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Biodegradation of Textile Dyes by Radish Peroxidase (Raphanus sativus L.) Immobilized on Coconut Fiber 萝卜过氧化物酶降解纺织染料的研究固定在椰子纤维上
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2023-01-30 DOI: 10.11648/j.cbe.20220704.11
Kennedy Costa da Conceicao, Patrick Alan Dantas Araujo, Alvaro Silva Lima, Laiza Canielas Krause, Alini Tinoco Fricks, Cleide Mara Farias Soares, Rebeca Yndira Cabrera-Padilla
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引用次数: 0
Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products. 含异腈和炔烃天然产物的生物合成。
IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-06-10 Epub Date: 2022-03-02 DOI: 10.1146/annurev-chembioeng-092120-025140
Antonio Del Rio Flores, Colin C Barber, Maanasa Narayanamoorthy, Di Gu, Yuanbo Shen, Wenjun Zhang

Natural products are a diverse class of biologically produced compounds that participate in fundamental biological processes such as cell signaling, nutrient acquisition, and interference competition. Unique triple-bond functionalities like isonitriles and alkynes often drive bioactivity and may serve as indicators of novel chemical logic and enzymatic machinery. Yet, the biosynthetic underpinnings of these groups remain only partially understood, constraining the opportunity to rationally engineer biomolecules with these functionalities for applications in pharmaceuticals, bioorthogonal chemistry, and other value-added chemical processes. Here, we focus our review on characterized biosynthetic pathways for isonitrile and alkyne functionalities, their bioorthogonal transformations, and prospects for engineering their biosynthetic machinery for biotechnological applications.

天然产物是一类种类繁多的生物化合物,参与细胞信号传递、营养获取和干扰竞争等基本生物过程。异腈和炔烃等独特的三键官能团通常具有生物活性,可作为新型化学逻辑和酶机制的指标。然而,人们对这些官能团的生物合成基础仍然只有部分了解,这限制了合理设计具有这些官能团的生物大分子以应用于制药、生物正交化学和其他增值化学过程的机会。在此,我们将重点回顾异腈和炔烃官能团的特征生物合成途径、它们的生物正交转化,以及将它们的生物合成机制工程化用于生物技术应用的前景。
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引用次数: 0
Transformation of Biopharmaceutical Manufacturing Through Single-Use Technologies: Current State, Remaining Challenges, and Future Development. 通过单用途技术实现生物制药制造的转型:现状、挑战和未来发展。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-06-10 DOI: 10.1146/annurev-chembioeng-092220-030223
Jasmin J. Samaras, M. Micheletti, W. Ding
Single-use technologies have transformed conventional biopharmaceutical manufacturing, and their adoption is increasing rapidly for emerging applications like antibody-drug conjugates and cell and gene therapy products. These disruptive technologies have also had a significant impact during the coronavirus disease 2019 pandemic, helping to advance process development to enable the manufacturing of new monoclonal antibody therapies and vaccines. Single-use systems provide closed plug-and-play solutions and enable process intensification and continuous processing. Several challenges remain, providing opportunities to advance single-use sensors and their integration with single-use systems, to develop novel plastic materials, and to standardize design for interchangeability. Because the industry is changing rapidly, a holistic analysis of the current single-use technologies is required, with a summary of the latest advancements in materials science and the implementation of these technologies in end-to-end bioprocesses.
一次性使用技术已经改变了传统的生物制药生产,并且它们在抗体药物偶联物以及细胞和基因治疗产品等新兴应用中的应用正在迅速增加。在2019年冠状病毒大流行期间,这些颠覆性技术也产生了重大影响,有助于推动工艺开发,使新的单克隆抗体疗法和疫苗得以生产。一次性使用系统提供封闭的即插即用解决方案,并实现过程强化和连续处理。一些挑战仍然存在,为推进一次性传感器及其与一次性系统的集成,开发新型塑料材料以及标准化互换性设计提供了机会。由于行业变化迅速,需要对当前的一次性技术进行全面分析,总结材料科学的最新进展以及这些技术在端到端生物过程中的应用。
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引用次数: 9
Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism. 工程化下一代CAR-T细胞:克服肿瘤缺氧和代谢。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-06-10 DOI: 10.1146/annurev-chembioeng-092120-092914
Tora Gao, Y. Chen
T cells engineered to express chimeric antigen receptors (CARs) have shown remarkable success in treating B-cell malignancies, reflected by multiple US Food and Drug Administration-approved CAR-T cell products currently on the market. However, various obstacles have thus far limited the use of approved products and constrained the efficacy of CAR-T cell therapy against solid tumors. Overcoming these obstacles will necessitate multidimensional CAR-T cell engineering approaches and better understanding of the intricate tumor microenvironment (TME). Key challenges include treatment-related toxicity, antigen escape and heterogeneity, and the highly immunosuppressive profile of the TME. Notably, the hypoxic and nutrient-deprived nature of the TME severely attenuates CAR-T cell fitness and efficacy, highlighting the need for more sophisticated engineering strategies. In this review, we examine recent advances in protein- and cell-engineering strategies to improve CAR-T cell safety and efficacy, with an emphasis on overcoming immunosuppression induced by tumor metabolism and hypoxia.
工程化表达嵌合抗原受体(CARs)的T细胞在治疗B细胞恶性肿瘤方面取得了显著成功,目前市场上多种美国食品和药物管理局批准的CAR-T细胞产品反映了这一点。然而,迄今为止,各种障碍限制了批准产品的使用,并限制了CAR-T细胞治疗实体瘤的疗效。克服这些障碍将需要多维CAR-T细胞工程方法和更好地理解复杂的肿瘤微环境(TME)。关键挑战包括治疗相关毒性、抗原逃逸和异质性,以及TME的高度免疫抑制特征。值得注意的是,TME的缺氧和营养缺乏性质严重削弱了CAR-T细胞的适应性和功效,这突出了对更复杂工程策略的需求。在这篇综述中,我们研究了蛋白质和细胞工程策略的最新进展,以提高CAR-T细胞的安全性和有效性,重点是克服肿瘤代谢和缺氧诱导的免疫抑制。
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引用次数: 10
Liquid-Phase Transmission Electron Microscopy for Reliable In Situ Imaging of Nanomaterials. 用于纳米材料可靠原位成像的液相透射电子显微镜。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-06-10 DOI: 10.1146/annurev-chembioeng-092120-034534
Jongbaek Sung, Yuna Bae, Hayoung Park, Sungsu Kang, Back Kyu Choi, Joodeok Kim, Jungwon Park
Liquid-phase transmission electron microscopy (LPTEM) is a powerful in situ visualization technique for directly characterizing nanomaterials in the liquid state. Despite its successful application in many fields, several challenges remain in achieving more accurate and reliable observations. We present LPTEM in chemical and biological applications, including studies for the morphological transformation and dynamics of nanoparticles, battery systems, catalysis, biomolecules, and organic systems. We describe the possible interactions and effects of the electron beam on specimens during observation and present sample-specific approaches to mitigate and control these electron-beam effects. We provide recent advances in achieving atomic-level resolution for liquid-phase investigation of structures anddynamics. Moreover, we discuss the development of liquid cell platforms and the introduction of machine-learning data processing for quantitative and objective LPTEM analysis.
液相透射电子显微镜(ltem)是一种强大的原位可视化技术,可以直接表征纳米材料的液态。尽管它在许多领域得到了成功的应用,但在获得更准确和可靠的观测结果方面仍然存在一些挑战。我们介绍了LPTEM在化学和生物学上的应用,包括纳米颗粒、电池系统、催化、生物分子和有机系统的形态转化和动力学研究。我们描述了在观察过程中电子束对样品可能的相互作用和影响,并提出了特定样品的方法来减轻和控制这些电子束效应。我们提供了在液相结构和动力学研究中实现原子级分辨率的最新进展。此外,我们还讨论了液细胞平台的发展以及引入定量和客观的LPTEM分析的机器学习数据处理。
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引用次数: 5
Advances in Manufacturing Cardiomyocytes from Human Pluripotent Stem Cells. 人多能干细胞制造心肌细胞的研究进展。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-06-10 DOI: 10.1146/annurev-chembioeng-092120-033922
Martha E Floy, Fathima Shabnam, Aaron D Simmons, Vijesh J Bhute, Gyuhyung Jin, Will A Friedrich, Alexandra B Steinberg, Sean P Palecek

The emergence of human pluripotent stem cell (hPSC) technology over the past two decades has provided a source of normal and diseased human cells for a wide variety of in vitro and in vivo applications. Notably, hPSC-derived cardiomyocytes (hPSC-CMs) are widely used to model human heart development and disease and are in clinical trials for treating heart disease. The success of hPSC-CMs in these applications requires robust, scalable approaches to manufacture large numbers of safe and potent cells. Although significant advances have been made over the past decade in improving the purity and yield of hPSC-CMs and scaling the differentiation process from 2D to 3D, efforts to induce maturation phenotypes during manufacturing have been slow. Process monitoring and closed-loop manufacturing strategies are just being developed. We discuss recent advances in hPSC-CM manufacturing, including differentiation process development and scaling and downstream processes as well as separation and stabilization.

在过去的二十年中,人类多能干细胞(hPSC)技术的出现为各种体外和体内应用提供了正常和患病人类细胞的来源。值得注意的是,hpsc来源的心肌细胞(hPSC-CMs)被广泛用于模拟人类心脏发育和疾病,并在治疗心脏病的临床试验中。hPSC-CMs在这些应用中的成功需要强大的、可扩展的方法来制造大量安全和有效的细胞。尽管在过去十年中,在提高hPSC-CMs的纯度和产量以及将分化过程从2D扩展到3D方面取得了重大进展,但在制造过程中诱导成熟表型的努力进展缓慢。过程监控和闭环制造策略才刚刚发展起来。我们讨论了hPSC-CM制造的最新进展,包括差异化工艺开发和规模化以及下游工艺以及分离和稳定。
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引用次数: 2
Hydrogen Production and Its Applications to Mobility. 氢气生产及其在流动性方面的应用。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-04-13 DOI: 10.1146/annurev-chembioeng-092220-010254
Andrés González-Garay, M. Bui, Diego Freire Ordóñez, Michael High, Adam Oxley, Nadine Moustafa, Paola A Sáenz Cavazos, P. Patrizio, Nixon Sunny, N. M. Dowell, Nilay Shah
Hydrogen has been identified as one of the key elements to bolster longer-term climate neutrality and strategic autonomy for several major countries. Multiple road maps emphasize the need to accelerate deployment across its supply chain and utilization. Being one of the major contributors to global CO2 emissions, the transportation sector finds in hydrogen an appealing alternative to reach sustainable development through either its direct use in fuel cells or further transformation to sustainable fuels. This review summarizes the latest developments in hydrogen use across the major energy-consuming transportation sectors. Rooted in a systems engineering perspective, we present an analysis of the entire hydrogen supply chain across its economic, environmental, and social dimensions. Providing an outlook on the sector, we discuss the challenges hydrogen faces in penetrating the different transportation markets. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 13 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
氢已被确定为支持几个主要国家长期气候中立和战略自主的关键因素之一。多个路线图强调需要加快整个供应链的部署和利用。作为全球二氧化碳排放的主要贡献者之一,运输部门发现氢是一种有吸引力的替代品,可以通过直接用于燃料电池或进一步转化为可持续燃料来实现可持续发展。这篇综述总结了主要能源消耗运输部门氢气使用的最新进展。从系统工程的角度出发,我们对整个氢气供应链的经济、环境和社会维度进行了分析。展望该行业,我们讨论了氢在渗透不同运输市场方面面临的挑战。《化学与生物分子工程年刊》第13卷预计最终在线出版日期为2022年10月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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引用次数: 7
Zeolitic Imidazolate Framework Membranes: Novel Synthesis Methods and Progress Toward Industrial Use. 咪唑酸沸石骨架膜:新的合成方法及工业应用进展。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-04-13 DOI: 10.1146/annurev-chembioeng-092320-120148
Dennis T. Lee, Peter Corkery, Sunghwan Park, Hae‐Kwon Jeong, M. Tsapatsis
In the last decade, zeolitic imidazolate frameworks (ZIFs) have been studied extensively for their potential as selective separation membranes. In this review, we highlight unique structural properties of ZIFs that allow them to achieve certain important separations, like that of propylene from propane, and summarize the state of the art in ZIF thin-film deposition on porous substrates and their modification by postsynthesis treatments. We also review the reported membrane performance for representative membrane synthesis approaches and attempt to rank the synthesis methods with respect to potential for scalability. To compare the dependence of membrane performance on membrane synthesis methods and operating conditions, we map out fluxes and separation factors of selected ZIF-8 membranes for propylene/propane separation. Finally, we provide future directions considering the importance of further improvements in scalability, cost effectiveness, and stable performance under industrially relevant conditions. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 13 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
在过去的十年里,沸石咪唑酸酯骨架(ZIFs)因其作为选择性分离膜的潜力而被广泛研究。在这篇综述中,我们强调了ZIF的独特结构特性,使其能够实现某些重要的分离,如丙烯与丙烷的分离,并总结了ZIF薄膜在多孔基底上沉积及其合成后处理改性的技术现状。我们还回顾了已报道的具有代表性的膜合成方法的膜性能,并试图根据可扩展性的潜力对合成方法进行排名。为了比较膜性能对膜合成方法和操作条件的依赖性,我们绘制了所选ZIF-8膜用于丙烯/丙烷分离的通量和分离因子。最后,考虑到在工业相关条件下进一步提高可扩展性、成本效益和稳定性能的重要性,我们提供了未来的方向。《化学与生物分子工程年刊》第13卷预计最终在线出版日期为2022年10月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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引用次数: 8
Medical 3D Printing: Tools and Techniques, Today and Tomorrow. 医疗3D打印:工具和技术,今天和明天。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-04-06 DOI: 10.1146/annurev-chembioeng-092220-015404
K. Willson, A. Atala
Three-dimensional printing is a still-emerging technology with high impact for the medical community, particularly in the development of tissues for the clinic. Many types of printers are under development, including extrusion, droplet, melt, and light-curing technologies. Herein we discuss the various types of 3D printers and their strengths and weaknesses concerning tissue engineering. Despite the advantages of 3D printing, challenges remain in the development of large, clinically relevant tissues. Advancements in bioink development, printer technology, tissue vascularization, and cellular sourcing/expansion are discussed, alongside future opportunities for the field. Trends regarding in situ printing, personalized medicine, and whole organ development are highlighted. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 13 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
三维打印是一种新兴的技术,对医学界有很大的影响,特别是在临床组织的开发方面。许多类型的打印机正在开发中,包括挤出、液滴、熔融和光固化技术。在这里,我们讨论了各种类型的3D打印机和他们的优缺点与组织工程。尽管3D打印具有诸多优势,但在开发大型临床相关组织方面仍存在挑战。讨论了生物墨水开发、打印机技术、组织血管化和细胞来源/扩展的进展,以及该领域未来的机会。强调了原位打印、个性化医疗和整个器官发展的趋势。预计《化学与生物分子工程年度评论》第13卷的最终在线出版日期为2022年10月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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引用次数: 10
Multilevel Mesoscale Complexities in Mesoregimes: Challenges in Chemical and Biochemical Engineering. 中尺度体系中的多级中尺度复杂度:化学和生物化学工程中的挑战。
IF 8.4 2区 工程技术 Q1 CHEMISTRY, APPLIED Pub Date : 2022-04-04 DOI: 10.1146/annurev-chembioeng-092220-115031
Jianhua Chen, Ying Ren, Wenlai Huang, Lin Zhang, Jinghai Li
This review discusses the complex behaviors in diverse chemical and biochemical systems to elucidate their commonalities and thus help develop a mesoscience methodology to address the complexities in even broader topics. This could possibly build a new scientific paradigm for different disciplines and could meanwhile provide effective tools to tackle the big challenges in various fields, thus paving a path toward combining the paradigm shift in science with the breakthrough in technique developments. Starting with our relatively fruitful understanding of chemical systems, the discussion focuses on the relatively pristine but very intriguing biochemical systems. It is recognized that diverse complexities are multilevel in nature, with each level being multiscale and the complexity emerging always at mesoscales in mesoregimes. Relevant advances in theoretical understandings and mathematical tools are summarized as well based on case studies, and the convergence between physics and mathematics is highlighted. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 13 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
这篇综述讨论了不同化学和生物化学系统中的复杂行为,以阐明它们的共性,从而有助于开发一种介观科学方法来解决更广泛主题中的复杂性。这可能为不同学科建立一个新的科学范式,同时为应对各个领域的重大挑战提供有效的工具,从而为科学范式的转变与技术发展的突破相结合铺平道路。从我们对化学系统相对富有成果的理解开始,讨论的重点是相对原始但非常有趣的生物化学系统。人们认识到,不同的复杂性本质上是多层次的,每个层次都是多尺度的,并且复杂性总是在中尺度中的中尺度出现。在案例研究的基础上,总结了理论理解和数学工具的相关进展,并强调了物理学和数学之间的趋同。《化学与生物分子工程年刊》第13卷预计最终在线出版日期为2022年10月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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引用次数: 1
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Annual review of chemical and biomolecular engineering
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