Clinical application of chimeric molecules for targeted protein degradation has been limited by unfavorable drug-like properties and biosafety concerns arising from nonspecific biodistribution after systemic administration. Here we develop a method to engineer platelets for degradation of either intracellular or extracellular proteins of interest (POIs) in vivo by covalently labeling heat shock protein 90 (HSP90) in platelets with a POI ligand. The degrader platelets (DePLTs) target wound areas and undergo activation. Depending on the tethered POI ligand and transport mechanism of the prelabeled HSP90, activated DePLTs can mediate targeted protein degradation in the target cell through the ubiquitin–proteasome machinery or the lysosome. HSP90 packaged into platelet-derived microparticles uses the ubiquitin–proteasome system to degrade intracellular POIs, whereas released free HSP90 redirects extracellular POIs to lysosomal degradation. In postsurgical breast cancer mouse models, DePLTs engineered with corresponding POI ligands effectively degrade intracellular bromodomain-containing protein 4 or extracellular programmed cell death ligand 1, thereby suppressing cancer recurrence or metastasis.
{"title":"Engineered platelets as targeted protein degraders and application to breast cancer models","authors":"Yu Chen, Samira Pal, Wen Li, Fengyuan Liu, Sichen Yuan, Quanyin Hu","doi":"10.1038/s41587-024-02494-8","DOIUrl":"https://doi.org/10.1038/s41587-024-02494-8","url":null,"abstract":"<p>Clinical application of chimeric molecules for targeted protein degradation has been limited by unfavorable drug-like properties and biosafety concerns arising from nonspecific biodistribution after systemic administration. Here we develop a method to engineer platelets for degradation of either intracellular or extracellular proteins of interest (POIs) in vivo by covalently labeling heat shock protein 90 (HSP90) in platelets with a POI ligand. The degrader platelets (DePLTs) target wound areas and undergo activation. Depending on the tethered POI ligand and transport mechanism of the prelabeled HSP90, activated DePLTs can mediate targeted protein degradation in the target cell through the ubiquitin–proteasome machinery or the lysosome. HSP90 packaged into platelet-derived microparticles uses the ubiquitin–proteasome system to degrade intracellular POIs, whereas released free HSP90 redirects extracellular POIs to lysosomal degradation. In postsurgical breast cancer mouse models, DePLTs engineered with corresponding POI ligands effectively degrade intracellular bromodomain-containing protein 4 or extracellular programmed cell death ligand 1, thereby suppressing cancer recurrence or metastasis.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"12 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.seppur.2024.130926
Feng He, Junhuan Tang, Qianxiang Xiao, Wen He, Qixu Chen, Ziyang Chang, Chongkun Zhao, Kai Liu, Hongqing Wang
In uranium(VI) (U(VI)) photoreduction, it is still a challenge to simultaneously degrade naturally coexisting organics and explore their impact on U(VI) photoreduction. Meanwhile, how to boost the separation and transport capability of photo-induced carriers is also a hot topic of current research. In this work, an ultrathin Bi2WO6/Bi2MoO6 Z-type heterojunction was developed for the simultaneous treatment of U(VI) and its co-existing organics (tannic acid (TA)). Ultrathin interface engineering increased the contact area and shortened the transmission distance of photo-induced carriers. As a result, ultrathin Bi2WO6/Bi2MoO6 exhibited highly efficient U(VI) removal rate (95.8 %) and TA degradation rate (97.2 %), which were much higher than those of bulk Bi2WO6/Bi2MoO6 and single ultrathin Bi2WO6. In addition, the material possessed excellent stability and recyclability. Importantly, TA not only enhanced U(VI) removal by eliminating holes, but also favored U(VI) removal by serving as a bridge to the catalyst for U(VI) adsorption. Finally, a new mechanism was proposed.
{"title":"Simultaneous photocatalytic treatment of wastewater containing uranium(VI) and tannic acid by ultrathin Bi2WO6/Bi2MoO6 heterojunction","authors":"Feng He, Junhuan Tang, Qianxiang Xiao, Wen He, Qixu Chen, Ziyang Chang, Chongkun Zhao, Kai Liu, Hongqing Wang","doi":"10.1016/j.seppur.2024.130926","DOIUrl":"https://doi.org/10.1016/j.seppur.2024.130926","url":null,"abstract":"In uranium(VI) (U(VI)) photoreduction, it is still a challenge to simultaneously degrade naturally coexisting organics and explore their impact on U(VI) photoreduction. Meanwhile, how to boost the separation and transport capability of photo-induced carriers is also a hot topic of current research. In this work, an ultrathin Bi<sub>2</sub>WO<sub>6</sub>/Bi<sub>2</sub>MoO<sub>6</sub> Z-type heterojunction was developed for the simultaneous treatment of U(VI) and its co-existing organics (tannic acid (TA)). Ultrathin interface engineering increased the contact area and shortened the transmission distance of photo-induced carriers. As a result, ultrathin Bi<sub>2</sub>WO<sub>6</sub>/Bi<sub>2</sub>MoO<sub>6</sub> exhibited highly efficient U(VI) removal rate (95.8 %) and TA degradation rate (97.2 %), which were much higher than those of bulk Bi<sub>2</sub>WO<sub>6</sub>/Bi<sub>2</sub>MoO<sub>6</sub> and single ultrathin Bi<sub>2</sub>WO<sub>6</sub>. In addition, the material possessed excellent stability and recyclability. Importantly, TA not only enhanced U(VI) removal by eliminating holes, but also favored U(VI) removal by serving as a bridge to the catalyst for U(VI) adsorption. Finally, a new mechanism was proposed.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"37 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.ijhydene.2024.11.396
Nan Jiang , Chang Su , Jiayou Li , Yuhan Zhang , Bing Wang , Bolong Jiang , Weijun Gao
The design of cost-effective oxygen reduction reaction (ORR) catalysts in microbial fuel cells (MFCs) remains a challenge. Herein, a mesoporous silica (mSiO2) assisted protection strategy is developed to synthesize highly dispersed CuCo nanoalloys embedded in nitrogen doped carbon Cu/Co-NC@mS catalyst using zeolitic imidazolate framework (ZIF) as carbon and nitrogen sources. The results revealed that the mSiO2 protection holds the potential to inhabit CuCo nanoalloys from aggregation and thus promotes the formation of highly dispersed small CuCo nanoparticles. The obtained catalyst with pyrolysis temperature (T) of 800 °C (Cu/Co-NC@mS-800) achieves the best ORR performance among Cu/Co-NC@mS-T catalysts, yielding a maximum power density of 1000 mW m−2 when employed as air cathode MFCs. The significantly enhanced ORR performance of Cu/Co-NC@mS-800 could be attributed to following aspects: a) highly dispersed small CuCo nanoalloy particles, improved mesoporous surface area and volume owing to mSiO2 protection; (b) the formation of concave regular dodecahedron mesoporous structure with thin graphtic carbon layer as support; (c) the synergetic effect between CuCo nanoalloys. This work provides a facile strategy for the preparation of highly dispersed bimetal nanoalloys with enhanced electrocatalytic performance for energy-related applications.
{"title":"Mesoporous silica-modified metal organic frameworks derived bimetallic electrocatalysts for oxygen reduction reaction in microbial fuel cells","authors":"Nan Jiang , Chang Su , Jiayou Li , Yuhan Zhang , Bing Wang , Bolong Jiang , Weijun Gao","doi":"10.1016/j.ijhydene.2024.11.396","DOIUrl":"10.1016/j.ijhydene.2024.11.396","url":null,"abstract":"<div><div>The design of cost-effective oxygen reduction reaction (ORR) catalysts in microbial fuel cells (MFCs) remains a challenge. Herein, a mesoporous silica (mSiO<sub>2</sub>) assisted protection strategy is developed to synthesize highly dispersed CuCo nanoalloys embedded in nitrogen doped carbon Cu/Co-NC@mS catalyst using zeolitic imidazolate framework (ZIF) as carbon and nitrogen sources. The results revealed that the mSiO<sub>2</sub> protection holds the potential to inhabit CuCo nanoalloys from aggregation and thus promotes the formation of highly dispersed small CuCo nanoparticles. The obtained catalyst with pyrolysis temperature (T) of 800 °C (Cu/Co-NC@mS-800) achieves the best ORR performance among Cu/Co-NC@mS-T catalysts, yielding a maximum power density of 1000 mW m<sup>−2</sup> when employed as air cathode MFCs. The significantly enhanced ORR performance of Cu/Co-NC@mS-800 could be attributed to following aspects: a) highly dispersed small CuCo nanoalloy particles, improved mesoporous surface area and volume owing to mSiO<sub>2</sub> protection; (b) the formation of concave regular dodecahedron mesoporous structure with thin graphtic carbon layer as support; (c) the synergetic effect between CuCo nanoalloys. This work provides a facile strategy for the preparation of highly dispersed bimetal nanoalloys with enhanced electrocatalytic performance for energy-related applications.</div></div>","PeriodicalId":337,"journal":{"name":"International Journal of Hydrogen Energy","volume":"97 ","pages":"Pages 571-580"},"PeriodicalIF":8.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.mechmachtheory.2024.105833
Zhibin Song , Yuanhao Zhang , Yifan Wu , Shiyu Li , Lixuan Zhao , Hongyu Cao , Rongjie Kang , Liwei Shi , Jian S. Dai
The majority of underwater vehicles currently use screw propellers as propulsion method. Despite screw propellers are being promoted to increase the efficiency through better designs and technologies, the circumferential flow caused by the rotation of screw propeller results in wasted energy. This paper proposes an ideal reciprocating straight propulsion paradigm that eliminates this waste by implementing straight backward thrust based on a foldable mechanism. This mechanism can implement a maximized propulsion during the propelling stroke and a minimized resistance during recovery by folding and unfolding the mechanism, which can be adjusted passively via the relative motion between the thruster mechanism and water avoiding using sensors and actuations. This principle makes the reciprocating straight propulsion simple and reliable to be achieved in practice. Besides, a modularized propulsion system with four identical independently thrusters based on the proposed mechanism was proposed, achieving various motion modes in underwater vehicles. The proposed propulsion mechanism was theoretically analyzed and verified through simulations and prototype tests. In mooring tests, the thrust provided by the proposed mechanism is similar to the simulation results. The propulsion performance indicator of an underwater vehicle with the proposed propulsor reached 66 %. The mechanism could turn even with one-sided propulsion.
{"title":"A new reciprocating straight propulsion for high propulsive hydrodynamic efficiency","authors":"Zhibin Song , Yuanhao Zhang , Yifan Wu , Shiyu Li , Lixuan Zhao , Hongyu Cao , Rongjie Kang , Liwei Shi , Jian S. Dai","doi":"10.1016/j.mechmachtheory.2024.105833","DOIUrl":"10.1016/j.mechmachtheory.2024.105833","url":null,"abstract":"<div><div>The majority of underwater vehicles currently use screw propellers as propulsion method. Despite screw propellers are being promoted to increase the efficiency through better designs and technologies, the circumferential flow caused by the rotation of screw propeller results in wasted energy. This paper proposes an ideal reciprocating straight propulsion paradigm that eliminates this waste by implementing straight backward thrust based on a foldable mechanism. This mechanism can implement a maximized propulsion during the propelling stroke and a minimized resistance during recovery by folding and unfolding the mechanism, which can be adjusted passively via the relative motion between the thruster mechanism and water avoiding using sensors and actuations. This principle makes the reciprocating straight propulsion simple and reliable to be achieved in practice. Besides, a modularized propulsion system with four identical independently thrusters based on the proposed mechanism was proposed, achieving various motion modes in underwater vehicles. The proposed propulsion mechanism was theoretically analyzed and verified through simulations and prototype tests. In mooring tests, the thrust provided by the proposed mechanism is similar to the simulation results. The propulsion performance indicator of an underwater vehicle with the proposed propulsor reached 66 %. The mechanism could turn even with one-sided propulsion.</div></div>","PeriodicalId":49845,"journal":{"name":"Mechanism and Machine Theory","volume":"205 ","pages":"Article 105833"},"PeriodicalIF":4.5,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The composition and structure of spinnable pitch was always the key issue of pitch-based carbon fiber preparation, with the foundation step of coal tar pitch purifying. In this work, wash oil was chosen as refining solvent due to its aromatic properties, compared with tetrahydrofuran (THF). Two isotropic spinnable pitches (WO-SP and THF-SP) were prepared by air-blowing of refined pitches, with similar elementary compositions, soften points (250 ℃) and aromaticity, but WO-SP displayed a slower descent of viscosity with temperature rising, which was related to the molecular weight distribution and aromatic structure. The main aromatic components of pitches/spinnable pitches were determined by using fluorescence excitation-emission spectroscopy with parallel factor analysis (EEM-PARAFAC), combined with a stepwise extraction and mass spectrometry analysis. Difference between WO-SP and THF-SP mainly lied in 9.16 wt% more proportion of components with molecular weight > 600 Da in the THF-soluble fraction of WO-SP, forming less pyrene-like structure (four fused rings) and more structure bigger than benzo[g,h,i]perylene (six fused rings). Meanwhile, WO-SP had 9.6 wt% more content of large quinoline-soluble components than THF-SP, with little aromatic structures smaller than five fused rings. These characteristics made carbon fiber from WO-SP with a better tensile strength of 790 ± 37 MPa and a tensile modulus of 40.8 ± 3.2 GPa, than that from THF-SP. Therefore, wash oil could be a promising refining solvent, and increasing the content and large aromatic structure of high molecular weight component in spinnable pitch was beneficial for improvement of carbon fiber performance.
{"title":"Preparation of pitch-based carbon fiber from medium coal tar pitch refined by wash oil","authors":"Pingping Zuo, Shaobo Fu, Xiaoqiang He, Hongxian Niu, Shijie Qu, Wenzhong Shen","doi":"10.1016/j.fuel.2024.133939","DOIUrl":"10.1016/j.fuel.2024.133939","url":null,"abstract":"<div><div>The composition and structure of spinnable pitch was always the key issue of pitch-based carbon fiber preparation, with the foundation step of coal tar pitch purifying. In this work, wash oil was chosen as refining solvent due to its aromatic properties, compared with tetrahydrofuran (THF). Two isotropic spinnable pitches (WO-SP and THF-SP) were prepared by air-blowing of refined pitches, with similar elementary compositions, soften points (250 ℃) and aromaticity, but WO-SP displayed a slower descent of viscosity with temperature rising, which was related to the molecular weight distribution and aromatic structure. The main aromatic components of pitches/spinnable pitches were determined by using fluorescence excitation-emission spectroscopy with parallel factor analysis (EEM-PARAFAC), combined with a stepwise extraction and mass spectrometry analysis. Difference between WO-SP and THF-SP mainly lied in 9.16 wt% more proportion of components with molecular weight > 600 Da in the THF-soluble fraction of WO-SP, forming less pyrene-like structure (four fused rings) and more structure bigger than benzo[g,h,i]perylene (six fused rings). Meanwhile, WO-SP had 9.6 wt% more content of large quinoline-soluble components than THF-SP, with little aromatic structures smaller than five fused rings. These characteristics made carbon fiber from WO-SP with a better tensile strength of 790 ± 37 MPa and a tensile modulus of 40.8 ± 3.2 GPa, than that from THF-SP. Therefore, wash oil could be a promising refining solvent, and increasing the content and large aromatic structure of high molecular weight component in spinnable pitch was beneficial for improvement of carbon fiber performance.</div></div>","PeriodicalId":325,"journal":{"name":"Fuel","volume":"384 ","pages":"Article 133939"},"PeriodicalIF":6.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.apenergy.2024.124989
Jinho Ha , Seongyoon Kim , Youngkwon Kim , Jung-Il Choi
This study proposes a framework for evaluating the electrochemical performance of a vanadium redox flow battery (VRFB) system. First, a numerical solver for redox flow battery is constructed to represent the multi-physics system through systems of ordinary differential equations, which describe the mass conservation of existing vanadium ions. The present numerical model is validated regarding the voltage by comparing its results with the experimental results of previous studies. Second, we identify the parameters in the governing equations using a genetic algorithm with the present numerical model. We select seven parameters by considering the physical meaning of each parameter related to the electrochemical performance. The voltage for the first charging/discharging cycle and capacity fade data are used to identify the selected parameters. The voltage and capacity fade estimated by the parameters identified using the numerical model align with the previous studies. Finally, we analyze the global sensitivity of the identified parameters in terms of the voltage and capacity fade using the total Sobol’ indices because the high sensitivity confirms that the identified parameters have reliable values. As expected, voltage- and capacity-related parameters show high total Sobol’ indices for the voltage and discharging capacity, respectively. Furthermore, we predict the performance of the VRFBs using the identified parameter set and numerical model during 30-cycle operations. Additionally, the performance is compared according to the current density and vanadium concentration in the electrolyte. The proposed framework can be used to evaluate the electrochemical characteristics of developed VRFBs by identifying parameters related to physical performance, such as voltage and capacity fade. Moreover, the identified parameters can be utilized to predict voltage and capacity performance, enabling the optimization of operating conditions and configurations of VRFBs.
{"title":"Capacity fade-aware parameter identification of zero-dimensional model for vanadium redox flow batteries","authors":"Jinho Ha , Seongyoon Kim , Youngkwon Kim , Jung-Il Choi","doi":"10.1016/j.apenergy.2024.124989","DOIUrl":"10.1016/j.apenergy.2024.124989","url":null,"abstract":"<div><div>This study proposes a framework for evaluating the electrochemical performance of a vanadium redox flow battery (VRFB) system. First, a numerical solver for redox flow battery is constructed to represent the multi-physics system through systems of ordinary differential equations, which describe the mass conservation of existing vanadium ions. The present numerical model is validated regarding the voltage by comparing its results with the experimental results of previous studies. Second, we identify the parameters in the governing equations using a genetic algorithm with the present numerical model. We select seven parameters by considering the physical meaning of each parameter related to the electrochemical performance. The voltage for the first charging/discharging cycle and capacity fade data are used to identify the selected parameters. The voltage and capacity fade estimated by the parameters identified using the numerical model align with the previous studies. Finally, we analyze the global sensitivity of the identified parameters in terms of the voltage and capacity fade using the total Sobol’ indices because the high sensitivity confirms that the identified parameters have reliable values. As expected, voltage- and capacity-related parameters show high total Sobol’ indices for the voltage and discharging capacity, respectively. Furthermore, we predict the performance of the VRFBs using the identified parameter set and numerical model during 30-cycle operations. Additionally, the performance is compared according to the current density and vanadium concentration in the electrolyte. The proposed framework can be used to evaluate the electrochemical characteristics of developed VRFBs by identifying parameters related to physical performance, such as voltage and capacity fade. Moreover, the identified parameters can be utilized to predict voltage and capacity performance, enabling the optimization of operating conditions and configurations of VRFBs.</div></div>","PeriodicalId":246,"journal":{"name":"Applied Energy","volume":"380 ","pages":"Article 124989"},"PeriodicalIF":10.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.jcsr.2024.109205
Qi Cai , Jiaming Ma , Yi Min Xie , Yongchao Zhang , Yiyi Zhou
Ensuring stability in the practical application of optimized trusses is essential. Conventional optimization formulations use cross-sectional areas and axial force of members as design variables, but imposing member buckling constraints results in a concave feasible set, making the problem challenging to solve. Additionally, unstable nodes within continuous parallel compressive members complicate the determination of buckling strength. Here, we present an algorithm named evolutionary truss optimization (ETO) to address both global instability and member buckling issues. Initially, a convex semidefinite constraint is integrated into the optimization framework to ensure global stability and resolve challenges posed by unstable nodes, ensuring accurate buckling lengths of members. Subsequently, the concave optimization problem is transformed into a series of convex optimization problems by iteratively linearizing member buckling constraints, mitigating convergence issues. Optimization results from two numerical examples show that the proposed method ensures both the global stability and member stability. Its effectiveness is validated through comparisons with results from existing algorithms.
{"title":"Topology optimization of trusses considering global stability and member buckling","authors":"Qi Cai , Jiaming Ma , Yi Min Xie , Yongchao Zhang , Yiyi Zhou","doi":"10.1016/j.jcsr.2024.109205","DOIUrl":"10.1016/j.jcsr.2024.109205","url":null,"abstract":"<div><div>Ensuring stability in the practical application of optimized trusses is essential. Conventional optimization formulations use cross-sectional areas and axial force of members as design variables, but imposing member buckling constraints results in a concave feasible set, making the problem challenging to solve. Additionally, unstable nodes within continuous parallel compressive members complicate the determination of buckling strength. Here, we present an algorithm named evolutionary truss optimization (ETO) to address both global instability and member buckling issues. Initially, a convex semidefinite constraint is integrated into the optimization framework to ensure global stability and resolve challenges posed by unstable nodes, ensuring accurate buckling lengths of members. Subsequently, the concave optimization problem is transformed into a series of convex optimization problems by iteratively linearizing member buckling constraints, mitigating convergence issues. Optimization results from two numerical examples show that the proposed method ensures both the global stability and member stability. Its effectiveness is validated through comparisons with results from existing algorithms.</div></div>","PeriodicalId":15557,"journal":{"name":"Journal of Constructional Steel Research","volume":"226 ","pages":"Article 109205"},"PeriodicalIF":4.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.jcsr.2024.109200
Maria Cristina Porcu , Manuel Buitrago , Pedro A. Calderón , Michele Garau , Mariano F. Cocco , Jose M. Adam
Risks of bridge collapse were and continue to be real as evidenced by classical (e.g. Québec Bridge, Canada 1919; Seongsu Bridge, South Korea 1994) and recent (e.g. Skagit River Bridge, USA 2013; Francis Scott Key Bridge, USA 2024) episodes of catastrophic collapses. The causes of each collapse are diverse (e.g. natural disasters, changing conditions, design errors, intentional attacks). Still, the conclusions are always the same: deaths, injuries and large amounts of direct and indirect economic losses. In order to avoid these catastrophes, structural robustness and monitoring strategies can be used to analyse the bridge's vulnerability and anticipate any local-initial failure that can spread to the whole structure in the form of a progressive collapse. The objective of this work was to use an integrative threat-dependent and threat-independent approach to analyse the structural robustness of a never-before-studied U-shaped open cross-section steel truss railway bridge structure. Eight failure scenarios were considered and analysed through computational modelling. The extracted results make it possible: (i) to connect structural robustness analysis outputs with the definition of a new structural health monitoring strategy of the bridge; and (ii) to implement the conclusions in the real bridge with more than 100 sensors and a non-assisted alarm system for preventing progressive collapse.
{"title":"Robustness-based assessment and monitoring of steel truss railway bridges to prevent progressive collapse","authors":"Maria Cristina Porcu , Manuel Buitrago , Pedro A. Calderón , Michele Garau , Mariano F. Cocco , Jose M. Adam","doi":"10.1016/j.jcsr.2024.109200","DOIUrl":"10.1016/j.jcsr.2024.109200","url":null,"abstract":"<div><div>Risks of bridge collapse were and continue to be real as evidenced by classical (e.g. Québec Bridge, Canada 1919; Seongsu Bridge, South Korea 1994) and recent (e.g. Skagit River Bridge, USA 2013; Francis Scott Key Bridge, USA 2024) episodes of catastrophic collapses. The causes of each collapse are diverse (e.g. natural disasters, changing conditions, design errors, intentional attacks). Still, the conclusions are always the same: deaths, injuries and large amounts of direct and indirect economic losses. In order to avoid these catastrophes, structural robustness and monitoring strategies can be used to analyse the bridge's vulnerability and anticipate any local-initial failure that can spread to the whole structure in the form of a progressive collapse. The objective of this work was to use an integrative threat-dependent and threat-independent approach to analyse the structural robustness of a never-before-studied U-shaped open cross-section steel truss railway bridge structure. Eight failure scenarios were considered and analysed through computational modelling. The extracted results make it possible: (i) to connect structural robustness analysis outputs with the definition of a new structural health monitoring strategy of the bridge; and (ii) to implement the conclusions in the real bridge with more than 100 sensors and a non-assisted alarm system for preventing progressive collapse.</div></div>","PeriodicalId":15557,"journal":{"name":"Journal of Constructional Steel Research","volume":"226 ","pages":"Article 109200"},"PeriodicalIF":4.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rational nanoscale structure engineering of electroactive nanoarchitecture is a very promising strategy for designing advanced capacitive deionization (CDI) materials. Herein, inspired by jellyfish physiological structure, open-mouthed MoS2/C hierarchical porous spheres were fabricated via direct-spray pyrolysis by adopting a strategy of coupling defective MoS2 with locally conductive network graphene quantum dots. Such a well-developed open-mouthed interconnected porous structure significantly stimulated the permeation of electrolyte ion the deep internal spaces of electrode, facilitated fast ion diffusion and provided abundant electrochemical adsorption sites, endowing the MoS2/C electrode with a remarkable desalination capacity of 118.83 mg g−1, an impressively rapid desalination rate of 51.35 mg g−1 min−1, and a good long-term cycle stability of 82 % after 50 cycles. This work inspires the design hierarchically porous composite materials with unique micro-nanostructures, offering a new viable route for the continuous and efficient production of CDI electrode materials.
{"title":"Spatial confinement of MoS2 nanoparticles in jellyfish-inspired open-mouthed spheres for high-capacity and ultrafast-rate sodium-ion capture","authors":"Xinyi Gong, Qingtao Ma, Luxiang Wang, Dianzeng Jia, Nannan Guo, Xuemei Wang","doi":"10.1016/j.cej.2024.158221","DOIUrl":"https://doi.org/10.1016/j.cej.2024.158221","url":null,"abstract":"Rational nanoscale structure engineering of electroactive nanoarchitecture is a very promising strategy for designing advanced capacitive deionization (CDI) materials. Herein, inspired by jellyfish physiological structure, open-mouthed MoS<sub>2</sub>/C hierarchical porous spheres were fabricated via direct-spray pyrolysis by adopting a strategy of coupling defective MoS<sub>2</sub> with locally conductive network graphene quantum dots. Such a well-developed open-mouthed interconnected porous structure significantly stimulated the permeation of electrolyte ion the deep internal spaces of electrode, facilitated fast ion diffusion and provided abundant electrochemical adsorption sites, endowing the MoS<sub>2</sub>/C electrode with a remarkable desalination capacity of 118.83 mg g<sup>−1</sup>, an impressively rapid desalination rate of 51.35 mg g<sup>−1</sup> min<sup>−1</sup>, and a good long-term cycle stability of 82 % after 50 cycles. This work inspires the design hierarchically porous composite materials with unique micro-nanostructures, offering a new viable route for the continuous and efficient production of CDI electrode materials.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"25 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1016/j.cej.2024.158177
Jingxiao Yu, Hongbin Pu, Da-Wen Sun
Terahertz time-domain spectroscopy (THz-TDS) encounters two issues in the detection field, which refer to the detection target for solid samples caused by the strong absorption of water and the large content target substance led by the low sensitivity. Fortunately, terahertz metamaterial (THz-MM) that can carry liquid samples and amplify signals solves the above problems well. In addition, the THz-MM can achieve the detection of trace substances through the resonance peak shift generated by designing suitable structures. However, since most researchers focus on designing complex structures rather than analyzing data, deep learning (DL) that can mine new features from original features and construct decision models is used to research the rich information in THz-MM sensor data. In the current research, a flexible transmissive THz-MM in the shape of a circle (‘O’ shape) was designed by depositing the gold on the polyimide substrate. Firstly, the structures referring to substrate thickness (ST), metal thickness (MT) and ring width (RW) were optimized, and the performances referring to principle, stability and sensitivity were evaluated. Next, the best THz-MM (ST: 16 µm, MT: 0.2 µm, RW: 6 µm) was prepared and characterized from morphology, thickness and consistency. Then, different concentrations of anthocyanins (R2: 0.9982) and tannic acid (R2: 0.9736) were successfully predicted by combining the resonance peak shifts. Finally, resonance peak descriptors were constructed and combined with DL referring to a fully connected neural network (FCNN) model to successfully identify different varieties of red wines (Precision: 91.11 %; Recall: 90.74 %, F1-score: 90.83 %; Accuracy: 90.74 %). Overall, the current research presents an advanced DL-driven THz-MM sensor, which promotes the process of THz-TDS technology in the food detection field
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