Pub Date : 2026-12-01Epub Date: 2026-02-03DOI: 10.1007/s11571-025-10407-x
Ziyue Yang, Kehan Wang, Yuhang Ming, Han Yang, Qiong Chen, Yong Peng, Wanzeng Kong
Camouflaged Object Detection (COD), the task of identifying objects concealed within their environments, has seen rapid growth due to its wide range of practical applications. We propose a human-machine collaboration framework for COD, leveraging the complementary strengths of computer vision (CV) models and noninvasive brain-computer interfaces (BCIs). Our approach introduces a multiview backbone to estimate uncertainty in CV predictions, utilizes this uncertainty during training to improve efficiency, and defers low-confidence cases to human evaluation via RSVP-based BCIs during testing for more reliable decision-making. Evaluated on the CAMO dataset, our framework achieves state-of-the-art results with an average improvement of 4.56% in balanced accuracy (BA) and 3.66% in the F1 score. For the best-performing participants, improvements reached 7.6% in BA and 6.66% in the F1 score. Training analysis showed a strong correlation between confidence and precision, while ablation studies confirmed the effectiveness of our training policy and human-machine collaboration strategy. This work reduces human cognitive load, improves system reliability, and provides a foundation for advancements in real-world COD applications and human-computer interaction. Our code and data are available at: https://github.com/ziyuey/Uncertainty-aware-human-machine-collaboration-in-camouflaged-object-identification.
{"title":"Uncertainty-aware human-machine collaboration in Camouflaged Object Detection.","authors":"Ziyue Yang, Kehan Wang, Yuhang Ming, Han Yang, Qiong Chen, Yong Peng, Wanzeng Kong","doi":"10.1007/s11571-025-10407-x","DOIUrl":"https://doi.org/10.1007/s11571-025-10407-x","url":null,"abstract":"<p><p>Camouflaged Object Detection (COD), the task of identifying objects concealed within their environments, has seen rapid growth due to its wide range of practical applications. We propose a human-machine collaboration framework for COD, leveraging the complementary strengths of computer vision (CV) models and noninvasive brain-computer interfaces (BCIs). Our approach introduces a multiview backbone to estimate uncertainty in CV predictions, utilizes this uncertainty during training to improve efficiency, and defers low-confidence cases to human evaluation via RSVP-based BCIs during testing for more reliable decision-making. Evaluated on the CAMO dataset, our framework achieves state-of-the-art results with an average improvement of 4.56% in balanced accuracy (BA) and 3.66% in the F1 score. For the best-performing participants, improvements reached 7.6% in BA and 6.66% in the F1 score. Training analysis showed a strong correlation between confidence and precision, while ablation studies confirmed the effectiveness of our training policy and human-machine collaboration strategy. This work reduces human cognitive load, improves system reliability, and provides a foundation for advancements in real-world COD applications and human-computer interaction. Our code and data are available at: https://github.com/ziyuey/Uncertainty-aware-human-machine-collaboration-in-camouflaged-object-identification.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"45"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-02-03DOI: 10.1007/s11571-025-10402-2
Yousef Dehghan, Yashar Sarbaz
The clinical manifestations of early-stage parkinsonian syndromes overlap, making accurate differential diagnosis crucial yet challenging. This study aimed to develop a system for automated differentiation of idiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). Our sample included clinical data and T1-weighted magnetic resonance imaging from 50 IPD, 47 PSP, and 38 CBS patients. We introduced an atlas-based approach to extract shape features from subcortical regions in each subject's native coordinate image space. The surface thickness and folding parameters were also extracted from cortical regions. A statistical analysis was conducted to identify regions with significant differences in the extracted features, followed by the employment of a feed-forward neural network to distinguish these patients. Significant structural differences were observed in several regions, including the thalamic nuclei, basal ganglia, midbrain, cerebellum, cingulate cortex, and insula. Using only cortical surface features, our diagnostic model outperformed the model that relied solely on subcortical shape features. However, the classifier achieved its best predictive performance when incorporating features from both cortical and subcortical structures, yielding an accuracy of 86.1% in a multi-class classification system and 96.1% for distinguishing IPD from PSP and CBS, as well as an accuracy of 94.2% for classifying CBS versus PSP in a two-class classification system. Our findings underscore the significance of cortical morphological patterns and demonstrate that the proposed methodology could potentially serve as an automated diagnostic system in clinical settings.
Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10402-2.
{"title":"Automated differentiation of parkinsonian disorders: an ROI-based analysis of subcortical shape and cortical surface features.","authors":"Yousef Dehghan, Yashar Sarbaz","doi":"10.1007/s11571-025-10402-2","DOIUrl":"https://doi.org/10.1007/s11571-025-10402-2","url":null,"abstract":"<p><p>The clinical manifestations of early-stage parkinsonian syndromes overlap, making accurate differential diagnosis crucial yet challenging. This study aimed to develop a system for automated differentiation of idiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). Our sample included clinical data and T1-weighted magnetic resonance imaging from 50 IPD, 47 PSP, and 38 CBS patients. We introduced an atlas-based approach to extract shape features from subcortical regions in each subject's native coordinate image space. The surface thickness and folding parameters were also extracted from cortical regions. A statistical analysis was conducted to identify regions with significant differences in the extracted features, followed by the employment of a feed-forward neural network to distinguish these patients. Significant structural differences were observed in several regions, including the thalamic nuclei, basal ganglia, midbrain, cerebellum, cingulate cortex, and insula. Using only cortical surface features, our diagnostic model outperformed the model that relied solely on subcortical shape features. However, the classifier achieved its best predictive performance when incorporating features from both cortical and subcortical structures, yielding an accuracy of 86.1% in a multi-class classification system and 96.1% for distinguishing IPD from PSP and CBS, as well as an accuracy of 94.2% for classifying CBS versus PSP in a two-class classification system. Our findings underscore the significance of cortical morphological patterns and demonstrate that the proposed methodology could potentially serve as an automated diagnostic system in clinical settings.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10402-2.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"30"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Place cells and head direction cells in the rodent brain encode spatial position and orientation, forming the neural basis for navigation and cognitive map construction. Inspired by these mechanisms, RatSLAM simulates their roles to achieve biologically inspired visual SLAM. However, traditional RatSLAM struggles with robust feature extraction in visually complex or dynamic environments, where features may be unstable or non-distinct. To address this, we integrate the AKAZE algorithm into the RatSLAM framework. AKAZE combines accelerated techniques with nonlinear diffusion filtering to construct a multi-scale nonlinear scale space, enabling efficient extraction of robust, scale-invariant features across spatial scales. These features are incorporated into RatSLAM's local view module to improve loop closure detection and mitigate odometry drift. Traditional evaluation approaches rely on real-time pose trajectories and cannot evaluate the trajectories based on the fully optimized experience maps, leading to inaccurate mapping performance assessments. Thus, we further propose a novel Ray-Based Map Metric Error Evaluation Method, which can directly compare the final experience maps generated by RatSLAM. Experiments on the KITTI dataset demonstrate that, compared with both ORB-RatSLAM and the ORB-SLAM3, the proposed AKAZE-RatSLAM achieves higher loop closure recall and mapping accuracy while maintaining a lightweight computational profile. In particular, CPU and memory measurements show that AKAZE-RatSLAM requires significantly less computational resources than ORB-SLAM3, confirming its suitability for real-time deployment on resource-limited robotic platforms. Furthermore, neuro-inspired analyses reveal that the pose cell network exhibits spatially localized and direction-selective firing patterns analogous to hippocampal place cells and head direction cells in rodents. Specifically, cells along the same row encode adjacent spatial regions, forming continuous place-field-like activations, whereas cells in the same column show distinct preferred orientations, indicating directional tuning. These biological characteristics confirm that the proposed AKAZE-RatSLAM not only enhances mapping performance and efficiency but also preserves the neurobiological plausibility of spatial representation, advancing the development of brain-inspired visual SLAM systems.
{"title":"A neuro-inspired visual SLAM approach using AKAZE feature extraction in complex and dynamic environments.","authors":"Ruibang Li, Yihong Wang, Xuying Xu, Fangfei Li, Fengzhen Tang, Xiaochuan Pan","doi":"10.1007/s11571-025-10386-z","DOIUrl":"https://doi.org/10.1007/s11571-025-10386-z","url":null,"abstract":"<p><p>Place cells and head direction cells in the rodent brain encode spatial position and orientation, forming the neural basis for navigation and cognitive map construction. Inspired by these mechanisms, RatSLAM simulates their roles to achieve biologically inspired visual SLAM. However, traditional RatSLAM struggles with robust feature extraction in visually complex or dynamic environments, where features may be unstable or non-distinct. To address this, we integrate the AKAZE algorithm into the RatSLAM framework. AKAZE combines accelerated techniques with nonlinear diffusion filtering to construct a multi-scale nonlinear scale space, enabling efficient extraction of robust, scale-invariant features across spatial scales. These features are incorporated into RatSLAM's local view module to improve loop closure detection and mitigate odometry drift. Traditional evaluation approaches rely on real-time pose trajectories and cannot evaluate the trajectories based on the fully optimized experience maps, leading to inaccurate mapping performance assessments. Thus, we further propose a novel Ray-Based Map Metric Error Evaluation Method, which can directly compare the final experience maps generated by RatSLAM. Experiments on the KITTI dataset demonstrate that, compared with both ORB-RatSLAM and the ORB-SLAM3, the proposed AKAZE-RatSLAM achieves higher loop closure recall and mapping accuracy while maintaining a lightweight computational profile. In particular, CPU and memory measurements show that AKAZE-RatSLAM requires significantly less computational resources than ORB-SLAM3, confirming its suitability for real-time deployment on resource-limited robotic platforms. Furthermore, neuro-inspired analyses reveal that the pose cell network exhibits spatially localized and direction-selective firing patterns analogous to hippocampal place cells and head direction cells in rodents. Specifically, cells along the same row encode adjacent spatial regions, forming continuous place-field-like activations, whereas cells in the same column show distinct preferred orientations, indicating directional tuning. These biological characteristics confirm that the proposed AKAZE-RatSLAM not only enhances mapping performance and efficiency but also preserves the neurobiological plausibility of spatial representation, advancing the development of brain-inspired visual SLAM systems.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"15"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12681500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-06DOI: 10.1007/s11571-025-10387-y
Boqiang Jia, Wenjie Wang, Xin Tian, Xiaohua Wang
In surgical procedures, surgeons can suffer from spontaneous hand tremors that can affect the accuracy of surgical robots. Therefore, it is necessary to measure and model the tremor signal by sensors to suppress hand tremor. This paper proposes a prediction method based on deep learning that integrates long-term and short-term features to achieve this goal. The long-term features of tremor signals are extracted using a bidirectional Long-short-term memory network, while the short-term features are extracted using a Temporal Convolutional Network. By integrating the long-term and short-term characteristics of tremor signals, this approach provides rich temporal information for signal estimation. In addition, genetic algorithm is used to obtain the optimal time step-size to fully explore the temporal correlation of signals, and an end data compensation strategy is adopted to ensure that the tremor filtering covers the entire process. The performance of the proposed method is evaluated by training and testing on the same dataset as other methods, and conducting suture experiments in a virtual surgical environment. The results show that our proposed model is superior to the existing methods, effectively reducing the tremor signals estimation error. This method can provide better tremor estimation and compensation performance, effectively suppressing the hand tremors and improving the surgical accuracy.
{"title":"Tremor estimation and filtering in robotic-assisted surgery.","authors":"Boqiang Jia, Wenjie Wang, Xin Tian, Xiaohua Wang","doi":"10.1007/s11571-025-10387-y","DOIUrl":"https://doi.org/10.1007/s11571-025-10387-y","url":null,"abstract":"<p><p>In surgical procedures, surgeons can suffer from spontaneous hand tremors that can affect the accuracy of surgical robots. Therefore, it is necessary to measure and model the tremor signal by sensors to suppress hand tremor. This paper proposes a prediction method based on deep learning that integrates long-term and short-term features to achieve this goal. The long-term features of tremor signals are extracted using a bidirectional Long-short-term memory network, while the short-term features are extracted using a Temporal Convolutional Network. By integrating the long-term and short-term characteristics of tremor signals, this approach provides rich temporal information for signal estimation. In addition, genetic algorithm is used to obtain the optimal time step-size to fully explore the temporal correlation of signals, and an end data compensation strategy is adopted to ensure that the tremor filtering covers the entire process. The performance of the proposed method is evaluated by training and testing on the same dataset as other methods, and conducting suture experiments in a virtual surgical environment. The results show that our proposed model is superior to the existing methods, effectively reducing the tremor signals estimation error. This method can provide better tremor estimation and compensation performance, effectively suppressing the hand tremors and improving the surgical accuracy.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"16"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12681507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-26DOI: 10.1007/s11571-025-10394-z
Qiang Li, Jiajin Huang, Haiyan Zhou
EEG signals are widely used in emotion recognition due to their capability for objective emotional state quantification. However, despite containing abundant frequency and spatial information, researchers continue to face challenges in extracting fine-grained discriminative features from these signals. We develop SC-SDT (Spectral Convolution-Spatial Differential Transformer), a novel framework that jointly models spectral and spatial characteristics through an integrated convolutional and transformer architecture. First the model is equipped with a Spectral Feature Embedding module that employs a sequential group-pointwise convolutional network. This enables the dynamic capture of both local spectral patterns within bands and global interactions across the frequency spectrum. Subsequently, a Spatial Feature Extraction module is designed to simultaneously mitigate attention noise and optimize functional connectivity mapping across EEG channels through its core differential attention mechanism. Finally, to enhance model robustness against inter-subject variability, we introduce supervised contrastive loss that explicitly enforces subject-invariant feature representations while preserving class discriminability. Employing a subject-independent experimental paradigm, we rigorously evaluated the proposed SC-SDT model on SEED, SEED-IV, and DEAP datasets to assess cross-subject generalization capabilities. Experimental results demonstrate that SC-SDT achieves competitive emotion classification performance by effectively modeling spectral-spatial neural signatures. Our analysis of its key components further reveals that the model not only pioneers the application of differential attention in EEG, but also offers a methodological foundation for efficient spectral-spatial feature extraction. The code for this paper is accessible at https://github.com/apolloCoder-byte/SC-SDT.
{"title":"SC-SDT: a framework with spectral convolution and spatial differential transformer for EEG-based emotion recognition.","authors":"Qiang Li, Jiajin Huang, Haiyan Zhou","doi":"10.1007/s11571-025-10394-z","DOIUrl":"https://doi.org/10.1007/s11571-025-10394-z","url":null,"abstract":"<p><p>EEG signals are widely used in emotion recognition due to their capability for objective emotional state quantification. However, despite containing abundant frequency and spatial information, researchers continue to face challenges in extracting fine-grained discriminative features from these signals. We develop SC-SDT (Spectral Convolution-Spatial Differential Transformer), a novel framework that jointly models spectral and spatial characteristics through an integrated convolutional and transformer architecture. First the model is equipped with a Spectral Feature Embedding module that employs a sequential group-pointwise convolutional network. This enables the dynamic capture of both local spectral patterns within bands and global interactions across the frequency spectrum. Subsequently, a Spatial Feature Extraction module is designed to simultaneously mitigate attention noise and optimize functional connectivity mapping across EEG channels through its core differential attention mechanism. Finally, to enhance model robustness against inter-subject variability, we introduce supervised contrastive loss that explicitly enforces subject-invariant feature representations while preserving class discriminability. Employing a subject-independent experimental paradigm, we rigorously evaluated the proposed SC-SDT model on SEED, SEED-IV, and DEAP datasets to assess cross-subject generalization capabilities. Experimental results demonstrate that SC-SDT achieves competitive emotion classification performance by effectively modeling spectral-spatial neural signatures. Our analysis of its key components further reveals that the model not only pioneers the application of differential attention in EEG, but also offers a methodological foundation for efficient spectral-spatial feature extraction. The code for this paper is accessible at https://github.com/apolloCoder-byte/SC-SDT.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"26"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145849050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-26DOI: 10.1007/s11571-025-10397-w
Zehui Xing, Xiyuan Wang, Junjun Huang, John W Schwieter, Huanhuan Liu
Numerous studies in the bilingual literature have shown that cognitive control adapts to several factors related to second language (L2) learning. However, whether third language (L3) learning influences cognitive control remains underexplored. In this longitudinal study, we analyzed behavioral performance and functional magnetic resonance imaging (fMRI) data among Chinese-English bilinguals at resting-state and during a flanker task both prior to English (L2) or Japanese (L3) learning and one year later. During brain resting-states for these same learners, we conducted a correlation analysis between language exam scores and functional connectivity strength of resting-state data after one year of study. The connectivity between the left anterior cingulate cortex (ACC) and the left precuneus was positively correlated with English listening performance, while the connectivity between the right supramarginal gyrus (SMG) and the right inferior parietal lobe (IPL) was negatively correlated with English oral performance. The behavioral results from the flanker task showed that after one year of L2 learning in a classroom setting, a significantly smaller flanker effect emerged among Chinese-English bilinguals. Moreover, brain imaging revealed that incongruent flanker trials elicited greater activation of the left superior frontal gyrus (SFG) than congruent trials. These behavioral and neural patterns were not found among Chinese-English bilinguals who had studied Japanese for one year. Taken together, these findings suggest that cognitive control adapts to L2 learning, but appears to be unaffected by L3 learning.
Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10397-w.
{"title":"Does learning a second or third language affect the adaptation of cognitive control in multilinguals? A longitudinal fMRI study.","authors":"Zehui Xing, Xiyuan Wang, Junjun Huang, John W Schwieter, Huanhuan Liu","doi":"10.1007/s11571-025-10397-w","DOIUrl":"https://doi.org/10.1007/s11571-025-10397-w","url":null,"abstract":"<p><p>Numerous studies in the bilingual literature have shown that cognitive control adapts to several factors related to second language (L2) learning. However, whether third language (L3) learning influences cognitive control remains underexplored. In this longitudinal study, we analyzed behavioral performance and functional magnetic resonance imaging (fMRI) data among Chinese-English bilinguals at resting-state and during a flanker task both prior to English (L2) or Japanese (L3) learning and one year later. During brain resting-states for these same learners, we conducted a correlation analysis between language exam scores and functional connectivity strength of resting-state data after one year of study. The connectivity between the left anterior cingulate cortex (ACC) and the left precuneus was positively correlated with English listening performance, while the connectivity between the right supramarginal gyrus (SMG) and the right inferior parietal lobe (IPL) was negatively correlated with English oral performance. The behavioral results from the flanker task showed that after one year of L2 learning in a classroom setting, a significantly smaller flanker effect emerged among Chinese-English bilinguals. Moreover, brain imaging revealed that incongruent flanker trials elicited greater activation of the left superior frontal gyrus (SFG) than congruent trials. These behavioral and neural patterns were not found among Chinese-English bilinguals who had studied Japanese for one year. Taken together, these findings suggest that cognitive control adapts to L2 learning, but appears to be unaffected by L3 learning.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10397-w.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"24"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145849081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-11-24DOI: 10.1007/s11571-025-10373-4
Ya Zhang, Honghui Zhang, Zhuan Shen
Abnormal τ and β-amyloid (Aβ) deposition in the brains of patients with Alzheimer's disease (AD) is significantly associated with cognitive decline. This abnormal deposition has been reported to be linked to increased excitatory and inhibitory time constants in neural circuits. In this paper, we focus on three typical electroencephalography (EEG) slowdowns clinically reported in association with AD, including decreased dominant frequency, decreased α rhythmic activity, and increased δ + θ rhythmic activity. Firstly, we demonstrate that changes in excitatory time constant, inhibitory time constants, and synaptic connection strength can induce the phenomenon of EEG slowdowns in early AD. Then, we are interested in the regulation of AD by traditional deep brain stimulation (DBS) and emerging optogenetic stimulation. High-frequency, high-pulse width, and high-amplitude DBS are more effective in reversing brain rhythm in AD, supporting the experiment that cortical high-frequency DBS may be an effective therapeutic way for dementia-related diseases. In particular, as a modification of traditional DBS, we find that oscillatory bursty stimulation can compensate for the shortcomings of DBS at low amplitude. However, it is physiologically difficult to target inhibitory interneurons with conventional electrical stimulation. Optogenetics is able to precisely stimulate pyramidal neurons and inhibitory interneurons observed in animal experiments. Our numerical results indicate that medium and low-frequency stimulation can better eliminate AD pathology. It should be noted that stimulation of inhibitory interneurons requires greater light intensity than stimulation of pyramidal neurons. Finally, we propose two optimization intermittent optogenetic stimulation protocols. These modeling results can reproduce some experimental phenomena and are expected to reveal the underlying pathological mechanisms and control strategies associated with cognitive dysfunction such as AD.
{"title":"Control analysis of deep brain stimulation and optogenetics for Alzheimer's disease under the computational cortex model.","authors":"Ya Zhang, Honghui Zhang, Zhuan Shen","doi":"10.1007/s11571-025-10373-4","DOIUrl":"https://doi.org/10.1007/s11571-025-10373-4","url":null,"abstract":"<p><p>Abnormal τ and β-amyloid (Aβ) deposition in the brains of patients with Alzheimer's disease (AD) is significantly associated with cognitive decline. This abnormal deposition has been reported to be linked to increased excitatory and inhibitory time constants in neural circuits. In this paper, we focus on three typical electroencephalography (EEG) slowdowns clinically reported in association with AD, including decreased dominant frequency, decreased <i>α</i> rhythmic activity, and increased δ + θ rhythmic activity. Firstly, we demonstrate that changes in excitatory time constant, inhibitory time constants, and synaptic connection strength can induce the phenomenon of EEG slowdowns in early AD. Then, we are interested in the regulation of AD by traditional deep brain stimulation (DBS) and emerging optogenetic stimulation. High-frequency, high-pulse width, and high-amplitude DBS are more effective in reversing brain rhythm in AD, supporting the experiment that cortical high-frequency DBS may be an effective therapeutic way for dementia-related diseases. In particular, as a modification of traditional DBS, we find that oscillatory bursty stimulation can compensate for the shortcomings of DBS at low amplitude. However, it is physiologically difficult to target inhibitory interneurons with conventional electrical stimulation. Optogenetics is able to precisely stimulate pyramidal neurons and inhibitory interneurons observed in animal experiments. Our numerical results indicate that medium and low-frequency stimulation can better eliminate AD pathology. It should be noted that stimulation of inhibitory interneurons requires greater light intensity than stimulation of pyramidal neurons. Finally, we propose two optimization intermittent optogenetic stimulation protocols. These modeling results can reproduce some experimental phenomena and are expected to reveal the underlying pathological mechanisms and control strategies associated with cognitive dysfunction such as AD.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"10"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12644327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145630690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-02-03DOI: 10.1007/s11571-025-10404-0
Sana Ullah Saqib, Shih-Hau Fang, Muhammad Asif Zahoor Raja, Kottakkaran Sooppy Nisar, Muhammad Shoaib
<p><p>Parkinson's disease (PD) is a multidimensional neurological condition designated by dopamine-sensitive neuron decline, which impairs generator and cognitive function. To study the dynamics of Parkinson's disease (PD), this paper presents a novel methodology that uses Intelligent Systems Neuro-Supervised Deep Learning Networks (INSDLNs). To describe the patterns of electrical activity in the brain metrics throughout various points in the central nervous system, we suggest a model based on mathematics governed by three distinct classes. To gain a deeper understanding of the fundamental processes underlying Parkinson's disease development, we aim to identify obscure trends within neurological data by leveraging intelligent neuro-supervised learning networks. This novel approach may lead to improved diagnostic and therapeutic approaches and holds promise for improving our understanding of the dynamics of Parkinson's disease (PD). By utilizing the features of an architecture containing multilayer recurrent layers, the suggested Intelligent Systems Neuro-Supervised Deep Learning Networks (INSDLNs) are designed. The input and target samples for INSDLNs were organizedand constructed from reference data that was formulated using the Adams method on a range of PI scenarios for modeling using a reliable numerical solver. To evaluate the impact on patterns of brain electrical activity, this method involved moving sensor positions.The differential equations are used for creating the dataset using Mathematica's ND solve function. The dataset for INSDLNs training was generated using the Adam stochastic solver. After that, this dataset is divided into three significant states: 80% is used for training, 10% is used for validation, and 15% is used for testing. The goal of these divisions is to effectively handle the difficulties presented by the dynamical model. The datasets, randomly divided into training, testing, and validation samples, were used to apply the INSDLNs created for the study. To ensure the model's stability and efficacy on various data sets, the procedure for segmentation was executed by optimizing a fitness function based on mean squared error. The proposed INSDLNs demonstrate accuracy, preciseness, and security through the achievement of minimal mean squared error (MSE), complete regression analysis (Rg. As), optimized error histograms (Err. Hg), auto-correlation of error (AC of Err), cross-correlation of input with error (CCIEr), and minimal absolute error (Ab. Er).When modeling the brain rhythms of Parkinson's disease, our INSDLNs outperformed LMBPA and BRM with very low error (MSE: 5.86E-12 ± 2.1E-12), nearly zero absolute error, and strong regression accuracy (R2 ≈ 0.998).A lower mean square error (MSE) shows that the suggested approach operates effectively and that the forecasts generated by the model are more reliable. Reaching an almost zero absolute error (Ab. Er) provides more evidence for INSDLNs. These results highlight the high
帕金森病(PD)是一种以多巴胺敏感神经元衰退为特征的多维神经系统疾病,其产生和认知功能受到损害。为了研究帕金森病(PD)的动力学,本文提出了一种使用智能系统神经监督深度学习网络(insdln)的新方法。为了描述贯穿中枢神经系统各个点的脑电活动模式,我们提出了一个基于数学的模型,该模型由三个不同的类别控制。为了更深入地了解帕金森病发展的基本过程,我们的目标是利用智能神经监督学习网络来识别神经学数据中的模糊趋势。这种新方法可能会改善诊断和治疗方法,并有望提高我们对帕金森病(PD)动力学的理解。通过利用包含多层循环层的体系结构的特征,设计了建议的智能系统神经监督深度学习网络(insdln)。insdln的输入和目标样本是根据参考数据组织和构建的,这些参考数据是使用亚当斯方法在一系列PI场景中制定的,使用可靠的数值求解器进行建模。为了评估对脑电活动模式的影响,这种方法涉及移动传感器的位置。微分方程用于使用Mathematica的ND solve函数创建数据集。insdln训练数据集使用Adam随机求解器生成。之后,该数据集被划分为三个显著状态:80%用于训练,10%用于验证,15%用于测试。这些划分的目的是为了有效地处理动态模型所带来的困难。数据集随机分为训练样本、测试样本和验证样本,用于应用为本研究创建的insdln。为了保证模型在各种数据集上的稳定性和有效性,通过基于均方误差的适应度函数优化来执行分割过程。所提出的insdln通过实现最小均方误差(MSE)、完全回归分析(Rg),证明了准确性、精确性和安全性。As),优化的误差直方图(Err。Hg),误差的自相关(Err的AC),输入与误差的互相关(CCIEr),最小绝对误差(Ab. Er)。在模拟帕金森病脑节律时,INSDLNs优于LMBPA和BRM,误差极低(MSE: 5.86E-12±2.11 e -12),绝对误差接近于零,回归精度强(R2≈0.998)。较低的均方误差(MSE)表明该方法运行有效,模型生成的预测更可靠。达到几乎为零的绝对误差(Ab. Er)为insdln提供了更多证据。这些结果突出了应用insdln和追求最佳解决方案所获得的更高的准确性和预测能力。
{"title":"Design of intelligent neuro-supervised deep learning networks to analyze brain electrical activity rhythms of Parkinson's disease model.","authors":"Sana Ullah Saqib, Shih-Hau Fang, Muhammad Asif Zahoor Raja, Kottakkaran Sooppy Nisar, Muhammad Shoaib","doi":"10.1007/s11571-025-10404-0","DOIUrl":"https://doi.org/10.1007/s11571-025-10404-0","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a multidimensional neurological condition designated by dopamine-sensitive neuron decline, which impairs generator and cognitive function. To study the dynamics of Parkinson's disease (PD), this paper presents a novel methodology that uses Intelligent Systems Neuro-Supervised Deep Learning Networks (INSDLNs). To describe the patterns of electrical activity in the brain metrics throughout various points in the central nervous system, we suggest a model based on mathematics governed by three distinct classes. To gain a deeper understanding of the fundamental processes underlying Parkinson's disease development, we aim to identify obscure trends within neurological data by leveraging intelligent neuro-supervised learning networks. This novel approach may lead to improved diagnostic and therapeutic approaches and holds promise for improving our understanding of the dynamics of Parkinson's disease (PD). By utilizing the features of an architecture containing multilayer recurrent layers, the suggested Intelligent Systems Neuro-Supervised Deep Learning Networks (INSDLNs) are designed. The input and target samples for INSDLNs were organizedand constructed from reference data that was formulated using the Adams method on a range of PI scenarios for modeling using a reliable numerical solver. To evaluate the impact on patterns of brain electrical activity, this method involved moving sensor positions.The differential equations are used for creating the dataset using Mathematica's ND solve function. The dataset for INSDLNs training was generated using the Adam stochastic solver. After that, this dataset is divided into three significant states: 80% is used for training, 10% is used for validation, and 15% is used for testing. The goal of these divisions is to effectively handle the difficulties presented by the dynamical model. The datasets, randomly divided into training, testing, and validation samples, were used to apply the INSDLNs created for the study. To ensure the model's stability and efficacy on various data sets, the procedure for segmentation was executed by optimizing a fitness function based on mean squared error. The proposed INSDLNs demonstrate accuracy, preciseness, and security through the achievement of minimal mean squared error (MSE), complete regression analysis (Rg. As), optimized error histograms (Err. Hg), auto-correlation of error (AC of Err), cross-correlation of input with error (CCIEr), and minimal absolute error (Ab. Er).When modeling the brain rhythms of Parkinson's disease, our INSDLNs outperformed LMBPA and BRM with very low error (MSE: 5.86E-12 ± 2.1E-12), nearly zero absolute error, and strong regression accuracy (R2 ≈ 0.998).A lower mean square error (MSE) shows that the suggested approach operates effectively and that the forecasts generated by the model are more reliable. Reaching an almost zero absolute error (Ab. Er) provides more evidence for INSDLNs. These results highlight the high","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"32"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain-controlled wheelchair (BCW) technology enables direct wheelchair control via brain-computer interfaces (BCIs), eliminating the need for physical limb interaction. Motor imagery-based BCIs (MI-BCIs) are widely used in non-invasive BCIs due to their ability to provide intuitive neural control without external stimuli. However, developing a BCW system based on MI-BCIs remains challenging, particularly in achieving reliable multi-class classification accuracy.To address this challenge, this study proposes an advanced feature extraction algorithm to enhance MI-BCI performance using a custom-built five-class MI-EEG dataset. The proposed method, EHT-CSP, integrates Ensemble Empirical Mode Decomposition Hilbert-Huang Transform (EEMD-HHT) with Time-Frequency Common Spatial Pattern (TFCSP). Specifically, it extracts marginal spectrum entropy and energy spectrum entropy via EEMD-HHT. It then combines these features with TFCSP-derived feature vectors to improve feature discrimination. The Light Gradient Boosting Machine is then employed for classification. The proposed MI-BCI system is evaluated through both offline analysis and real-world BCW obstacle avoidance experiments. Results demonstrate that the algorithm achieves an average classification accuracy of 78.45%, with all participants successfully completing BCW navigation tasks. In this study, LightGBM and EHT-CSP are compared with other algorithms respectively, and it is verified that the proposed model is superior to the existing models.
{"title":"Five-class motor imagery BCI classification and its application to brain-controlled wheelchairs.","authors":"Hongguang Pan, Bingyang Teng, Zesheng Liu, Shiyu Tong, Xinyu Yu, Zhuoyi Li","doi":"10.1007/s11571-026-10412-8","DOIUrl":"https://doi.org/10.1007/s11571-026-10412-8","url":null,"abstract":"<p><p>Brain-controlled wheelchair (BCW) technology enables direct wheelchair control via brain-computer interfaces (BCIs), eliminating the need for physical limb interaction. Motor imagery-based BCIs (MI-BCIs) are widely used in non-invasive BCIs due to their ability to provide intuitive neural control without external stimuli. However, developing a BCW system based on MI-BCIs remains challenging, particularly in achieving reliable multi-class classification accuracy.To address this challenge, this study proposes an advanced feature extraction algorithm to enhance MI-BCI performance using a custom-built five-class MI-EEG dataset. The proposed method, EHT-CSP, integrates Ensemble Empirical Mode Decomposition Hilbert-Huang Transform (EEMD-HHT) with Time-Frequency Common Spatial Pattern (TFCSP). Specifically, it extracts marginal spectrum entropy and energy spectrum entropy via EEMD-HHT. It then combines these features with TFCSP-derived feature vectors to improve feature discrimination. The Light Gradient Boosting Machine is then employed for classification. The proposed MI-BCI system is evaluated through both offline analysis and real-world BCW obstacle avoidance experiments. Results demonstrate that the algorithm achieves an average classification accuracy of 78.45%, with all participants successfully completing BCW navigation tasks. In this study, LightGBM and EHT-CSP are compared with other algorithms respectively, and it is verified that the proposed model is superior to the existing models.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"38"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-01Epub Date: 2026-01-14DOI: 10.1115/1.4069564
Sebastian Barrutia, Christian Knuth, Daniel Ferris
Pediatric exoskeletons have the potential to aid the walking of children with neuromuscular conditions such as crouch gait. However, current exoskeleton devices often rely on bulky batteries and motors. Recent developments in 3D-printing technologies now allow the construction of lightweight yet stiff parts that are easy to customize and use for pediatric applications. We present the mechanical design of a 3D-printed and spring-powered knee exoskeleton for gait assistance. The device had a mass of ∼1.25 kg per leg and provided a knee extensor moment during the stance phase of gait, simulating the spring-like behavior of the knee. Conversely, the exoskeleton provided no resistance during swing to allow free motion of the joint. To validate the device, we recruited two neurologically intact children to walk on a treadmill with and without the exoskeleton while we recorded kinematics, kinetics, and muscle activity data. Our exoskeleton generated knee extensor moments proportional to its angular excursion and had a peak mean moment of ∼0.1 N·m/kg during stance. Kinetic data showed that subjects decreased their biological knee moment and joint spring-like behavior to compensate for the added exoskeleton moment and stiffness, respectively. We ultimately show that the device is robust and capable of generating extensor moments comparable to devices used to assist the knee in children with crouch gait.
{"title":"Design and Preliminary Testing of a Lightweight and Low-Cost Knee Exoskeleton For Human Gait Assistance.","authors":"Sebastian Barrutia, Christian Knuth, Daniel Ferris","doi":"10.1115/1.4069564","DOIUrl":"https://doi.org/10.1115/1.4069564","url":null,"abstract":"<p><p>Pediatric exoskeletons have the potential to aid the walking of children with neuromuscular conditions such as crouch gait. However, current exoskeleton devices often rely on bulky batteries and motors. Recent developments in 3D-printing technologies now allow the construction of lightweight yet stiff parts that are easy to customize and use for pediatric applications. We present the mechanical design of a 3D-printed and spring-powered knee exoskeleton for gait assistance. The device had a mass of ∼1.25 kg per leg and provided a knee extensor moment during the stance phase of gait, simulating the spring-like behavior of the knee. Conversely, the exoskeleton provided no resistance during swing to allow free motion of the joint. To validate the device, we recruited two neurologically intact children to walk on a treadmill with and without the exoskeleton while we recorded kinematics, kinetics, and muscle activity data. Our exoskeleton generated knee extensor moments proportional to its angular excursion and had a peak mean moment of ∼0.1 N·m/kg during stance. Kinetic data showed that subjects decreased their biological knee moment and joint spring-like behavior to compensate for the added exoskeleton moment and stiffness, respectively. We ultimately show that the device is robust and capable of generating extensor moments comparable to devices used to assist the knee in children with crouch gait.</p>","PeriodicalId":49305,"journal":{"name":"Journal of Medical Devices-Transactions of the Asme","volume":"20 2","pages":"021009"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}