Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-86-88
G. Danilova, A. Klinnikova, N. Aleksandrova
At the present time very little is known about interactions between systemic inflammation and control of respiration. The aim of this study was to compare the respiratory effects of the main inflammatory cytokine TNF - α before and after pretreatment with diclofenac, a nonspecific cyclooxygenase (COX) inhibitor. In experiments on anesthetized, tracheostomized rats, pneumotachometry method was used to measure peak airflow and respiratory rate. The ventilatory response to hypoxia was investigated by the rebreathing method. It is shown that an increase in the systemic level of TNF – α causes a significant increase in the minute volume of respiration, tidal volume, the average speed of the inspiratory flow. In contrast the slope of the hypoxic ventilatory response decreased after administration of TNF-α. Diclofenac pretreatment eliminated these respiratory effects of TNF - α. The data indicate that the ability of TNF - α to enhance basal ventilation and to reduce the ventilatory hypoxic response is mediated by the cyclooxygenase pathway. Key words: tumor necrosis factor – α, hypoxia, prostaglandins, peripheral chemoreception, respiration.
{"title":"The role of prostaglandins in the realization of respiratory effects of TNF-α in case of hypoxia","authors":"G. Danilova, A. Klinnikova, N. Aleksandrova","doi":"10.34014/mpphe.2021-86-88","DOIUrl":"https://doi.org/10.34014/mpphe.2021-86-88","url":null,"abstract":"At the present time very little is known about interactions between systemic inflammation and control of respiration. The aim of this study was to compare the respiratory effects of the main inflammatory cytokine TNF - α before and after pretreatment with diclofenac, a nonspecific cyclooxygenase (COX) inhibitor. \u0000In experiments on anesthetized, tracheostomized rats, pneumotachometry method was used to measure peak airflow and respiratory rate. The ventilatory response to hypoxia was investigated by the rebreathing method. It is shown that an increase in the systemic level of TNF – α causes a significant increase in the minute volume of respiration, tidal volume, the average speed of the inspiratory flow. In contrast the slope of the hypoxic ventilatory response decreased after administration of TNF-α. Diclofenac pretreatment eliminated these respiratory effects of TNF - α. The data indicate that the ability of TNF - α to enhance basal ventilation and to reduce the ventilatory hypoxic response is mediated by the cyclooxygenase pathway. \u0000Key words: tumor necrosis factor – α, hypoxia, prostaglandins, peripheral chemoreception, respiration.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125458473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-201-203
A. I. Fedorina, O. Gafurov
Migraine is a debilitating neurological disorder that affects approximately 1 billion people worldwide. It is known that migraine is associated with the activity of the trigeminal nerve, therefore, many studies are aimed at studying changes in the activity of the meningeal nerve fibers. It is known that inflammatory processes accompanied by temperature rise are often accompanied by headaches. Therefore, we investigated the effect of temperature increase on trigeminal nerve activity. It turned out that temperature increase leads to a significant increase in the frequency of action potentials in the trigeminal nerve. Key words: migraine, trigeminal nerve, cluster analysis, action potential.
{"title":"The effect of temperature on the activity of the trigeminal nerve in the rat meningeal sheath","authors":"A. I. Fedorina, O. Gafurov","doi":"10.34014/mpphe.2021-201-203","DOIUrl":"https://doi.org/10.34014/mpphe.2021-201-203","url":null,"abstract":"Migraine is a debilitating neurological disorder that affects approximately 1 billion people worldwide. It is known that migraine is associated with the activity of the trigeminal nerve, therefore, many studies are aimed at studying changes in the activity of the meningeal nerve fibers. It is known that inflammatory processes accompanied by temperature rise are often accompanied by headaches. Therefore, we investigated the effect of temperature increase on trigeminal nerve activity. It turned out that temperature increase leads to a significant increase in the frequency of action potentials in the trigeminal nerve. \u0000Key words: migraine, trigeminal nerve, cluster analysis, action potential.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126556095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-57-60
A. P. Vlasov, V. Ryazantsev, T. A. Muratova, M. V. Volkova, N.Yu. Stepanov, I. Mashnin
In order to find informative statically significant laboratory criteria for endotoxicosis in the diagnosis of acute renal injury, a clinical and biochemical study of 40 patients with acute renal injury developed against the background of renal urological and extrarenal surgical pathology was conducted. The results of the study demonstrate pronounced changes in the mechanisms of antioxidant protection that develop in patients with acute renal injury. Deviations from the initial level of the studied criteria are interrelated with many links of pathogenesis, where one of the central links is ischemia of the renal parenchyma. The progression of endogenous intoxication, taking into account the data obtained, confirmed by a decrease in prooxidant protection contributes to the progression of intrarenal changes, aggravating functional changes in renal and extrarenal injuries. Key words: significance of endotoxicosis criteria, acute renal injury, endotoxicosis, serum creatinine, glomerular filtration rate.
{"title":"Prognostic value of endotoxicosis criteria in the diagnosis of acute renal injury","authors":"A. P. Vlasov, V. Ryazantsev, T. A. Muratova, M. V. Volkova, N.Yu. Stepanov, I. Mashnin","doi":"10.34014/mpphe.2021-57-60","DOIUrl":"https://doi.org/10.34014/mpphe.2021-57-60","url":null,"abstract":"In order to find informative statically significant laboratory criteria for endotoxicosis in the diagnosis of acute renal injury, a clinical and biochemical study of 40 patients with acute renal injury developed against the background of renal urological and extrarenal surgical pathology was conducted. The results of the study demonstrate pronounced changes in the mechanisms of antioxidant protection that develop in patients with acute renal injury. Deviations from the initial level of the studied criteria are interrelated with many links of pathogenesis, where one of the central links is ischemia of the renal parenchyma. The progression of endogenous intoxication, taking into account the data obtained, confirmed by a decrease in prooxidant protection contributes to the progression of intrarenal changes, aggravating functional changes in renal and extrarenal injuries. \u0000Key words: significance of endotoxicosis criteria, acute renal injury, endotoxicosis, serum creatinine, glomerular filtration rate.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127572527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-236-239
I. A. Shevnin, O. Ragozin, O. V. Ragozina, N. A. Ilyushchenko, B. Z. Jafarova
Undifferentiated forms of DST are widespread among children living in Khanty-Mansiysk, in connection with which it is relevant to assess the influence of this pathology on the formation of posture in schoolchildren of the North. Determination of the type of posture and the identification of stigmas of dysembryogenesis was carried out in 208 schoolchildren of the city of Khanty-Mansiysk. Posture types were divided into: normal, round, flat and stooped. Participants with the number of stigmas from 0 to 5 were allocated to the comparison group (n = 66), the rest (6 or more) made up the study group (n = 143). A card was entered, including 43 hair dryers. The study found that the incidence of UCTD among children in the Khanty-Mansi Autonomous Okrug-Yugra is noticeably higher than among those living in temperate latitudes and has a negative effect on the formation of posture. Key words: North, posture, physical development, undifferentiated connective tissue dysplasia.
{"title":"he specifics of posture formation among schoolchildren living in the city of Khanty-Mansiysk against the background of undifferentiated connective tissue dysplasia","authors":"I. A. Shevnin, O. Ragozin, O. V. Ragozina, N. A. Ilyushchenko, B. Z. Jafarova","doi":"10.34014/mpphe.2021-236-239","DOIUrl":"https://doi.org/10.34014/mpphe.2021-236-239","url":null,"abstract":"Undifferentiated forms of DST are widespread among children living in Khanty-Mansiysk, in connection with which it is relevant to assess the influence of this pathology on the formation of posture in schoolchildren of the North. Determination of the type of posture and the identification of stigmas of dysembryogenesis was carried out in 208 schoolchildren of the city of Khanty-Mansiysk. Posture types were divided into: normal, round, flat and stooped. Participants with the number of stigmas from 0 to 5 were allocated to the comparison group (n = 66), the rest (6 or more) made up the study group (n = 143). A card was entered, including 43 hair dryers. The study found that the incidence of UCTD among children in the Khanty-Mansi Autonomous Okrug-Yugra is noticeably higher than among those living in temperate latitudes and has a negative effect on the formation of posture. \u0000Key words: North, posture, physical development, undifferentiated connective tissue dysplasia.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114814488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-108-111
A. E. Kim, E. B. Shustov, A. V. Lemeshchenko
In a study on healthy athletes of the track and field profile, it was shown that the hypoxia of physical activity is most fully reflected by the indicator of specific oxygen debt (maximum oxygen debt divided by 1000 J of work performed). When simulating load hypoxia in laboratory animals, direct registration of the arising oxygen debt is technically difficult to implement, and its indirect signs may be a decrease in peripheral blood saturation, excessive tachycardia, and hyperlactatemia of the post-load period. Key words: hypoxia of physical activity, oxygen debt, athletes, laboratory animals, blood lactate, physical activity.
{"title":"Justification of the choice of indicators for assessing load hypoxia in humans and laboratory animals","authors":"A. E. Kim, E. B. Shustov, A. V. Lemeshchenko","doi":"10.34014/mpphe.2021-108-111","DOIUrl":"https://doi.org/10.34014/mpphe.2021-108-111","url":null,"abstract":"In a study on healthy athletes of the track and field profile, it was shown that the hypoxia of physical activity is most fully reflected by the indicator of specific oxygen debt (maximum oxygen debt divided by 1000 J of work performed). When simulating load hypoxia in laboratory animals, direct registration of the arising oxygen debt is technically difficult to implement, and its indirect signs may be a decrease in peripheral blood saturation, excessive tachycardia, and hyperlactatemia of the post-load period. \u0000Key words: hypoxia of physical activity, oxygen debt, athletes, laboratory animals, blood lactate, physical activity.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121521889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-48-51
M.A. Viderker, E. Rassadina
Currently, digitalization affects various sectors of the economy. The state plays a significant role in regulating digitalization. Digital transformation opens up great prospects for the ecology and nature management industry. The main advanced technologies that will allow the industry to reach a qualitatively new level are big data, the Internet of Things and artificial intelligence. The introduction of digital technologies and platform solutions into an integrated environmental monitoring system will allow to quickly carry out integrated collection, processing and analysis of data, forecasting and management decisions on environmental protection issues, and ensure the openness of data and decisions made. Key words: digital technologies, digitalization, digital economy, ecology, nature management, environmental monitoring.
{"title":"Prospects for digitalization of the environmental monitoring system","authors":"M.A. Viderker, E. Rassadina","doi":"10.34014/mpphe.2021-48-51","DOIUrl":"https://doi.org/10.34014/mpphe.2021-48-51","url":null,"abstract":"Currently, digitalization affects various sectors of the economy. The state plays a significant role in regulating digitalization. Digital transformation opens up great prospects for the ecology and nature management industry. The main advanced technologies that will allow the industry to reach a qualitatively new level are big data, the Internet of Things and artificial intelligence. The introduction of digital technologies and platform solutions into an integrated environmental monitoring system will allow to quickly carry out integrated collection, processing and analysis of data, forecasting and management decisions on environmental protection issues, and ensure the openness of data and decisions made. \u0000Key words: digital technologies, digitalization, digital economy, ecology, nature management, environmental monitoring.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116763132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-94-97
N. Ilyushenko, Yu.O. Gainutdinova, Z.B. Eskindyrova, O. V. Ragozina, I. A. Shevnin, B. Z. Jafarova
The article analyzes the data of an anthropometric and somatotypological study of 164 boys and 93 girls of the northern region, different sexual somatotypes with different severity of signs-phenes of undifferentiated connective tissue dysplasia. It was found that 44% of boys and 22% of girls with d, according to sexual somatic differentiation, correspond to the biological sex, 34% of boys and 53% of girls have mild gender dysplasia in the form of mesomorphy, and 19% of boys and 21% of girls have signs of sex inversion. Undifferentiated connective tissue dysplasia affects the severity of morphotypological differences between sexual somatotypes and the appearance of signs of gracialization within them. Key words: northern region, adolescence, sexual dimorphism, undifferentiated connective tissue dysplasia.
{"title":"Sexual dimorphism in the physical development of boys and girls of the northern region with an established dysplastic phenotype","authors":"N. Ilyushenko, Yu.O. Gainutdinova, Z.B. Eskindyrova, O. V. Ragozina, I. A. Shevnin, B. Z. Jafarova","doi":"10.34014/mpphe.2021-94-97","DOIUrl":"https://doi.org/10.34014/mpphe.2021-94-97","url":null,"abstract":"The article analyzes the data of an anthropometric and somatotypological study of 164 boys and 93 girls of the northern region, different sexual somatotypes with different severity of signs-phenes of undifferentiated connective tissue dysplasia. It was found that 44% of boys and 22% of girls with d, according to sexual somatic differentiation, correspond to the biological sex, 34% of boys and 53% of girls have mild gender dysplasia in the form of mesomorphy, and 19% of boys and 21% of girls have signs of sex inversion. Undifferentiated connective tissue dysplasia affects the severity of morphotypological differences between sexual somatotypes and the appearance of signs of gracialization within them. \u0000Key words: northern region, adolescence, sexual dimorphism, undifferentiated connective tissue dysplasia.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129496102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-121-125
A. S. Kuznetsov, Y.Y. Bikbaeva, I.A. Kuznetsov, M.A. Skvortsova, S. Ananiev, D. Pavlov, I. F. Aizatullin, R. Yakupov
The paper presents the data on the use of percutaneous electrical spinal cord stimulation in patients in the acute period of rehabilitation treatment after ischemic stroke. It was revealed that inclusion of percutaneous electrostimulation of the spinal cord into the rehabilitation program improves the quality of motor skills recovery and can be used in the correction of locomotor functions during rehabilitation after ischemic stroke. Key words: ischemic stroke, percutaneous electrical spinal cord stimulation.
{"title":"Physical methods of motor function correction in the acute period of rehabilitation after ischemic stroke","authors":"A. S. Kuznetsov, Y.Y. Bikbaeva, I.A. Kuznetsov, M.A. Skvortsova, S. Ananiev, D. Pavlov, I. F. Aizatullin, R. Yakupov","doi":"10.34014/mpphe.2021-121-125","DOIUrl":"https://doi.org/10.34014/mpphe.2021-121-125","url":null,"abstract":"The paper presents the data on the use of percutaneous electrical spinal cord stimulation in patients in the acute period of rehabilitation treatment after ischemic stroke. It was revealed that inclusion of percutaneous electrostimulation of the spinal cord into the rehabilitation program improves the quality of motor skills recovery and can be used in the correction of locomotor functions during rehabilitation after ischemic stroke. \u0000Key words: ischemic stroke, percutaneous electrical spinal cord stimulation.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129750251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-180-183
E. Slesareva, R.V. Ureneva, S. M. Slesarev, O.V. Lyapeykova
The kidneys autopsy material of persons with arterial hypertension in different duration was examined. Morphometry of the renal corpuscle area and cortical and juxtamedullary nephrons vascular glomeruli was performed. There were 4 groups - a control group (with a normal blood pressure level), and groups with arterial hypertension - the initial stage (group 2), arterial hypertension for 5-10 years (group 3), long-term arterial hypertension - more than 10 years (group 4). It was found that cortical nephrons are distinguished by earlier and more pronounced hyperplasia of the vascular glomerulus, they are more rapidly exposed to sclerosis, which appears in the 5-10th year of the course of the disease. The hyperplasia of the vascular glomerulus components is progressively increasing in juxtaglomerular nephrons, they are less susceptible to sclerosis processes. Key words: arterial hypertension, juxtaglomerular apparatus, juxtamedullary nephrons, vascular glomerulus.
{"title":"The pathomorphology of the renal cortex depending of arterial hypertension duration course","authors":"E. Slesareva, R.V. Ureneva, S. M. Slesarev, O.V. Lyapeykova","doi":"10.34014/mpphe.2021-180-183","DOIUrl":"https://doi.org/10.34014/mpphe.2021-180-183","url":null,"abstract":"The kidneys autopsy material of persons with arterial hypertension in different duration was examined. Morphometry of the renal corpuscle area and cortical and juxtamedullary nephrons vascular glomeruli was performed. There were 4 groups - a control group (with a normal blood pressure level), and groups with arterial hypertension - the initial stage (group 2), arterial hypertension for 5-10 years (group 3), long-term arterial hypertension - more than 10 years (group 4). It was found that cortical nephrons are distinguished by earlier and more pronounced hyperplasia of the vascular glomerulus, they are more rapidly exposed to sclerosis, which appears in the 5-10th year of the course of the disease. The hyperplasia of the vascular glomerulus components is progressively increasing in juxtaglomerular nephrons, they are less susceptible to sclerosis processes. \u0000Key words: arterial hypertension, juxtaglomerular apparatus, juxtamedullary nephrons, vascular glomerulus.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115035589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.34014/mpphe.2021-177-180
S. Svitko, K. Koroleva, G. F. Sitdikova, K. A. Petrova
Nitric oxide (NO) is a gaseous signaling molecule that regulates a number of physiological functions, including its role in the formation of migraine has been established. NO is endogenously produced in the body from L-arginine by NO synthase. The NO donor, nitroglycerin, is a trigger of migraine in humans and is widely used in the modeling of this disease in animals, which suggests the involvement of components of the NO signaling cascade in the pathogenesis of migraine. Based on the results obtained, it was found that an increase in the concentration of both the substrate for the synthesis of NO, L-arginine, and the NO donor, sodium nitroprusside, has a pro-nociceptive effect in the afferents of the trigeminal nerve. In this case, the effect of sodium nitroprusside is associated with the activation of intracellular soluble guanylate cyclase. Key words: nitric oxide, migraine, trigeminal nerve, L-arginine, guanylate cyclase, sodium nitroprusside, nociception.
{"title":"The role of nitric oxide in the regulation of the electrical activity of the trigeminal nerve in the rat","authors":"S. Svitko, K. Koroleva, G. F. Sitdikova, K. A. Petrova","doi":"10.34014/mpphe.2021-177-180","DOIUrl":"https://doi.org/10.34014/mpphe.2021-177-180","url":null,"abstract":"Nitric oxide (NO) is a gaseous signaling molecule that regulates a number of physiological functions, including its role in the formation of migraine has been established. NO is endogenously produced in the body from L-arginine by NO synthase. The NO donor, nitroglycerin, is a trigger of migraine in humans and is widely used in the modeling of this disease in animals, which suggests the involvement of components of the NO signaling cascade in the pathogenesis of migraine. Based on the results obtained, it was found that an increase in the concentration of both the substrate for the synthesis of NO, L-arginine, and the NO donor, sodium nitroprusside, has a pro-nociceptive effect in the afferents of the trigeminal nerve. In this case, the effect of sodium nitroprusside is associated with the activation of intracellular soluble guanylate cyclase. \u0000Key words: nitric oxide, migraine, trigeminal nerve, L-arginine, guanylate cyclase, sodium nitroprusside, nociception.","PeriodicalId":378573,"journal":{"name":"Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127896302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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