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M3T-attention: a multi-level multi-scale temporal attention transformer for EEG hand movement trajectory decoding. m3t -注意:脑电手动轨迹译码的多层次多尺度时间注意转换器。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2026-02-03 DOI: 10.1007/s11571-025-10403-1
Lei Zhu, Peng Jiang, Aiai Huang, Jianhai Zhang, Peng Yuan

In recent years, brain-computer interface (BCI) technology has made significant progress in the fields of neural engineering and human-computer interaction. Among these advances, decoding upper-limb movements from electroencephalography (EEG) signals has become a key research focus. However, most existing studies concentrate on discrete classification tasks (e.g., motor imagery recognition), while the prediction of three-dimensional continuous movement trajectories still faces several major challenges. These include the low signal-to-noise ratio of EEG signals, substantial inter-subject variability that limits generalizability, and the high degrees of freedom in 3D trajectories, which increase decoding complexity. To address these challenges and improve the accuracy of decoding continuous 3D hand movement trajectories from EEG signals, this study proposes a Multi-level Multi-scale Temporal Attention Transformer framework (M3T-Attention). The model is designed to extract temporal features across multiple time scales from EEG signals and integrate them via cross-scale attention mechanisms, enabling a nonlinear mapping from 0.5 to 12 Hz EEG signals to 3D kinematic parameters (position, velocity, and acceleration). The model was trained using EEG and wrist kinematic data from the WAY-EEG-GAL dataset. Experimental results show that the proposed method achieves Pearson correlation coefficients (PCCs) of 0.8816, 0.8841, and 0.8711 on the X, Y, and Z axes, respectively, demonstrating robust prediction performance across all subjects and outperforming existing state-of-the-art approaches. In summary, through comparative experiments, statistical significance analysis, and ablation studies, we have fully verified its ability to capture neural coding patterns. It significantly enhances the decoding performance from EEG signals to movement trajectories, offering new approaches for BCI applications in complex motor control scenarios. We have made the model's source code publicly available on GitHub repository URL: https://github.com/jjspp/M3T_Attention.

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引用次数: 0
Ethical risks and considerations of the integration of Brain-Computer Interfaces with Artificial Intelligence. 脑机接口与人工智能集成的伦理风险与思考。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2026-02-05 DOI: 10.1007/s11571-025-10380-5
Yuyu Cao, Hengyuan Yang, Yuhang Xue, Fan Wang, Tianwen Li, Lei Zhao, Yunfa Fu

In recent years, with the rapid development of Brain-Computer Interface (BCI) and Artificial Intelligence (AI) technologies, a trend of increasing integration between the two has emerged. In some practical applications, BCI has been combined with AI to enhance the overall performance of systems, including usability, user experience, and satisfaction, especially in terms of intelligent capabilities. However, this technological integration also introduces new or exacerbates existing ethical risks, such as neural privacy breaches, cross-domain misuse, and unclear system responsibility attribution. This paper discusses the novel or more severe ethical challenges arising from the fusion of BCI and AI technologies, as well as measures and strategies to address these ethical issues, calling for the establishment of more comprehensive ethical guidelines and governance frameworks. It is hoped that this paper will contribute to a deeper understanding and reflection on the ethical risks and corresponding regulations related to the integration of BCI and AI technologies.

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引用次数: 0
Optimized cortical EEG modeling for Parkinson disease diagnosis with snow Shepherd Stride tuning mechanism. 基于雪牧羊人跨步调谐机制的帕金森病皮质脑电模型优化
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2026-02-06 DOI: 10.1007/s11571-025-10406-y
Morarjee Kolla, Rudra Kumar Madapuri, Prabhakar Kandukuri, Shobarani Salvadi, Satyakiaranmaie Tadepalli, Ramesh Gajula

Parkinson's disease (PD) is a neurodegenerative disease that causes extensive impacts on cognitive and motor function, hence making correct and early diagnosis essential for efficient clinical management and enhancement of the quality of life. Analysis using EEG has now become a safe and possible method for the identification of neural abnormalities in PD. Nevertheless, current models must struggle with several constraints: high false detection rates, poor generalizability across subjects, sensitivity to EEG noise pollution, and the inability to extract deep cortical representations, which have the capability to distinguish between healthy and Parkinson patterns. To alleviate these issues, the current paper proposes a novel CortiMoS-Net (Cortical Modeling with Stacked Autoencoder and MobileNet) capable of accurately detecting Parkinson's disease from EEG signals. CortiMoS-Net architecture combines deep stacked autoencoders with low-computation MobileNet convolution blocks such that low-complexity learning of complex cortical activity patterns is supplemented with computational scalability. To achieve further enhanced model convergence and optimization of learnable parameters, the present work also proposes an enhanced hybrid optimization technique named Snow Shepherd Stride Configuration Tuning (S3C-Tune). The proposed pipeline is initiated with raw EEG signal recording, preprocessing, and peak picking for the intent of artifact removal and detection of neurologically intriguing events. Model parameters are tuned by the S3C-Tune algorithm to realize maximal training accuracy. Such a pipeline hybrid enables extensive cortical modeling as well as efficient optimization and results in correct PD vs. healthy subject classification. Experimental results confirm the effectiveness of the suggested approach with better accuracy, precision, recall, and F1-score of 0.99 and minimum error rate and minimum loss of 0.01 and 0.05, respectively. The suggested model also indicates maximum prediction correctness of 0.99 and mean efficiency measure of 0.95 as compared to a large number of state-of-the-art hybrid deep learning approaches.

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引用次数: 0
EEG emotion recognition across subjects based on deep feature aggregation and multi-source domain adaptation. 基于深度特征聚合和多源域自适应的脑电情感识别。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2025-11-24 DOI: 10.1007/s11571-025-10379-y
Kunqiang Lin, Ying Li, Yiren He, Zihan Jiang, Renjie He, Xianzhe Wang, Hongxu Guo, Lei Guo

Electroencephalography (EEG) can objectively reflect an individual's emotional state. However, due to significant inter-subject differences, existing methods exhibit low generalization performance in emotion recognition across different individuals. Therefore, an EEG emotion classification framework based on deep feature aggregation and multi-source domain adaptation is proposed by us. First, we design a deep feature aggregation module that introduces a novel approach for extracting EEG hemisphere asymmetry features and integrates these features with the frequency and spatiotemporal characteristics of the EEG signals. Additionally, a multi-source domain adaptation strategy is proposed, where multiple independent feature extraction sub-networks are employed to process each domain separately, extracting discriminative features and thereby alleviating the feature shift problem between domains. Then, a domain adaptation strategy is employed to align multiple source domains with the target domain, thereby reducing inter-domain distribution discrepancies and facilitating effective cross-domain knowledge transfer. Simultaneously, to enhance the learning ability of target samples near the decision boundary, pseudo-labels are dynamically generated for the unlabeled samples in the target domain. By leveraging predictions from multiple classifiers, we calculate the average confidence of each pseudo-label group and select the pseudo-label set with the highest confidence as the final label for the target sample. Finally, the mean of the outputs from multiple classifiers is used as the model's final prediction. A comprehensive set of experiments was performed using the publicly available SEED and SEED-IV datasets. The findings indicate that the method we proposed outperforms alternative methods.

脑电图(EEG)可以客观地反映个体的情绪状态。然而,由于主体间差异较大,现有的情绪识别方法在个体间的泛化性能较差。为此,我们提出了一种基于深度特征聚合和多源域自适应的脑电情绪分类框架。首先,我们设计了一个深度特征聚合模块,引入了一种提取脑半球不对称特征的新方法,并将这些特征与脑电信号的频率和时空特征相结合。此外,提出了一种多源域自适应策略,利用多个独立的特征提取子网络分别对每个域进行处理,提取有区别的特征,从而缓解域间的特征转移问题。然后,采用领域自适应策略将多个源领域与目标领域对齐,从而减少领域间分布差异,促进有效的跨领域知识转移。同时,为了增强决策边界附近目标样本的学习能力,对目标域内未标记的样本动态生成伪标签。通过利用多个分类器的预测,我们计算每个伪标签组的平均置信度,并选择置信度最高的伪标签集作为目标样本的最终标签。最后,使用多个分类器输出的平均值作为模型的最终预测。使用公开可用的SEED和SEED- iv数据集进行了一套全面的实验。研究结果表明,我们提出的方法优于其他方法。
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引用次数: 0
Multimodal biometric authentication systems: exploring EEG and signature. 多模态生物识别认证系统:探索脑电图和签名。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2025-12-06 DOI: 10.1007/s11571-025-10389-w
Banee Bandana Das, Chinthala Varnitha Reddy, Ujwala Matha, Chinni Yandapalli, Saswat Kumar Ram

Biometric traits are unique characteristics of an individual's body or behavior that can be used for identification and authentication. Biometric authentication uses unique physiological and behavioral traits for secure identity verification. Traditional unimodal biometric authentication systems often suffer from spoofing attacks, sensor noise, forgery, and environmental dependencies. To overcome these limitations, our work presents multimodal biometric authentication integrated with the characteristics of electroencephalograph (EEG) signals and handwritten signatures to enhance security, efficiency, and robustness. EEG-based authentication uses the brainwave patterns' intrinsic and unforgeable nature, while signature recognition demonstrates an additional behavioral trait for effectiveness. Our system processes EEG data of an individual with 14-channel readings, and the signature with the images ensures a seamless fusion of both modalities.Combining physiological and behavioral biometrics, our approach will significantly decrease the risk of unimodal authentication, including forgery, spoofing, and sensor failures. Our system, evaluated on a dataset of 30 subjects with genuine and forged data, demonstrates a 97% accuracy. Designed for small organizations, the modular structure, low computation algorithms, and simplicity of the hardware promote deployment scalability.

生物特征是个体身体或行为的独特特征,可用于身份识别和认证。生物识别认证使用独特的生理和行为特征进行安全身份验证。传统的单峰生物识别认证系统经常受到欺骗攻击、传感器噪声、伪造和环境依赖性的影响。为了克服这些限制,我们的工作提出了结合脑电图(EEG)信号和手写签名特征的多模态生物识别认证,以提高安全性、效率和鲁棒性。基于脑电图的身份验证利用了脑电波模式固有的和不可伪造的特性,而签名识别则展示了额外的行为特征来提高有效性。我们的系统以14通道读数处理个人的脑电图数据,图像签名确保两种模式的无缝融合。结合生理和行为生物识别技术,我们的方法将显著降低单峰认证的风险,包括伪造、欺骗和传感器故障。我们的系统在30个对象的真实和伪造数据集上进行了评估,准确率达到97%。专为小型组织设计,模块化结构、低计算算法和硬件的简单性提高了部署的可扩展性。
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引用次数: 0
Distance-dependent connectivity in the brain facilitates high dynamical and structural complexity. 大脑中距离依赖的连接促进了高度动态和结构的复杂性。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2025-12-26 DOI: 10.1007/s11571-025-10398-9
Victor J Barranca

Recent experiments have revealed that the inter-regional connectivity of the cerebral cortex exhibits strengths spanning over several orders of magnitude and decaying with distance. We demonstrate this to be a fundamental organizing feature that fosters high complexity in both connectivity structure and network dynamics, achieving an advantageous balance between integration and differentiation of information. This is verified through analysis of a multi-scale neuronal network model with nonlinear integrate-and-fire dynamics, incorporating inter-regional connection strengths decaying exponentially with spatial separation at the macroscale as well as small-world local connectivity at the microscale. Through numerical simulation and optimization over the model parameterspace, we show that inter-regional connectivity over intermediate spatial scales naturally facilitates maximally heterogeneous connection strengths, agreeing well with experimental measurements. In addition, we formulate complementary notions of structural and dynamical complexity, which are computationally feasible to calculate for large multi-scale networks, and we show that high complexity manifests for each over a similar parameter regime. We expect this work may help explain the link between distance-dependence in brain connectivity and the richness of neuronal network dynamics in achieving robust brain computations and effective information processing.

最近的实验表明,大脑皮层的区域间连通性表现出跨越几个数量级的优势,并随着距离的增加而衰减。我们证明这是一个基本的组织特征,它在连接结构和网络动态方面都促进了高度复杂性,在信息的整合和分化之间实现了有利的平衡。这一点通过一个多尺度神经网络模型的分析得到了验证,该模型具有非线性的积分与火灾动力学,在宏观尺度上考虑了区域间连接强度随空间分离呈指数衰减,在微观尺度上考虑了小世界局部连通性。通过在模型参数空间上的数值模拟和优化,我们发现在中间空间尺度上的区域间连通性自然地促进了最大的异质连接强度,与实验测量结果吻合得很好。此外,我们提出了结构复杂性和动态复杂性的互补概念,这些概念在计算上是可行的,可以用于大型多尺度网络的计算,并且我们表明,在类似的参数范围内,每个网络都表现出高复杂性。我们希望这项工作可以帮助解释大脑连接的距离依赖性和丰富的神经网络动力学之间的联系,从而实现强大的大脑计算和有效的信息处理。
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引用次数: 0
Melatonin-enabled omics: understanding plant responses to single and combined abiotic stresses for climate-smart agriculture. 褪黑激素组学:了解植物对气候智能型农业的单一和联合非生物胁迫的反应。
IF 4.7 2区 农林科学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2026-12-01 Epub Date: 2026-01-27 DOI: 10.1080/21645698.2026.2614130
Ali Raza, Yiran Li, Sidra Charagh, Chunli Guo, Mengkai Zhao, Zhangli Hu

Climate change-driven single and combined abiotic stresses pose escalating threats to sustainable, climate-smart agriculture and global food security. Melatonin (MLT, a powerful plant biostimulant) has established noteworthy potential in improving stress tolerance by regulating diverse physiological, biochemical, and molecular responses. Therefore, this review delivers a comprehensive synopsis of MLT-enabled omics responses across genomics, transcriptomics, proteomics, metabolomics, miRNAomics, epigenomics, phenomics, ionomics, and microbiomics levels that collectively regulate plant adaptation to multiple abiotic stresses. We also highlight the crosstalk between these omics layers and the power of integrated multi-omics (panomics) approaches to harness the complex regulatory networks underlying MLT-enabled stress tolerance. Lastly, we argue for translating these omics insights into actionable strategies through advanced genetic engineering and synthetic biology platforms to develop MLT-enabled, stress-smart crop plants.

气候变化驱动的单一和综合非生物压力对可持续、气候智慧型农业和全球粮食安全构成越来越大的威胁。褪黑素(Melatonin, MLT)是一种强效的植物生物刺激剂,它通过调节多种生理、生化和分子反应,在改善逆境耐受性方面具有显著的潜力。因此,本综述提供了基因组学、转录组学、蛋白质组学、代谢组学、mirna组学、表观基因组学、表型组学、离子组学和微生物组学水平的mlt组学响应的综合概述,这些组学水平共同调节植物对多种非生物胁迫的适应。我们还强调了这些组学层之间的串扰,以及综合多组学(panomics)方法的力量,以利用mlt支持的耐受性背后的复杂调控网络。最后,我们主张通过先进的基因工程和合成生物学平台将这些组学见解转化为可操作的策略,以开发mlt支持的压力智能作物。
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引用次数: 0
A novel dilated Bi-LSTM framework for depression detection from speech signals through feature fusion. 基于特征融合的扩展Bi-LSTM语音信号抑制检测框架。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2026-02-03 DOI: 10.1007/s11571-026-10411-9
Uma Jaishankar, Jagannath H Nirmal, Girish Gidaye

A crucial method for determining a person's mental health and assessing their degree of depression is depression detection. To identify depression through speech or conversation, a number of sophisticated methods and questionnaires have been created. The constraints of the current system are as follows: reduced effectiveness as a result of poor feature selection and extraction, problems with interpretability, and the difficulty of identifying depression in different languages. As a result, the proposed model is presented to offer improved accuracy and efficient performance. While adaptive threshold-based pre-processing (AdaT) is used to eliminate quiet and unnecessary information, the twinned Savitzky-Golay filter (TSaG) is used to minimize noise in the dataset. To turn the signal into an image, a Synchro-Squeezed Adaptive Wavelet Transform Algorithm (SSawT) is employed. The Singular Empirical Decomposition and Sparse Autoencoder (SiFE) model is used to extract linear and deep features. Input's deep, linear, and statistical properties are combined using the Weighted Soft Attention-based Fusion (WSAttF) model. From the fused features, the Chaotic Mud Ring Optimization algorithm (ChMR) chooses the best features. A Dilated Convolutional Neural Network (CNN) based Bidirectional-Long Short Term Memory-Bi-LSTM (DiCBiL) is used to detect different stages of depression, which lowers error rates and increases detection accuracy. The proposed method achieves 93.22% of F1-score, 93.11% precision, 93.12% recall, and 93.31% accuracy on the DAIC-WOZ original test set. During the testing time, two more datasets, namely AVEC 2019 and MELD, are used to validate the proposed performance, attaining an accuracy of 93.91% and 85.34% respectively.

Supplementary information: The online version contains supplementary material available at 10.1007/s11571-026-10411-9.

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引用次数: 0
Synaptic summation shapes information transfer in GABA-glutamate co-transmission. 突触汇总影响gaba -谷氨酸共传递的信息传递。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2025-11-14 DOI: 10.1007/s11571-025-10383-2
Belle Krubitski, Cesar Ceballos, Ty Roachford, Rodrigo F O Pena

Co-transmission, the release of multiple neurotransmitters from a single neuron, is an increasingly recognized phenomenon in the nervous system. A particularly interesting combination of neurotransmitters exhibiting co-transmission is glutamate and GABA, which, when co-released from neurons, demonstrate complex biphasic activity patterns that vary depending on the time or amplitude differences from the excitatory (AMPA) or inhibitory (GABAA) signals. Naively, the outcome signal produced by these differences can be functionally interpreted as simple mechanisms that only add or remove spikes by excitation or inhibition. However, the complex interaction of multiple time-scales and amplitudes may deliver a more complex temporal coding, which is experimentally difficult to access and interpret. In this work, we employ an extensive computational approach to distinguish these postsynaptic co-transmission patterns and how they interact with dendritic filtering and ionic currents. We specifically focus on modeling the summation patterns and their flexible dynamics that arise from the many combinations of temporal and amplitude co-transmission differences. Our results indicate a number of summation patterns that excite, inhibit, and act transiently, which have been previously attributed to the interplay between the intrinsic active and passive electrical properties of the postsynaptic dendritic membrane. Our computational framework provides an insight into the complex interplay that arises between co-transmission and dendritic filtering, allowing for a mechanistic understanding underlying the integration and processing of co-transmitted signals in neural circuits.

Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10383-2.

共同传递,即多个神经递质从单个神经元释放,是神经系统中越来越被认识到的现象。一种特别有趣的神经递质组合表现为谷氨酸和GABA,当它们从神经元中共同释放时,表现出复杂的双相活动模式,其变化取决于兴奋性(AMPA)或抑制性(GABAA)信号的时间或振幅差异。天真地认为,这些差异产生的结果信号在功能上可以解释为仅仅通过激发或抑制来增加或消除尖峰的简单机制。然而,多个时间尺度和振幅的复杂相互作用可能会产生更复杂的时间编码,这在实验上很难获得和解释。在这项工作中,我们采用了广泛的计算方法来区分这些突触后共传递模式以及它们如何与树突过滤和离子电流相互作用。我们特别关注建模的总和模式和他们的灵活的动态,从时间和振幅共透射差异的许多组合产生。我们的研究结果表明,一些求和模式可以短暂地激发、抑制和作用,这些模式先前归因于突触后树突膜固有的主动和被动电特性之间的相互作用。我们的计算框架提供了对共同传输和树突滤波之间复杂相互作用的洞察,允许对神经回路中共同传输信号的整合和处理进行机制理解。补充资料:在线版本提供补充资料,网址为10.1007/s11571-025-10383-2。
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引用次数: 0
Leveraging Swin Transformer for advanced sentiment analysis: a new paradigm. 利用Swin Transformer进行高级情感分析:一个新范例。
IF 3.9 3区 工程技术 Q2 NEUROSCIENCES Pub Date : 2026-12-01 Epub Date: 2025-11-27 DOI: 10.1007/s11571-025-10378-z
Gaurav Kumar Rajput, Saurabh Kumar Srivastava, Namit Gupta

As healthcare text data becomes increasingly complex, it is vital for sentiment analysis to capture local patterns and global contextual dependencies. In this paper, we propose a hybrid Swin Transformer-BiLSTM-Spatial MLP (Swin-MLP) model that leverages hierarchical attention, shifted-window mechanisms, and spatial MLP layers to extract features from domain-specific healthcare text better. The framework is tested on domain-specific datasets for Drug Review and Medical Text, and performance is assessed against baseline models (BERT, LSTM, and GRU). Our findings show that the Swin-MLP model performs significantly better overall, achieving superior metrics (accuracy, precision, recall, F1-score, and AUC) and improving mean accuracy by 1-2% over BERT. Statistical tests to assess significance (McNemar's test and paired t-test) indicate that improvements are statistically significant (p < 0.05), suggesting the efficacy of the architectural innovations. The results' implications indicate that the model is robust, efficiently converges to classification, and is potentially helpful for a wide range of domain-specific sentiment analyses in healthcare. We will examine future research directions into exploring lightweight attention mechanisms, cross-domain multimodal sentiment analysis, federated learning to protect privacy, and hardware implications for rapid training and inference.

随着医疗保健文本数据变得越来越复杂,情感分析捕获本地模式和全局上下文依赖关系至关重要。在本文中,我们提出了一种混合Swin Transformer-BiLSTM-Spatial MLP (Swin-MLP)模型,该模型利用分层注意、移动窗口机制和空间MLP层来更好地从特定领域的医疗保健文本中提取特征。该框架在药物审查和医学文本的特定领域数据集上进行测试,并根据基线模型(BERT、LSTM和GRU)评估性能。我们的研究结果表明,swwin - mlp模型总体上表现更好,实现了更好的指标(准确率、精度、召回率、f1分数和AUC),平均准确率比BERT提高了1-2%。评估显著性的统计检验(McNemar检验和配对t检验)表明,改善具有统计学意义(p
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引用次数: 0
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