化学最新文献

{"title":"Potential adoption of electrochemical biosensors for cancer DNA biomarker detection in liquid biopsies: A systematic review","authors":"Anouk Peymen ,&nbsp;Thijs Van der Snickt ,&nbsp;Alejandro Valverde ,&nbsp;Scott Ailliet ,&nbsp;Karen Zwaenepoel ,&nbsp;Pieter Mestdagh ,&nbsp;Karolien De Wael","doi":"10.1016/j.talanta.2026.129488","DOIUrl":"10.1016/j.talanta.2026.129488","url":null,"abstract":"<div><h3>Background</h3><div>The detection of actionable DNA biomarkers in liquid biopsies is essential for advancing precision oncology. While conventional techniques such as PCR and NGS are highly accurate, their high cost, complexity, and slow turnaround time limit widespread clinical applications. Electrochemical biosensors present a promising alternative through their portability, affordability, and rapid analysis capabilities.</div></div><div><h3>Objective</h3><div>This systematic review evaluates the current status and potential clinical adoption of electrochemical biosensors for detecting cancer DNA biomarkers in liquid biopsies, focusing on their sensitivity and specificity compared to standard PCR-based methods.</div></div><div><h3>Methods</h3><div>A comprehensive search across PubMed, Scopus, and Web of Science was conducted up to August 2025, yielding 1723 articles. After applying PRISMA guidelines with strict inclusion and exclusion criteria, 31 studies were selected. The quality of the selected studies was assessed using the SURE checklist. Data on biosensor design, amplification strategies, detection limits, and clinical applicability were extracted.</div></div><div><h3>Results</h3><div>Most biosensors achieved femtomolar to attomolar detection limits (LODs), reaching the required sensitivity limits for germline and somatic mutations respectively These LODs were achieved primarily via signal amplification strategies using redox mediators, nanomaterials, and strand displacement assays. Target amplification was less common and did not demonstrate consistent superiority. Specificity was enhanced through modified probes, enzymatic cleavage, magnetic separation, and blocking agents, though assessment methods varied. In general, covalently immobilized probes improved stability and sensitivity. However, most assays were validated in buffer with synthetic DNA, limiting clinical relevance.</div></div><div><h3>Conclusions</h3><div>With respect to their performance, electrochemical biosensors exhibit considerable potential for clinical integration. In particular when integrating different signal amplification strategies, such as a synergistic approach of redox mediators and nanocomposites, or combining target and signal amplification to reach the required sensitivity limits. Nonetheless, their clinical integration requires evaluation in complex biological samples, more thorough selectivity studies, and rigorous validation on patient samples. When standard validation assays can be provided and performed, electrochemical biosensing assays hold great promise for the detection of cancer DNA biomarkers in liquid biopsies.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"304 ","pages":"Article 129488"},"PeriodicalIF":6.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic bead-assisted extraction combined with ID-LC-MS/MS for simultaneous quantification of fat-soluble vitamins A, D, E, and K in human serum","authors":"Qingqing Pan ,&nbsp;Jing Lin ,&nbsp;Chunlan Tang ,&nbsp;Tao Yu ,&nbsp;Min Shen ,&nbsp;Guangliang Wu ,&nbsp;Huoyan Ji","doi":"10.1016/j.talanta.2026.129520","DOIUrl":"10.1016/j.talanta.2026.129520","url":null,"abstract":"<div><div>This study developed and validated a high-throughput method based on automated magnetic solid-phase extraction (MSPE) with isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) for the simultaneous and accurate quantification of five fat-soluble vitamins (VA, 25(OH)D₃, 25(OH)D₂, VE, and VK₁) in human serum. For the MSPE, a functionalized silica-based magnetic core-shell material was synthesized, featuring a poly (polystyrene-co-divinylbenzene-co-N-vinylpyrrolidone) coating and a covalently immobilized 2-vinylbenzofuran affinity ligand linked via a hydrophilic polyethylene glycol spacer. This design facilitated efficient enrichment and purification of the target analytes. The validated method demonstrated excellent specificity, with complete chromatographic separation, without significant matrix effects or interferences. It exhibited superior sensitivity and linearity, with a satisfactory linear response (<em>R</em>² &gt; 0.995 for all analytes) and a low limit of quantification (0.15 ng/mL-0.49 μg/mL). Recoveries were between 90.48 % and 101.95 %, while precision was satisfactory with intra-day and inter-day coefficients of variation (CV) below 7.14 % and 4.68 %, respectively. The accuracy of the method was further demonstrated by analyzing NIST standard reference material SRM 968f and SRM 972a, with a mean bias within ±7 %. Compared to traditional liquid-liquid extraction (LLE) process, the automated MSPE process efficiently extracted the target analytes from serum within 11 min through systematic optimization. Furthermore, method comparison showed a good agreement between the clinical routine LLE method and the MSPE method established. In addition, the method performed well in external quality assessment schemes, also confirming high accuracy and reliability. This robust methodology provides a powerful analytical tool for the precise monitoring of fat-soluble vitamins and nutritional status assessment in clinical practice and has the potential to promote the development of laboratory automation.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"304 ","pages":"Article 129520"},"PeriodicalIF":6.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometrics-assisted validation of a high-throughput method for quantitative analysis of multiclass phytohormones across plant matrices by UHPLC-QQQ-MS/MS for targeted metabolomics","authors":"Tingting Tong ,&nbsp;Lili He ,&nbsp;Liya Qiao ,&nbsp;Yaqin Zhou ,&nbsp;Jieqiong Li ,&nbsp;Jie Liang ,&nbsp;Jine Fu ,&nbsp;Shugen Wei ,&nbsp;Gaowu Huang ,&nbsp;Xianghua Xia","doi":"10.1016/j.talanta.2026.129541","DOIUrl":"10.1016/j.talanta.2026.129541","url":null,"abstract":"<div><div>The quantification of phytohormones in plant samples is significantly challenging because of their trace concentrations and the complex plant matrix. This study establishes and optimizes a simple and fast method for simultaneous quantification of multiclass phytohormones using ultra high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UHPLC-QQQ-MS) for high-throughput targeted metabolomics analysis. It is characterized by simplicity and operational feasibility, and it involves sequential steps of ultrasound-assisted extraction, centrifugation, and nitrogen flow-drying. The assessment of sample preprocessing method employs the technique for order preference by similarity to an ideal solution (TOPSIS) chemometrics-assisted approach, and methanol containing 1% formic acid was selected as the optimal extraction solvent. Quantitative analysis is performed via a multiple reaction monitoring method. The method was validated satisfactory for 31 phytohormones, the specific concentration levels used to estimate recovery and precision were 0.25–200 ng/mL, and the results showed good linearity (correlation coefficients: 0.9910–0.9999), sensitivity (LOD: 0.01–2.87 ng/g; LOQ: 0.02–8.70 ng/g), accuracy (recovery rates: 64.50–129.67%), precision (relative standard deviations &lt;20%, except for IAA-Trp), and its applicability to a variety species of medicinal plant was verified, including <em>Taxillus chinensis</em> (DC.) Danser, <em>Ophiopogon japonicus</em> (L.f.) Ker-Gawl, <em>Citrus grandis</em> “Tomentosa,” <em>Plumeria rubra L.</em> “Acutifolia,” and <em>Pogostemon cablin</em> (Blanco) Benth. In the real samples analyzed, auxins concentrations exceeded 4.07 μg/g, salicylic acids concentrations ranged from 0.027 to 79.7 μg/g, and concentrations of other categorize of phytohormones were below 1 μg/g. The established method demonstrated high throughput, accuracy, stability, and reliability. It can be extended to cover additional phytohormone types and diverse application scenarios. This method serves as a potent tool for investigating the function of multiclass phytohormones in the regulation of secondary metabolite accumulation in medicinal plants, elucidating complex signal transduction mechanisms and interaction networks, and laying the groundwork for improving the quality of Chinese medicinal materials.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"304 ","pages":"Article 129541"},"PeriodicalIF":6.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular design of donor–acceptor driven AIE active blue–red emitters for organic electronics","authors":"Reshma J. Pandhare,&nbsp;Shruti N. Sonavane,&nbsp;Purav M. Badani,&nbsp;Rajesh M. Kamble","doi":"10.1016/j.jphotochem.2026.117101","DOIUrl":"10.1016/j.jphotochem.2026.117101","url":null,"abstract":"<div><div>A set of seven donor–acceptor (D–A) derivatives were successfully synthesized via palladium-catalyzed Buchwald Hartwig (C − N) coupling amination reaction by systematically varying the donor substituents on the dithieno[2,3-<em>a</em>:3′,2′-<em>c</em>]phenazine core. Their structural modifications were carefully correlated with optoelectronic properties through comprehensive spectroscopic and electrochemical investigations. The absorption profiles showed unique intramolecular charge transfer (ICT) transitions between 445 and 512 nm, while the emission spectra exhibited positive solvatochromism, with blue–red luminescence maxima covered within 474–651 nm. Solid-state photoluminescence studies further confirmed aggregation-induced emission (AIE) behaviour in THF–H₂O mixtures, initiating from nanoaggregate formation, as confirmed by FEG-SEM analysis. Electrochemical measurements provided HOMO and LUMO energy levels in the range of −4.53 to −5.66 eV and − 3.13 to −3.39 eV, respectively. Density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations determined the singlet–triplet energy gaps (ΔE_ST) to fall between 0.008 and 0.81 eV. Importantly, dye <strong>6</strong> exhibited pH-responsive luminescence, which demonstrates its potential for application in optical data encryption. Therefore, the combination of suitable HOMO–LUMO alignment with known bipolar materials, pronounced solid-state emission, and additional functional sensing ability underscores these D–A derivatives as favorable candidates for next-generation solid-state emissive and bipolar charge-transporting materials in organic electronics.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"476 ","pages":"Article 117101"},"PeriodicalIF":4.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIE-active thienopyrimidine derivatives: from photoluminescent and insecticidal agents to carbonized electrodes for energy storage","authors":"Amira Zaki Ebrahim ,&nbsp;Mahmoud S. Tolba ,&nbsp;Ahmed A.K. Mohammed ,&nbsp;Mohamed A. Gad ,&nbsp;Adel M. Kamal El-Dean ,&nbsp;Osama Younis","doi":"10.1016/j.jphotochem.2026.117077","DOIUrl":"10.1016/j.jphotochem.2026.117077","url":null,"abstract":"<div><div>A new series of thienopyrimidines was synthesized and characterized by FT-IR, ¹H/¹³C NMR, and HRMS. Their optical properties were systematically studied in various solvents, as well as in mixed systems to probe aggregation-induced emission (AIE). All compounds exhibited two main absorption bands, assigned to π–π* and intramolecular charge transfer (ICT) transitions, which showed solvent-dependent shifts and moderate solvatochromism. Photoluminescence studies revealed structured emissions in solution and strong AIE responses in DMSO/toluene mixtures, whereas fluorescence quenching occurred in DMSO/water systems, except for compound <strong>7</strong>, which exhibited dual emission at high water fractions. Density functional theory (DFT) calculations clarified the electronic structures and intermolecular interactions, consistent with experimental data. Molecular docking studies revealed strong binding affinities toward nicotinic acetylcholine receptor (nAChR) and cyclin-dependent kinase 2 (CDK2), suggesting potential biological applications. Insecticidal assays against <em>A. gossypii</em> confirmed measurable activity for all compounds, with <strong>2</strong> and <strong>5</strong> displaying the highest toxicity, comparable to that of acetamiprid. To broaden the functional scope, two low-molecular-weight derivatives (<strong>2a</strong> and <strong>7</strong>) were carbonized under argon at 400 °C to produce carbonized materials (C-400-I and C-400-II). Electrochemical characterization by cyclic voltammetry and galvanostatic charge–discharge revealed a predominant capacitive behavior and specific capacitances of up to 7.7 F g⁻¹ at a current density of 0.5 A g⁻¹. The superior performance of C-400-I (40 μL) is attributed to enhanced surface accessibility and ion transport. This multifunctionality arises from the intrinsic heteroatom-rich thienopyrimidine framework, which governs excited-state behavior, biological interactions, and the formation of electrochemically active carbonized materials upon thermal conversion. This work integrates molecular photophysics, bioactivity, and carbonization-based energy storage, positioning AIE-active thienopyrimidine derivatives as multifunctional materials for optical, biological, and electrochemical applications.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"476 ","pages":"Article 117077"},"PeriodicalIF":4.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and performance regulation of TiO2/Bi2O3 photocatalyst with Z-scheme heterojunction","authors":"Xiaojun Wen,&nbsp;Lei Liao,&nbsp;Yi He,&nbsp;Yingrong Jin,&nbsp;Ping Ren,&nbsp;Liang He,&nbsp;Changjie Jiang,&nbsp;Wei Yuan","doi":"10.1016/j.jphotochem.2026.117074","DOIUrl":"10.1016/j.jphotochem.2026.117074","url":null,"abstract":"<div><div>Composite photocatalysts with <em>Z</em>-scheme and S-scheme heterojunctions show promising application potential, yet their synthesis remains challenging due to immature construction techniques. In this study, commercial TiO₂ and calcined Bi₂O₃ were used as raw materials. By regulating the oxygen vacancy concentration on the surfaces of TiO₂ and Bi₂O₃ nanoparticles, and thereby modulating the surface energy levels of the TiO₂ and Bi₂O₃ particles, a TiO₂/Bi₂O₃ composite photocatalyst with a <em>Z</em>-scheme heterojunction was constructed via a hydrothermal method. The results indicate that the metallic bismuth formed during hydrothermal treatment bridges Bi₂O₃ and TiO₂. At a Bi₂O₃-to-TiO₂ mass ratio of 9:100 (sample TB9), the composite catalyst achieves 99.5% degradation of methylene blue and retains excellent stability over five cycles. This work proposes a strategy for constructing heterojunction photocatalysts by modulating surface energy levels, offering a novel approach for developing efficient photocatalytic materials.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"476 ","pages":"Article 117074"},"PeriodicalIF":4.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and enhanced photoluminescence of Eu3+/Sm3+ co-doped CaLa4Ti4O15 red-emitting phosphor for white light-emitting diodes","authors":"Liqiao Pan,&nbsp;Wentao Zhang,&nbsp;Siwei Luo,&nbsp;Xu Zhong,&nbsp;Xinrui Niu","doi":"10.1016/j.jphotochem.2026.117064","DOIUrl":"10.1016/j.jphotochem.2026.117064","url":null,"abstract":"<div><div>A novel perovskite-type CaLa₄Ti₄O₁₅:Eu³⁺, Sm³⁺ red-emitting phosphor was synthesized via the sol-combustion method. The luminescence intensity at 622 nm of CaLa₄Ti₄O₁₅:Eu³⁺, Sm³⁺ phosphor was approximately 1.79 times higher than that of CaLa₄Ti₄O₁₅:Eu³⁺. This was attributed to the energy transfer process between Sm³⁺ and Eu³⁺ ions. Moreover, the color purity of the CaLa₄Ti₄O₁₅:Eu³⁺, Sm³⁺ phosphor reached 94.74%, and the quantum efficiencies were measured as 42.04% (internal) and 30.15% (external), respectively. White light-emitting diodes (<em>w</em>-LEDs) were fabricated by combining the CaLa₄Ti₄O₁₅:Eu³⁺, Sm³⁺ phosphor with commercial blue/green phosphors on an n-UV chip (λ = 395 nm). The <em>w</em>-LEDs exhibited bright white light with a color rendering index of 87.5 and a correlated color temperature of 4700 K. These results indicate that the CaLa₄Ti₄O₁₅:Eu³⁺, Sm³⁺ phosphor has great potential for practical application as the red component in white light-emitting diodes.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"476 ","pages":"Article 117064"},"PeriodicalIF":4.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sensitive pH fluorescent probe with large Stokes shift and narrow transition for lysosome imaging during cell cycle","authors":"Bochao Chen ,&nbsp;Jixiang Zhang ,&nbsp;Yifan Zhong ,&nbsp;Xi Liu ,&nbsp;Ji Xu ,&nbsp;Ningning Cui ,&nbsp;Jin Zhou","doi":"10.1016/j.talanta.2026.129534","DOIUrl":"10.1016/j.talanta.2026.129534","url":null,"abstract":"<div><div>Intracellular pH plays a crucial role in regulating cellular functions, and its subtle changes can influence normal physiological activities and contribute to various diseases. Although numerous probes have been developed for detecting microenvironmental pH in living cells, their broad dynamic ranges induce blurred imaging boundaries and may generate false-positive results, compromising the accurate detection of subtle pH fluctuations. In response to these issues, we designed and synthesized a novel 1,8-naphthalic anhydride-based pH fluorescent probe (<strong>NAM</strong>) that demonstrated highly sensitive responses to pH changes with a narrow transition range spanning just 2.4 pH units. The pH responsiveness of <strong>NAM</strong> originated from the deprotonation of its aniline group, which induced an enhanced intramolecular charge transfer (ICT) process. This mechanism enables <strong>NAM</strong> to exhibit a remarkable 15-fold fluorescence enhancement at 569 nm with a pKa value of 6.71 and a significant Stokes shift of 112 nm. Furthermore, <strong>NAM</strong> specifically targets lysosomes and was successfully employed to detect intracellular pH fluctuations induced by lipopolysaccharide (LPS), nutrient deprivation and chloroquine treatment. Significantly, we demonstrate for the first time that <strong>NAM</strong> achieved pH imaging analysis across different cell cycle phases. During the transition from G0/G1 to S phase, intracellular pH gradually alkalinizes, followed by rapid acidification in the G2/M phase. These observations reflected the dynamic balance between energy storage and consumption during cell cycle progression. These distinctive features position <strong>NAM</strong> as a promising tool for investigating physiological and pathological processes associated with abnormal pH variations.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"304 ","pages":"Article 129534"},"PeriodicalIF":6.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of curcumin encapsulation in amino-β-cyclodextrin: Insights from spectroscopic and molecular dynamic simulation techniques","authors":"Parichat Sutthisawatkul ,&nbsp;Bo Albinsson ,&nbsp;Patchreenart Saparpakorn ,&nbsp;Nonthaphon Plotoon ,&nbsp;Onuma Mongkhon ,&nbsp;Thitinun Karpkird","doi":"10.1016/j.jphotochem.2026.117109","DOIUrl":"10.1016/j.jphotochem.2026.117109","url":null,"abstract":"<div><div>Curcumin (Cur) is a bioactive compound found in turmeric that is and widely used in pharmaceutical applications. However, it has poor water solubility and low chemical stability. In this work, amino-β-cyclodextrin (ACD) was used to form an inclusion complex with curcumin. The photophysical properties of curcumin in the ACD inclusion complex were studied at various pH values. The steady-state absorption spectrum of the Cur: ACD inclusion complex showed a blue shift of the absorption band at 340 nm In addition, ACD enhanced the otherwise weak fluorescence of curcumin in aqueous solutions. Time-resolved fluorescence decay analysis revealed that the excited state consisted of three components which tentatively correspond to the c<em>is</em>-diketo form, the excited-state intramolecular proton transfer (ESIPT) of the keto-enol tautomer and solvent reorganization of curcumin. The average fluorescence lifetime of curcumin increased in the presence of ACD. Molecular dynamic (MD) simulations showed that the amino moiety blocked the narrow rim of ACD, resulting in a difference in the orientation and non-linear extended conjugation of the curcumin molecule when bound to ACD at different pH values. Moreover, the photostability of curcumin was significantly improved upon inclusion complex formation with ACD. These results demonstrated that amino-β-cyclodextrin inclusion enhanced effectively the photophysical and photochemical properties of curcumin.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"476 ","pages":"Article 117109"},"PeriodicalIF":4.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An AIE-active probe for visual detection of H2S and bioimaging application","authors":"Hai-Yan Li ,&nbsp;Ling-Li Cai ,&nbsp;Li-Li Wang ,&nbsp;Wei-Zhen Tang ,&nbsp;Xun-Guang Bian ,&nbsp;Guo-Long Gu ,&nbsp;Yong Nian ,&nbsp;Ying Liu ,&nbsp;Jin Wang","doi":"10.1016/j.jphotochem.2026.117095","DOIUrl":"10.1016/j.jphotochem.2026.117095","url":null,"abstract":"<div><div>Hydrogen sulfide is a vital endogenous gaseous signaling molecule which exerts profound regulatory roles across a broad spectrum of physiological and pathological pathways. Herein, we devised an Aggregation-induced emission (AIE)-active fluorescent probe <strong>S</strong> via facile Schiff base condensation. The schiff base probe <strong>S</strong> exhibits a rapid response and low detection limit of 18 nM for H₂S in aqueous solution. Furthermore, probe <strong>S</strong> exhibits versatile applications in information encryption and bio-imaging.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"476 ","pages":"Article 117095"},"PeriodicalIF":4.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}