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Carbon-coated anodic aluminum oxide: Synthesis, characterization, and applications 碳涂层阳极氧化铝:合成、表征和应用
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-26 DOI: 10.1063/5.0210821
Hongyu Liu, Zheng-Ze Pan, Tetsuji Itoh, Takashi Kyotani, Hirotomo Nishihara
Ordered porous carbon materials with regularly arranged pores and adjustable pore sizes have attracted significant attention due to their versatile applications across various fields. In this context, uniform carbon coating of anodic aluminum oxide (AAO) membranes is an effective approach to fabricating an ordered array of cylindrical carbonaceous nanopores with adjustable pore diameter and length. The resulting carbon-coated AAO (C/AAO) composite exhibits a meticulously ordered array of meso/macropores, devoid of inter-particle pores and resistance, setting it apart from conventional ordered porous carbons with powder forms. The pore dimensions of C/AAO can be precisely controlled over a wide range, and the carbon chemistry can be customized through heteroatom doping and chemical modifications, all without altering the pore structure. These inherent advantages position C/AAO as a highly promising material with broad application prospects. This review article provides a comprehensive overview of the synthesis and characterization of C/AAO and related materials, along with their diverse utilization in the fields of optics, field emission, gas sensing, energy storage, electrocatalyst support, and bionics. Furthermore, an outlook on the C/AAO materials is given at the end, highlighting their potential and associated challenges.
有序多孔碳材料具有规则排列的孔隙和可调节的孔径,因其在各个领域的广泛应用而备受关注。在这种情况下,在阳极氧化铝(AAO)膜上均匀涂碳是制造具有可调孔径和长度的有序圆柱形碳质纳米孔阵列的有效方法。由此获得的碳包覆 AAO(C/AAO)复合材料呈现出细致有序的中孔/宏孔阵列,颗粒间没有孔隙和阻力,使其有别于传统的粉末状有序多孔碳。C/AAO 的孔隙尺寸可以在很大范围内精确控制,而且可以通过杂原子掺杂和化学修饰来定制碳化学成分,所有这些都不会改变孔隙结构。这些固有优势使 C/AAO 成为一种极具潜力的材料,具有广阔的应用前景。这篇综述文章全面概述了 C/AAO 及相关材料的合成和表征,以及它们在光学、场发射、气体传感、能量存储、电催化剂支持和仿生学等领域的多种用途。此外,最后还对 C/AAO 材料进行了展望,强调了它们的潜力和相关挑战。
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引用次数: 0
Design considerations for digital light processing bioprinters 数字光处理生物打印机的设计考虑因素
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-26 DOI: 10.1063/5.0187558
Carlos Ezio Garciamendez-Mijares, Francisco Javier Aguilar, Pavel Hernandez, Xiao Kuang, Mauricio Gonzalez, Vanessa Ortiz, Ricardo A. Riesgo, David S. Rendon Ruiz, Victoria Abril Manjarrez Rivera, Juan Carlos Rodriguez, Francisco Lugo Mestre, Penelope Ceron Castillo, Abraham Perez, Lourdes Monserrat Cruz, Khoon S. Lim, Yu Shrike Zhang
With the rapid development and popularization of additive manufacturing, different technologies, including, but not limited to, extrusion-, droplet-, and vat-photopolymerization-based fabrication techniques, have emerged that have allowed tremendous progress in three-dimensional (3D) printing in the past decades. Bioprinting, typically using living cells and/or biomaterials conformed by different printing modalities, has produced functional tissues. As a subclass of vat-photopolymerization bioprinting, digital light processing (DLP) uses digitally controlled photomasks to selectively solidify liquid photocurable bioinks to construct complex physical objects in a layer-by-layer manner. DLP bioprinting presents unique advantages, including short printing times, relatively low manufacturing costs, and decently high resolutions, allowing users to achieve significant progress in the bioprinting of tissue-like complex structures. Nevertheless, the need to accommodate different materials while bioprinting and improve the printing performance has driven the rapid progress in DLP bioprinters, which requires multiple pieces of knowledge ranging from optics, electronics, software, and materials beyond the biological aspects. This raises the need for a comprehensive review to recapitulate the most important considerations in the design and assembly of DLP bioprinters. This review begins with analyzing unique considerations and specific examples in the hardware, including the resin vat, optical system, and electronics. In the software, the workflow is analyzed, including the parameters to be considered for the control of the bioprinter and the voxelizing/slicing algorithm. In addition, we briefly discuss the material requirements for DLP bioprinting. Then, we provide a section with best practices and maintenance of a do-it-yourself DLP bioprinter. Finally, we highlight the future outlooks of the DLP technology and their critical role in directing the future of bioprinting. The state-of-the-art progress in DLP bioprinter in this review will provide a set of knowledge for innovative DLP bioprinter designs.
随着增材制造技术的快速发展和普及,出现了各种不同的技术,包括但不限于基于挤压、液滴和大桶光聚合的制造技术,这些技术在过去几十年中推动了三维(3D)打印技术的巨大进步。生物打印通常使用活细胞和/或生物材料,并通过不同的打印模式来制作功能性组织。作为大桶光聚合生物打印的一个子类,数字光处理(DLP)利用数字控制的光掩模选择性地固化液态光固化生物墨水,以逐层方式构建复杂的物理对象。DLP 生物打印技术具有独特的优势,包括打印时间短、制造成本相对较低、分辨率相当高,使用户能够在类组织复杂结构的生物打印方面取得重大进展。尽管如此,在生物打印的同时适应不同材料并提高打印性能的需求推动了 DLP 生物打印机的快速发展,而这需要生物学以外的光学、电子学、软件和材料等多方面的知识。因此,有必要对 DLP 生物打印机的设计和组装中最重要的注意事项进行全面回顾。本综述首先分析了硬件方面的独特考虑因素和具体实例,包括树脂槽、光学系统和电子设备。在软件方面,我们分析了工作流程,包括控制生物打印机和体素化/切片算法需要考虑的参数。此外,我们还简要讨论了 DLP 生物打印的材料要求。然后,我们介绍了DLP生物打印机的最佳实践和维护。最后,我们强调了 DLP 技术的未来展望及其在引导生物打印未来发展中的关键作用。本综述中介绍的 DLP 生物打印机的最新进展将为 DLP 生物打印机的创新设计提供一系列知识。
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引用次数: 0
Why is it challenging to improve the thermoelectric properties of n-type Bi2Te3 alloys? 为什么改善 n 型 Bi2Te3 合金的热电特性具有挑战性?
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-25 DOI: 10.1063/5.0205096
Peyala Dharmaiah, Sung-Jin Jung, Jin-Sang Kim, Seong Keun Kim, Seung-Hyub Baek
The successful application of nanotechnologies in enhancing thermoelectric properties of n-type Bi2Te3 alloys remains a formidable challenge, despite significant advancements in their p-type counterparts. The distinctive challenges inherent to n-type materials include the complex relationships between defect structures and electron concentration, and the strong anisotropy of thermoelectric properties. Electrons originate from various defect structures, such as impurity dopants, vacancies, antisite defects, and grain/domain boundaries, which sensitively varies depending on material synthesis processes. Moreover, the pronounced anisotropic nature of thermoelectric properties requires grain alignment along specific crystallographic directions. Therefore, the challenges in achieving high-performance n-type Bi2Te3 alloys lie in the difficulties of independently controlling defect structures (electron concentration), textured microstructures (electron/phonon transport property), and nanofeatures. This review aims to provide a comprehensive understanding of the difficulties and challenges associated with these aspects, and to discuss potential routes for realizing high-performance n-type Bi2Te3 alloys.
尽管在 n 型 Bi2Te3 合金的 p 型材料方面取得了重大进展,但成功应用纳米技术增强其热电特性仍然是一项艰巨的挑战。n 型材料固有的独特挑战包括缺陷结构与电子浓度之间的复杂关系,以及热电特性的强烈各向异性。电子来自各种缺陷结构,如杂质掺杂物、空位、反位元缺陷和晶粒/晶域边界,其敏感性随材料合成工艺的不同而变化。此外,热电特性明显的各向异性要求晶粒沿着特定的晶体学方向排列。因此,实现高性能 n 型 Bi2Te3 合金的挑战在于难以独立控制缺陷结构(电子浓度)、纹理微结构(电子/声子传输特性)和纳米特性。本综述旨在全面了解与这些方面相关的困难和挑战,并探讨实现高性能 n 型 Bi2Te3 合金的潜在途径。
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引用次数: 0
3D printing of bio-inspired porous polymeric solar steam generators for efficient and sustainable desalination 用于高效和可持续海水淡化的生物启发多孔聚合物太阳能蒸汽发生器的三维打印技术
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-23 DOI: 10.1063/5.0200505
Yanbei Hou, Ming Gao, Xueyu Bai, Lihua Zhao, Hejun Du, Kun Zhou
Freshwater scarcity is a pressing issue worldwide, and solar steam generators (SSGs) have emerged as a promising device for seawater desalination, harnessing renewable solar energy to facilitate sustainable water evaporation. The facile fabrication approach for SSG with complex topologies to achieve high water evaporation efficiency remains a challenge. Herein, a MIL-101 (Fe)-derived C@Fe3O4 ink was employed to multi-jet fusion (MJF) printing of polymeric porous SSGs with specific topologies. The optimized porous structure endows the printed SSGs with capillary force, greatly promoting water transport. The tree-like topology enables high water evaporation rates under various simulated solar radiation conditions. A finite element model was built to fully understand the light-to-thermal energy conversion and water evaporation processes. Moreover, the MJF-printed SSGs exhibit self-cleaning properties and can automatically remove accumulated salt on their surfaces, enabling sustainable desalination. During prolonged testing, the water evaporation rate of the SSGs remained relatively stable and reached as high as 1.55 kg m−2 h−1. Additionally, the desalinated water met the standards for direct drinking water. This study presents a state-of-the-art technology for producing efficient SSGs for desalination and introduces a novel method for MJF printing of functional nanocomposites.
淡水匮乏是全球面临的一个紧迫问题,而太阳能蒸汽发生器(SSG)利用可再生太阳能促进可持续的水蒸发,已成为海水淡化的一种前景广阔的设备。如何轻松制造具有复杂拓扑结构的太阳能蒸汽发生器,以实现较高的水蒸发效率,仍然是一项挑战。本文采用 MIL-101 (Fe)衍生的 C@Fe3O4 墨水,通过多喷射融合(MJF)打印出具有特定拓扑结构的聚合物多孔 SSG。优化的多孔结构赋予印刷 SSG 以毛细力,极大地促进了水的传输。树状拓扑结构可在各种模拟太阳辐射条件下实现高水蒸发率。为了全面了解光-热能转换和水蒸发过程,我们建立了一个有限元模型。此外,MJF 印刷 SSG 还具有自清洁特性,能自动清除表面积聚的盐分,从而实现可持续的海水淡化。在长期测试过程中,SSG 的水蒸发率保持相对稳定,高达 1.55 kg m-2 h-1。此外,淡化后的水符合直接饮用水的标准。本研究提出了一种生产用于海水淡化的高效 SSG 的先进技术,并介绍了一种 MJF 印刷功能纳米复合材料的新方法。
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引用次数: 0
Spin-anomalous-Hall unidirectional magnetoresistance in light-metal/ferromagnetic-metal bilayers 轻金属/铁磁性金属双层膜中的自旋反常-霍尔单向磁阻
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-22 DOI: 10.1063/5.0194720
QiKun Huang, Xiaotian Cui, Shun Wang, Ronghuan Xie, Lihui Bai, Yufeng Tian, Qiang Cao, Shishen Yan
Nonreciprocal magnetotransport is one of the central topics in spintronics because of its importance for electrically probing magnetic information. Among numerous electrical probes used to read magnetic orders, unidirectional magnetoresistance (UMR), characterized by sign changes upon reversal of either current or magnetization, is currently a matter of great interest and has been identified in various spin–orbit-coupled bilayer systems composed of an (anti)ferromagnetic layer and a nonmagnetic layer with strong spin Hall effect. A recent theoretical work predicts that a spin-anomalous-Hall (SAH) UMR in those metallic conducting bilayers can originate from the spin-anomalous-Hall effect of the ferromagnetic layer and the structural inversion asymmetry. However, this type of UMR has not been reported experimentally. Here, we give the experimental evidence of spin-anomalous-Hall UMR in the light-metal/ferromagnetic-metal Cu/Co bilayers, where the emergence of net nonequilibrium spin density is attributed to the interfacial spin leakage asymmetry due to the spin memory loss effect at the Cu/Co interface and multiple spin reflections. We also show a highly tunable UMR in the Cu/Co/CuOx trilayer by varying the Cu thickness, which is due to the competition between the orbital Rashba effect in Co/CuOx and the spin-anomalous-Hall effect in Cu/Co. Our work widens the material choice for UMR device applications and provides an alternative approach to detect in-plane magnetization without an external spin polarizer.
非互惠磁传输是自旋电子学的核心课题之一,因为它对电探测磁信息非常重要。在众多用于读取磁序的电探针中,单向磁阻(UMR)是目前备受关注的一个问题,其特征是电流或磁化反向时的符号变化,并已在各种自旋轨道耦合双层系统中被发现,这些系统由一个(反)铁磁层和一个具有强自旋霍尔效应的非磁层组成。最近的一项理论研究预测,这些金属导电双层膜中的自旋反常霍尔(SAH)超导磁共振可能源于铁磁层的自旋反常霍尔效应和结构反转不对称。然而,这种类型的 UMR 还未见实验报道。在这里,我们给出了轻金属/铁磁金属铜/钴双层膜中自旋反常-霍尔 UMR 的实验证据,非平衡自旋净密度的出现归因于铜/钴界面自旋记忆损失效应和多重自旋反射导致的界面自旋泄漏不对称。我们还展示了通过改变铜的厚度在 Cu/Co/CuOx 三层中实现高度可调的 UMR,这是由于 Co/CuOx 中的轨道拉什巴效应和 Cu/Co 中的自旋反常-霍尔效应之间的竞争造成的。我们的研究拓宽了 UMR 器件应用的材料选择范围,并提供了一种无需外部自旋极化器即可检测面内磁化的替代方法。
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引用次数: 0
Glows, arcs, ohmic discharges: An electrode-centered review on discharge modes and the transitions between them 辉光、电弧、欧姆放电:以电极为中心的放电模式及其转换回顾
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-19 DOI: 10.1063/5.0205274
André Anders
Ever since they have been studied, gas discharges have been classified by their visual appearance as well as by their current and voltage levels. Glow and arc discharges are the most prominent and well-known modes of discharges involving electrodes. In a first approximation, they are distinguished by their current and voltage levels, and current–voltage characteristics are a common way to display their relations. In this review, glow discharges are defined by their individual electron emission mechanism such as secondary electron emission by photons and primary ions, and arcs by their respective collective mechanism such as thermionic or explosive electron emission. Emitted electrons are accelerated in the cathode sheath and play an important role in sustaining the discharge plasma. In some cases, however, electron emission is not important for sustaining the plasma, and consequently we have neither a glow nor an arc discharge but a third type of discharge, the ohmic discharge. In part 1 of this review, these relationships are explained for quasi-stationary discharges, culminating with updated graphical presentations of I–V characteristics (Figs. 15 and 16). In part 2, further examples are reviewed to include time-dependent discharges, discharges with electron trapping (hollow cathode, E×B discharges) and active anode effects.
自从对气体放电进行研究以来,就一直根据其视觉外观以及电流和电压水平对其进行分类。辉光放电和电弧放电是涉及电极的最突出、最著名的放电模式。近似而言,它们是根据电流和电压水平来区分的,而电流-电压特性是显示它们之间关系的常用方法。在本综述中,辉光放电是根据其各自的电子发射机制(如光子和原离子的二次电子发射)来定义的,而电弧则是根据其各自的集体机制(如热电子发射或爆炸电子发射)来定义的。发射的电子在阴极鞘中加速,在维持放电等离子体方面发挥着重要作用。但在某些情况下,电子发射对维持等离子体并不重要,因此我们既没有辉光放电,也没有电弧放电,而是第三种放电,即欧姆放电。在本综述的第 1 部分中,我们将解释准稳态放电的这些关系,并以最新的图表形式展示 I-V 特性(图 15 和图 16)。在第 2 部分中,我们将回顾更多的例子,包括随时间变化的放电、电子俘获放电(空心阴极、E×B 放电)和活性阳极效应。
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引用次数: 0
Carbon-based implantable bioelectronics 碳基植入式生物电子学
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-19 DOI: 10.1063/5.0160168
Shan Liu, Xue Li, Li Gan, Sutong Liu, Hongzhi Luo, Xiaoxin Du, Samah A. Loutfy, Hong Tan, Jinhong Guo, Chenzhong Li
Real-time health monitoring and precision treatment are important in the biomedical field. Researchers have focused on unique gadgets with peculiar functions, which have emerged from the merging of electronic components with biological systems. Because implantable bioelectronics can sense bodily information or elicit bodily reactions in living creatures from sites outside the body, they are becoming helpful and promising remedies for a variety of ailments. Carbon materials are more suitable than other materials for the manufacture of implantable medical electronics due to their excellent biocompatibility, fatigue resistance, and low specific gravity. Therefore, carbon materials can apply to a wide range of implantable drug delivery devices, biosensors, therapeutic stimulators, and energy storage and play irreplaceable roles in neurological, cardiovascular, gastrointestinal, and locomotor systems, among others. This review aims to offer researchers insight into carbon-based implantable bioelectronics in the biomedical field. Initially, various types of carbon materials were introduced. Subsequently, it delves into carbon-based implantable bioelectronics from four perspectives: implantable actuators, biosensors, drug delivery systems, and power supplies. Furthermore, we anticipate the future direction and potential applications of carbon-based implantable bioelectronics. Given the evolving field of nanotechnology and bioelectronics, we are optimistic that these devices will foster significant breakthroughs and innovations in the biomedical sector. Ultimately, this review aims to assist researchers in navigating the choices and directions of carbon-based implantable bioelectronics, thereby promoting the advancement of the biomedical field and contributing positively to the health and welfare of humankind.
实时健康监测和精确治疗在生物医学领域非常重要。研究人员重点研究了电子元件与生物系统融合后产生的具有独特功能的小工具。由于植入式生物电子元件可以从体外感知生物体内的信息或引起生物体内的反应,因此正在成为治疗各种疾病的有用且有前景的疗法。碳材料具有良好的生物相容性、抗疲劳性和低比重,因此比其他材料更适合制造植入式医疗电子设备。因此,碳材料可广泛应用于植入式给药装置、生物传感器、治疗刺激器和能量存储,在神经系统、心血管系统、肠胃系统和运动系统等方面发挥着不可替代的作用。本综述旨在让研究人员深入了解生物医学领域的碳基植入式生物电子学。首先介绍了各种类型的碳材料。随后,文章从四个方面深入探讨了碳基植入式生物电子学:植入式致动器、生物传感器、给药系统和电源。此外,我们还展望了碳基植入式生物电子学的未来发展方向和潜在应用。鉴于纳米技术和生物电子学领域的不断发展,我们乐观地认为,这些设备将促进生物医学领域的重大突破和创新。最终,本综述旨在帮助研究人员把握碳基植入式生物电子学的选择和发展方向,从而促进生物医学领域的进步,为人类的健康和福祉做出积极贡献。
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引用次数: 0
Navigating challenges and solutions in quantitative photoacoustic imaging 驾驭定量光声成像的挑战和解决方案
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-16 DOI: 10.1063/5.0202401
Ruochong Zhang, Rabia'tul A'dawiah, Tristan Wen Jie Choo, Xiuting Li, Ghayathri Balasundaram, Yi Qi, Yonggeng Goh, Renzhe Bi, Malini Olivo
Photoacoustic imaging, an emerging modality that seamlessly combines advantages of optical absorption contrast and ultrasound resolution, holds great promise for noninvasive imaging of biological tissues. Its applications span across diverse fields, such as dermatology, oncology, cardiology, and neurology. However, achieving accurate image reconstruction and physiological parameters quantification from raw photoacoustic signals presents a significant challenge. This challenge primarily arises from the inherent heterogeneity of tissues, encompassing variations in optical fluence and acoustic properties. In addition, incomplete information acquired from a limited view also leads to artifacts, image distortions, and reduced spatial resolution. Furthermore, robust spectral unmixing approach is another key step to restore the initial biochemical components' distribution with complex or unknown background absorption. To overcome these hurdles, researchers have proposed numerous state-of-the-art techniques, aiming to improve the accuracy and reliability of quantitative photoacoustic imaging (qPAI) in heterogeneous tissue. This review aims to comprehensively overview recent developments over the past decade, for addressing four main challenges frequently encountered in qPAI: limited-view reconstruction, acoustic heterogeneity, optical fluence fluctuations, and robust spectral unmixing, which serves as a reference for readers seeking to understand the specific challenges and corresponding solutions in this field.
光声成像是一种新兴模式,它完美地结合了光学吸收对比度和超声分辨率的优势,在生物组织的无创成像方面大有可为。它的应用横跨皮肤病学、肿瘤学、心脏病学和神经病学等多个领域。然而,从原始光声信号实现精确的图像重建和生理参数量化是一项重大挑战。这一挑战主要源于组织固有的异质性,包括光通量和声学特性的变化。此外,从有限视角获取的信息不完整也会导致伪影、图像失真和空间分辨率降低。此外,在复杂或未知背景吸收的情况下,要还原初始生化成分的分布,另一个关键步骤是采用稳健的光谱非混合方法。为了克服这些障碍,研究人员提出了许多最先进的技术,旨在提高异质组织中定量光声成像(qPAI)的准确性和可靠性。本综述旨在全面综述过去十年来的最新发展,以解决 qPAI 中经常遇到的四大难题:有限视角重建、声学异质性、光通量波动和稳健光谱非混合,为读者了解该领域的具体难题和相应解决方案提供参考。
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引用次数: 0
Electrode materials and structures in UV photodetectors 紫外光检测器中的电极材料和结构
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-16 DOI: 10.1063/5.0214668
Weixin Ouyang, Mingmin Zhang
Electrodes can be recognized as the bridges between photodetectors (PDs) and outer measurement circuits. The interfacial electric properties between electrodes and sensitive materials would dominate the separation and collection of photo-induced charge carrier, which are recognized as one of the critical factors influencing the photo-detecting performance. In this paper, the electrode materials used in UV PDs are summarized and categorized according to their components. Then, the effects of electrode configurations (such as the contact types, band structure, and electrode structure) on the photoelectric performances of UV PDs are discussed. Varied kinds of specific electrodes such as transparent electrodes, flexible electrodes, and bio-originated electrodes are described. Finally, the perspective of electrodes in UV PDs is presented, which provides guidance for their future development.
电极是光电探测器(PD)与外部测量电路之间的桥梁。电极与敏感材料之间的界面电特性将主导光诱导电荷载流子的分离和收集,这被认为是影响光检测性能的关键因素之一。本文总结了紫外光分光器件中使用的电极材料,并根据其成分进行了分类。然后,讨论了电极配置(如接触类型、带状结构和电极结构)对紫外光分光器件光电性能的影响。还介绍了各种特定电极,如透明电极、柔性电极和生物电极。最后,介绍了紫外光分光器件中电极的前景,为其未来发展提供了指导。
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引用次数: 0
Tailoring lyotropic liquid crystals for skin barrier penetration: Exploring composition and structure–function relationships 为皮肤屏障渗透定制各向同性液晶:探索成分和结构功能关系
IF 15 1区 物理与天体物理 Q1 PHYSICS, APPLIED Pub Date : 2024-07-16 DOI: 10.1063/5.0204909
Sakshi Priya, Vaibhavi Meghraj Desai, Gautam Singhvi
Lyotropic liquid crystals (LLCs) have garnered attention as a promising nanocarrier delivery system for enhancing skin permeation owing to their unique structural properties, such as improved drug loading and controlled drug release and versatility. LLCs are greatly explored for topical drug delivery owing to their strong bio-adhesive nature and structural similarity to the biological membranes when applied topically, which improves skin retention and permeation of the drugs. This review explores the functionality of structural design, especially the optimization of micellar systems, hexagonal and lamellar phases, and bicontinuous cubic and sponge phases, to achieve efficient skin permeation of therapeutic loaded LLCs. Furthermore, customization of surfactant to achieve skin compatibility and permeation is explored along with incorporating molecular modifications, functionalization, and the influence of surfactant hydrophilic–lipophilic balance. Additionally, the review illuminates the impact of LLCs curvature and the engineering of ordered and disordered phases for optimal drug release. Emerging advanced techniques such as surface modification with various ligands, stimuli-responsive LLCs for on-demand drug release, and combination therapies with multifunctional LLCs for synergistic effects that can promote targeted and site-specific drug delivery have also been discussed. The detailed findings have been discussed in this review with appropriate case studies. Challenges and future perspectives in designing and formulating LLCs for skin permeation are addressed to ignite future research. The knowledge and advancements presented in this review pave the way for developing next-generation LLCs-based systems, enabling enhanced permeation through the skin and opening new possibilities in the treatment of various dermatological conditions.
Lyotropic Liquid Crystals(LLCs)具有独特的结构特性,如改善药物负载、控制药物释放和多功能性等,因此作为一种有前途的纳米载体给药系统而备受关注。LLC 具有很强的生物粘附性,在局部应用时与生物膜的结构相似,可改善皮肤对药物的保留和渗透,因此被广泛用于局部给药。本综述探讨了结构设计的功能性,特别是胶束系统、六方相和薄片相以及双连续立方相和海绵相的优化,以实现负载治疗药物的 LLCs 的高效皮肤渗透。此外,还探讨了如何定制表面活性剂以实现皮肤相容性和渗透性,以及分子修饰、功能化和表面活性剂亲水-亲油平衡的影响。此外,综述还阐明了有限责任公司曲率的影响以及有序和无序相的工程设计,以实现最佳的药物释放效果。此外,还讨论了新出现的先进技术,如用各种配体进行表面修饰、按需释放药物的刺激响应型有限责任公司,以及用多功能有限责任公司进行组合疗法以产生协同效应,从而促进靶向和特定部位给药。本综述结合适当的案例研究讨论了详细的研究结果。本综述还探讨了设计和配制皮肤渗透有限责任公司所面临的挑战和未来前景,以推动未来的研究。本综述中介绍的知识和进展为开发基于 LLCs 的下一代系统铺平了道路,从而增强了皮肤渗透性,为治疗各种皮肤病开辟了新的可能性。
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引用次数: 0
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