We proposed an effective strategy involving a differential distribution of voltages among dynodes to significantly enhance the gain and stability of discrete dynode electron multipliers (DEMs) under continuous electron bombardment. The effects of the differential voltage distribution on the DEM performance were systematically investigated through experiments and numerical simulations. The differential voltage distribution of 7:7:7:7:7:5:5:5:5 enables the DEM to achieve a gain of $3.4times 10^{{4}}$