Journal of Anesthesia, Analgesia and Critical Care (Online)最新文献

Background: Social media platforms, initially developed for recreational use, have evolved into major sources for disseminating information, including medical information for patients and healthcare providers in many disciplines. This study aimed to evaluate the educational potential of YouTube® videos in teaching tracheal intubation to first-year anesthesiology residents.

Methods: This study was approved by the Ethical Committee of "University Federico II-AORN A. Cardarelli" (protocol no. 00010735). We analyzed the first 10 YouTube videos identified via the search term "tracheal intubation." Each video was evaluated for misinformation and informational completeness via a 5-item Likert scale. After providing written consent, fifty-seven first-year anesthesiology residents watched these videos and completed a 22-item questionnaire before and after viewing. Each correct answer received one point, whereas incorrect answers received 0 points, allowing for comparisons of knowledge acquisition.

Results: The videos exhibited moderate quality (median score, 3; range, 1-5) and low informational completeness (median score, 1.432; range, 1.000-2.046). Residents' scores increased modestly by one point after viewing (from 13 to 14; p < 0.001). Misinformation was positively correlated with the number of followers (beta coefficient: 0.00002, p < 0.001), video duration (beta coefficient: 0.0042, p < 0.05), and linking ratio (beta coefficient: 0.242, p < 0.05). Conversely, informational completeness was inversely correlated with video duration (beta coefficient: - 0.001121, p < 0.05) and the thumbs-up/view ratio (beta coefficient: - 67.4697, p < 0.05).

Conclusions: While YouTube® has potential as an accessible educational tool, current video selection offers limited improvement in residents' understanding of tracheal intubation. Our findings highlight the need for greater curation and better-quality control of medical educational content on YouTube® to optimize its effectiveness and provide accurate information. Institutions could play a key role in producing reliable, guideline-based videos that better support learning objectives in anesthesiology training.

Background: The prevalence of frailty is increasing as the global population continues to age. Frailty is associated with poor perioperative outcomes including increased morbidity and mortality. The purpose of this study is to examine current practices and perspectives of anesthesiogists in Italy on the provision of care for elderly surgical patients with frailty.

Methods: We conducted a national survey. Data were collected via an online questionnaire distributed by the Italian Society of Anaesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Responses were collected over 24 weeks between October 2022 and March 2023.

Results: Seven-hundred thirteen anesthetists completed the survey. A total of 39.8% (277) of respondents were working in university hospitals. Frailty scoring was routinely performed in 51.8% of care settings. Only 26.3% of organizations surveyed had a dedicated pathway for perioperative management of frail elderly patients. The most common method for frailty assessment was the subjective assessment by the anesthesiologist (58.3%). More than half of the participants reported the use of ERAS items in most cases. Almost half of respondents reported the use of postoperative screening tools for delirium (45% of respondents).

Discussion: While these results point to the resistance to clinical implementation of frailty assessment, they also highlight the perceived need for careful management. This can help in identifying elderly patients who may require targeted perioperative management and in ensuring the preservation of cognitive and functional status.

Parvalbumin-positive (PV⁺) interneurons (basket and chandelier cells) regulate the firing rate of pyramidal neurons in the cerebral cortex and play a key role in the generation of network oscillations in the cerebral cortex. A growing body of evidence suggest that cortical PV⁺ interneurons become overactive in chronic pain and contribute to nociceptive sensitization by inhibiting a top-down analgesic pathway. Here, we provide further support to this hypothesis showing that intracortical infusion of the GABA_A receptor antagonist, bicuculline, caused analgesia in a mouse model of chronic inflammatory pain, although it reduced pain thresholds in healthy mice. We propose that mGlu5 metabotropic glutamate receptors and perineuronal nets (PNNs) shape the activity of PV⁺ interneurons in chronic pain, generating a form of maladaptive plasticity that enhances behavioural pain responses. mGlu5 receptors might be locally targeted by drugs activated by light delivered in cortical regions of the pain matrix, whereas the density of PNNs enwrapping PV⁺ interneurons might be reduced by local activation of PNN-degrading enzyme, such as type-9 matrix metalloproteinase. These strategies, which may require invasive treatments, might be beneficial in the management of severe pain which is refractory to conventional pharmacological and non-pharmacological interventions.

Background: Surgery in the Trendelenburg position (TP) with pneumoperitoneum (PP) is beneficial in several aspects but is associated with postoperative complications, such as postoperative nausea and vomiting (PONV). The mechanism behind this is unknown, but an increase in intracranial pressure (ICP) has been suggested. There are several studies of non-invasively estimated ICP during surgery in TP with PP. The association between perioperative estimated ICP and postoperative complications has not yet been reviewed.

Methods: We performed a scoping review of peer-reviewed clinical studies reporting on both perioperative estimation of ICP and postoperative complications in patients undergoing surgery in TP with PP. The literature search was performed in February 2025 on PubMed, CINAHL, and Web of Science.

Results and conclusions: Ten of 12 included studies suggested associations between perioperative elevation of estimated ICP and postoperative complications, most notably PONV. This may have clinical implications since elevated ICP can be treated. Future research should focus on the association between perioperative ICP estimation and postoperative complications and the effects of ICP-lowering strategies on postoperative outcomes.

Background: Intraoperative hypotension (IOH) during non-cardiac surgery is closely associated with postoperative complications. Hypotensive events are more likely during major open vascular surgery. We prospectively investigated whether our institutional algorithm of cardiocirculatory management, which included the Hypotension Prediction Index (HPI), a predictive model of hypotension of the Hemosphere™ platform (Edwards Lifescience, Irwin, CA, USA), was able to reduce the incidence and severity of intraoperative hypotension during open abdominal aortic aneurysm repair.

Methods: A multi-center observational study was conducted at IRCCS-Humanitas Research Hospital (Milan) and AO Mauriziano Umberto I Hospital (Turin) between July 2022 and September 2023, enrolling patients undergoing elective open abdominal aortic aneurysm repair. A hemodynamic protocol based on the Acumen-HPI Hemosphere™ platform was employed, integrating advanced parameters (e.g., HPI, Ea-dyn, dP/dt) and tailored interventions to minimize intraoperative hypotension. The primary endpoint was cumulative intraoperative hypotension time < 10% of surgical time, with secondary endpoints including incidence of hypotensive events, time-weighted averages of MAP < 65 mmHg (TWA65) and < 50 mmHg (TWA50), and postoperative complications.

Results: We enrolled 53 patients submitted to open abdominal aortic repair. The primary endpoint (time in hypotension < 10%) was successfully reached: 5 [1-10] %. The targeted time-weighted average (< 0.40 mmHg) both for MAP < 65 mmHg (TWA65) and MAP < 50 mmHg (severe hypotension; TWA50) were reached: TWA65 = 0.26 [0.04-0.65] mmHg and TWA50 = 0.00 [0.00-0.01].

Conclusions: Our hemodynamic management algorithm based on the HPI and other parameters of the Hemosphere™ platform was able to limit the incidence and severity of intraoperative hypotension during open abdominal aortic repair.

Trial registration: NCT05478564.

Labor analgesia is increasingly widespread throughout the world with a rate ranging from 10 to 60%. The benefits regarding clinical and non-clinical maternal-fetal outcomes are currently discussed in international scientific literature. Even stage of labor needs a different and appropriate approach to control the pain; however, different techniques are reported in literature. The following study intends to give a brief overview of the characteristics of the different neuraxial and non-neuraxial techniques currently available and the non-technical skills necessary for effective assistance to pregnant women, providing insights on the topic to understand critical issues at the same time. After bibliographic research since 2018 to 2023, many randomized controlled trials, literature reviews, systematic reviews, and metanalysis were evaluated to create this brief overview. The following pharmacological and non-pharmacological approaches were assessed: spinal techniques, such as epidural analgesia (EA), combined spinal-epidural (CSE), dural puncture epidural (DPE), and continuous spinal anesthesia (CSA); pharmacological administration of nitrous oxide (N₂O) and systemic opioids (morphine, fentanyl, and pethidine); as the third one transcutaneous electric nerve stimulation (TENS), acupressure/acupuncture, aromatherapy, and breathing exercises. All the assessed approaches are relatively safe and effective, but the association of technical and non-technical skills is needed to improve the maternal and fetus outcome. More studies are needed to clarify what is the best approach to labor analgesia.

Background: Neuromuscular blocking agents (NMBAs) are routinely used in anesthesia practice. An undetected, incomplete recovery of neuromuscular function at the end of surgery potentially exposes patients to clinical deterioration in the postoperative period. The aim of this study was to investigate the incidence of postoperative residual neuromuscular blockade (RNMB) in a cohort of patients receiving NMBAs.

Methods: We enrolled 90 spontaneously breathing adult patients admitted to the recovery room (RR) after completion of surgeries having received at least 1 dose of NMBA. Anesthesia management, the dosage of NMBA used, and whether monitoring of neuromonitoring function was employed or if a reversal agent was administered were all at the discretion of the attending anesthesiologist, who was unaware that neuromuscular function was going to be monitored in the RR. The primary objective of this study was to determine the incidence of RNMB (defined as a train-of-four ratio ≤ 0.9). The secondary objectives were the number of postoperative adverse respiratory events and, for exploratory purposes, the estimation of potential risk factors through logistic regression analysis.

Results: RNMB occurred in 5 (5%) patients who had received only one dose of NMBA at induction of anesthesia. Two patients with RNMB (40%) required O₂ supplementation during monitoring in the RR, compared to 11 patients in the rest of the sample (13%). Additionally, 2 of these patients (2%) required O₂ supplementation before hospital discharge due to O₂ desaturation < 92%. None of the patients with RNMB had received a reversal of neuromuscular blockade at the end of surgery. The association between RNMB and potential risk factors, assessed through multivariable logistic regression did not yield significant results for any of the considered variables.

Conclusions: RNMB can occur even when a single dose of NMBAs is administered. Despite decades of extensive literature on the risks of RNMB and recent guidelines, routine monitoring of neuromuscular function and pharmacologic reversal of NMBA is still substandard. Routine monitoring of neuromuscular function is strongly advocated to enhance the level of patient care.

Trial registration: The study was registered at ClinicalTrials.gov ( NCT06193213 , date of registration: 05/01/2024).