors":"A. Ibrahim, W. Moussa","doi":"10.1109/ICMENS.2004.69","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.69","url":null,"abstract":"This paper defines a finite element modeling protocol developed on a reported fabricated hydrogel structures inside a microfluidic channel for the purpose of fluid control. The modeling was done using ANSYS 8.0 Multiphysics software. A reported convergence of polymerization time to Young’s modulus E was used. The modeling was done to verify the reported convergence.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133509100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-08-25DOI: 10.1109/ICMENS.2004.1508906
Jingmin Han, Xiaodong Wang, D. Kwok
Self-Assembled Monolayers (SAMs) derived from the adsorption of organothiols onto gold have been extensively investigated for studying their potential applications to Micro- and Nanofluidics system. However, nearly all applications rely on SAMs' stability. Because high energy gold is easy to absorb organic contaminant from ambient, totally wetting gold surface can not be obtained in the laboratory environment. Flame annealing the gold surface before adsorption not only remove the organic contaminant, it also shaves the "rolling hills" on the evaporated gold surface. SAMs formed on annealed gold surface have better structure and stability than those formed on evaporated gold. These properties will be helpful for potential application on microfluidics system as a surface modification. Ex situ spectroscopic ellipsometry, and Fourier Transform Infrared (FTIR) were used to characterize the structure of SAMs.
{"title":"Structure and Stability of Self-Assembled Monolayers for Octadecanethiol Adsorbed onto Flame-Annealed Gold Substrate and Its Potential Application to Microfluidics","authors":"Jingmin Han, Xiaodong Wang, D. Kwok","doi":"10.1109/ICMENS.2004.1508906","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.1508906","url":null,"abstract":"Self-Assembled Monolayers (SAMs) derived from the adsorption of organothiols onto gold have been extensively investigated for studying their potential applications to Micro- and Nanofluidics system. However, nearly all applications rely on SAMs' stability. Because high energy gold is easy to absorb organic contaminant from ambient, totally wetting gold surface can not be obtained in the laboratory environment. Flame annealing the gold surface before adsorption not only remove the organic contaminant, it also shaves the \"rolling hills\" on the evaporated gold surface. SAMs formed on annealed gold surface have better structure and stability than those formed on evaporated gold. These properties will be helpful for potential application on microfluidics system as a surface modification. Ex situ spectroscopic ellipsometry, and Fourier Transform Infrared (FTIR) were used to characterize the structure of SAMs.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116126317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Existing commercially available long range piezoelectric actuators have limited load carrying capacity due to the fact that frictions are used as the load bearing mechanism. In order to improve the load carry capacity for long range piezoelectric actuators with nanometer resolutions, a novel design that employs the self-lock concept has been reported. In this paper, we study the input-output displacement relations for this new design. In particular, we investigate the losses of the actuator displacement due to elastic deformations when a large force is applied. For a given load, a minimum value exists for the stroke command to ensure a non-zero output displacement. A positioning strategy was proposed to achieve a nanometer scale positioning process in a long distance. Experimental results were also given to support the analysis.
{"title":"Modeling and Experiments of Input-Output Displacement Relations for a Piezoelectric Nanopositioner","authors":"Lin Wu, Qiao Sun","doi":"10.1109/ICMENS.2004.96","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.96","url":null,"abstract":"Existing commercially available long range piezoelectric actuators have limited load carrying capacity due to the fact that frictions are used as the load bearing mechanism. In order to improve the load carry capacity for long range piezoelectric actuators with nanometer resolutions, a novel design that employs the self-lock concept has been reported. In this paper, we study the input-output displacement relations for this new design. In particular, we investigate the losses of the actuator displacement due to elastic deformations when a large force is applied. For a given load, a minimum value exists for the stroke command to ensure a non-zero output displacement. A positioning strategy was proposed to achieve a nanometer scale positioning process in a long distance. Experimental results were also given to support the analysis.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121064594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-08-25DOI: 10.1109/ICMENS.2004.1509013
Z. Shervani, Y. Ikushima, Juncheng Liu
We have developed new water-in-CO₂ microemulsions under supercritical conditions of CO₂ bulk phase. Using fluorinated AOT surfactants and hydrogenated n-butanol as a cosurfactant, microemulsion solutions were obtained which could dissolve large amount of water as large as W₀=49 at 35°C. Where W₀ is the molar ratio of water-to-surfactant. Using varieties of surfactants and amount of cosurfactant, the composition of microemulsion has been established which gives capabilities to prepare different size nanomaterials in the range of 3 to 10 nm depending on the size of the core of microemulsion droplets. Size of the nanomaterials can be controlled with narrow size distribution by adjusting the W₀ values of microemulsion solution. In this presentation, I shall describe the preparation of water-in-CO₂ microemulsions as a function of water content, pressure of CO₂, surfactant concentration, and amount of cosurfactant added. The new CO₂ microemulsions will replace the existing conventional media used for preparation of nanomaterials until now because of non-toxic, cheap, easily recyclable bulk phase CO₂ used in these solutions at moderately low temperature of 35°C.
{"title":"Development of ‘Green and Clean’ Reaction Media for Inorganic and Organic Nanomaterials","authors":"Z. Shervani, Y. Ikushima, Juncheng Liu","doi":"10.1109/ICMENS.2004.1509013","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.1509013","url":null,"abstract":"We have developed new water-in-CO₂ microemulsions under supercritical conditions of CO₂ bulk phase. Using fluorinated AOT surfactants and hydrogenated n-butanol as a cosurfactant, microemulsion solutions were obtained which could dissolve large amount of water as large as W₀=49 at 35°C. Where W₀ is the molar ratio of water-to-surfactant. Using varieties of surfactants and amount of cosurfactant, the composition of microemulsion has been established which gives capabilities to prepare different size nanomaterials in the range of 3 to 10 nm depending on the size of the core of microemulsion droplets. Size of the nanomaterials can be controlled with narrow size distribution by adjusting the W₀ values of microemulsion solution. In this presentation, I shall describe the preparation of water-in-CO₂ microemulsions as a function of water content, pressure of CO₂, surfactant concentration, and amount of cosurfactant added. The new CO₂ microemulsions will replace the existing conventional media used for preparation of nanomaterials until now because of non-toxic, cheap, easily recyclable bulk phase CO₂ used in these solutions at moderately low temperature of 35°C.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124491880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper addresses the fundamentals of RF switches providing a comparison between semiconductor and RF MEMS switches. The basis of comparison is introduced by defining a figure of merit that is a function of the off-state capacitance and the on-state resistance. A simple transmission line model is presented to illustrate the impact of the switch off-state capacitance on the switch isolation and frequency range of operation. The figure of merit analysis given in this paper demonstrates that RF MEMS switches have superior insertion loss and isolation performance in comparison to MESFET and p-i-n diode switches. The paper also addresses several other design considerations beside insertion loss and isolation for selecting the right RF switch. A discussion is given on the potential use of RF MEMS switches in satellite and wireless applications.
{"title":"A Comparison between RF MEMS Switches and Semiconductor Switches","authors":"P. Grant, M. Denhoff, R. Mansour","doi":"10.1109/ICMENS.2004.10","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.10","url":null,"abstract":"This paper addresses the fundamentals of RF switches providing a comparison between semiconductor and RF MEMS switches. The basis of comparison is introduced by defining a figure of merit that is a function of the off-state capacitance and the on-state resistance. A simple transmission line model is presented to illustrate the impact of the switch off-state capacitance on the switch isolation and frequency range of operation. The figure of merit analysis given in this paper demonstrates that RF MEMS switches have superior insertion loss and isolation performance in comparison to MESFET and p-i-n diode switches. The paper also addresses several other design considerations beside insertion loss and isolation for selecting the right RF switch. A discussion is given on the potential use of RF MEMS switches in satellite and wireless applications.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121030902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiuqin Chen, Shaoming Yang, M. Hasegawa, K. Takeuchi, K. Kawabe, S. Motojima
The carbon microcoils (CMC) with a high elasticity and coiling-chirality was prepared by the Ni catalyzed pyrolysis of acetylene containing a small amount of H2S. The morphology and their mechanical and electrical properties, especially tactile sensing properties, were examined. It was found that superelastic CMC, which could be extended and contracted to more than 15 times of the original coil length, could be obtained by controlling the reaction conditions. The extension of CMC was very high sensitive for applied load, and could be detected very low applied load of milligram orders. The electrical resistivity (R) of the CMC increased with the extension and decreased with the contraction. Inductance (L) and capacitance (C) of CMC/polysilicone composites extensively changed with the extension and contraction of the composite under various touching modes, such as pressing, picking, stretching, etc. It was supposed that these tactile sensing properties were affected by novel LCR composite hybrid resonance.
{"title":"Novel Tactile Sensors Manufactured by Carbon Microcoils","authors":"Xiuqin Chen, Shaoming Yang, M. Hasegawa, K. Takeuchi, K. Kawabe, S. Motojima","doi":"10.1109/ICMENS.2004.117","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.117","url":null,"abstract":"The carbon microcoils (CMC) with a high elasticity and coiling-chirality was prepared by the Ni catalyzed pyrolysis of acetylene containing a small amount of H2S. The morphology and their mechanical and electrical properties, especially tactile sensing properties, were examined. It was found that superelastic CMC, which could be extended and contracted to more than 15 times of the original coil length, could be obtained by controlling the reaction conditions. The extension of CMC was very high sensitive for applied load, and could be detected very low applied load of milligram orders. The electrical resistivity (R) of the CMC increased with the extension and decreased with the contraction. Inductance (L) and capacitance (C) of CMC/polysilicone composites extensively changed with the extension and contraction of the composite under various touching modes, such as pressing, picking, stretching, etc. It was supposed that these tactile sensing properties were affected by novel LCR composite hybrid resonance.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114272314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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