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Cerebellar hypomyelination, white matter vacuolization, and prolonged presence of atypical porcine pestivirus in pigs with congenital tremor type A-II. A-II型先天性震颤猪的小脑髓鞘化、白质空泡化和非典型猪瘟病毒的长期存在
IF 1.7 2区 农林科学 Q2 PATHOLOGY Pub Date : 2026-03-01 Epub Date: 2025-09-13 DOI: 10.1177/03009858251372559
Anna Bergfeldt, Mette Myrmel, Birgit Ranheim, Frida Aae, Randi Sørby

Atypical porcine pestivirus (APPV) is responsible for congenital tremor (CT) type A-II in pigs, a globally distributed neurological disease, with many unresolved questions regarding its pathogenesis and pathology. This descriptive case-control study assessed the viral load of APPV and its association with lesions in the central nervous system (CNS), as piglets born with severe clinical signs of CT recovered from clinical disease. The virus was found in all pigs with CT across 3 age groups (newborn, 3-week-old, 4- to 5-month-old CT pigs) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The highest viral load was observed in the spinal cord of newborns and in the cerebellum of older groups. No APPV was detected in control pigs. Histologic evaluation revealed variable vacuolization in the CNS white matter of CT-affected pigs, which was most prominent in the spinal cord, cerebellum, and cerebrum of newborns, and in the cerebellum and cerebrum of 3-week-old pigs. Transmission electron microscopy demonstrated hypomyelination in newborn and 3-week-old CT pigs, but myelin levels comparable to those of control pigs in 4- to 5-month-old CT pigs. This research demonstrates the prolonged presence of APPV in the CNS of pigs born with severe signs of CT. Variable white matter vacuolization and hypomyelination can be found up to 3 weeks of age, but myelin levels normalize in older pigs, suggesting a delayed myelination process. Further research is needed to confirm the primary cellular target for APPV in the CNS and to understand how the virus affects the myelination process.

非典型猪瘟病毒(APPV)引起猪先天性震颤(CT) a - ii型,是一种全球分布的神经系统疾病,其发病机制和病理仍有许多未解决的问题。这项描述性病例对照研究评估了在出生时有严重CT临床症状的仔猪从临床疾病中恢复时,APPV的病毒载量及其与中枢神经系统(CNS)病变的关系。采用逆转录-定量聚合酶链反应(RT-qPCR)在3个年龄组(新生儿、3周龄、4至5月龄的CT猪)的所有CT猪中发现了该病毒。在新生儿的脊髓和老年人的小脑中观察到最高的病毒载量。对照组猪未检测到APPV。组织学评价显示,ct感染猪的中枢神经系统白质出现可变空泡化,新生儿的脊髓、小脑和大脑以及3周龄猪的小脑和大脑空泡化最为突出。透射电子显微镜显示新生和3周龄CT猪的髓鞘形成较低,但髓鞘水平与4- 5月龄CT猪的对照猪相当。本研究表明,在出生时出现严重CT症状的猪的中枢神经系统中,APPV的存在时间较长。可在3周龄时发现白质空泡变和髓鞘形成减少,但在老年猪中髓鞘水平恢复正常,提示髓鞘形成过程延迟。需要进一步的研究来确认APPV在中枢神经系统中的主要细胞靶点,并了解该病毒如何影响髓鞘形成过程。
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引用次数: 0
Microbial and Genomic Information Synergistically Contribute to Predicting Swine Performance Across Production Systems. 微生物和基因组信息协同有助于预测猪生产系统的生产性能。
IF 1.9 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2026-03-01 Epub Date: 2025-09-24 DOI: 10.1111/jbg.70014
Christian Maltecca, Enrico Mancin, Jicai Jiang, Maria Chiara Fabbri, Riccardo Bozzi, Clint Schwab, Francesco Tiezzi

Microbiota composition represents a promising tool in precision farming, simultaneously serving as a benchmark of environmental challenge, a predictor of animal physiological status, and a direct target for host selection. In this paper, we compared the ability of microbiota composition and genomic information to predict swine performance in two production settings, namely a purebred nucleus (NU) and a terminal cross commercial population (TE). Microbiota consistently predicted all traits in both scenarios (NU-TE: training on NU to predict TE; TE-NU: training on TE to predict NU) and at two time points: mid-test and off-test. The highest correlation (i.e., prediction accuracy) was achieved for back fat, with values of 0.08 and 0.04, and 0.30 and 0.23 for mid and off-tests, predicting from nucleus to terminal, and vice versa. Similarly, daily gains correlations were 0.05 and 0.04, and 0.18 and 0.15 for the same time points and scenario combinations. Including genomic information yielded correlations ranging from low for loin area to moderate for back fat (0.19 nucleus to terminal, 0.16 for the opposite). Microbiota had higher prediction accuracies than genomic for back fat both from nucleus to terminal and vice versa (+0.11, +0.07) and daily gain (+0.08, +0.02) at off-test. Lower accuracies were obtained for the IMF. Including genomic and microbial information produced higher accuracies than microbiota or genomic alone for back fat (0.37 and 0.29 for nucleus to terminal and opposite) and daily gain (0.19 and 0.21 for nucleus to terminal and opposite). Results for other traits differed for different scenarios. Results show that microbiota composition effectively predicted most growth and carcass traits, particularly growth and fat deposition, across production systems, prediction scenarios (NU-TE and TE-NU), and time points (mid-test and off-test). These findings highlight the potential of microbiota profiles to predict phenotypes across production systems and support their use as a tool for selecting animals in environments they have not been exposed to.

微生物群组成是精准农业中一个很有前途的工具,同时可以作为环境挑战的基准,动物生理状态的预测指标,以及宿主选择的直接目标。在本文中,我们比较了微生物群组成和基因组信息在两种生产环境下预测猪生产性能的能力,即纯种核心(NU)和终端杂交商业群体(TE)。微生物群在两种情况下(NU-TE:在NU上训练以预测TE; TE-NU:在TE上训练以预测NU)和两个时间点(测试中期和测试结束)一致地预测了所有性状。背部脂肪获得了最高的相关性(即预测精度),其值为0.08和0.04,中期和非测试为0.30和0.23,从核到末端预测,反之亦然。同样,日收益相关性为0.05和0.04,相同时间点和情景组合的日收益相关性为0.18和0.15。包括基因组信息得出的相关性范围从腰部面积低到背部脂肪中等(0.19核到末端,0.16相反)。在非试验条件下,微生物群对背脂肪(+0.11,+0.07)和日增重(+0.08,+0.02)的预测精度均高于基因组学。IMF的准确性较低。包含基因组和微生物信息比单独使用微生物群或基因组信息对背部脂肪和日增重(分别为0.37和0.29和0.19)和日增重(分别为0.19和0.21)的准确性更高。在不同的情况下,其他特征的结果也有所不同。结果表明,在不同的生产系统、不同的预测情景(NU-TE和TE-NU)和不同的时间点(测试中和测试结束),微生物群组成可以有效地预测大部分生长和胴体性状,尤其是生长和脂肪沉积。这些发现强调了微生物群谱在预测生产系统表型方面的潜力,并支持它们作为一种工具在动物未暴露的环境中选择动物。
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引用次数: 0
Unravelling Twin Births in German Holstein Cows: Phenotypic Associations, Genetic Analysis and Potential Underlying Genes and Hormones. 解开德国荷斯坦奶牛的双胞胎:表型关联,遗传分析和潜在的潜在基因和激素。
IF 1.9 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2026-03-01 Epub Date: 2025-08-21 DOI: 10.1111/jbg.70012
Laura Hüneke, Hatem Alkhoder, Dierck Segelke, Georg Thaller, Christin Schmidtmann

Twin births in dairy cattle are rare but present significant challenges for animal welfare, as both the health of the cow and the calves are affected. This causes economic losses, which prompts breeders to select against twin births and identify associated risk factors. This study examines the phenotypic relationship between milk yield, fertility traits and twin births in German Holstein cattle using a large, population-wide dataset. GEBV correlations for twin births, milk production and fertility traits were estimated. Genome-wide association studies (GWAS) were conducted for calving numbers 1-3 in order to explore the genetic background in more detail. The twin birth rate showed a strong phenotypic association with milk production and a moderate phenotypic association with the timing of successful insemination. However, GEBV correlations were low: 0.04 with milk yield and -0.10 to 0.01 with fertility traits. GWAS revealed two potential candidate genes on BTA11: LHCGR and FSHR, which encode receptors for LH and FSH, two hormones crucial to estrus. In contrast to the first calving, significantly associated regions on BTA5 and BTA25 were found in calving numbers 2 and 3. This study demonstrates the interaction between genotype and environment, concluding that a genetic predisposition for twin births, in combination with a favourable endocrine state (environment), increases the likelihood of twin births.

奶牛的双胞胎是罕见的,但对动物福利构成重大挑战,因为奶牛和小牛的健康都会受到影响。这会造成经济损失,这促使育种者对双胞胎进行选择,并确定相关的风险因素。本研究使用大型种群数据集研究了德国荷斯坦牛产奶量、生育性状和双胞胎之间的表型关系。估计GEBV与双胞胎出生、产奶量和生育性状的相关性。为了更详细地探索遗传背景,我们对产犊数1-3进行了全基因组关联研究(GWAS)。双胞胎出生率与产奶量表现出强烈的表型关联,与成功授精的时间表现出适度的表型关联。GEBV与产奶量的相关性为0.04,与育性性状的相关性为-0.10 ~ 0.01。GWAS发现BTA11上有两个潜在的候选基因:LHCGR和FSHR,它们编码LH和FSH的受体,这两种激素对发情至关重要。与第一次产犊相比,在2号和3号产犊中发现了BTA5和BTA25的显著相关区域。这项研究证明了基因型和环境之间的相互作用,结论是双胞胎出生的遗传易感性,加上有利的内分泌状态(环境),增加了双胞胎出生的可能性。
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引用次数: 0
Effects of Sedation on Rectal Temperature During Equine Dental Procedures Performed in Cold to Warm Ambient Temperatures. 马在冷到暖的环境温度下进行牙科手术时镇静对直肠温度的影响。
IF 0.9 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2025-09-03 DOI: 10.1177/08987564251371523
Amanda J Norman, Colleen M Turner, Jane M Manfredi

Sedation is important for safe equine dental procedures, but it is unknown if there is a higher risk of sedation causing hypothermia in procedures performed during cold months. The authors hypothesize that sedation for a dental procedure will significantly decrease rectal body temperature in cold as compared to warm ambient temperatures. Adult equids (N = 246), from a private equine dentistry practice, that underwent dental equilibration, were selected for the study. Each horse's weight was estimated and sedation was administered intravenously (0.01 mg/kg detomidine and 0.01 mg/kg butorphanol) and intramuscularly (0.5 mg/kg xylazine and 0.03 mg/kg acepromazine). Ambient and serial rectal temperatures (presedation [PRE], 15 min after initial intravenous sedation [POST15], and at the end of the procedure [END]) were recorded. Statistics included Shapiro-Wilks test, Spearman's correlation coefficient, and a Friedman test with Dunn's posthoc test (significant at P < .05). Ambient temperatures ranged from -7.8 °C to 30 °C. The median (95% confidence interval) rectal temperature was PRE: 37.4 (37.2 °C-37.7 °C), POST15: 37.5 (37.2 °C-37.8 °C), and END: 37.4 (37.1 °C-37.7 °C). POST15 temperatures were significantly increased from PRE (P = .001) to END (P = .005) temperatures. PRE to END temperatures were not significantly different (P > .9). There was a weak positive correlation between ambient and POST15 temperatures (rho = .26, P < .001) and END temperatures (rho = .25, P < .001). Seven animals became hypothermic (<36 °C), only 2 at ambient temperatures below 4.44 °C. Rectal body temperature in equids after sedation at ambient temperatures between -7 °C and 30 °C remains at a safe level in most instances, suggesting dental procedures can be performed under sedation during cold weather.

镇静对于安全的马牙科手术很重要,但尚不清楚在寒冷的月份进行的手术中,镇静是否有更高的风险导致体温过低。作者假设,与温暖的环境温度相比,牙科手术的镇静会显著降低低温下的直肠体温。成年马(N = 246),来自私人马牙科诊所,接受牙齿平衡,被选为研究对象。估计每匹马的体重,并静脉注射镇静剂(0.01 mg/kg德托咪定和0.01 mg/kg丁托啡诺)和肌肉注射镇静剂(0.5 mg/kg噻嗪和0.03 mg/kg乙酰丙嗪)。记录环境温度和连续直肠温度(术前[PRE]、初始静脉镇静后15分钟[POST15]和手术结束时[end])。统计方法包括Shapiro-Wilks检验、Spearman相关系数、Friedman检验和Dunn事后检验(P =显著)。001)到END (P = .005)温度。前后温度无显著差异(P < 0.05)。环境温度和15年后温度之间存在微弱的正相关(rho =。26, P =。25日,警
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引用次数: 0
Renal oxalosis in African green monkeys (Chlorocebus sabaeus) in St. Kitts. 圣基茨非洲绿猴肾草化病的研究。
IF 1.7 2区 农林科学 Q2 PATHOLOGY Pub Date : 2026-03-01 Epub Date: 2025-10-23 DOI: 10.1177/03009858251382150
Samantha Zayas, Amy Beierschmitt, Roberta M Palmour, Patrick O Pithua, Pompei Bolfa

Renal oxalosis has been reported in New and Old-World monkeys. Occasional reports describe a low prevalence of subclinical renal oxalosis, but these typically lack supporting evidence of primary oxalosis or toxicity and may be a natural background lesion. In a retrospective cross-sectional postmortem observation study, 12 of 156 (7.7%) African green monkeys (AGMs) (Chlorocebus sabaeus) from the Behavioural Science Foundation (St. Kitts) colony had histological evidence of oxalate-induced nephrosis (renal oxalosis). Histologically, affected tubules from both the cortex and medulla were ectatic; expanded several times normal size; and lined by attenuated, degenerative, regenerative, or necrotic epithelium with intraluminal, pale yellow, translucent, variably shaped, crystals that were birefringent under polarized light (calcium oxalate). The tubules were often surrounded by multinucleated macrophages. To identify independent predictors of renal oxalosis, we fit a multivariable logistic regression model with robust ("sandwich") standard errors, including sex, age, and birth origin, as categorical covariates. Several enrichment food items were found to be oxalate-rich: sweet potato (95.9 mg/100 g), pumpkin (64.6 mg/100 g), and bananas (169 mg/100 g). There was a significant increase in the prevalence of calcium oxalate concretions with age, from 0% in young monkeys to 18.6% in aged individuals, likely due to longer exposure to oxalate-rich produce and a cumulative effect. Due to the large ingestion of oxalate-rich foods, diet is suspected to be a major cause of subclinical oxalosis in the St. Kitts AGM, raising awareness of this potential background finding during their use as laboratory animals in toxicologic and other research studies.

在新旧大陆的猴子中都有肾草化病的报道。偶尔有报道称亚临床肾草化病的发病率很低,但这些报道通常缺乏原发性草化病或毒性的支持证据,可能是一种自然背景病变。在一项回顾性横断面死后观察研究中,来自行为科学基金会(圣基茨)群体的156只非洲绿猴(绿猴)中有12只(7.7%)有草酸盐引起的肾病(肾草酸中毒)的组织学证据。组织学上,皮层和髓质的受累小管均呈扩张;膨胀数倍于正常大小的;内膜为衰减的、退行性的、再生的或坏死的上皮,腔内呈淡黄色、半透明、形状各异的晶体,在偏振光下呈双折射(草酸钙)。小管常被多核巨噬细胞包围。为了确定肾草化病的独立预测因子,我们拟合了一个具有稳健(“三明治”)标准误差的多变量逻辑回归模型,包括性别、年龄和出生来源,作为分类协变量。几种富含草酸的食物被发现富含草酸:甘薯(95.9毫克/100克)、南瓜(64.6毫克/100克)和香蕉(169毫克/100克)。随着年龄的增长,草酸钙结块的患病率显著增加,从年轻猴子的0%增加到老年人的18.6%,可能是由于长时间接触富含草酸的农产品和累积效应。由于大量摄入富含草酸的食物,饮食被怀疑是圣基茨AGM亚临床草酸中毒的主要原因,在将其用作毒理学和其他研究的实验动物时,提高了对这一潜在背景发现的认识。
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引用次数: 0
Hemosiderosis in St. Kitts African green monkeys (Chlorocebus sabaeus). 圣基茨非洲绿猴的含铁血黄素病。
IF 1.7 2区 农林科学 Q2 PATHOLOGY Pub Date : 2026-03-01 Epub Date: 2025-11-27 DOI: 10.1177/03009858251391385
Samantha Zayas, John Buchweitz, Amy Beierschmitt, Roberta M Palmour, Dalen Agnew, Patrick O Pithua, Pompei Bolfa

Hepatic hemosiderosis has not been systematically studied in African green monkeys (Chlorocebus sabaeus). We aimed to determine the prevalence of histologic hepatic hemosiderosis in this species, demographic predictors of its presence and severity, and the quantitative relationship between histological grade and hepatic iron concentration. We evaluated liver samples of 155 African green monkeys from a research colony in St. Kitts (24 juveniles, 89 adults, 42 geriatrics) using histology (hematoxylin and eosin, Perls Prussian blue) to semiquantitatively grade (0-4) hemosiderin deposits. Quantitative hepatic iron was measured via coupled plasma mass spectrometry in 146 samples. Overall, 63.9% (99/155; P < .001 vs 50%) exhibited histological hemosiderin deposits. The grade distribution was 52 (33.5%) grade 0, 29 (18.7%) grade 1, 23 (14.8%) grade 2, 25 (16.1%) grade 3, and 26 (16.8%) grade 4. Wild-caught origin was protective (odds ratio (OR) = 0.10, 95% confidence interval (CI) = 0.04-0.29, P < .001), while geriatric age was associated with iron accumulation (OR = 8.92, 95% CI = 2.06-10.61, P = .003). Ordinal regression confirmed lower odds of higher grades in wild-caught (OR = 0.095, 95% CI = 0.047-0.193, P < .001) and higher odds of higher grades in adult monkeys (OR = 4.2, 95% CI = 1.43-12.35, P = .009). Trend tests (z = 9.81, P < .0001) and Spearman's ρ = 0.82 (P < .0001) confirmed a strong association between pathology and iron burden. Recommended iron requirements may be excessive for certain life stages in this species. Colony-born and younger animals are at highest risk, while adult males show protection. Histological grading correlates strongly with quantitative iron measures, validating its use as a semiquantitative surrogate.

非洲绿猴(Chlorocebus sabaeus)肝含铁血黄素病尚未有系统的研究。我们的目的是确定该物种的组织学肝含铁血黄素沉着的患病率,其存在和严重程度的人口统计学预测因素,以及组织学分级与肝铁浓度之间的定量关系。我们利用组织学(苏木精和伊红,珀尔斯普鲁士蓝)对来自圣基茨研究群体的155只非洲绿猴的肝脏样本(24只幼猴,89只成年猴,42只老年猴)进行了半定量分级(0-4)含铁血黄素沉积。采用耦合等离子体质谱法对146份样品进行肝铁定量测定。总体而言,63.9% (99/155;P < 0.001 vs 50%)表现出组织学上的含铁血黄素沉积。年级分布为0级52人(33.5%)、1级29人(18.7%)、2级23人(14.8%)、3级25人(16.1%)、4级26人(16.8%)。野生捕获的来源是保护性的(优势比(OR) = 0.10, 95%可信区间(CI) = 0.04-0.29, P < 0.001),而老年年龄与铁积累有关(OR = 8.92, 95% CI = 2.06-10.61, P = 0.003)。有序回归证实,野生捕获的猴子获得高分的几率较低(OR = 0.095, 95% CI = 0.047 ~ 0.193, P < 0.001),成年猴子获得高分的几率较高(OR = 4.2, 95% CI = 1.43 ~ 12.35, P = 0.009)。趋势检验(z = 9.81, P < 0.0001)和Spearman ρ = 0.82 (P < 0.0001)证实病理与铁负荷之间有很强的相关性。在这个物种的某些生命阶段,铁的推荐需要量可能过高。殖民地出生的和年轻的动物风险最高,而成年雄性则表现出保护作用。组织学分级与定量铁测量密切相关,证实其作为半定量替代指标的使用。
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引用次数: 0
Estimation of Genetic Parameters for Deviation in Age at Market Weight and Deviation in Weight at Market Age in Menz Sheep. 门兹羊市售体重年龄偏差和市售体重偏差遗传参数的估计。
IF 1.9 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2026-03-01 Epub Date: 2025-10-30 DOI: 10.1111/jbg.70023
Zeleke Tesema Wondie, Shanbel Besufkad, Aschalew Abebe, Shenkute Goshme, Asfaw Bisrat, Ayele Abebe, Alemnew Araya, Tesfaye Zewdie, Chekol Demis, Liuelseged Alemayehu, Erdachew Yitagesu, Tefera Mekonnen, Firdawok Ayele, Derb Aydefruhim, Tesfa Getachew, Enyew Alemnew, Solomon Gizaw, Tesfaye Getachew, Berhanu Belay, Barbara Rischkowsky, Yu Jiang, Aynalem Haile

Reducing the number of days from birth to slaughter is one strategy to improve animal feed and environmental efficiency. The export market use yearling sheep weighing 22-30 kg and usually purchases from large and small-scale traders at an early age (lambs weighing ≥ 15 kg) for mutton production. Hence, this study aimed to derive a new trait phenotype, which helps to reduce sheep market age without adverse effects on the market weight of Menz sheep and to evaluate the extent of exploitable genetic variation in this new trait. To this end, 11,258 lambs weighing ≥ 15 kg between 66 and 395 days of age were considered in this study. Co (variance) components and heritability estimates for novel traits were estimated using the average information restricted maximum likelihood method in WOMBAT fitting the animal model. The best-fitted model was selected from six models based on likelihood ratio test and Akaike's information criterion. The days-to-market weight of 16.3% of the animals was shorter by 48.2 days (with an estimated breeding value of -26.2 days) compared to the mean of the contemporary groups. The market weight of 15.5% of the animals was higher by 1.73 kg compared to the mean of the contemporary groups. There was a phenotypic variability of deviation in age at market weight (DAMW) and deviation in weight at market age (DWMA) for the sheep population in Molalie village compared to other villages. Likewise, the genetic standard deviation for DAMW and DWMA was 25 days and 0.79 kg, respectively. Based on the best-fitted model, the direct heritability estimate for DAMW and DWMA was 0.65 and 0.57, respectively. In addition, the maternal genetic effect explains 28% of the phenotypic variation in DAMW and 26% of the phenotypic variation in DWMA. The DAMW of Menz sheep in Dargegn and Molalie villages decreased significantly by 2.113 and 1.192 days year-1, respectively. The observed additive genetic variance for DAMW suggests further scope for genetic improvement in the flock to reduce the days-to-market weight of Menz sheep. Including this novel trait in a breeding objective could shorten days to market weight without necessarily reducing the genetic merit of the live weight included in the breeding objective.

减少从出生到屠宰的天数是改善动物饲料和环境效率的一种策略。出口市场使用体重22-30公斤的一岁羊,通常从大型和小规模贸易商那里购买幼龄羊(体重≥15公斤的羔羊)用于羊肉生产。因此,本研究旨在获得一种新的性状表型,该表型有助于降低羊的市场年龄,而不会对门兹羊的市场体重产生不利影响,并评估该新性状的可利用遗传变异程度。为此,本研究选取了11,258只66 ~ 395日龄体重≥15 kg的羔羊。利用平均信息限制最大似然法在袋熊中拟合动物模型,估计新性状的Co(方差)分量和遗传力。根据似然比检验和赤池信息准则从6个模型中选出最优拟合模型。与同时代群体的平均体重相比,16.3%的动物到市场的体重缩短了48.2天(估计繁殖值为-26.2天)。15.5%的动物的市场体重比同时代群体的平均体重高出1.73 kg。与其他村庄相比,Molalie村绵羊种群在市重年龄偏差(DAMW)和市重年龄偏差(DWMA)方面存在表型变异。DAMW和DWMA的遗传标准差分别为25 d和0.79 kg。基于最佳拟合模型,DAMW和DWMA的直接遗传力估计分别为0.65和0.57。此外,母系遗传效应解释了DAMW中28%的表型变异和DWMA中26%的表型变异。达尔根村和Molalie村Menz羊的平均生存期(DAMW)分别显著降低了2.113天和1.192天。观察到的DAMW的加性遗传变异表明,在羊群中有进一步的遗传改进空间,以降低门兹羊的日数到市场重量。在育种目标中包括这种新性状可以缩短到上市重量的天数,而不一定会降低育种目标中包括的活重的遗传优点。
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引用次数: 0
Correlated Genetic Changes in Commercial Traits to Selection for High Growth in Red Tilapia (Oreochromis spp.). 红罗非鱼(Oreochromis spp.)商业性状的相关遗传变化与高生长选择。
IF 1.9 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2026-03-01 Epub Date: 2025-10-09 DOI: 10.1111/jbg.70020
Tran Huu Phuc, Pham Dang Khoa, Nguyen Thi Dang, Tran Thi Mai Huong, Huynh Thi Bich Lien, Vo Thi Hong Tham, Nguyen Huynh Duy, Nguyen Hong Nguyen

The present study examined correlated responses in commercial traits of economic importance resulting from selection for high growth over eight years in a population of red tilapia (Oreochromis spp.). During this period, data on total length, body colour and survival were recorded for 75,950 individual fish, which were progeny of 1203 dams and 608 sires. Our restricted maximum likelihood-mixed model analysis showed that selection for increased body weight produced concomitant positive changes in animal length by 3.1%. A correlated increase of 4.9% per generation was also observed for the survival rate in this population. Body hue colour, a trait of commercial interest, displayed a slight increase of 1.8% per generation. The substantial improvement in total length is consistent with the high genetic correlation (rg) between body weight and length (rg = 0.84). Body weight was weakly but significantly correlated genetically with the survival rate during the grow-out period from stocking to harvest. However, the genetic correlations between weight (or length) and body hue colour were not significant. Furthermore, there were substantial heritable genetic variations in these traits, with heritability estimates ranging from 0.12 to 0.36. Maternal and common full-sib effects accounted for 2.5%-17% of the total phenotypic variation. It is concluded that selection for increased body weight resulted in desirable correlated responses in complex quantitative traits of red tilapia, and these genetic characters will continue to respond to selection, given the substantial genetic variation in this red tilapia population.

本研究考察了红罗非鱼(Oreochromis spp.)种群在8年的高生长选择中对经济上重要的商业性状的相关响应。在此期间,记录了75,950条鱼的总长度、身体颜色和存活率的数据,这些鱼是1203条坝和608条鱼的后代。我们的限制性最大似然混合模型分析显示,选择增加体重会导致动物体长出现3.1%的正变化。该种群的存活率每代增加4.9%。体色是一种具有商业价值的性状,每代增加1.8%。总体长的显著提高与体重与体长的高度遗传相关(rg = 0.84)是一致的。从放养到收获的生育期,体重与成活率的遗传相关性虽弱但显著。然而,体重(或长度)与体色之间的遗传相关性不显著。此外,这些性状存在大量可遗传的遗传变异,遗传率估计在0.12至0.36之间。母系和普通全同胞效应占总表型变异的2.5%-17%。综上所述,增加体重的选择导致了红罗非鱼复杂数量性状的相关响应,并且考虑到红罗非鱼群体中存在的大量遗传变异,这些遗传性状将继续响应选择。
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引用次数: 0
Genomic Analysis of Taurine and Indicine Ancestry in the Montana Tropical Composite Population. 蒙大拿州热带复合种群中牛磺酸和Indicine祖先的基因组分析。
IF 1.9 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Pub Date : 2026-03-01 Epub Date: 2025-09-29 DOI: 10.1111/jbg.70017
Camila Alves Dos Santos, El Hamidi Hay, Elisangela Chicaroni de Mattos Oliveira, Rafael Espigolan, José Bento Sterman Ferraz, Tiago do Prado Paim

The Montana Tropical cattle, a Taurine and Indicine composite, were developed in Brazil since 1994 and were based on crossing four biological types of cattle: zebu (mainly Nelore), tropical adapted taurine (mainly Senepol and Romosinuano), British taurine (mainly Angus) and continental taurine (as Charolais, Simental and Limousin). This study aimed to characterise the genetic ancestry of this composite breed at the genomic level. Principal component analysis revealed the composite in intermediate space between indicine and taurine but closer to the Taurine cluster, which is consistent with its multi-breed origin. The ADMIXTURE analysis indicated the Montana Tropical to be composed of several progenitor breeds without an indication of a dominant breed. Local ancestry analysis showed the Montana animals to have an average of 24% (standard deviation of ±5.41) Zebu ancestry. The total taurine ancestry was 62%, consisting of 19.6% (±6.96) from tropical adapted taurine, 20.1% (±5.99) from British taurine, 21.92% (±7.79) from continental taurine and 14% (±5.26) of the genome was undetermined. Based on the pedigree, these animals would have 20.8% ± 8.5% Zebu, 50.5% ± 14.4% tropical adapted taurine, 21.1% ± 13.5% British taurine and 7.6% ± 5.1% of continental European taurine in their composition. The genomic regions in the composite originating from each biological type highlight the trait complementarity each genetic group contributes. For example, the genomic region of high tropical adapted taurine ancestry was shown to harbour the slick hair locus, and the regions of high indicine ancestry are associated with high length of productive life. This study unravels the complex genetic ancestry of the Montana Tropical composite, highlighting the effective blend of ancestral gene pools that enhance key production and adaptation traits.

蒙大拿热带牛是牛磺酸和Indicine的混合物,自1994年以来在巴西开发,基于杂交四种生物类型的牛:zebu(主要是Nelore),热带适应牛磺酸(主要是Senepol和Romosinuano),英国牛磺酸(主要是Angus)和大陆牛磺酸(如Charolais, Simental和Limousin)。本研究的目的是在基因组水平上表征这种复合品种的遗传祖先。主成分分析表明,该复合物位于牛磺酸和茚的中间空间,但更接近牛磺酸簇,这与它的多品种起源一致。admix分析表明,蒙大拿热带品种由几个祖先品种组成,没有一个优势品种的迹象。当地祖先分析表明,蒙大拿州动物平均有24%(标准差为±5.41)的泽布祖先。总牛磺酸血统为62%,其中19.6%(±6.96)来自热带适应牛磺酸,20.1%(±5.99)来自英国牛磺酸,21.92%(±7.79)来自大陆牛磺酸,14%(±5.26)基因组未确定。根据家谱,这些动物的组成中含有20.8%±8.5%的Zebu, 50.5%±14.4%的热带适应牛磺酸,21.1%±13.5%的英国牛磺酸和7.6%±5.1%的欧洲大陆牛磺酸。合成物中源自每种生物类型的基因组区域突出了每种遗传组所贡献的性状互补性。例如,高热带适应牛磺酸祖先的基因组区域被证明具有光滑的毛发位点,高热带适应牛磺酸祖先的区域与较长的生产寿命相关。这项研究揭示了蒙大拿州热带复合植物的复杂遗传祖先,突出了祖先基因库的有效混合,增强了关键的生产和适应性状。
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引用次数: 0
Reviewer List 2025. 评审名单2025。
IF 1.1 4区 农林科学 Q3 VETERINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-01 DOI: 10.1080/00480169.2026.2615682
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引用次数: 0
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