Pub Date : 2019-08-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.08.003
Yue-ming Liu, Yanni Yan, Yang Li
Objective: To evaluate the clinical efficacy of a domestic radioactive applicator for the treatment of circumscribed choroidal hemagioma. Methods: This was a retrospective consecutive observational study. Forty-three patients were diagnosed clinically and radiologically with circumscribed choroidal hemagiomain Beijing Tongren Hospital from February 2010 to August 2018. All patients had exudative retinal detachment and were treated by a domestic radioactive applicator. The size of the tumor (maximum base diameter, maximum height) was recorded by color doppler ultrasound imaging (CDI). Changes insubretinal fluid were observed by indirect ophthalmoscopy and optical coherence tomography (OCT). The changes invisual acuity, intraocular pressure, tumor size and subretinal fluid were compared before and after surgery and the occurrence rates of complications were noted. Data were compared by a paired t-test and Wilcoxon rank sum test. Results: There was a statistically significant difference in visual acuity between the most recent follow-up (2.03±1.45) and pre-operation (2.14±1.36) (Z=-2.348, P=0.019), and no significant difference in intraocular pressure between the most recent follow-up (13.6±6.0 mmHg) and pre-operation (12.5±4.2 mmHg) (Z=-1.419, P=0.3). Tumor size had regressed compared to pre-operative measurements inmaximum basal diameter: The most recent follow-up was 10.3±2.5 mm, pre-operation was 12.3±3.2 mm (t=8.862, P<0.001); maximum height: the most recent follow-up was 2.6±1.3 mm, pre-operation was 4.8±1.4 mm (t=10.387, P<0.001). Subretinal fluid was not observed in any patients. Furthermore, damages to the optic nerve, retina and macula or radiational cataract were not observed. Conclusion: A domestic radioactive applicator can be used to treat circumscribed choroidal hemagioma, which can cause the tumor to regress, lead to absolute absorption of the subretinal fluid, avoid enucleation and protect visual function. Key words: choroidal hemangioma; radiotherapy; applicator; radioactive Iodine125
目的:评价国产放射性涂布器治疗局限性脉络膜血肿的临床疗效。方法:回顾性连续观察研究。2010年2月至2018年8月，对北京同仁医院临床及影像学诊断的局限性脉络膜血肿患者43例进行分析。所有患者均有渗出性视网膜脱离，均采用国产放射性涂抹器治疗。彩色多普勒超声成像(CDI)记录肿瘤大小(最大基底直径、最大高度)。通过间接检眼镜和光学相干断层扫描(OCT)观察视网膜下液的变化。比较手术前后视力、眼压、肿瘤大小、视网膜下液的变化及并发症的发生情况。数据比较采用配对t检验和Wilcoxon秩和检验。结果:近期随访视力(2.03±1.45)与术前(2.14±1.36)差异有统计学意义(Z=-2.348, P=0.019);近期随访眼压(13.6±6.0 mmHg)与术前(12.5±4.2 mmHg)差异无统计学意义(Z=-1.419, P=0.3)。与术前测量的最大基底直径相比，肿瘤大小有所下降:最近随访为10.3±2.5 mm，术前为12.3±3.2 mm (t=8.862, P<0.001);最大高度:最近随访为2.6±1.3 mm，术前为4.8±1.4 mm (t=10.387, P<0.001)。所有患者均未见视网膜下积液。此外，视神经、视网膜、黄斑及放射性白内障未见损伤。结论:国产放射性涂布器可用于治疗局限性脉络膜血肿，可使肿瘤消退，使视网膜下液完全吸收，避免眼球摘除术，保护视功能。关键词:脉络膜血管瘤;放射治疗;涂布;放射性Iodine125
{"title":"The Safety and Efficacy of a Domestic Radioactive Applicator for the Treatment of Circumscribed Choroidal Hemangioma","authors":"Yue-ming Liu, Yanni Yan, Yang Li","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.08.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.08.003","url":null,"abstract":"Objective: \u0000To evaluate the clinical efficacy of a domestic radioactive applicator for the treatment of circumscribed choroidal hemagioma. \u0000 \u0000 \u0000Methods: \u0000This was a retrospective consecutive observational study. Forty-three patients were diagnosed clinically and radiologically with circumscribed choroidal hemagiomain Beijing Tongren Hospital from February 2010 to August 2018. All patients had exudative retinal detachment and were treated by a domestic radioactive applicator. The size of the tumor (maximum base diameter, maximum height) was recorded by color doppler ultrasound imaging (CDI). Changes insubretinal fluid were observed by indirect ophthalmoscopy and optical coherence tomography (OCT). The changes invisual acuity, intraocular pressure, tumor size and subretinal fluid were compared before and after surgery and the occurrence rates of complications were noted. Data were compared by a paired t-test and Wilcoxon rank sum test. \u0000 \u0000 \u0000Results: \u0000There was a statistically significant difference in visual acuity between the most recent follow-up (2.03±1.45) and pre-operation (2.14±1.36) (Z=-2.348, P=0.019), and no significant difference in intraocular pressure between the most recent follow-up (13.6±6.0 mmHg) and pre-operation (12.5±4.2 mmHg) (Z=-1.419, P=0.3). Tumor size had regressed compared to pre-operative measurements inmaximum basal diameter: The most recent follow-up was 10.3±2.5 mm, pre-operation was 12.3±3.2 mm (t=8.862, P<0.001); maximum height: the most recent follow-up was 2.6±1.3 mm, pre-operation was 4.8±1.4 mm (t=10.387, P<0.001). Subretinal fluid was not observed in any patients. Furthermore, damages to the optic nerve, retina and macula or radiational cataract were not observed. \u0000 \u0000 \u0000Conclusion: \u0000A domestic radioactive applicator can be used to treat circumscribed choroidal hemagioma, which can cause the tumor to regress, lead to absolute absorption of the subretinal fluid, avoid enucleation and protect visual function. \u0000 \u0000 \u0000Key words: \u0000choroidal hemangioma; radiotherapy; applicator; radioactive Iodine125","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"10 1","pages":"576-580"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90565244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To identify potential laboratory risk factors for diabetic retinopathy (DR) among diabetic patients. Methods: In this hospital-based, cross-sectional comparative study, all diabetic inpatients at the endocrinology department, Yueqing Affiliated Hospital of Wenzhou Medical University from July 2013 to June 2015 were included. The fundus images of all participants after mydriasis was taken for the assessment of DR. Based on the fundus condition, the patients were divided into a DR group and a no-DR group. A t-test and Chi-square test were used for the comparison between the laboratory findings of the two groups.The potential risk factors of DR were evaluated by multiple logistic regression. Results: A total of 426 patients were enrolled in our study. Mean age of the participants was 64.5±11.0. There were 223 patients with diabetic retinopathy and 203 patients without diabetic retinopathy, based on a fundus assessment by the ETDRS system. After multiple regression analysis, it was found that higher levels of fasting blood glucose (OR=1.08, P=0.014), hemoglobin Alc (HbA1C) (OR=1.15, P=0.004), monocyte (OR=4.02, P=0.014), and proteinuria (OR=2.15, P=0.014) were positive correlation factor of DR. While higher levels of postprandial 2 hr C-peptide (OR=0.92, P=0.047), albumin (OR=0.92, P=0.001), mean corpuscular hemoglobin (MCH) (OR=0.88, P=0.030) and mean corpuscular volume (MCV) (OR=0.93, P=0.004) were negative correlation factor of DR. Conclusion: Our study show that some laboratory indexes are associated with the presence of DR and may be a risk factor for DR. More studies are needed to investigate the causal relationships and mechanisms. Key words: diabetic retinopathy; laboratory finding; risk fact
{"title":"An Exploratory Study of Laboratory Findings of Hematuria as Risk Factors for Diabetic Retinopathy","authors":"Dandan Lin, Yan Zheng, Xiang Chen, Qiang Zhao, Jiayu Deng, Xinjie Yu, Guoyi Zhou","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.08.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.08.010","url":null,"abstract":"Objective: \u0000To identify potential laboratory risk factors for diabetic retinopathy (DR) among diabetic patients. \u0000 \u0000 \u0000Methods: \u0000In this hospital-based, cross-sectional comparative study, all diabetic inpatients at the endocrinology department, Yueqing Affiliated Hospital of Wenzhou Medical University from July 2013 to June 2015 were included. The fundus images of all participants after mydriasis was taken for the assessment of DR. Based on the fundus condition, the patients were divided into a DR group and a no-DR group. A t-test and Chi-square test were used for the comparison between the laboratory findings of the two groups.The potential risk factors of DR were evaluated by multiple logistic regression. \u0000 \u0000 \u0000Results: \u0000A total of 426 patients were enrolled in our study. Mean age of the participants was 64.5±11.0. There were 223 patients with diabetic retinopathy and 203 patients without diabetic retinopathy, based on a fundus assessment by the ETDRS system. After multiple regression analysis, it was found that higher levels of fasting blood glucose (OR=1.08, P=0.014), hemoglobin Alc (HbA1C) (OR=1.15, P=0.004), monocyte (OR=4.02, P=0.014), and proteinuria (OR=2.15, P=0.014) were positive correlation factor of DR. While higher levels of postprandial 2 hr C-peptide (OR=0.92, P=0.047), albumin (OR=0.92, P=0.001), mean corpuscular hemoglobin (MCH) (OR=0.88, P=0.030) and mean corpuscular volume (MCV) (OR=0.93, P=0.004) were negative correlation factor of DR. \u0000 \u0000 \u0000Conclusion: \u0000Our study show that some laboratory indexes are associated with the presence of DR and may be a risk factor for DR. More studies are needed to investigate the causal relationships and mechanisms. \u0000 \u0000 \u0000Key words: \u0000diabetic retinopathy; laboratory finding; risk fact","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"82 10 1","pages":"614-618"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80065249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.08.008
Jinyi Wang, X. Feng
Objective: To compare the first generation stereoscopic test charts, the third generation stereoscopic test charts, random-dot stereograms and the distance randot stereotest in patients with intermittent exotropia. Methods: In this prospective study, 51 patients with intermittent exotropia were examined by the first generation stereoscopic test charts, the third generation stereoscopic test charts, random-dot stereograms and the Distance Randot stereotest preoperatively and 2 and 10 weeks postoperatively. A wilcoxon signed-rank test and chi-square test were used. Results: The differences between the third generation and first generation stereoscopic test charts had no statistical significance (U=1.338, P=0.181), but the results of the third generation stereoscopic test charts were superior to that of the first generation stereoscopic test charts. Preoperatively and 2 and 10 weeks postoperatively, the results between the first generation and the third generation stereoscopic test charts showed improvement and the differences were statistically significant (χ2=65.5, 58.5, both P<0.001). The differences between the Distance Randot stereotest and random-dot stereograms had no statistical significance (U=1.332, P=0.183), but the results of the Distance Randot test were superior to that of random-dot stereograms. Preoperatively and 2 and 10 weeks postoperatively, the results of the random-dot stereograms and the Distance Randot stereotest showed improvement and the differences were statistically significant (χ2=76.0, 77.0, both P<0.001). Conclusions: Surgical intervention is of significance for improving the near and distance stereopsis of patients with intermittent exotropia. The third generation stereoscopic test charts can replace the first generation stereoscopic test charts in the examination of near stereopsis, and the Distance Randot test can replace the random-dot stereograms in the examination of distance stereopsis. Key words: intermittent exotropia; stereopsis; stereoscopic test charts; the distance randot stereotest
{"title":"A Comparison of Different Stereoacuity Tests","authors":"Jinyi Wang, X. Feng","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.08.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.08.008","url":null,"abstract":"Objective: \u0000To compare the first generation stereoscopic test charts, the third generation stereoscopic test charts, random-dot stereograms and the distance randot stereotest in patients with intermittent exotropia. \u0000 \u0000 \u0000Methods: \u0000In this prospective study, 51 patients with intermittent exotropia were examined by the first generation stereoscopic test charts, the third generation stereoscopic test charts, random-dot stereograms and the Distance Randot stereotest preoperatively and 2 and 10 weeks postoperatively. A wilcoxon signed-rank test and chi-square test were used. \u0000 \u0000 \u0000Results: \u0000The differences between the third generation and first generation stereoscopic test charts had no statistical significance (U=1.338, P=0.181), but the results of the third generation stereoscopic test charts were superior to that of the first generation stereoscopic test charts. Preoperatively and 2 and 10 weeks postoperatively, the results between the first generation and the third generation stereoscopic test charts showed improvement and the differences were statistically significant (χ2=65.5, 58.5, both P<0.001). The differences between the Distance Randot stereotest and random-dot stereograms had no statistical significance (U=1.332, P=0.183), but the results of the Distance Randot test were superior to that of random-dot stereograms. Preoperatively and 2 and 10 weeks postoperatively, the results of the random-dot stereograms and the Distance Randot stereotest showed improvement and the differences were statistically significant (χ2=76.0, 77.0, both P<0.001). \u0000 \u0000 \u0000Conclusions: \u0000Surgical intervention is of significance for improving the near and distance stereopsis of patients with intermittent exotropia. The third generation stereoscopic test charts can replace the first generation stereoscopic test charts in the examination of near stereopsis, and the Distance Randot test can replace the random-dot stereograms in the examination of distance stereopsis. \u0000 \u0000 \u0000Key words: \u0000intermittent exotropia; stereopsis; stereoscopic test charts; the distance randot stereotest","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"1 1","pages":"602-607"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82371644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.08.014
Yuejia Li
With the continuous improvement and innovation of modern refractive surgery technology and the development of artificial lens materials and design, the refractive surgery is changing with each passing day, and more and more people choose surgery to correct refractive error. Refractive surgery is a selective operation. The postoperative satisfaction of patients is closely related to clinical efficacy, which has clinical guiding significance for patients to choose individualized treatment plan. This paper reviews the research progress of patient satisfaction after different refractive surgery. Key words: refractive error; refractive surgery; patient satisfaction
{"title":"Research Progress of Patient Satisfaction after Different Refractive Surgery","authors":"Yuejia Li","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.08.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.08.014","url":null,"abstract":"With the continuous improvement and innovation of modern refractive surgery technology and the development of artificial lens materials and design, the refractive surgery is changing with each passing day, and more and more people choose surgery to correct refractive error. Refractive surgery is a selective operation. The postoperative satisfaction of patients is closely related to clinical efficacy, which has clinical guiding significance for patients to choose individualized treatment plan. This paper reviews the research progress of patient satisfaction after different refractive surgery. \u0000 \u0000 \u0000Key words: \u0000refractive error; refractive surgery; patient satisfaction","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"35 1","pages":"636-640"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85224753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To observe the characteristics of an early high intraocular pressure angle adhesion after large-diameter penetrating keratoplasty (LDPK) using anterior segment swept-source optical coherence tomography (SS-OCT) and to evaluate the anterior segment SS-OCT forguiding the treatment of high intraocular pressureafter penetrating keratoplasty. Methods: This was a retrospective observational study. Fifteen patients (15 eyes) with high intraocular pressure (IOP) in the early stage after LDPK in the Eye Hospital of Shandong Province were selectedfrom January to June 2017. Postoperative anterior segment SS-OCT was used to record the adhesion and extent of peripheral anterior synechia. Treatment plans were then developed for the patients. The relationships between preoperative etiology, preoperative intraocular pressure, intraoperative graft size, treatment plans and adhesion angle rangewerecompared and data were analyzed using the Mann-Whitney U test and the Kruskal-Wallis H test. Results: Clear images of the chamber angle were obtained with SS-OCT from allpatients with early high intraocular pressure after LDPK. There were 10 cases of anterior chamber angle adhesion (10/15), 5 cases of nocturnal adhesion (5/15), and the average adhesion range was 42° (0~183°). There was no significant difference in the range of adhesion angle between different preoperative causes (Z=-0.072, P=0.943). Preoperative high intraocular pressure was compared with preoperative normal intraocular pressure and there was a larger angle adhesion range. The difference was statistically significant (Z=-1.935, P=0.043). Alarge area of the implant had an extended range of adhesion, and the difference was statistically significant (Z=-2.506, P=0.012). All patients were followed up until normal intraocular pressure was obtained. The range of the adhesion angle in the combined surgery group was larger than that in the drug-only group. The difference was statistically significant (Z=-3.133, P=0.002), and all of the adhesion angle ranges>180° were treated with surgery. Conclusions: Anterior segment SS-OCT examination can help to find peripheral anterior synechiain patients with early high intraocular pressure after large-diameter penetrating keratoplasty. Preoperative intraocular pressure and intraoperative graft size affects the range of peripheral anterior synechia. For peripheral anterior synechia range of more than 180°, patients should have early filtering surgery if drugs are ineffective. Key words: keratoplasty, penetrating; tomography, optical coherence; high intraocular pressure; peripheral anterior synechia
{"title":"Evaluation of Anterior Segment Swept-Frequency OCT Used for Guidance in Early High Intraocular Pressure Therapy after Large Diameter Penetrating Keratoplasty","authors":"Sai Zhang, Xin Wang, Ting Li, Fangnan Duan, Shengjia Guan, Shuting Wang, X. Qi, Hua Gao","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.08.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.08.006","url":null,"abstract":"Objective: \u0000To observe the characteristics of an early high intraocular pressure angle adhesion after large-diameter penetrating keratoplasty (LDPK) using anterior segment swept-source optical coherence tomography (SS-OCT) and to evaluate the anterior segment SS-OCT forguiding the treatment of high intraocular pressureafter penetrating keratoplasty. \u0000 \u0000 \u0000Methods: \u0000This was a retrospective observational study. Fifteen patients (15 eyes) with high intraocular pressure (IOP) in the early stage after LDPK in the Eye Hospital of Shandong Province were selectedfrom January to June 2017. Postoperative anterior segment SS-OCT was used to record the adhesion and extent of peripheral anterior synechia. Treatment plans were then developed for the patients. The relationships between preoperative etiology, preoperative intraocular pressure, intraoperative graft size, treatment plans and adhesion angle rangewerecompared and data were analyzed using the Mann-Whitney U test and the Kruskal-Wallis H test. \u0000 \u0000 \u0000Results: \u0000Clear images of the chamber angle were obtained with SS-OCT from allpatients with early high intraocular pressure after LDPK. There were 10 cases of anterior chamber angle adhesion (10/15), 5 cases of nocturnal adhesion (5/15), and the average adhesion range was 42° (0~183°). There was no significant difference in the range of adhesion angle between different preoperative causes (Z=-0.072, P=0.943). Preoperative high intraocular pressure was compared with preoperative normal intraocular pressure and there was a larger angle adhesion range. The difference was statistically significant (Z=-1.935, P=0.043). Alarge area of the implant had an extended range of adhesion, and the difference was statistically significant (Z=-2.506, P=0.012). All patients were followed up until normal intraocular pressure was obtained. The range of the adhesion angle in the combined surgery group was larger than that in the drug-only group. The difference was statistically significant (Z=-3.133, P=0.002), and all of the adhesion angle ranges>180° were treated with surgery. \u0000 \u0000 \u0000Conclusions: \u0000Anterior segment SS-OCT examination can help to find peripheral anterior synechiain patients with early high intraocular pressure after large-diameter penetrating keratoplasty. Preoperative intraocular pressure and intraoperative graft size affects the range of peripheral anterior synechia. For peripheral anterior synechia range of more than 180°, patients should have early filtering surgery if drugs are ineffective. \u0000 \u0000 \u0000Key words: \u0000keratoplasty, penetrating; tomography, optical coherence; high intraocular pressure; peripheral anterior synechia","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"26 1","pages":"591-596"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74291545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.08.004
Xiao-yan Zhang
Objective: To observe the effect of minimally invasive vitrectomy combined with local complete exfoliation in the treatment of choroidal melanoma. Methods: By retrospective analysis, 13 choroidal melanoma patients (13 eyes) were selected in the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine from January 2014 to December 2017. The patients were treated with minimally invasive vitrectomy combined with complete local exfoliation. Systemic metastasis and local scleral and optic nerve invasion were excluded. Mean basal diameter of the tumor was 11.2±4.2 mm. Average height diameter was 9.2±1.1 mm. Tumors were located at the posterior pole and at the equator in 11 cases. Minimally invasive vitrectomy was adopted in combination with intraventricular resection, then the tumors were removed completely. Two of the tumors were large enough to reach the anterior equatorial ciliary body. Minimally invasive vitrectomy was adopted in combination with tumor dissection from the scleral flap. The patients underwent primary surgery with silicone oil and lens retention. Patients were followed up from postoperative 6 months to 54 months. Local and systemic exams were done every 6 months. Results: All 13 patients were diagnosed with choroidal melanoma by pathological diagnosis. During the follow-up, there was no recurrence, or systemic or ocular metastasis. Postoperative best corrected visual acuity (BCVA) was 0.3-0.9 LogMAR, 0.8-0.9 LogMAR (38.4%) in 5 patients and BCVA 0.3-0.8 LogMAR (61.5%) in 8 patients. After 3 months, 13 patients underwent silicone oil extraction. Phacoemulsification was performed on 8 patients with complicated cataract, and intraocular lens implantation was performed on 5 patients. Three patients (23.1%) had proliferative retinopathy at the tumor resection site after surgery, and silicone oil was used again to reposition the retina without intraocular lens implantation. Conclusions: Based on the size and location of the tumor, complete intraocular and extraocular local exfoliation combined with minimally invasive vitrectomy is an effective method for the treatment of choroidal melanoma. It preserves both the eyeball and vision. Key words: choroidal melanoma; minimally invasive surgery; vitrectomy; combined surgery
{"title":"Minimally Invasive Vitrectomy Combined with Local Intact Exfoliation for the Treatment of Choroidal Melanoma","authors":"Xiao-yan Zhang","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.08.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.08.004","url":null,"abstract":"Objective: \u0000To observe the effect of minimally invasive vitrectomy combined with local complete exfoliation in the treatment of choroidal melanoma. \u0000 \u0000 \u0000Methods: \u0000By retrospective analysis, 13 choroidal melanoma patients (13 eyes) were selected in the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine from January 2014 to December 2017. The patients were treated with minimally invasive vitrectomy combined with complete local exfoliation. Systemic metastasis and local scleral and optic nerve invasion were excluded. Mean basal diameter of the tumor was 11.2±4.2 mm. Average height diameter was 9.2±1.1 mm. Tumors were located at the posterior pole and at the equator in 11 cases. Minimally invasive vitrectomy was adopted in combination with intraventricular resection, then the tumors were removed completely. Two of the tumors were large enough to reach the anterior equatorial ciliary body. Minimally invasive vitrectomy was adopted in combination with tumor dissection from the scleral flap. The patients underwent primary surgery with silicone oil and lens retention. Patients were followed up from postoperative 6 months to 54 months. Local and systemic exams were done every 6 months. \u0000 \u0000 \u0000Results: \u0000All 13 patients were diagnosed with choroidal melanoma by pathological diagnosis. During the follow-up, there was no recurrence, or systemic or ocular metastasis. Postoperative best corrected visual acuity (BCVA) was 0.3-0.9 LogMAR, 0.8-0.9 LogMAR (38.4%) in 5 patients and BCVA 0.3-0.8 LogMAR (61.5%) in 8 patients. After 3 months, 13 patients underwent silicone oil extraction. Phacoemulsification was performed on 8 patients with complicated cataract, and intraocular lens implantation was performed on 5 patients. Three patients (23.1%) had proliferative retinopathy at the tumor resection site after surgery, and silicone oil was used again to reposition the retina without intraocular lens implantation. \u0000 \u0000 \u0000Conclusions: \u0000Based on the size and location of the tumor, complete intraocular and extraocular local exfoliation combined with minimally invasive vitrectomy is an effective method for the treatment of choroidal melanoma. It preserves both the eyeball and vision. \u0000 \u0000 \u0000Key words: \u0000choroidal melanoma; minimally invasive surgery; vitrectomy; combined surgery","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"2 1","pages":"581-585"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80691342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.07.006
Xue-qun Huang
Objective: To compare the differences in corneal asphericity and contrast sensitivity under different conditions before and after Q-value-guided femtosecond laser in situ keratomileusis (FS-LASIK) and standard FS-LASIK for myopia, and evaluation of the efficacy of the two surgical methods for treating myopia. Methods: This was a prospective cohort study. A total of 64 moderate and low myopia patients (33 patients, 64 eyes, in the Q-guided group and 31 patients, 62 eyes, in the standard group) who were treated by FS-LASIK were selected from Laser Center, the First Affiliated Hospital of Anhui Medical University, during the same period. Visual acuity, Q-value, corneal aberration and contrast sensitivity were measured and compared before and after surgery. All the cases were followed up at 1 and 3 months. A repeated measures analysis of variance, t-test and rank sum test were used for data analysis. Results: There was no statistically significant difference for the data before surgery. The uncorrected visual acuity (UCVA) and residual refractive error of all eyes were not significantly different between the two groups after 3 months of follow-up. In the corneal 6 mm range, there was no significant difference in Q-value, spherical aberration or coma between the two groups at 3 months postoperatively. In the corneal 4.5 mm range, the Q-values and spherical aberrations of the Q-value-guided group were significantly less than that for the standard LASIK group (tSA=2.00, P=0.04; tQ=2.28, P=0.03). After surgery, contrast sensitivity in the two groups returned to preoperative levels at different spatial frequencies in various environments, and it tended to be stable at 3 months after surgery. At 3 months after surgery, the visual quality of the Q-value-guided group was better than that of the standard group under mesopic circumstances with glare (Z3 c/d=-2.0, P=0.044; Z6 c/d=-2.1, P=0.034). Conclusions: Q-value-guided LASIK for myopia and astigmatism is as safe and effective as standard FS-LASIK. Further more, Q-value-guided LASIK results in better visual quality than standard FS-LASIK under mesopic circumstances with glare. Key words: laser in situ keratomileusis; femtosecond laser; wavefront aberration; visual quality
{"title":"Clinical Study of Corneal Asphericity and Visual Quality after Q-Factor-Guided and Standard FS-LASIK","authors":"Xue-qun Huang","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.07.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.07.006","url":null,"abstract":"Objective: \u0000To compare the differences in corneal asphericity and contrast sensitivity under different conditions before and after Q-value-guided femtosecond laser in situ keratomileusis (FS-LASIK) and standard FS-LASIK for myopia, and evaluation of the efficacy of the two surgical methods for treating myopia. \u0000 \u0000 \u0000Methods: \u0000This was a prospective cohort study. A total of 64 moderate and low myopia patients (33 patients, 64 eyes, in the Q-guided group and 31 patients, 62 eyes, in the standard group) who were treated by FS-LASIK were selected from Laser Center, the First Affiliated Hospital of Anhui Medical University, during the same period. Visual acuity, Q-value, corneal aberration and contrast sensitivity were measured and compared before and after surgery. All the cases were followed up at 1 and 3 months. A repeated measures analysis of variance, t-test and rank sum test were used for data analysis. \u0000 \u0000 \u0000Results: \u0000There was no statistically significant difference for the data before surgery. The uncorrected visual acuity (UCVA) and residual refractive error of all eyes were not significantly different between the two groups after 3 months of follow-up. In the corneal 6 mm range, there was no significant difference in Q-value, spherical aberration or coma between the two groups at 3 months postoperatively. In the corneal 4.5 mm range, the Q-values and spherical aberrations of the Q-value-guided group were significantly less than that for the standard LASIK group (tSA=2.00, P=0.04; tQ=2.28, P=0.03). After surgery, contrast sensitivity in the two groups returned to preoperative levels at different spatial frequencies in various environments, and it tended to be stable at 3 months after surgery. At 3 months after surgery, the visual quality of the Q-value-guided group was better than that of the standard group under mesopic circumstances with glare (Z3 c/d=-2.0, P=0.044; Z6 c/d=-2.1, P=0.034). \u0000 \u0000 \u0000Conclusions: \u0000Q-value-guided LASIK for myopia and astigmatism is as safe and effective as standard FS-LASIK. Further more, Q-value-guided LASIK results in better visual quality than standard FS-LASIK under mesopic circumstances with glare. \u0000 \u0000 \u0000Key words: \u0000laser in situ keratomileusis; femtosecond laser; wavefront aberration; visual quality","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"12 1","pages":"514-520"},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73478742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.07.001
Yuyu Zhao, Zhongxing Chen, Luting Pan, Qing Wang, Fan Zhang
Objective: To evaluate the effect of cycloplegiaon new ocular biometry measurements using the IOLMaster 700 and OA-2000 biometers and assess the differences and agreements between the two devices. Methods: In this prospective, comparative, observational study of ocular measurements on 133 cataracts, measurements of axial length (AL), mean keratometry (Km), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) were performed by a single operator using the two devices before and after pupil dilation. The measurement order of the two devices was determined according to the random number table. A paired t-test was applied to evaluate the differences with and without cycloplegia on each device. Bland-Altman plots and a paired t-test were used to evaluate the agreements and differences between the two devices with and without cycloplegia. Results: Cycloplegia had no significant effect on AL or Km. However, ACD and CCT significantly increased by 0.06 mm and 2-3 μm post-cycloplegia on both devices. The IOLMaster 700 LT measurements significantly decreased by 0.01 mm (t=-6.26, P<0.001) and WTW increased by 0.12 mm (t=7.06, P<0.001) after pupil dilation. ACD measurements with OA-2000 were higher by 0.04 mm (t=-13.36, P<0.001; t=-15.08, P<0.001) and LT by 0.07 mm (t=-11.11, P<0.001; t=-8.42, P<0.001), which were statistically significant, compared to the IOLMaster 700 before and after pupil dilation, while CCT was smaller by 17 μm (t=30.55, P<0.001; t=28.80, P<0.001). The 95% limits of agreement in both devices were -0.79 to 0.81 mm pre-cycloplegia and -0.44 to 0.81 mm post-cycloplegia. All measurements had good agreements between the two devices, except for WTW. Conclusions: Cycloplegia affects ACD and CCT, but not AL or Km measurements. LT decreased and WTW increased on the IOLMaster 700 after pupil dilation. Generally, there is good agreement between the IOLMaster 700 and OA-2000, except for WTW. Thus, either can be used for the preoperative examination of cataracts. Key words: IOLMaster 700; OA-2000; cataract; cycloplegia
目的:评价睫状体麻痹对使用IOLMaster 700和OA-2000生物计进行眼部生物测量的影响，并评估两者之间的差异和一致性。方法:本研究对133例白内障患者进行了前瞻性、对比性、观察性研究，在瞳孔扩张前后，由一名操作员分别使用这两种仪器测量眼轴长(AL)、平均角膜度数(Km)、前房深度(ACD)、晶状体厚度(LT)、角膜中央厚度(CCT)和白对白(WTW)。根据随机数表确定两个装置的测量顺序。采用配对t检验来评估每种设备上有和没有独眼麻痹的差异。使用Bland-Altman图和配对t检验来评估两种装置在患有和不患有独眼麻痹的情况下的一致性和差异。结果:单眼截瘫对AL和Km均无显著影响。然而，两种装置的ACD和CCT均显著增加0.06 mm和2-3 μm。瞳孔扩张后IOLMaster 700 LT测量值显著降低0.01 mm (t=-6.26, P<0.001)， WTW升高0.12 mm (t=7.06, P<0.001)。OA-2000的ACD测量值高出0.04 mm (t=-13.36, P<0.001;t=-15.08, P<0.001)， LT降低0.07 mm (t=-11.11, P<0.001;t=-8.42, P<0.001)，与瞳孔扩张前后的IOLMaster 700相比，差异有统计学意义，而CCT则小17 μm (t=30.55, P<0.001;t = 28.80, P < 0.001)。两种器械的95%一致性限分别为-0.79 ~ 0.81 mm前和-0.44 ~ 0.81 mm后。除了WTW之外，两个设备之间的所有测量结果都很吻合。结论:睫状体麻痹影响ACD和CCT，但不影响AL和Km测量。瞳孔扩张后IOLMaster 700的LT降低，WTW升高。一般来说，IOLMaster 700和OA-2000之间有很好的一致性，除了WTW。因此，两种方法均可用于白内障术前检查。关键词:IOLMaster 700;oa - 2000;白内障;睫状肌麻痹
{"title":"The Effect of Cycloplegia on the IOLMaster 700 and OA-2000 Biometry in Cataract Patients","authors":"Yuyu Zhao, Zhongxing Chen, Luting Pan, Qing Wang, Fan Zhang","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.07.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.07.001","url":null,"abstract":"Objective: \u0000To evaluate the effect of cycloplegiaon new ocular biometry measurements using the IOLMaster 700 and OA-2000 biometers and assess the differences and agreements between the two devices. \u0000 \u0000 \u0000Methods: \u0000In this prospective, comparative, observational study of ocular measurements on 133 cataracts, measurements of axial length (AL), mean keratometry (Km), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) were performed by a single operator using the two devices before and after pupil dilation. The measurement order of the two devices was determined according to the random number table. A paired t-test was applied to evaluate the differences with and without cycloplegia on each device. Bland-Altman plots and a paired t-test were used to evaluate the agreements and differences between the two devices with and without cycloplegia. \u0000 \u0000 \u0000Results: \u0000Cycloplegia had no significant effect on AL or Km. However, ACD and CCT significantly increased by 0.06 mm and 2-3 μm post-cycloplegia on both devices. The IOLMaster 700 LT measurements significantly decreased by 0.01 mm (t=-6.26, P<0.001) and WTW increased by 0.12 mm (t=7.06, P<0.001) after pupil dilation. ACD measurements with OA-2000 were higher by 0.04 mm (t=-13.36, P<0.001; t=-15.08, P<0.001) and LT by 0.07 mm (t=-11.11, P<0.001; t=-8.42, P<0.001), which were statistically significant, compared to the IOLMaster 700 before and after pupil dilation, while CCT was smaller by 17 μm (t=30.55, P<0.001; t=28.80, P<0.001). The 95% limits of agreement in both devices were -0.79 to 0.81 mm pre-cycloplegia and -0.44 to 0.81 mm post-cycloplegia. All measurements had good agreements between the two devices, except for WTW. \u0000 \u0000 \u0000Conclusions: \u0000Cycloplegia affects ACD and CCT, but not AL or Km measurements. LT decreased and WTW increased on the IOLMaster 700 after pupil dilation. Generally, there is good agreement between the IOLMaster 700 and OA-2000, except for WTW. Thus, either can be used for the preoperative examination of cataracts. \u0000 \u0000 \u0000Key words: \u0000IOLMaster 700; OA-2000; cataract; cycloplegia","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"31 1","pages":"481-487"},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85525979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.07.009
T. Cui, Jin Zhou, Z. Wang
Objective: To analyze the factors that may lead to an abnormal vault after implantation of the implantable collamer lens (ICL). Methods: This research was based on the retrospective analysis of sixty patients (67 eyes) who underwent ICL V4c replacement after collamer lens implantation with a V4c lens in the Chengdu Aier Eye Hospital between November 2014 and November 2017. The replacement was performed because of abnormal vaults of the initial lens implantations, either less than 250 μm or more than 750 μm. Seventy patients (70 eyes) were randomly chosen as the control group from those who underwent ICL implantation during the same period and had normal vaults (250 to 750 μm). Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), manifest refraction, intraocular pressure (IOP), corneal endothelial cell density (ECD), and lens thickness (LT) were measured before surgery. The posterior chamber angle, height of the ciliary processes (T value), sulcus-to-sulcus (STS) horizontal distance, STS vertical distance, and anterior chamber depth (ACD) were measured by an ultrasound biomicroscope (UBM). All patients were followed more than 6 months. UCVA, manifest refraction, BCVA, IOP, ECD, and vault height were measured. Data were analyzed using a t-test and multiple linear regression. Results: There were significant differences between the high vault group and the low vault group for posterior chamber angle and ICL size and ACD (all P<0.001). There were significant differences between the high vault group and normal vault group for ICL size and posterior chamber angle. Posterior chamber angle, ICL size, STS horizontal distance, T value, ACD, and LT were statistically significant factors for the abnormal vault (adjusted, R2=0.608, F=5.84, P<0.001). Eight eyes had a vault less than 250 μm after implantable collamer lens replacement in the low vault group. Whereas the vault was normal after ICL replacement in all eyes of the high vault group. There were no serious complications such as anterior subcapsular cataract, high intraocular pressure, or corneal endothelial decompensation during the observation period. Conclusions: Multiple ciliary sulcus factors affect vault after ICL implantation. T value, posterior chamber angle, STS horizontal distance, ACD, ICL size, and LT may be related to an abnormal vault. For cases where abnormal vault may occur, the ICL size can be determined in conjunction with the posterior angle to help achieve a proper vault. Key words: vault; posterior chamber angle; height of ciliary processes; lens thickness
{"title":"Retrospective Analysis of Factors Affecting Abnormal Vault after ICL Implantation","authors":"T. Cui, Jin Zhou, Z. Wang","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.07.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.07.009","url":null,"abstract":"Objective: \u0000To analyze the factors that may lead to an abnormal vault after implantation of the implantable collamer lens (ICL). \u0000 \u0000 \u0000Methods: \u0000This research was based on the retrospective analysis of sixty patients (67 eyes) who underwent ICL V4c replacement after collamer lens implantation with a V4c lens in the Chengdu Aier Eye Hospital between November 2014 and November 2017. The replacement was performed because of abnormal vaults of the initial lens implantations, either less than 250 μm or more than 750 μm. Seventy patients (70 eyes) were randomly chosen as the control group from those who underwent ICL implantation during the same period and had normal vaults (250 to 750 μm). Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), manifest refraction, intraocular pressure (IOP), corneal endothelial cell density (ECD), and lens thickness (LT) were measured before surgery. The posterior chamber angle, height of the ciliary processes (T value), sulcus-to-sulcus (STS) horizontal distance, STS vertical distance, and anterior chamber depth (ACD) were measured by an ultrasound biomicroscope (UBM). All patients were followed more than 6 months. UCVA, manifest refraction, BCVA, IOP, ECD, and vault height were measured. Data were analyzed using a t-test and multiple linear regression. \u0000 \u0000 \u0000Results: \u0000There were significant differences between the high vault group and the low vault group for posterior chamber angle and ICL size and ACD (all P<0.001). There were significant differences between the high vault group and normal vault group for ICL size and posterior chamber angle. Posterior chamber angle, ICL size, STS horizontal distance, T value, ACD, and LT were statistically significant factors for the abnormal vault (adjusted, R2=0.608, F=5.84, P<0.001). Eight eyes had a vault less than 250 μm after implantable collamer lens replacement in the low vault group. Whereas the vault was normal after ICL replacement in all eyes of the high vault group. There were no serious complications such as anterior subcapsular cataract, high intraocular pressure, or corneal endothelial decompensation during the observation period. \u0000 \u0000 \u0000Conclusions: \u0000Multiple ciliary sulcus factors affect vault after ICL implantation. T value, posterior chamber angle, STS horizontal distance, ACD, ICL size, and LT may be related to an abnormal vault. For cases where abnormal vault may occur, the ICL size can be determined in conjunction with the posterior angle to help achieve a proper vault. \u0000 \u0000 \u0000Key words: \u0000vault; posterior chamber angle; height of ciliary processes; lens thickness","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"75 1","pages":"534-539"},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80658068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-25DOI: 10.3760/CMA.J.ISSN.1674-845X.2019.07.010
Hongjuan Wang, Ying-Ying Gao, Xiu-ying Li
Objective: To observe the clinical efficacy of oral azithromycin in patients with moderate to severe meibomian gland dysfunction (MGD), and the structural changes in meibomian glands. Methods: This was a prospective clinical study. Forty-nine patients (98 eyes) who had moderate to severe MGD were recruited in the Second Affiliated Hospital, Fujian Medical University, from April 2016 to January 2017. All patients underwent comprehensive ocular surface examination and slit lamp examination and were divided into two groups: 26 patients in the observation group and 23 patients in the control group. The observation group was given artificial tears and oral azithromycin 500 mg once daily for 3 days, then stopped for 7 days. There were 10 days in a treatment cycle with a total of three cycles for the treatment.The control group received only artificial tear treatment. All patients underwent modified meibomian gland compression during the first visit and for each follow-up, all of which were combined with eyelid hot compress and blepharospasm cleaning. Then an ocular check-up was performed, including the following aspects: Ocular surface disease index (OSDI), noninvasive first break-up time (NIF-BUT), noninvasive average break-up time (NIAvg-BUT), tear meniscus height (TMH), R-scan, loss rate of the meibomian gland, assessment of meibomian gland orifices, meibum quality score, meibum expression score, fluorescein stain test (FL), and Schirmer Ⅰ test (SⅠT) between pre-therapy and post-treatment. Data were analyzed by an independent samples t test, Mann-Whitney U test, paired t test and Wilcoxon paired rank sum test. Results: After treatment, the assessment of meibomian gland orifices (Z=-3.093), meibum quality score (Z=-2.501), meibum expression score (Z=-3.175) as well as FL (Z=-2.602) of the control group were improved compared with those before treatment, with statistically significant differences (P<0.05). However, there were no statistically significant differences in other indexes in the control group. After treatment, the OSDI (t=6.174), loss rate of the meibomian gland (t=2.402), assessment of meibomian gland orifices (Z=-5.192), meibum quality score (Z=-5.073), meibum expression score (Z=-4.807), and FL (Z=-3.587) of the observation group were improved compared with those before treatment, with statistically significant differences (P<0.05). There were no statistically significant differences in other indexes in the observation group. Statistically significant differences were observed in OSDI (t=-3.778), NIAvg-BUT (Z=-2.043), loss rate of the meibomian gland (t=-2.123), assessment of meibomian gland orifices (Z=-6.318), meibum quality score (Z=-5.852), meibum expression score (Z=-3.951) and SⅠT (Z=-2.462) between the two groups after treatment (P<0.05) and the observation group improved more obviously, but no statistically significant differences in other indexes after treatment. Conclusions: Oral azithromycin can be used to t
{"title":"Oral Azithromycin for the Treatment of Moderate to Severe Meibomian Gland Dysfunction","authors":"Hongjuan Wang, Ying-Ying Gao, Xiu-ying Li","doi":"10.3760/CMA.J.ISSN.1674-845X.2019.07.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-845X.2019.07.010","url":null,"abstract":"Objective: \u0000To observe the clinical efficacy of oral azithromycin in patients with moderate to severe meibomian gland dysfunction (MGD), and the structural changes in meibomian glands. \u0000 \u0000 \u0000Methods: \u0000This was a prospective clinical study. Forty-nine patients (98 eyes) who had moderate to severe MGD were recruited in the Second Affiliated Hospital, Fujian Medical University, from April 2016 to January 2017. All patients underwent comprehensive ocular surface examination and slit lamp examination and were divided into two groups: 26 patients in the observation group and 23 patients in the control group. The observation group was given artificial tears and oral azithromycin 500 mg once daily for 3 days, then stopped for 7 days. There were 10 days in a treatment cycle with a total of three cycles for the treatment.The control group received only artificial tear treatment. All patients underwent modified meibomian gland compression during the first visit and for each follow-up, all of which were combined with eyelid hot compress and blepharospasm cleaning. Then an ocular check-up was performed, including the following aspects: Ocular surface disease index (OSDI), noninvasive first break-up time (NIF-BUT), noninvasive average break-up time (NIAvg-BUT), tear meniscus height (TMH), R-scan, loss rate of the meibomian gland, assessment of meibomian gland orifices, meibum quality score, meibum expression score, fluorescein stain test (FL), and Schirmer Ⅰ test (SⅠT) between pre-therapy and post-treatment. Data were analyzed by an independent samples t test, Mann-Whitney U test, paired t test and Wilcoxon paired rank sum test. \u0000 \u0000 \u0000Results: \u0000After treatment, the assessment of meibomian gland orifices (Z=-3.093), meibum quality score (Z=-2.501), meibum expression score (Z=-3.175) as well as FL (Z=-2.602) of the control group were improved compared with those before treatment, with statistically significant differences (P<0.05). However, there were no statistically significant differences in other indexes in the control group. After treatment, the OSDI (t=6.174), loss rate of the meibomian gland (t=2.402), assessment of meibomian gland orifices (Z=-5.192), meibum quality score (Z=-5.073), meibum expression score (Z=-4.807), and FL (Z=-3.587) of the observation group were improved compared with those before treatment, with statistically significant differences (P<0.05). There were no statistically significant differences in other indexes in the observation group. Statistically significant differences were observed in OSDI (t=-3.778), NIAvg-BUT (Z=-2.043), loss rate of the meibomian gland (t=-2.123), assessment of meibomian gland orifices (Z=-6.318), meibum quality score (Z=-5.852), meibum expression score (Z=-3.951) and SⅠT (Z=-2.462) between the two groups after treatment (P<0.05) and the observation group improved more obviously, but no statistically significant differences in other indexes after treatment. \u0000 \u0000 \u0000Conclusions: \u0000Oral azithromycin can be used to t","PeriodicalId":10142,"journal":{"name":"Chinese Journal of Optometry & Ophthalmology","volume":"79 1","pages":"540-548"},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90854463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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