Feng Li, Liang Sun, Zongyuan Zhang, Xuan Wang, He Qi, Yannan Bin, Jia-Ze Li, Yacheng Yang, Yonghao Xu, Siyu Chen, Mingsheng Long, Lei Shan, Li-Feng Zhu, Chunchang Wang, Jiwei Zhai
Development of high-performance lead-free AgNbO3 (AN)-based antiferroelectrics (AFEs) have emerged as promising candidate for high-power energy-storage capacitors. Routine trial-and-error method in enhancing energy-storage density (Wrec) and efficiency (η) encounters great challenges since extensive latent space are explored for composition screening. Using machine learning (ML) algorithms, a two-layer stacking framework termed as SS-PAN (stacking strategy for predicting AN-based ceramics) is proposed here for designing high-performance AN-based AFEs. This framework achieves a high R2 score of 0.82 through cross validation and outperforms individual ML model. The predicted composition represented by Li0.01Ag0.99Nb0.5Ta0.5O3, possesses a quasi-linear P-E loop and an ultrahigh Wrec of 16.6 J cm−3 and η of 92.6% with an excellent figure of merit of 224.3 J cm−3 is achieved at electric field of 108 kV mm−1 in MLCC. Based on SHapley Additive exPlanations analysis, high prediction accuracy is enabled by precisely selecting features of tolerance factor and electron affinity of B-site element. Notably, local structure for Li0.01Ag0.99Nb0.5Ta0.5O3 composition is thoroughly decoded by STEM and DFT calculations, where highly polar short-range antiferroelectric nanodomains with strong localized dipole moments are induced by Li/Ta co-doping. This work imparts a potent potential of data-driven methodology for seeking emergent relaxor AFEs for advanced dielectric capacitor applications.
{"title":"Superior Energy-Storage Performance Enabled by Machine Learning Accelerated Composition Design for Lead-Free Antiferroelectrics","authors":"Feng Li, Liang Sun, Zongyuan Zhang, Xuan Wang, He Qi, Yannan Bin, Jia-Ze Li, Yacheng Yang, Yonghao Xu, Siyu Chen, Mingsheng Long, Lei Shan, Li-Feng Zhu, Chunchang Wang, Jiwei Zhai","doi":"10.1002/smll.202514461","DOIUrl":"https://doi.org/10.1002/smll.202514461","url":null,"abstract":"Development of high-performance lead-free AgNbO<sub>3</sub> (AN)-based antiferroelectrics (AFEs) have emerged as promising candidate for high-power energy-storage capacitors. Routine trial-and-error method in enhancing energy-storage density (<i>W<sub>rec</sub></i>) and efficiency (<i>η</i>) encounters great challenges since extensive latent space are explored for composition screening. Using machine learning (ML) algorithms, a two-layer stacking framework termed as SS-PAN (stacking strategy for predicting AN-based ceramics) is proposed here for designing high-performance AN-based AFEs. This framework achieves a high R<sup>2</sup> score of 0.82 through cross validation and outperforms individual ML model. The predicted composition represented by Li<sub>0.01</sub>Ag<sub>0.99</sub>Nb<sub>0.5</sub>Ta<sub>0.5</sub>O<sub>3</sub>, possesses a quasi-linear <i>P-E</i> loop and an ultrahigh <i>W<sub>rec</sub></i> of 16.6 J cm<sup>−3</sup> and <i>η</i> of 92.6% with an excellent figure of merit of 224.3 J cm<sup>−3</sup> is achieved at electric field of 108 kV mm<sup>−1</sup> in MLCC. Based on SHapley Additive exPlanations analysis, high prediction accuracy is enabled by precisely selecting features of tolerance factor and electron affinity of <i>B</i>-site element. Notably, local structure for Li<sub>0.01</sub>Ag<sub>0.99</sub>Nb<sub>0.5</sub>Ta<sub>0.5</sub>O<sub>3</sub> composition is thoroughly decoded by STEM and DFT calculations, where highly polar short-range antiferroelectric nanodomains with strong localized dipole moments are induced by Li/Ta co-doping. This work imparts a potent potential of data-driven methodology for seeking emergent relaxor AFEs for advanced dielectric capacitor applications.","PeriodicalId":228,"journal":{"name":"Small","volume":"45 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingzhao Yang, Jipeng Luo, Peixia Qi, Hongya Li, Jialin Deng, Yongchen Song, Lunxiang Zhang, Quan Shi
Passive cooling, particularly those combining evaporative and radiative mechanisms, has attracted growing interest due to its low energy requirements for powering electronic devices and integrated systems. However, complex fabrication, low thermal conductivity, and inherent trade-offs between competing cooling mechanisms hinder their potential for commercial application. To address these challenges, we combine hexagonal boron nitride (hBN) with 1-ethyl-3-methylimidazolium acetate (Emim Ac, EA) ionic liquid and fabricate an ionic composite film via a facile, scalable solvent evaporation method. This approach eliminates the need for specialized equipment and intricate steps in traditional cooling materials. The composite film achieves synergistic passive cooling by simultaneously leveraging the evaporative and radiative mechanisms. The incorporation of hBN significantly enhances thermal conductivity to 0.51 W·m–1·K–1, representing a 200% improvement over conventional materials such as silica gel and MOFs. The optimized film structure demonstrates a high-water sorption capacity (0.55 g/g) and an exceptional desorption enthalpy (1307 J/g), enabling efficient evaporative cooling. Furthermore, the film demonstrates a low desorption temperature of 40 °C and remarkable flexibility, making it suitable for diverse thermal management applications. Practical tests verify its effectiveness, lowering the temperature of computer CPUs by more than 5 °C within 8 min and reducing the temperature of photovoltaic (PV) cells by up to 10 °C. By integrating thermal conduction, water evaporation, and thermal radiation, this work presents a high-performance, zero-energy-consumption cooling strategy with broad applicability in electronics and energy systems.
{"title":"Scalable Ionogel Film with Enhanced Thermal Conductivity for High-Efficiency Passive Cooling via Sorption–Radiation Balance","authors":"Mingzhao Yang, Jipeng Luo, Peixia Qi, Hongya Li, Jialin Deng, Yongchen Song, Lunxiang Zhang, Quan Shi","doi":"10.1021/acsami.5c22701","DOIUrl":"https://doi.org/10.1021/acsami.5c22701","url":null,"abstract":"Passive cooling, particularly those combining evaporative and radiative mechanisms, has attracted growing interest due to its low energy requirements for powering electronic devices and integrated systems. However, complex fabrication, low thermal conductivity, and inherent trade-offs between competing cooling mechanisms hinder their potential for commercial application. To address these challenges, we combine hexagonal boron nitride (hBN) with 1-ethyl-3-methylimidazolium acetate (Emim Ac, EA) ionic liquid and fabricate an ionic composite film via a facile, scalable solvent evaporation method. This approach eliminates the need for specialized equipment and intricate steps in traditional cooling materials. The composite film achieves synergistic passive cooling by simultaneously leveraging the evaporative and radiative mechanisms. The incorporation of hBN significantly enhances thermal conductivity to 0.51 W·m<sup>–1</sup>·K<sup>–1</sup>, representing a 200% improvement over conventional materials such as silica gel and MOFs. The optimized film structure demonstrates a high-water sorption capacity (0.55 g/g) and an exceptional desorption enthalpy (1307 J/g), enabling efficient evaporative cooling. Furthermore, the film demonstrates a low desorption temperature of 40 °C and remarkable flexibility, making it suitable for diverse thermal management applications. Practical tests verify its effectiveness, lowering the temperature of computer CPUs by more than 5 °C within 8 min and reducing the temperature of photovoltaic (PV) cells by up to 10 °C. By integrating thermal conduction, water evaporation, and thermal radiation, this work presents a high-performance, zero-energy-consumption cooling strategy with broad applicability in electronics and energy systems.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"9 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1016/j.apsusc.2026.166288
Li Ye, Yongchao Liang, Wenqiang Li, Qian Chen, Jian Xiong
Achieving effective adsorption and sensing of H2 has become one of the most challenging and difficult tasks for maintaining a sustainable environment. The first-principles density functional theory was used for exploring the adsorption and sensing properties of H2, CO, HCN, CH4, and NH3 gas molecules on the Pt-WSe2 and GaN/WSe2 structures. By conducting calculations, the most stable adsorption configuration was identified. To begin with, the adsorption properties indicated that all gas molecules were physically adsorbed onto the WSe2 substrate. Furthermore, the Pt atoms were stably anchored at the S(H) site on the surface of WSe2, resulted in an increase of 0.33 eV in the adsorption energy for H2. The density of states further confirms that this modification alters the electronic properties of WSe2, thereby enhancing its adsorption performance. Finally, the GW surface in the WSe2/GaN heterostructure significantly enhanced the adsorption energy of H2 to −2.048 eV and improved the adsorption performance for CO, HCN, CH4, and NH3 molecules. Recovery times at room temperature were calculated for multiple configurations, predicting ultra-high selectivity and favorable recovery times for Pt-WSe2 toward all four gases except CH4. The adsorption mechanism is controlled by the changes in conductivity caused by charge transfer. These theoretical studies provide the theoretical basis for the practical application of monolayer WSe2 in hydrogen sensing and gas adsorption.
{"title":"First-principles study on effective hydrogen adsorption and gas sensing on WSe2 surface by Pt modification and GaN heterojunction construction","authors":"Li Ye, Yongchao Liang, Wenqiang Li, Qian Chen, Jian Xiong","doi":"10.1016/j.apsusc.2026.166288","DOIUrl":"https://doi.org/10.1016/j.apsusc.2026.166288","url":null,"abstract":"Achieving effective adsorption and sensing of H<sub>2</sub> has become one of the most challenging and difficult tasks for maintaining a sustainable environment. The first-principles density functional theory was used for exploring the adsorption and sensing properties of H<sub>2</sub>, CO, HCN, CH<sub>4</sub>, and NH<sub>3</sub> gas molecules on the Pt-WSe<sub>2</sub> and GaN/WSe<sub>2</sub> structures. By conducting calculations, the most stable adsorption configuration was identified. To begin with, the adsorption properties indicated that all gas molecules were physically adsorbed onto the WSe<sub>2</sub> substrate. Furthermore, the Pt atoms were stably anchored at the S(H) site on the surface of WSe<sub>2</sub>, resulted in an increase of 0.33 eV in the adsorption energy for H<sub>2</sub>. The density of states further confirms that this modification alters the electronic properties of WSe<sub>2</sub>, thereby enhancing its adsorption performance. Finally, the GW surface in the WSe<sub>2</sub>/GaN heterostructure significantly enhanced the adsorption energy of H<sub>2</sub> to −2.048 eV and improved the adsorption performance for CO, HCN, CH<sub>4</sub>, and NH<sub>3</sub> molecules. Recovery times at room temperature were calculated for multiple configurations, predicting ultra-high selectivity and favorable recovery times for Pt-WSe<sub>2</sub> toward all four gases except CH<sub>4</sub>. The adsorption mechanism is controlled by the changes in conductivity caused by charge transfer. These theoretical studies provide the theoretical basis for the practical application of monolayer WSe<sub>2</sub> in hydrogen sensing and gas adsorption.","PeriodicalId":247,"journal":{"name":"Applied Surface Science","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lluís Martínez-Belenguer, Kateřina Zítová, Jose Pedro Cerón-Carrasco, Belén Lerma-Berlanga, Antonio Leyva-Pérez
Subnano and nanometric metal clusters are ultrasmall aggregates in which most atoms are exposed on the surface, directly interacting with reactants and enabling highly efficient catalysis. However, metal carbonate clusters have been barely prepared and used in catalysis. Here, we report the synthesis of ultrasmall, ligand-free MgCO3 clusters formed via CO2 capture with MgCl2, with an average composition of [MgCO3]5·3H2O. These clusters exhibit catalytic activity in various nucleophilic alcohol addition reactions, showing a 5-fold enhancement compared to bulk MgCO3 and CaCO3–triethylamine clusters. These results pave the way for synthesis of ultrasmall alkaline metal carbonate clusters beyond Ca, which can be employed as efficient catalysts in organic synthesis.
{"title":"Ligand-Free MgCO3 Nanoclusters Catalyze Nucleophilic Alcohol Addition Reactions","authors":"Lluís Martínez-Belenguer, Kateřina Zítová, Jose Pedro Cerón-Carrasco, Belén Lerma-Berlanga, Antonio Leyva-Pérez","doi":"10.1021/acsami.5c21329","DOIUrl":"https://doi.org/10.1021/acsami.5c21329","url":null,"abstract":"Subnano and nanometric metal clusters are ultrasmall aggregates in which most atoms are exposed on the surface, directly interacting with reactants and enabling highly efficient catalysis. However, metal carbonate clusters have been barely prepared and used in catalysis. Here, we report the synthesis of ultrasmall, ligand-free MgCO<sub>3</sub> clusters formed via CO<sub>2</sub> capture with MgCl<sub>2</sub>, with an average composition of [MgCO<sub>3</sub>]<sub>5</sub>·3H<sub>2</sub>O. These clusters exhibit catalytic activity in various nucleophilic alcohol addition reactions, showing a 5-fold enhancement compared to bulk MgCO<sub>3</sub> and CaCO<sub>3</sub>–triethylamine clusters. These results pave the way for synthesis of ultrasmall alkaline metal carbonate clusters beyond Ca, which can be employed as efficient catalysts in organic synthesis.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"89 1","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanopore sodium storage underpins the characteristic low-voltage plateau in hard carbon (HC) anodes. Yet, the interfacial impact of electrolyte additives on this confined process remains largely elusive. Herein, we unveil a pore-blocking mechanism in sugarcane bagasse-based hard carbon (SuHC) induced by fluoroethylene carbonate (FEC), a widely used solid electrolyte interphase (SEI) forming additive. Using a combination of electrochemical analysis, spectroscopy, electron microscopy, and density functional theory, we demonstrate that FEC decomposition induces NaF-rich deposits in near-surface pore domains and pore-entrance regions, which impede Na+ intercalation and suppress the low-voltage plateau. High-resolution transmission electron microscopy (HRTEM) reveals NaF-matching crystallites in subsurface regions close to particle edges. This interfacial chemistry drives a mechanistic shift from diffusion-dominated intercalation to surface-limited capacitive storage. Our findings highlight the critical importance of additive–structure compatibility and offer design principles for tailoring electrolyte formulations for nanoporous carbon anodes in next-generation SIBs.
{"title":"Design principles for fluoroethylene carbonate additive–electrode compatibility in nanoporous sugarcane bagasse-based hard carbon sodium ion anodes","authors":"Jiahan Fu, Sheng Li, Chaofan Luo, Honglin Hu, Tianshun Xiong, Xin Li, Junyou Yang, Guangwei Huang, Jianfang Li, Yubo Luo, Canhuang Zhang","doi":"10.1039/d5ta09846g","DOIUrl":"https://doi.org/10.1039/d5ta09846g","url":null,"abstract":"Nanopore sodium storage underpins the characteristic low-voltage plateau in hard carbon (HC) anodes. Yet, the interfacial impact of electrolyte additives on this confined process remains largely elusive. Herein, we unveil a pore-blocking mechanism in sugarcane bagasse-based hard carbon (SuHC) induced by fluoroethylene carbonate (FEC), a widely used solid electrolyte interphase (SEI) forming additive. Using a combination of electrochemical analysis, spectroscopy, electron microscopy, and density functional theory, we demonstrate that FEC decomposition induces NaF-rich deposits in near-surface pore domains and pore-entrance regions, which impede Na<small><sup>+</sup></small> intercalation and suppress the low-voltage plateau. High-resolution transmission electron microscopy (HRTEM) reveals NaF-matching crystallites in subsurface regions close to particle edges. This interfacial chemistry drives a mechanistic shift from diffusion-dominated intercalation to surface-limited capacitive storage. Our findings highlight the critical importance of additive–structure compatibility and offer design principles for tailoring electrolyte formulations for nanoporous carbon anodes in next-generation SIBs.","PeriodicalId":82,"journal":{"name":"Journal of Materials Chemistry A","volume":"211 1","pages":""},"PeriodicalIF":11.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoliang Deng, Lina Wu, Boxin Chen, Xiaohui Tang, Shiying Xu, Yinxing Huang, Fan Pan, Jun Lu, Xianquan Feng
Inflammation plays a pivotal role in fostering an immunosuppressive tumor microenvironment, which diminishes tumor immunogenic cell death (ICD) and subsequently promotes tumor recurrence and metastasis. The COX-2/PGE2 signaling axis has been identified as a crucial regulator in the establishment of immunosuppressive conditions. Herein, this work developed an excipient-free nanomedicine (IPC NPs) via non-covalent self-assembly, integrating indocyanine green and paclitaxel (dual ICD inducers) with celecoxib (COX-2/PGE2 inhibitor) for combined chemo-photothermal therapy with anti-inflammatory effects. The IPC NPs displayed monodisperse characteristics with optimal near-infrared responsiveness, significantly enhancing tumor tissue permeation while demonstrating synergistic chemo-photothermal cytotoxicity against triple-negative breast cancer (TNBC). Notably, IPC NPs-encapsulated celecoxib effectively remodeled the tumor inflammatory microenvironment by attenuating therapy-induced inflammatory responses, thereby potentiating ICD. This triple therapy regimen promoted dendritic cell maturation, enhanced cytotoxic T lymphocyte infiltration into tumor tissues, and upregulated effector memory T cell populations in TNBC. These immunomodulatory effects substantially ameliorated the immunosuppressive tumor microenvironment, leading to significant inhibition of primary tumor growth and metastasis. Collectively, this work presents a novel carrier-free nanotherapeutic strategy that synergistically combines chemo-photothermal-inflammatory suppression therapy, offering a promising approach for TNBC.
{"title":"Self-Assembled Carrier-Free Nanomedicines Potentiate Chemo-Photothermal Immunotherapy by Overcoming Prostaglandin E2-Mediated Immunosuppression","authors":"Xiaoliang Deng, Lina Wu, Boxin Chen, Xiaohui Tang, Shiying Xu, Yinxing Huang, Fan Pan, Jun Lu, Xianquan Feng","doi":"10.1002/smll.202512540","DOIUrl":"https://doi.org/10.1002/smll.202512540","url":null,"abstract":"Inflammation plays a pivotal role in fostering an immunosuppressive tumor microenvironment, which diminishes tumor immunogenic cell death (ICD) and subsequently promotes tumor recurrence and metastasis. The COX-2/PGE2 signaling axis has been identified as a crucial regulator in the establishment of immunosuppressive conditions. Herein, this work developed an excipient-free nanomedicine (IPC NPs) via non-covalent self-assembly, integrating indocyanine green and paclitaxel (dual ICD inducers) with celecoxib (COX-2/PGE2 inhibitor) for combined chemo-photothermal therapy with anti-inflammatory effects. The IPC NPs displayed monodisperse characteristics with optimal near-infrared responsiveness, significantly enhancing tumor tissue permeation while demonstrating synergistic chemo-photothermal cytotoxicity against triple-negative breast cancer (TNBC). Notably, IPC NPs-encapsulated celecoxib effectively remodeled the tumor inflammatory microenvironment by attenuating therapy-induced inflammatory responses, thereby potentiating ICD. This triple therapy regimen promoted dendritic cell maturation, enhanced cytotoxic T lymphocyte infiltration into tumor tissues, and upregulated effector memory T cell populations in TNBC. These immunomodulatory effects substantially ameliorated the immunosuppressive tumor microenvironment, leading to significant inhibition of primary tumor growth and metastasis. Collectively, this work presents a novel carrier-free nanotherapeutic strategy that synergistically combines chemo-photothermal-inflammatory suppression therapy, offering a promising approach for TNBC.","PeriodicalId":228,"journal":{"name":"Small","volume":"46 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rania M. Needa, Hosny Ibrahim, Ahmed F. A. Youssef, Rabeay Y. A. Hassan
The development of nanostructured electrochemical platforms for rapid and selective sensing of coexisting biomolecules remains a key challenge in food analysis. Herein, selenium oxide nanostructures (SeO2NSs) were synthesized and integrated into carbon-based electrodes to enable the simultaneous electrochemical detection of ascorbic acid (AA) and oxalic acid (OA) in complex food matrices. Comprehensive morphological, structural, and electrochemical characterization studies confirmed the uniform distribution, high surface area, and excellent redox activity of the SeO2NSs. Under optimized chronoamperometric conditions, the SeO2NS-modified electrode exhibited wide linear response ranges of 5.0–550 µM for OA and 5.0–455 µM for AA, with low detection limits of 0.50 µM and 0.43 µM, respectively. The sensor demonstrated remarkable selectivity and stability against common interfering species, ensuring accurate quantification in real samples. Thus, the developed platform was successfully applied to the simultaneous determination of AA and OA in fresh fruits and vegetables (guava, spinach, and mango) and in beverages derived from coffee beans and tea leaves. This work highlights the potential of selenium oxide nanostructures as efficient electroactive materials for high-performance, cost-effective, and reliable electrochemical sensing in food-quality monitoring and safety assessment.
{"title":"Selenium oxide nanostructure-based electrodes for rapid and simultaneous electrochemical determination of oxalic and ascorbic acids in food matrices","authors":"Rania M. Needa, Hosny Ibrahim, Ahmed F. A. Youssef, Rabeay Y. A. Hassan","doi":"10.1039/d5nr04332h","DOIUrl":"https://doi.org/10.1039/d5nr04332h","url":null,"abstract":"The development of nanostructured electrochemical platforms for rapid and selective sensing of coexisting biomolecules remains a key challenge in food analysis. Herein, selenium oxide nanostructures (SeO<small><sub>2</sub></small>NSs) were synthesized and integrated into carbon-based electrodes to enable the simultaneous electrochemical detection of ascorbic acid (AA) and oxalic acid (OA) in complex food matrices. Comprehensive morphological, structural, and electrochemical characterization studies confirmed the uniform distribution, high surface area, and excellent redox activity of the SeO<small><sub>2</sub></small>NSs. Under optimized chronoamperometric conditions, the SeO<small><sub>2</sub></small>NS-modified electrode exhibited wide linear response ranges of 5.0–550 µM for OA and 5.0–455 µM for AA, with low detection limits of 0.50 µM and 0.43 µM, respectively. The sensor demonstrated remarkable selectivity and stability against common interfering species, ensuring accurate quantification in real samples. Thus, the developed platform was successfully applied to the simultaneous determination of AA and OA in fresh fruits and vegetables (guava, spinach, and mango) and in beverages derived from coffee beans and tea leaves. This work highlights the potential of selenium oxide nanostructures as efficient electroactive materials for high-performance, cost-effective, and reliable electrochemical sensing in food-quality monitoring and safety assessment.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liquid metals (LMs) are emerging as highly promising materials for wearable devices owing to their exceptional properties, such as high electrical and thermal conductivity, biocompatibility, flexibility, and unique surface characteristics. Through surface engineering with ligands, polymers, and nanomaterials, LMs can be processed into stable bioinks with enhanced oxidation resistance, adhesion, and multifunctionality. These bioinks are further integrated into microneedle and patch-based wearables via fabrication strategies, including photolithography, micromolding, 3D printing, screen and inkjet printing, and direct writing. Such integration enables diverse biomedical applications, ranging from physiological signal monitoring and sweat or temperature sensing to wound healing, antibacterial therapy, and controlled drug delivery. Despite these advances, challenges remain in application maturity, long-term stability, biocompatibility, and scalable manufacturing. Accordingly, this review summarizes these challenges and outlines future directions for LM-based wearable biomedical devices.
{"title":"Engineering Liquid Metal Nanoparticles for Wearable Devices","authors":"Yuxuan Chen, Zhiheng Zhang, Shan He, Guozhen Liu","doi":"10.1021/acsnano.5c18099","DOIUrl":"https://doi.org/10.1021/acsnano.5c18099","url":null,"abstract":"Liquid metals (LMs) are emerging as highly promising materials for wearable devices owing to their exceptional properties, such as high electrical and thermal conductivity, biocompatibility, flexibility, and unique surface characteristics. Through surface engineering with ligands, polymers, and nanomaterials, LMs can be processed into stable bioinks with enhanced oxidation resistance, adhesion, and multifunctionality. These bioinks are further integrated into microneedle and patch-based wearables via fabrication strategies, including photolithography, micromolding, 3D printing, screen and inkjet printing, and direct writing. Such integration enables diverse biomedical applications, ranging from physiological signal monitoring and sweat or temperature sensing to wound healing, antibacterial therapy, and controlled drug delivery. Despite these advances, challenges remain in application maturity, long-term stability, biocompatibility, and scalable manufacturing. Accordingly, this review summarizes these challenges and outlines future directions for LM-based wearable biomedical devices.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rational proton engineering offers a powerful strategy for enhancing the hydrogen evolution reaction (HER) performance of single-atom catalysts (SACs). Notably, achieving concerted proton management across multiple reaction steps presents a highly efficient approach, yet it remains more challenging to implement than single-step regulation. Here, we propose a domino-type proton provision-conversion-spillover programming for Pt SACs in acidic HER, enabled by ultrathin porous nitrogen-doped carbon (main 1–2 atomic layers, sub-1 nm) encapsulated TiN nanowires with tips as dual-support tip-platform (Pt-NC1@TiN NWs). Experimental and theoretical results demonstrate that this platform triggers tip-distance-spillover domino effects to drive a proton cascade throughout HER. Specifically, NC1@TiN nanotips induce tip-enhanced effect that promotes interfacial proton accessibility. Concurrently, the short-distance Pt/TiN vertical coupling optimizes electronic modulation of unsaturated Pt-N2 sites to enhance their intrinsic activity. Exposed TiN sites function as hydrogen spillover centers to facilitate H2 desorption. Consequently, Pt-NC1@TiN NWs achieve a superior Pt mass activity of 153.5 A/mgPt@-100 mV, surpassing Pt/C by two orders of magnitude. Notably, it reaches 2 A/cm2 at low cell voltage of 1.75 V and sustains stable operation at 1 A/cm2 for 1200 h in proton exchange membrane water electrolyzer (PEMWE). This work indicates the potential of harnessing multi-step domino processes for advanced catalyst design.
{"title":"Proton Provision-Conversion-Spillover Cascade Programming on Dual Supported Pt Atoms for Robust Hydrogen Production","authors":"Mansheng Liao, Yuan Zhang, Qianyi Lin, Kaiming Liang, Yayun Hong, Lei Zhang","doi":"10.1002/adma.202522479","DOIUrl":"https://doi.org/10.1002/adma.202522479","url":null,"abstract":"Rational proton engineering offers a powerful strategy for enhancing the hydrogen evolution reaction (HER) performance of single-atom catalysts (SACs). Notably, achieving concerted proton management across multiple reaction steps presents a highly efficient approach, yet it remains more challenging to implement than single-step regulation. Here, we propose a domino-type proton provision-conversion-spillover programming for Pt SACs in acidic HER, enabled by ultrathin porous nitrogen-doped carbon (main 1–2 atomic layers, sub-1 nm) encapsulated TiN nanowires with tips as dual-support tip-platform (Pt-NC<sub>1</sub>@TiN NWs). Experimental and theoretical results demonstrate that this platform triggers tip-distance-spillover domino effects to drive a proton cascade throughout HER. Specifically, NC<sub>1</sub>@TiN nanotips induce tip-enhanced effect that promotes interfacial proton accessibility. Concurrently, the short-distance Pt/TiN vertical coupling optimizes electronic modulation of unsaturated Pt-N<sub>2</sub> sites to enhance their intrinsic activity. Exposed TiN sites function as hydrogen spillover centers to facilitate H<sub>2</sub> desorption. Consequently, Pt-NC<sub>1</sub>@TiN NWs achieve a superior Pt mass activity of 153.5 A/mg<sub>Pt</sub>@-100 mV, surpassing Pt/C by two orders of magnitude. Notably, it reaches 2 A/cm<sup>2</sup> at low cell voltage of 1.75 V and sustains stable operation at 1 A/cm<sup>2</sup> for 1200 h in proton exchange membrane water electrolyzer (PEMWE). This work indicates the potential of harnessing multi-step domino processes for advanced catalyst design.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"6 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Effective delivery to dendritic cells (DCs) is crucial for the clinical translation of STING agonists, however, current cyclic dinucleotide (CDN) therapies are hindered by inefficient cytosolic delivery and off-target activation-induced T cell exhaustion. Here, a high-fidelity, dengue virus-mimetic platform (CDN@VLP) is engineered to leverage natural tropism for precise cytosolic release in immature DCs. Compared to conventional lipid nanoparticles, CDN@VLP enhances DC-specific uptake by 1.9-fold while reducing non-specific T cell internalization in tumors by 14.8-fold, achieving comparable antitumor efficacy at one-fortieth the dose of free CDN. Systematic screening identifies an optimal VLP subtype that improves targeted accumulation in type 1 conventional DCs (cDC1s)—a subset essential for STING pathway activation—by 2.3-fold and amplifies durable type I interferon responses, resulting in a 12.8-fold increase in IFN-β production. Transcriptomic analysis further reveals that CDN@VLP promotes cDC1 recruitment into tumors by enhancing the secretion of key chemokines (XCL1, CCL4, and CCL5), suggesting an additional mechanism of action. By mimicking viral tropism, the CDN@VLP platform establishes a paradigm for precision STING activation, overcoming the trade-off between potency and specificity in cDC1-targeted immunotherapy.
{"title":"Bioinspired Engineered Virus-Mimetic Vesicles for Enhanced Cytosolic Delivery of STING Agonists Into Dendritic Cells","authors":"Shi-Zhen Geng, Yaru Shi, Jinjin Yang, Yiwen Gao, Zhehao Zhang, Hao Wu, Pan-Miao Liu, Jinjin Shi, Yiling Yang, Jian-Jun Yang","doi":"10.1002/adma.202520019","DOIUrl":"https://doi.org/10.1002/adma.202520019","url":null,"abstract":"Effective delivery to dendritic cells (DCs) is crucial for the clinical translation of STING agonists, however, current cyclic dinucleotide (CDN) therapies are hindered by inefficient cytosolic delivery and off-target activation-induced T cell exhaustion. Here, a high-fidelity, dengue virus-mimetic platform (CDN@VLP) is engineered to leverage natural tropism for precise cytosolic release in immature DCs. Compared to conventional lipid nanoparticles, CDN@VLP enhances DC-specific uptake by 1.9-fold while reducing non-specific T cell internalization in tumors by 14.8-fold, achieving comparable antitumor efficacy at one-fortieth the dose of free CDN. Systematic screening identifies an optimal VLP subtype that improves targeted accumulation in type 1 conventional DCs (cDC1s)—a subset essential for STING pathway activation—by 2.3-fold and amplifies durable type I interferon responses, resulting in a 12.8-fold increase in IFN-β production. Transcriptomic analysis further reveals that CDN@VLP promotes cDC1 recruitment into tumors by enhancing the secretion of key chemokines (XCL1, CCL4, and CCL5), suggesting an additional mechanism of action. By mimicking viral tropism, the CDN@VLP platform establishes a paradigm for precision STING activation, overcoming the trade-off between potency and specificity in cDC1-targeted immunotherapy.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"59 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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