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A Comprehensive Theoretical Study of Drug Delivery at Nanoscale 纳米尺度药物传递的综合理论研究
Pub Date : 2017-02-15 DOI: 10.15406/JNMR.2017.05.00106
Rq Sofi, S. Majeed, A. Sofi
Nanotechnology, an interdisciplinary science that incorporates physics, chemistry, biology, etc. involves creation and utilization of materials, devices or systems on the nanometer scale and is currently undergoing unexpected development on many fronts. It finds numerous applications in material strengthening and fabrication, healthcare, agriculture, processing and storage of foods, robotics for human welfare, energy conservation and utilization, transport, manufacturing of safe and quality products and security at global level [1-11]. Besides, these unparalleled applications it has incredible potential for revolutionizing all fields of technology and is expected to create innovations and play a vital role in various biomedical applications like, drug delivery systems, molecular imaging, biomarkers, therapeutics, diagnostics, cancer therapy, biosensors, etc. Synthesis via benign route and building of orderly drug delivery systems are very important for medical and health-care. In this field, nano-based drug delivery system specifically nanoparticles have developed a great modification that provides new opportunities to move over hindrances and flaws of conventional drug delivery methods like enhance solubility of drugs, diminish drug toxicity, beshields drugs from deterioration, ineffective and benign delivery of drugs to specific target sites in the body, etc. [12-15].
纳米技术是一门集物理、化学、生物学等学科于一体的跨学科科学,涉及在纳米尺度上创造和利用材料、器件或系统,目前在许多方面正经历着意想不到的发展。它在材料强化和制造、医疗保健、农业、食品加工和储存、人类福利机器人、能源节约和利用、运输、制造安全和优质产品以及全球层面的安全方面有许多应用[1-11]。此外,这些无与伦比的应用具有令人难以置信的潜力,可以彻底改变所有技术领域,并有望在各种生物医学应用中创造创新并发挥重要作用,如药物输送系统、分子成像、生物标志物、治疗学、诊断学、癌症治疗、生物传感器等。良性合成和有序给药系统的建立对医疗卫生具有重要意义。在这一领域,纳米给药系统,特别是纳米颗粒已经发展出了巨大的改进,为克服传统给药方法的障碍和缺陷提供了新的机会,如提高药物的溶解度,降低药物毒性,屏蔽药物变质,将药物无效和良性地递送到体内特定靶点等[12-15]。
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引用次数: 0
Nanoneurology - Drug Delivery across the Brain Protective Barriers 纳米神经病学-跨脑保护屏障的药物传递
Pub Date : 2017-02-09 DOI: 10.15406/JNMR.2017.05.00105
A. Fymat
Submit Manuscript | http://medcraveonline.com Abbreviations: AD: Alzheimer Disease; Apo-E: ApoLipoprotein-E; BBB: Blood Brain Barrier; Brainpeps: BBB Peptide Database; CNS: Central Nervous System; CSF: CerebroSpinal Fluid; EPIC: Engineered Peptide Compound; HAD: HIVAssociated Dementia; HIFU: High Intensity Focused Ultrasound; HIV: HIV Encephalitis; HIV: Human Immunodeficiency Virus; LPR: Lipoprotein Related Protein; MEN: Magneto-Electric Nanoparticles; MS: Multiple Sclerosis; ND: Nano Device; NP: Nano Particle; PD: Parkinson Disease; P-gP: P-Glycoprotein; PLGA: Poly Lactic co-Glycolic Acid; PNS: Peripheral Nervous System; RNA: Ribo Nucleic Acid
投稿| http://medcraveonline.com缩写:AD: Alzheimer Disease;Apo-E:载脂蛋白e;血脑屏障;Brainpeps:血脑屏障肽数据库;CNS:中枢神经系统;CSF:脑脊液;EPIC:工程肽化合物;HAD: hiv相关痴呆;HIFU:高强度聚焦超声;HIV: HIV脑炎;HIV:人类免疫缺陷病毒;脂蛋白相关蛋白;MEN:磁电纳米粒子;MS:多发性硬化症;ND:纳米器件;NP:纳米粒子;PD:帕金森病;P-gP: 22;聚乳酸共乙醇酸;PNS:周围神经系统;RNA:核糖核酸
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引用次数: 7
Preparation and Characterization of Polyaniline/ZnO Composite Sensor 聚苯胺/ZnO复合传感器的制备与表征
Pub Date : 2017-01-23 DOI: 10.15406/JNMR.2017.05.00104
Akanksha Mehto, V. R. Mehto, Jyotsana Chauhan, I. B. Singh, P. Rk, Ey
Polyaniline/ZnO nanocomposite thin films were prepared via an electrochemical synthesis route on ITO coated glass substrates. ZnO nanoparticles were uniformly dispersed in to the polyaniline matrix. Interaction between ZnO nanoparticle and polyaniline has been studied using X-ray diffraction (XRD), UV-Vis absorption spectroscopy, PL spectroscopy, AFM and I-V characteristics. The ammonia gas sensing behaviors of the polyaniline/ZnO composites were examined at room temperature. It was observed that the composite films showed good sensitivity, improved doping state and enhanced photoluminescence behaviour.
采用电化学合成的方法在ITO镀膜玻璃衬底上制备了聚苯胺/ZnO纳米复合薄膜。ZnO纳米粒子均匀地分散在聚苯胺基体中。采用x射线衍射(XRD)、紫外可见吸收光谱(UV-Vis)、PL光谱(PL)、原子力显微镜(AFM)和I-V特性研究了ZnO纳米粒子与聚苯胺的相互作用。在室温下对聚苯胺/ZnO复合材料的氨气传感行为进行了研究。结果表明,复合薄膜具有良好的灵敏度,改善了掺杂状态,增强了光致发光性能。
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引用次数: 18
Chemical Synthesis of Vanadium Oxide (V2O5) Nanoparticles Prepared by Sodium Metavanadate 偏氰酸钠制备氧化钒纳米颗粒的化学合成
Pub Date : 2017-01-18 DOI: 10.15406/JNMR.2017.05.00103
Majid Farahm, Jou, N. Abaeiyan
Nano-materials have unique physical properties that have attracted more and more attention as a cathode in rechargeable ion batteries and selective gas sensors such as ammonia because of their high surface area and redox activity [1-3]. Biological activity of vanadium pentoxide nanomaterial depends on factors such as the type of the derivative, manner of its administration, dose, length of treatment, and also individualand species-specific sensitivity to the administered compound [4]. V2O5 nanomaterial is amphoteric in nature. Vanadium is correlated to its degree of oxidation (vanadylvanadate ion) and chemical form (organic inorganic ligand) [5-7]. The existence of the various vanadate species depends on the pH and on the total concentration of vanadium. Their occurrence can be accounted for condensation equilibrium; it is evident that only in very dilute solutions are monomeric vanadium ions found, and increases in concentration, particularly if the solution is acidic, lead to polymerization [8-10]. Vanadium oxygen systems (V2O5, VO2) are prototype stronglycorrelated materials that have been widely-studied by theoretical and experimental condensed-matter and materials community for more than half a century [11]. Vanadium oxide is a well-known catalyst among various metal oxides, and so many fundamental studies have been developed wide-spreadingly centering on catalytic oxidation [12]. They show metal-semiconductor transition, which implies an abrupt change in optical and electrical properties [13]. That is why this oxide is used in thermal sensing and switching. Vanadium pentoxide based materials are known to display several types of chromogenic effects, as a window for solar cells and for transmittance modulation in smart windows with potential applications in architecture, automotives and nanomedicine [14]. It shows an atypical behaviour because it cannot be defined exactly either as a cathodically or as anodically colouring material. V2O5 exhibit multi-colored electrochromism allowing the use in electrochromic (EC) displays color filters and other optical devices [15].
纳米材料具有独特的物理性质,由于其高表面积和氧化还原活性,作为可充电离子电池和选择性气体传感器(如氨)的阴极,越来越受到人们的关注[1-3]。五氧化二钒纳米材料的生物活性取决于衍生物的类型、给药方式、剂量、治疗时间,以及个体和物种对所给化合物的特异性敏感性等因素[4]。V2O5纳米材料具有两性性质。钒与其氧化程度(vanadylvanadate离子)和化学形态(有机无机配体)相关[5-7]。各种钒酸盐种类的存在取决于pH值和钒的总浓度。它们的出现可以用缩合平衡来解释;很明显,只有在非常稀的溶液中才会发现单体钒离子,而浓度的增加,特别是如果溶液是酸性的,会导致聚合[8-10]。钒氧体系(V2O5, VO2)是原型强相关材料,半个多世纪以来已被凝聚态和材料界广泛研究[11]。氧化钒是各种金属氧化物中较为知名的催化剂,围绕催化氧化展开了大量基础研究[12]。它们表现出金属-半导体转变,这意味着光学和电学性质的突然变化[13]。这就是为什么这种氧化物被用于热感测和开关。众所周知,五氧化二钒基材料显示出几种类型的显色效应,作为太阳能电池的窗口和智能窗口的透射率调制,在建筑、汽车和纳米医学中具有潜在的应用[14]。它表现出一种非典型的行为,因为它不能被精确地定义为阴极或阳极着色材料。V2O5表现出多色电致变色,可用于电致变色(EC)显示器、滤色器和其他光学器件[15]。
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引用次数: 54
Heavy Metals Removal from Industrial Wastewater by Nano Adsorbent Prepared from Cucumis Melopeel Activated Carbon 黄瓜皮活性炭纳米吸附剂去除工业废水中的重金属
Pub Date : 2017-01-10 DOI: 10.15406/JNMR.2017.05.00102
M. Manjuladevi, M. Oviyaasri
Activated carbon produced from Cucumis Melopeel (CM) was used as adsorbent to remove Cr6+, Cd2+, Ni2+ and Pb2+ ions from Battery industry and electroplating industrial wastewater. Batch adsorption experiment was conducted to examine the effects of adsorbent dosage, contact time, pH and metal ion concentration on adsorption of Cr6+, Cd2+, Ni2+ and Pb2+ ions from the wastewater. The obtained results showed that, the adsorption of the metal ions was adsorbent dosage, contact time, pH and metal ion concentration dependent. The optimum adsorbent dosage, metal ion concentration and pH, were found to be at 250 mg, 100 mg/L and pH 3 to 6 respectively. The study also showed that activated carbon prepared from Cucumis Melopeel can be efficiently used as low cost alternative for removal of metal ions.
以黄瓜皮为原料制备活性炭作为吸附剂,对电池工业和电镀工业废水中的Cr6+、Cd2+、Ni2+和Pb2+离子进行了脱除。通过间歇式吸附实验,考察了吸附剂用量、接触时间、pH和金属离子浓度对废水中Cr6+、Cd2+、Ni2+和Pb2+离子吸附的影响。所得结果表明,对金属离子的吸附与吸附剂用量、接触时间、pH和金属离子浓度有关。最佳吸附剂用量为250 mg,金属离子浓度为100 mg/L, pH为3 ~ 6。研究还表明,以黄瓜皮为原料制备的活性炭可作为低成本去除金属离子的有效替代品。
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引用次数: 15
Cellular Functions Analyses Based on Nanorobotics 基于纳米机器人的细胞功能分析
Pub Date : 2017-01-09 DOI: 10.15406/JNMR.2017.05.00101
Shayan Shahsavari
Recently, Miyako group reported a new type of nano transporters that made of a liposome that decorated by a composition of carbon nanohorns (CNHs) and magnetic nanoparticles (MNPs) (Figure 1). This structure permeated into cells by a Neodymium magnet. Nano transporters not only could be moved by the magnetic field but also can be stimulated by NIR laser to control the release of liposome contains at a target place in organisms. This hybrid system has provided opportunities for analyses of biomolecular processes in organisms. As an achievement, enzymatic reaction controlled in the cancerous cells in vitro and transgene mice model in vivo [6]. β-galactosidase (β-Gal) is an enzyme that often over expressed in primary colorectal, breast, andovarian cancers [7]. The existence of this substance could be monitored by an enzymatic reaction in living cells. So, non-fluorescent fluorescein di-β-D-galactopyranoside (FDG) was loaded inside liposome part of the system.
最近,Miyako小组报道了一种新型的纳米转运体,它由碳纳米角(CNHs)和磁性纳米颗粒(MNPs)组成的脂质体组成(图1)。这种结构通过钕磁铁渗透到细胞中。纳米转运体不仅可以在磁场的作用下移动,而且可以在近红外激光的刺激下控制生物体内脂质体的释放。这种杂交系统为分析生物体的生物分子过程提供了机会。作为一项成果,酶促反应在体外控制癌细胞和转基因小鼠体内模型[6]。β-半乳糖苷酶(β-Gal)是一种在原发性结直肠癌、乳腺癌和卵巢癌中经常过表达的酶。这种物质的存在可以通过活细胞中的酶促反应来监测。因此,非荧光荧光素di-β- d -半乳糖吡喃苷(FDG)被装载在系统的脂质体部分。
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引用次数: 2
Can Nanotechnology help Push the Limit for Early Cancer Diagnostics 纳米技术能帮助突破早期癌症诊断的极限吗
Pub Date : 2017-01-05 DOI: 10.15406/jnmr.2017.05.00100
M. Agrawal, Abhijit Biswas
J Nanomed Res 2017, 5(1): 00100 connected with it). Therefore, applications of these techniques are limited due to the lack of sufficient sensitivity to detect small numbers of malignant cells in the primary or even metastatic sites [1]. It is also difficult to detect specific cancer cell-surface markers, which are not only a target for cancer therapy but can also assist in the diagnosis and staging of cancer. Other challenges include inadequate drug concentrations reaching the tumor and the limited ability to monitor therapeutic responses thus leading to significant complications such as multidrug resistance due to poor drug delivery [1].
纳米材料学报,2017,5(1):00100 [J] .链接本文:因此,由于缺乏足够的灵敏度来检测原发部位甚至转移部位的少量恶性细胞,这些技术的应用受到限制[1]。特异性癌细胞表面标志物的检测也很困难,这些标志物不仅是癌症治疗的靶点,而且还可以帮助癌症的诊断和分期。其他挑战包括到达肿瘤的药物浓度不足以及监测治疗反应的能力有限,从而导致严重的并发症,如由于药物递送不良而产生的多药耐药[1]。
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引用次数: 1
Luminescent Probe Based Techniques for Hypoxia Imaging. 基于发光探针的缺氧成像技术。
Pub Date : 2017-01-01 Epub Date: 2017-11-20 DOI: 10.15406/jnmr.2017.06.00160
Sana Sandhu, LeNaiya Kydd, Justyn Jaworski

Hypoxia is a condition of tissue environments wherein a lower than normal level of oxygen is available, and it serves as the root cause and indicator of various diseases. Detection of hypoxia in tumors is imperative for furthering our understanding of the pathological effects and the development of proper treatments, as it is well established that hypoxic tumors are able to impede the cancer treatment process by being resistant to many therapies. It is important therefore to be able to detect hypoxia in tissues and tumors through in vivo imaging methods. A growing area for detection of hypoxia in vivo is the use of fluorescent/luminescent probes which has accelerated in recent years. The continued quest for improvements in selectivity and sensitivity has inspired researchers to pursue new strategies for fluorescence/luminescent probe design. This review will discuss various luminescent probes based on small molecules, dyes, macromolecules, and nanoparticles for sensitive and specific detection of oxygen levels directly or by indirect mechanisms such as the presence of enzymes or related factors that arise in a hypoxic environment. Following the particular mechanism of detection, each probe has specific structural and photophysical properties which permit its selectivity and sensitivity. These probes show promise in terms of low toxicity and high specificity among other merits discussed, and in providing new dimensions for hypoxia detection, these works contribute to future potential methods for clinical diagnosis of hypoxic tissues and tumors.

缺氧是组织环境中氧气含量低于正常水平的一种状态,是各种疾病的根源和指标。检测肿瘤中的缺氧对我们进一步了解病理效应和开发适当的治疗方法至关重要,因为缺氧肿瘤能够对许多疗法产生抗药性,从而阻碍癌症治疗进程。因此,通过体内成像方法检测组织和肿瘤中的缺氧情况非常重要。近年来,荧光/发光探针的使用在体内缺氧检测领域不断发展。对提高选择性和灵敏度的不断追求激发了研究人员对荧光/发光探针设计新策略的追求。本综述将讨论基于小分子、染料、大分子和纳米粒子的各种发光探针,这些探针可直接或通过间接机制(如缺氧环境中出现的酶或相关因素)灵敏而特异地检测氧气水平。根据特定的检测机制,每种探针都具有特定的结构和光物理特性,从而使其具有选择性和灵敏度。这些探针具有低毒性和高特异性等优点,为缺氧检测提供了新的维度,这些研究成果为未来临床诊断缺氧组织和肿瘤的潜在方法做出了贡献。
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引用次数: 0
Liposomal nanotechnology - A new frontier for sport and exercise nutrition? 脂质体纳米技术-运动和运动营养的新前沿?
Pub Date : 2016-12-20 DOI: 10.15406/jnmr.2016.04.00098
M. Higgins, M. D. Boit
There are many orally ingested nutrients which cannot be fully absorbed by the human body. For this reason scientists have been experimenting with different techniques to improve nutrient bioavailability. Among these techniques microencapsulation has been extensively used in industry in recent years, especially liposomal technology. Briefly, polar lipids are used to create spherical capsules, called liposomes, where solids, liquids or gaseous materials compounds can be entrapped. This technique is used to stabilize certain compounds in nutritional supplements and fortified foods, which would otherwise slowly degrade and lose their nutritional value, as well as improve their bioavailability. Although there has been limited research investigating nutrients that potentially might impact exercise performance (e.g. liposomal vitamin C and liposomal iron), there is currently no published evidence for the use of liposomal supplementation in this context. With the potential to augment nutrient bioavailability, further research should consider the application of liposomal formulations as a strategy to improve exercise performance.
有许多口服的营养物质不能被人体完全吸收。出于这个原因,科学家们一直在试验不同的技术来提高营养物质的生物利用度。其中微胶囊化技术近年来在工业上得到了广泛的应用,尤其是脂质体技术。简而言之,极性脂质被用来制造球形胶囊,称为脂质体,其中可以捕获固体,液体或气体物质化合物。该技术用于稳定营养补充剂和强化食品中的某些化合物,否则这些化合物将缓慢降解并失去其营养价值,并提高其生物利用度。尽管对可能影响运动表现的营养素(如脂质体维生素C和脂质体铁)的研究有限,但目前还没有发表的证据表明在这种情况下使用脂质体补充剂。由于有可能增加营养物质的生物利用度,进一步的研究应该考虑将脂质体制剂作为一种改善运动表现的策略。
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引用次数: 0
Investigations on the Relativistic Interactions in One-Electron Atoms with Modified Anharmonic Oscillator 带有修正非谐振子的单电子原子的相对论相互作用研究
Pub Date : 2016-12-16 DOI: 10.15406/JNMR.2016.4.00097
A. Maireche
One of the interesting problems of the relativistic quantum mechanics is to find exact solutions to the Klein-Gordon (to the treatment of a zero-spin particle) and Dirac (spin 1⁄2 particles and anti-particles) equations for certain potentials of the physical interest, in recent years, considerable efforts have been done to obtain the analytical solution of central and non-central physics problems for different areas of atoms, nuclei, and hadrons, numerous papers of the physicist have discussed in details all the necessary information for the quantum system and in particularly the bound states solutions [1-21]. Some of these potentials are known to play important roles in many fields, one of such potential is the anharmonic oscillator has been a subject of many studies, it is a central potential of nuclear shell model, etc [20,21]. The ordinary quantum structures obey the standard Weyl-Heisenberg algebra in both Schrödinger and Heisenberg (the operators are depended on time) pictures, respectively, as (Throughout this paper the natural unit 1 = =  c are employed):
相对论量子力学的一个有趣的问题是找到克莱恩-戈登(零自旋粒子的处理)和狄拉克(自旋1 / 2粒子和反粒子)方程对某些物理势的精确解,近年来,在获得原子、原子核和强子不同区域的中心和非中心物理问题的解析解方面已经做了相当大的努力。这位物理学家的许多论文都详细讨论了量子系统的所有必要信息,特别是束缚态解[1-21]。其中一些势已知在许多领域发挥着重要作用,其中一种势是非谐振子一直是许多研究的主题,它是核壳模型的中心势等[20,21]。普通量子结构分别在Schrödinger和Heisenberg(算子依赖于时间)图中服从标准Weyl-Heisenberg代数,即(全文采用自然单位1 = =):
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引用次数: 4
期刊
Journal of Nanomedicine Research
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