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2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS 2013) : Taipei, Taiwan, 20-24 January 2013. IEEE International Conference on Micro Electro Mechanical Systems (26th : 2013 : Taipei, Taiwan)最新文献

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Magnetic valves with programmable timing capability for fluid control in paper-based microfluidics 具有可编程定时能力的磁阀,用于纸基微流体的流体控制
Philip Zwanenburg, Xiao Li, Xinyu Liu
Multi-step analytical tests such as enzyme-linked immunosorbent assay (ELISA) require delivery of multiple fluids into a reaction zone and counting of incubation time at different steps. This paper presents a new type of paper-based magnetic valves that can count the time and turn on or off a fluidic flow accordingly, enabling timed fluid control in paper-based microfluidics. The timing function of these valves is realized using a paper timing channel with an ionic resistor, which can detect the event of a solution flowing through the resistor and trigger an electromagnet (through a simple circuit) to open or close a paper cantilever valve. Based on this principle, we developed normally-open and normally-closed valves with a timing period up to 30.3±2.1 minutes (sufficient for ELISA on paper-based platforms). Using the normally-open valve, we performed an enzyme-based colorimetric reaction commonly used for signal amplification of ELISAs, which requires a timed delivery of enzyme substrate to a reaction zone. This design adds a new fluid-control component to the tool set for developing paper-based microfluidic devices, and has the potential to improve the user-friendliness of these devices.
多步骤分析测试,如酶联免疫吸附试验(ELISA),需要将多种液体输送到反应区,并在不同步骤上计算孵育时间。本文提出了一种新型的纸基电磁阀,它可以计算时间并相应地打开或关闭流体流动,从而实现纸基微流体的定时控制。这些阀的定时功能是通过带有离子电阻器的纸质定时通道来实现的,该通道可以检测溶液流过电阻器的事件,并触发电磁铁(通过简单的电路)打开或关闭纸质悬臂阀。基于这一原理,我们开发了常开常闭阀,定时时间可达30.3±2.1分钟(足以在纸质平台上进行ELISA)。使用常开阀,我们进行了酶基比色反应,通常用于elisa的信号扩增,这需要将酶底物定时递送到反应区。该设计为开发基于纸张的微流体装置的工具集增加了一个新的流体控制组件,并有可能提高这些装置的用户友好性。
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引用次数: 3
Tactical grade micro gyroscope with dual capcitive/optical sensing 战术级微型陀螺仪,具有双俘获/光学传感
R. Maimon, O. Lahav, Y. Gerson, O. Zohar, H. Berko, S. Krylov
This paper introduces a design, fabrication, integration and characterization, of a novel high-grade single axis tuning fork gyroscope (TFG), based on dual detection techniques - capacitive and optic (DDT-CO). This is the first time that the capacitive and optical sensing approaches are used, for the registering of the in-plane drive and in-plane sense mode responses. The two techniques are combined in the same fully functional vacuum packaged device with integrated electronics. We present the results of the rate-table performance study, and the sensor's main figures of merit. We show that the use of dual sensing significantly simplifies the silicon on insulator (SOI) fabrication process, allowing the achievement of tactical grade performance, including angular random walk (ARW) less than 0.15 °/√hr and in-run bias instability (BI) less than 2 °/hr.
本文介绍了一种基于电容和光学双检测技术(DDT-CO)的新型高档单轴音叉陀螺仪(TFG)的设计、制造、集成和表征。这是第一次使用电容和光学传感方法来记录平面内驱动和面内检测模式响应。这两种技术结合在同一个功能齐全的真空封装设备与集成电子。我们给出了速率表性能研究的结果,以及传感器的主要优点。研究表明,双传感的使用显著简化了绝缘体上硅(SOI)的制造过程,实现了战术级性能,包括角随机漫步(ARW)小于0.15°/√hr,运行中偏置不稳定性(BI)小于2°/hr。
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引用次数: 8
Piezoresistive membrane-type surface stress sensor arranged in arrays for cancer diagnosis through breath analysis 压阻膜式表面应力传感器阵列布置,通过呼吸分析诊断癌症
F. Loizeau, Hans Peter Lang, Terunobu Akiyama, S. Gautsch, P. Vettiger, A. Tonin, Genki Yoshikawa, C. Gerber, N. D. Rooij
We present the fabrication, characterization and successful medical application of a membrane-type surface stress sensor (MSS), arranged in arrays for molecular detection in gaseous phase. Made out of SOI substrate, a round membrane with a diameter of 500 μm and a thickness of 2.5 μm is suspended by four sensing beams with integrated p-type piezoresistors, composing a full Wheatstone bridge. The membrane is coated with a thin polymer layer, which reacts with volatile molecules and produces a deflection of the membrane. The membranes were functionalized with various polymers and characterized as humidity sensors with a sensitivity of 87 mV/%RH and a time constant (Tau63%) of 1.3 s. Finally, through breath analysis and the use of principal component analysis (PCA), we were able, in a double blind trial, to distinguish cancer patients and healthy persons.
我们介绍了一种膜型表面应力传感器(MSS)的制造,表征和成功的医学应用,该传感器排列在阵列中用于气相分子检测。由SOI衬底制成直径为500 μm,厚度为2.5 μm的圆形薄膜,由四个集成p型压敏电阻的传感梁悬挂,构成一个完整的惠斯通电桥。膜上涂有一层薄薄的聚合物层,该聚合物层与挥发性分子反应并产生膜的偏转。该膜被各种聚合物功能化,具有87 mV/%RH的灵敏度和1.3 s的时间常数(Tau63%)的湿度传感器特性。最后,通过呼吸分析和主成分分析(PCA)的使用,我们能够在双盲试验中区分癌症患者和健康人。
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引用次数: 13
Magnetically-actuated variable optical attenuators using ferrofluid-doped elastomer implemented by combination of soft lithography and inkjet printing technologies 结合软光刻和喷墨打印技术实现磁致可变光衰减器
S. de Pedro, V. Cadarso, X. Muñoz‐Berbel, J. Plaza, J. Sort, J. Brugger, S. Buttgenbach, A. Llobera
This paper reports the implementation of magnetic variable optical attenuators (M-VOA) by soft lithography (SLT) and using polydimethylsiloxane (PDMS) as constituent material. Two different fabrication protocols are used and compared. In the first case, a two-layer structure containing a clean PDMS layer on a magnetic PDMS (M-PDMS) layer is fabricated by SLT. M-PDMS is obtained by doping clean PDMS with different ferrofluid (FF) amounts. The second protocol consists of selectively dispensing droplets of FF by the inkjet printing technique (IPT) on a clean and non-cured PDMS structure previously defined by SLT. The optical and mechanical properties of structures fabricated using both protocols and containing similar ferrofluid amounts are compared.
本文报道了以聚二甲基硅氧烷(PDMS)为组成材料,采用软光刻技术(SLT)实现磁性可变光衰减器(M-VOA)。采用并比较了两种不同的制作方案。在第一种情况下,通过SLT制备了两层结构,其中包含磁性PDMS (M-PDMS)层上的清洁PDMS层。M-PDMS是通过掺杂不同铁磁流体(FF)量的纯净PDMS得到的。第二种方案包括通过喷墨打印技术(IPT)在先前由SLT定义的清洁且未固化的PDMS结构上选择性地分配FF液滴。比较了两种方法制备的结构和含有相似铁磁流体量的结构的光学和力学性能。
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引用次数: 4
Development of flexible tactile sensor based on contact resistance of integrated carbon nanotubes 基于集成碳纳米管接触电阻的柔性触觉传感器研制
J. Lee, S. Pyo, M.-O Kim, T. Chung, H. Lee, S.-C Lim, J. Park, J. Kim
We have developed a novel three dimensional tactile sensor based on vertically aligned carbon nanotubes. The carbon nanotubes were directly synthesized on silicon microstructures and these CNTs-on-microstructures were integrated to flexible polydimethylsiloxane layers. Each tactile sensor has four sensing parts and the direction of force can be detected by monitoring the increase or decrease of electrical resistance in each sensing part. High gauge factor up to 272 and fast response less than 10 ms have been experimentally verified from the presented tactile sensor. The deviated contact resistance change from the initial value was less than 3% after repeated force input of 15 mN for 180,000 cycles.
我们开发了一种基于垂直排列碳纳米管的新型三维触觉传感器。在硅微结构上直接合成碳纳米管,并将这些碳纳米管集成到柔性聚二甲基硅氧烷层上。每个触觉传感器有四个传感部分,通过监测每个传感部分电阻的增减来检测力的方向。实验验证了该传感器的测量系数高达272,响应速度小于10 ms。在15 mN的重复力输入18万次后,接触电阻偏差比初始值变化小于3%。
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引用次数: 5
High sensitive 3D tactile sensor with the structure of elastic pyramids on piezoresistive cantilevers 采用压阻悬臂梁弹性金字塔结构的高灵敏度三维触觉传感器
N. Thanh-Vinh, N. Binh-Khiem, K. Matsumoto, I. Shimoyama
We propose a highly sensitive three-dimensional tactile sensor using the structure of elastic micro pyramids pressing on piezoresistive cantilevers. In the structure of the sensor we proposed, the forces acting on the surface of the elastomer were transmitted to the cantilevers through the pyramids. The key point of our sensor was that the cantilevers were not completely embedded inside the elastomer: a cavity under each cantilever enabled the larger deformation and thus the larger resistance change of the cantilever. Therefore the high sensitivity of the sensor could be obtained. Moreover, by using four cantilevers aligned with four pyramids, the three-dimensional force sensor was realized. The sensitivities of our sensor to forces in normal and lateral directions were about 50 times and 2.4 times higher, respectively, compared to those of a tactile sensor with the ultrathin cantilevers embedded inside an elastomer [1].
我们提出了一种高灵敏度的三维触觉传感器,采用弹性微金字塔压在压阻悬臂梁上的结构。在我们提出的传感器结构中,作用在弹性体表面的力通过金字塔传递给悬臂梁。我们的传感器的关键是悬臂梁没有完全嵌入弹性体中:每个悬臂梁下的空腔使得悬臂梁的变形更大,从而使悬臂梁的阻力变化更大。因此,该传感器具有较高的灵敏度。此外,采用四个悬臂梁与四个金字塔对齐,实现了三维力传感器。与在弹性体中嵌入超薄悬臂的触觉传感器相比,我们的传感器对法向和侧向力的灵敏度分别高出约50倍和2.4倍[1]。
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引用次数: 7
A microfabricated paper-based microbial fuel cell 一种微型纸基微生物燃料电池
A. Fraiwan, S. Mukherjee, S. Sundermier, S. Choi
We report a paper-based microbial fuel cell (MFC) generating a maximum power of 5.5 μW/cm2. The MFC features (1) a paper-based proton exchange membrane by infiltrating sulfonated sodium polystyrene sulfonate and (2) micro-fabricated paper chambers by patterning hydrophobic barriers of photoresist. Once a sample was added to the device, a current of 74 μA generated without any startup time. This paper-based MFC has the advantages of ease of use, low production cost, and high portability. The voltage produced was increased by 1.9× when two MFC devices were linked in series while operating lifetime was significantly enhanced in parallel.
我们报道了一种纸基微生物燃料电池(MFC),其最大功率为5.5 μW/cm2。MFC的特点是:(1)渗透磺化聚苯乙烯磺酸钠的纸基质子交换膜和(2)通过光刻胶的疏水屏障图案化的微制造纸室。一旦将样品加入到器件中,无需任何启动时间即可产生74 μA的电流。基于纸张的MFC具有使用方便、生产成本低、便携性高等优点。两个MFC器件串联时产生的电压提高了1.9倍,并联时工作寿命明显延长。
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引用次数: 7
Batch-fabricated MEMS retarding potential analyzer for high-accuracy ion energy measurements 用于高精度离子能量测量的批量制造MEMS延迟电位分析仪
E. Heubel, L. Velásquez-García
We report the design, fabrication, and experimental characterization of a novel fully microfabricated retarding potential analyzer (RPA) with performance better than the state-of-the-art. Our device comprises a set of bulk-micromachined electrode grids with apertures and inter-electrode spacing compatible with high-density plasma measurements; the thick electrodes also make our ion energy sensor more resistant to ablation in harsh environments than previously reported miniaturized RPAs. Our RPA includes a set of microfabricated deflection springs for robust and compliant alignment of the grid apertures across the grid stack, which greatly increases the signal strength and minimizes the ion interception, resulting in a tenfold improvement in peak signal amplitude compared to an RPA with unaligned grids and similar inter-electrode spacing.
我们报告了一种新型的全微制造延迟电位分析仪(RPA)的设计,制造和实验表征,其性能优于最先进的技术。我们的设备包括一组体积微机械电极网格,其孔径和电极间距与高密度等离子体测量兼容;厚电极也使我们的离子能量传感器在恶劣环境下比以前报道的小型化rpa更耐烧蚀。我们的RPA包括一组微加工偏转弹簧,用于在网格堆栈上对网格孔进行稳健和柔性对齐,这大大增加了信号强度并最大限度地减少了离子截获,与未对齐网格和类似电极间距的RPA相比,峰值信号幅度提高了十倍。
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引用次数: 3
Attoliter order droplet formation using nanochannels and enzyme reaction inside a droplet 利用纳米通道和液滴内的酶反应形成四升级液滴
H. Wakioka, S. Yamamoto, K. Tabata, M. Sugiyama
This paper reports a droplet formation device having nanochannels fabricated with femtosecond-laser-assisted etching. With the combination of nanochannels embedded in a substrate and microchannels on the substrate surface, approximately 650 nm diameter water phase liquid droplets (approximately 150 aL in volume) have been produced. In addition, we confirmed that enzyme reaction inside a femtoliter or attoliter droplet was digitally observed by fluorescence for the first time. Such droplets can be used for single-molecule enzymology instead of conventional arrays of femtoliter chambers [1].
本文报道了一种利用飞秒激光辅助蚀刻技术制备的具有纳米通道的液滴形成装置。通过衬底内嵌纳米通道和衬底表面微通道的结合,制备出了直径约650 nm(体积约150 aL)的水相液滴。此外,我们首次证实了用荧光技术对飞升或飞升液滴内的酶反应进行了数字观察。这种液滴可以用于单分子酶学,而不是传统的飞升室阵列[1]。
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引用次数: 1
Single-layer “domino” diodes via optofluidic lithography for ultra-low Reynolds number applications 单层“多米诺骨牌”二极管通过光流光刻超低雷诺数的应用
R. Sochol, C. Glick, K. Lee, T. Brubaker, A. Lu, M. Wah, S. Gao, E. Hicks, K. T. Wolf, K. Iwai, L. P. Lee, L. Lin
Autonomous fluidic components are critical to the advancement of integrated micro/nanofluidic circuitry for lab-on-a-chip applications, such as point-of-care (POC) molecular diagnostics and on-site chemical detection. Previously, a wide range of self-regulating microfluidic components, such as fluidic diodes, have been developed; however, achieving effective functionality at ultra-low Reynolds number (e.g., Re <; 0.05) has remained a significant challenge. To overcome this issue, here we introduce single-layer microfluidic “domino” diodes, which utilize free-standing rotational microstructures - constructed in situ via optofluidic lithography - in order to passively regulate the fluidic resistance based on the flow polarity, thereby enabling flow rectification under ultra-low Re conditions. COMSOL simulation results revealed a theoretical Diodicity (Di) of 31 for a singular domino diode component. Experimental results (for systems with four microstructures) revealed Di's ranging from 13.0±1.9 to 25.4±1.9 corresponding to 0.025 <; Re <; 0.030 and 0.010 <; Re <; 0.015 flow, respectively, which represent the largest Di's reported for Re <; 0.05 fluid flow.
自主流体元件对于集成微/纳米流体电路的进步至关重要,用于芯片上的实验室应用,如护理点(POC)分子诊断和现场化学检测。在此之前,已经开发了各种自调节微流控元件,如流控二极管;然而,在超低雷诺数(例如,Re <;0.05)仍然是一个重大挑战。为了克服这个问题,我们引入了单层微流控“多米诺骨牌”二极管,它利用独立的旋转微结构-通过光流光刻技术原位构建-以被动调节基于流动极性的流体阻力,从而实现超低Re条件下的流动整流。COMSOL仿真结果表明,单个多米诺二极管组件的理论二极管度(Di)为31。实验结果表明(对于具有四种微观结构的体系),Di的范围为13.0±1.9 ~ 25.4±1.9,对应于0.025 <;Re <;0.030和0.010 <;Re <;分别为0.015流量,这代表了Re <;0.05流体流动。
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引用次数: 7
期刊
2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS 2013) : Taipei, Taiwan, 20-24 January 2013. IEEE International Conference on Micro Electro Mechanical Systems (26th : 2013 : Taipei, Taiwan)
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