Jie Sun, Guicong Hu, Luran Jiang, Wen Chang, Sai An, Bo Qi, Yu-Fei Song
The electrochemistry recognition of enantiomeric chiral molecules holds great significance for the pharmaceutical industry and scientific research. However, enhancing sensitivity and selectivity simultaneously, and elucidating chiral recognition mechanism, are two primary challenges. Here, an electrochemical chiral sensor L-C4-PMoV/GO is developed by confining chiral imidazole cations (L-C4) and [PMo10V2]5− (PMoV) signal anions within the interlayer of graphene oxide (GO). The L-C4-PMoV/GO is highly sensitive to recognition towards the chiral drug Levodopa (L-DOPA), which exhibits 16 times higher than the L-C4/GO. In addition, the enantioselectivity of ΔS = 19.92 is achieved. Mechanism studies suggest that the chiral confinement effect plays a crucial role in the synergism between the signal site PMoV and the enantioselectivity L-C4. In the chiral-confined microenvironment, the chiral induction from L-C4 to PMoV is facilitated, which results in the distortion of Mo (V)─O bonds. The hydrogen-bonding networks among the L-C4, Mo (V)─O, and DOPA generate the adsorption energy difference between the L/D-DOPA, as revealed by the in situ Raman spectroscopy and theoretical calculation. Compared to the conventional techniques, the electrochemical sensor shows comparable enantiomer excess (ee) value determination, low limits of detection (LOD) (6.7 nm for L-DOPA, 50.6 nm for D-DOPA), and portability, enabling practical chiral recognition.
{"title":"Engineering Chiral Confinement Environment in Polyoxometalate Intercalated Graphene Oxide Sensor for Electrochemical Enantioselective Recognition","authors":"Jie Sun, Guicong Hu, Luran Jiang, Wen Chang, Sai An, Bo Qi, Yu-Fei Song","doi":"10.1002/smll.202410895","DOIUrl":"https://doi.org/10.1002/smll.202410895","url":null,"abstract":"The electrochemistry recognition of enantiomeric chiral molecules holds great significance for the pharmaceutical industry and scientific research. However, enhancing sensitivity and selectivity simultaneously, and elucidating chiral recognition mechanism, are two primary challenges. Here, an electrochemical chiral sensor L-C<sub>4</sub>-PMoV/GO is developed by confining chiral imidazole cations (L-C<sub>4</sub>) and [PMo<sub>10</sub>V<sub>2</sub>]<sup>5−</sup> (PMoV) signal anions within the interlayer of graphene oxide (GO). The L-C<sub>4</sub>-PMoV/GO is highly sensitive to recognition towards the chiral drug Levodopa (L-DOPA), which exhibits 16 times higher than the L-C<sub>4</sub>/GO. In addition, the enantioselectivity of Δ<i>S</i> = 19.92 is achieved. Mechanism studies suggest that the chiral confinement effect plays a crucial role in the synergism between the signal site PMoV and the enantioselectivity L-C<sub>4</sub>. In the chiral-confined microenvironment, the chiral induction from L-C<sub>4</sub> to PMoV is facilitated, which results in the distortion of Mo (V)─O bonds. The hydrogen-bonding networks among the L-C<sub>4</sub>, Mo (V)─O, and DOPA generate the adsorption energy difference between the L/D-DOPA, as revealed by the in situ Raman spectroscopy and theoretical calculation. Compared to the conventional techniques, the electrochemical sensor shows comparable enantiomer excess (ee) value determination, low limits of detection (LOD) (6.7 n<span>m</span> for L-DOPA, 50.6 n<span>m</span> for D-DOPA), and portability, enabling practical chiral recognition.","PeriodicalId":228,"journal":{"name":"Small","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guoqing Zhu, Yulin Xie, Junrong Wang, Man Wang, Yanrong Qian, Qianqian Sun, Yunlu Dai, Chunxia Li
Adv. Mater. 2024, 36, 2409066
DOI: 10.1002/adma.202409066
The authors regret that the sequence for experimental groups in Figure 8c,d was labeled incorrectly, which has been revised. This correction does not affect any experimental results, discussions, or conclusions reported in the paper. The authors sincerely apologize for any inconvenience caused.
Revised Figure 8. Anti-tumor therapy in vivo. a) Anti-tumor experimental procedure of BALB/c mice. b,c) Tumor growth curve from day 1 to day 15 after different treatments. d) Tumor images after different treatments. e) Tumor sections stained by H&E and TUNEL after different treatments. f) H&E stained lung sections and lung tissue photos. g) Tumor weight after different treatments. Data were presented as mean ± S.D. (n = 5). Content of h) spermine, i) spermidine and j) polyamines in tumor. Data were presented as mean ± S.D. (n = 3). Statistical significance is assessed by an unpaired Student's two-sided t-test. *p < 0.05; **p < 0.01; ***p < 0.001.
{"title":"Correction to “Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy”","authors":"Guoqing Zhu, Yulin Xie, Junrong Wang, Man Wang, Yanrong Qian, Qianqian Sun, Yunlu Dai, Chunxia Li","doi":"10.1002/adma.202500790","DOIUrl":"https://doi.org/10.1002/adma.202500790","url":null,"abstract":"<p><i>Adv. Mater</i>. <b>2024</b>, <i>36</i>, 2409066</p>\u0000<p>DOI: 10.1002/adma.202409066</p>\u0000<p>The authors regret that the sequence for experimental groups in Figure 8c,d was labeled incorrectly, which has been revised. This correction does not affect any experimental results, discussions, or conclusions reported in the paper. The authors sincerely apologize for any inconvenience caused.</p>\u0000<p><img alt=\"image\" loading=\"lazy\" src=\"/cms/asset/6d666022-2b5c-4c59-8579-373e2fc78f1e/adma202500790-gra-0001.png\"/></p>\u0000<p><b>Revised Figure 8</b>. Anti-tumor therapy in vivo. a) Anti-tumor experimental procedure of BALB/c mice. b,c) Tumor growth curve from day 1 to day 15 after different treatments. d) Tumor images after different treatments. e) Tumor sections stained by H&E and TUNEL after different treatments. f) H&E stained lung sections and lung tissue photos. g) Tumor weight after different treatments. Data were presented as mean ± S.D. (<i>n</i> = 5). Content of h) spermine, i) spermidine and j) polyamines in tumor. Data were presented as mean ± S.D. (<i>n</i> = 3). Statistical significance is assessed by an unpaired Student's two-sided <i>t</i>-test. <sup>*</sup><i>p</i> < 0.05; <sup>**</sup><i>p</i> < 0.01; <sup>***</sup><i>p</i> < 0.001.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"1 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.scriptamat.2025.116684
Mingyu Gong , Haijian Chu , Yong Mao , Jian Wang
Intermetallic precipitates are strategically introduced to strengthen metallic alloys. Severe plastic deformation associated with dislocations interactions often causes destabilization of intermetallic precipitates in metallic alloys. Based on molecular dynamics simulations of non-coplanar dislocation dipole interactions, we reported anomalous reactions of forming vacancy-type defects (vacancy cluster, void and prismatic dislocation loop) in typical intermetallic compounds (i.e. L12-Ni3Al, L10-TiAl, and B2-NiAl). Compared with the reactions in metals, the formation of vacancy-type defects is attributed to the larger core energies and interaction forces of a dislocation dipole and the lowering formation energies of vacancies within the dislocation cores in intermetallic compounds. These vacancy-type defects are immobile and pin the motion of dislocations, locally disorder the crystal, and facilitate self-diffusion of alloying elements, consequently deteriorating structural stability of intermetallic precipitates.
{"title":"Anomalous interactions of non-coplanar dislocation dipole in intermetallic compounds","authors":"Mingyu Gong , Haijian Chu , Yong Mao , Jian Wang","doi":"10.1016/j.scriptamat.2025.116684","DOIUrl":"10.1016/j.scriptamat.2025.116684","url":null,"abstract":"<div><div>Intermetallic precipitates are strategically introduced to strengthen metallic alloys. Severe plastic deformation associated with dislocations interactions often causes destabilization of intermetallic precipitates in metallic alloys. Based on molecular dynamics simulations of non-coplanar dislocation dipole interactions, we reported anomalous reactions of forming vacancy-type defects (vacancy cluster, void and prismatic dislocation loop) in typical intermetallic compounds (i.e. L1<sub>2</sub>-Ni<sub>3</sub>Al, L1<sub>0</sub>-TiAl, and B2-NiAl). Compared with the reactions in metals, the formation of vacancy-type defects is attributed to the larger core energies and interaction forces of a dislocation dipole and the lowering formation energies of vacancies within the dislocation cores in intermetallic compounds. These vacancy-type defects are immobile and pin the motion of dislocations, locally disorder the crystal, and facilitate self-diffusion of alloying elements, consequently deteriorating structural stability of intermetallic precipitates.</div></div>","PeriodicalId":423,"journal":{"name":"Scripta Materialia","volume":"263 ","pages":"Article 116684"},"PeriodicalIF":5.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In article number 2418466, Huijian Ye, Lixin Xu, and co-workers present a hyperbranched polymer grafting with a conjugated double bond serves as a trapping effect through addition reaction with free radicals, which delays the formation of electrical treeing at initial stage of breakdown. The combination of suppressed conduction loss and maintaining intrinsic breakdown contributes to the outstanding high-temperature energy density and efficiency in the polyetherimide nanocomposite.
{"title":"Ultrahigh Energy Storage Capability in Polyetherimide-Based Polymer Dielectrics Through Trapping Free Radicals Strategy (Adv. Funct. Mater. 14/2025)","authors":"Huilei Jiang, Dingyu Zheng, Huijian Ye, Lixin Xu","doi":"10.1002/adfm.202570082","DOIUrl":"https://doi.org/10.1002/adfm.202570082","url":null,"abstract":"<p><b>Polymer Dielectrics</b></p><p>In article number 2418466, Huijian Ye, Lixin Xu, and co-workers present a hyperbranched polymer grafting with a conjugated double bond serves as a trapping effect through addition reaction with free radicals, which delays the formation of electrical treeing at initial stage of breakdown. The combination of suppressed conduction loss and maintaining intrinsic breakdown contributes to the outstanding high-temperature energy density and efficiency in the polyetherimide nanocomposite.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"35 14","pages":""},"PeriodicalIF":18.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.202570082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabio Bersano, Michele Aldeghi, Niccolò Martinolli, Victor Boureau, Thibault Aboud, Michele Ghini, Pasquale Scarlino, Gian Salis, Adrian M. Ionescu
Semiconductor Quantum Dots
In article number 2419940, Fabio Bersano, Adrian M. Ionescu, and co-workers achieve electrostatic and magnetic control in a silicon-on-insulator nanowire through ferromagnetic gates magnetized along the direction of carrier flow. The magnetic gate stack, alternating with a standard metallic one, is integrated into a front-end-of-line–compatible process.
{"title":"Integration of Cobalt Ferromagnetic Control Gates for Electrical and Magnetic Manipulation of Semiconductor Quantum Dots (Adv. Funct. Mater. 14/2025)","authors":"Fabio Bersano, Michele Aldeghi, Niccolò Martinolli, Victor Boureau, Thibault Aboud, Michele Ghini, Pasquale Scarlino, Gian Salis, Adrian M. Ionescu","doi":"10.1002/adfm.202570080","DOIUrl":"https://doi.org/10.1002/adfm.202570080","url":null,"abstract":"<p><b>Semiconductor Quantum Dots</b></p><p>In article number 2419940, Fabio Bersano, Adrian M. Ionescu, and co-workers achieve electrostatic and magnetic control in a silicon-on-insulator nanowire through ferromagnetic gates magnetized along the direction of carrier flow. The magnetic gate stack, alternating with a standard metallic one, is integrated into a front-end-of-line–compatible process.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"35 14","pages":""},"PeriodicalIF":18.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.202570080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.mseb.2025.118237
Halemah I. El-Saeedy , Huriyyah A. Alturaifi , Hisham A. Saleh
Ni0.94Zn0.06O films grown at 723 K on clean glass substrates via spray pyrolysis technique, thereafter, the deposited films were annealed at temperatures of 773, and 823 K respectively, for 1 hr. The deposited films were structurally characterized using X-ray diffraction (XRD), a field emission scanning electron microscope (FE-SEM) interfaced with energy-dispersive X-ray spectroscopy (EDAX) and a high-resolution transmission electron microscope (HRTEM),). The prepared films are found to belong to cubic structures based on X-ray data. An increase in particle size with increasing temperature was found by evaluating the variation of the particle size D, strain, ε and dislocation density, δ as a function of the annealing temperatures. The analysis of the optical transmission spectra in the 200–2500 nm wavelength range shows that the refractive index n increases with the annealing temperature, but the optical band gap Eg value decreases. Two different types of conduction mechanisms are revealed by the film resistance dependence of temperature measured between 300 and 600 K. For these types, the activation energy ΔEg values decrease as the annealing temperature increases.
{"title":"Evaluation of Ni0.94Zn0.06O thin film performance and characterization for optoelectronic applications: Structural, optical, and electrical perspectives","authors":"Halemah I. El-Saeedy , Huriyyah A. Alturaifi , Hisham A. Saleh","doi":"10.1016/j.mseb.2025.118237","DOIUrl":"10.1016/j.mseb.2025.118237","url":null,"abstract":"<div><div>Ni<sub>0.94</sub>Zn<sub>0.06</sub>O films grown at 723 <em>K</em> on clean glass substrates via spray pyrolysis technique, thereafter, the deposited films were annealed at temperatures of 773, and 823 <em>K</em> respectively, for 1 hr. The deposited films were structurally characterized using X-ray diffraction (XRD), a field emission scanning electron microscope (FE-SEM) interfaced with energy-dispersive X-ray spectroscopy (EDAX) and a high-resolution transmission electron microscope (HRTEM),). The prepared films are found to belong to cubic structures based on X-ray data. An increase in particle size with increasing temperature was found by evaluating the variation of the particle size D, strain, ε and dislocation density, <em>δ</em> as a function of the annealing temperatures. The analysis of the optical transmission spectra in the 200–2500 nm wavelength range shows that the refractive index n increases with the annealing temperature, but the optical band gap <em>E<sub>g</sub></em> value decreases. Two different types of conduction mechanisms are revealed by the film resistance dependence of temperature measured between 300 and 600 K. For these types, the activation energy Δ<em>E<sub>g</sub></em> values decrease as the annealing temperature increases.</div></div>","PeriodicalId":18233,"journal":{"name":"Materials Science and Engineering: B","volume":"318 ","pages":"Article 118237"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.mseb.2025.118282
Alina Cismaru, Mircea Dragoman, Sergiu Iordănescu, Cosmin Obreja, Valentin Buiculescu, Hamza El Ghannudi, Cătălin Pârvulescu, Damir Mladenovic, Mihaela Carp, Oana Brâncoveanu
In this paper a novel CO2 sensor based on two types of metasurface-based antennas coated with single wall carbon nanotubes (SWCNTs), and functionalized with carbon nitride nanosheets (g-C3N4) as a gas adsorber is presented. The antenna A1 with complementary split-ring resonators (CSRRs) integrated into the patch and covered with CNTs works at 16.06 GHz (A1 CNT) and the antenna A2 with CSRRs incorporated into the ground plane covered with CNTs works at 17.06 GHz. The experimental results demonstrate a shift in frequency with almost 5 MHz for A1 CNT and with almost 15 MHz for A2 CNT at the concentration level of 1800 ppm. The interaction between CO2 and the CNTs covering the metasurface-based antennas produced a good sensitivity, of 2.7 kHz/ppm for A1 CNT and 8.3 kHz/ppm for A2 CNT at the concentration level of 1800 ppm.
{"title":"CO2 detection using microwave metasurface-based antennas covered with carbon nanotubes","authors":"Alina Cismaru, Mircea Dragoman, Sergiu Iordănescu, Cosmin Obreja, Valentin Buiculescu, Hamza El Ghannudi, Cătălin Pârvulescu, Damir Mladenovic, Mihaela Carp, Oana Brâncoveanu","doi":"10.1016/j.mseb.2025.118282","DOIUrl":"10.1016/j.mseb.2025.118282","url":null,"abstract":"<div><div>In this paper a novel CO<sub>2</sub> sensor based on two types of metasurface-based antennas coated with single wall carbon nanotubes (SWCNTs), and functionalized with carbon nitride nanosheets (g-C<sub>3</sub>N<sub>4</sub>) as a gas adsorber is presented. The antenna A1 with complementary split-ring resonators (CSRRs) integrated into the patch and covered with CNTs works at 16.06 GHz (A1 CNT) and the antenna A2 with CSRRs incorporated into the ground plane covered with CNTs works at 17.06 GHz. The experimental results demonstrate a shift in frequency with almost 5 MHz for A1 CNT and with almost 15 MHz for A2 CNT at the concentration level of 1800 ppm. The interaction between CO<sub>2</sub> and the CNTs covering the metasurface-based antennas produced a good sensitivity, of 2.7 kHz/ppm for A1 CNT and 8.3 kHz/ppm for A2 CNT at the concentration level of 1800 ppm.</div></div>","PeriodicalId":18233,"journal":{"name":"Materials Science and Engineering: B","volume":"318 ","pages":"Article 118282"},"PeriodicalIF":3.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.jallcom.2025.180226
Wang Zhijuan, Zhou Huajing, Yuan Yuan, Guan Qingqing, He Liang, Miao Yingchun
Exploring photocatalysts with the merits of simple and economical preparation, excellent efficiency of charge separation and ease of scaling up holds paramount importance for photocatalytic degradation of emerging contaminants (ECs). In this pursuit, a biochar-based photocatalyst was fabricated from paper mill sludge (PMS) via a straightforward one-step pyrolysis. Notably, the pyrolysis temperature emerged as a pivotal factor that modulated the phase composition and structural defects (including surface oxygen vacancy and carbon defects) of materials, thus further influencing the band structure, the migration of interfacial photoexcited charges and the efficaciousness of the separation of e−/h+ pairs. Specifically, the PMS-derived biochar pyrolyzed at 550 oC (SBC550) exhibited excellent photocatalytic degradation efficiency towards bisphenol S (BPS) with 86.5% of BPS being degraded within 180 min. The optimum performance of SBC550 was attributed to the ingenious and fitting construction of a multi-heterostructure comprising Ca2Fe2O5/Fe3O4 embedded within S-doped graphitic carbon (SDC), enhanced electron transfer stemmed from appropriate structural defects as well as the facilitative electron shuttle effect endowed by the porous carbonaceous substrate. Besides, 1O2 and h+ were confirmed to be the main ROS attributed to the elimination of BPS and its degradation routes of phenoxy radical and electrophilic cycloaddition of 1O2 were reasonably deduced based on the HR-MS tests and DFT calculations. Collectively, this work provided crucial and new insights into the utilization of PMS in the domain of photocatalytic strategy for tackling the challenge of emerging pollutants.
{"title":"Efficient photocatalyst with multi-heterostructures and appropriate structural defects simply from paper mill sludge for photodegradation of Bisphenol-S","authors":"Wang Zhijuan, Zhou Huajing, Yuan Yuan, Guan Qingqing, He Liang, Miao Yingchun","doi":"10.1016/j.jallcom.2025.180226","DOIUrl":"https://doi.org/10.1016/j.jallcom.2025.180226","url":null,"abstract":"Exploring photocatalysts with the merits of simple and economical preparation, excellent efficiency of charge separation and ease of scaling up holds paramount importance for photocatalytic degradation of emerging contaminants (ECs). In this pursuit, a biochar-based photocatalyst was fabricated from paper mill sludge (PMS) via a straightforward one-step pyrolysis. Notably, the pyrolysis temperature emerged as a pivotal factor that modulated the phase composition and structural defects (including surface oxygen vacancy and carbon defects) of materials, thus further influencing the band structure, the migration of interfacial photoexcited charges and the efficaciousness of the separation of e<sup>−</sup>/h<sup>+</sup> pairs. Specifically, the PMS-derived biochar pyrolyzed at 550<!-- --> <sup>o</sup>C (SBC550) exhibited excellent photocatalytic degradation efficiency towards bisphenol S (BPS) with 86.5% of BPS being degraded within 180<!-- --> <!-- -->min. The optimum performance of SBC550 was attributed to the ingenious and fitting construction of a multi-heterostructure comprising Ca<sub>2</sub>Fe<sub>2</sub>O<sub>5</sub>/Fe<sub>3</sub>O<sub>4</sub> embedded within S-doped graphitic carbon (SDC), enhanced electron transfer stemmed from appropriate structural defects as well as the facilitative electron shuttle effect endowed by the porous carbonaceous substrate. Besides, <sup>1</sup>O<sub>2</sub> and h<sup>+</sup> were confirmed to be the main ROS attributed to the elimination of BPS and its degradation routes of phenoxy radical and electrophilic cycloaddition of <sup>1</sup>O<sub>2</sub> were reasonably deduced based on the HR-MS tests and DFT calculations. Collectively, this work provided crucial and new insights into the utilization of PMS in the domain of photocatalytic strategy for tackling the challenge of emerging pollutants.","PeriodicalId":344,"journal":{"name":"Journal of Alloys and Compounds","volume":"25 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation on the cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis and ferroptosis are usually asynchronous due to the opposite effect of cystine transport on them. Herein, systematic glucose deprivation, by both inhibiting upstream glucose uptake and promoting downstream glucose consumption, is proposed to synchronously evoke disulfidptosis and ferroptosis. As an example, Au nanodots and Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) are employed to regulate the SLC7A11/GSH/GPX4 axis for performing disulfidptosis- and ferroptosis-mediated tumor therapy synchronously. In this scenario, Au nanodots exhibit glucose oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit glucose uptake by downregulating glucose transporter 1, depriving glucose fundamentally. The systematical glucose deprivation limits the supplement of NADPH and suppresses cystine/cysteine transformation on the SLC7A11/GSH/GPX4 axis, thus solving the contradiction of cystine transport on disulfidptosis and ferroptosis. In addition, the efficient delivery of exogenous iron ions by FeOOH@Fe-Ap@Au NSs and self-supplied H2O2 through Au nanodots-catalytic glucose oxidation facilitate intracellular Fenton reaction and therewith help to amplify ferroptosis. As a result of synchronous occurrence of disulfidptosis and ferroptosis, FeOOH@Fe-Ap@Au NSs exhibit good efficacy in an ovarian cancer therapeutic model.
{"title":"Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis","authors":"Mengsi Zhang, Hao Zheng, Xuanqi Zhu, Shuwei Liu, Hao Jin, Yang Chen, Lanlan Wan, Songling Zhang, Hao Zhang","doi":"10.1021/acsnano.5c00730","DOIUrl":"https://doi.org/10.1021/acsnano.5c00730","url":null,"abstract":"Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation on the cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis and ferroptosis are usually asynchronous due to the opposite effect of cystine transport on them. Herein, systematic glucose deprivation, by both inhibiting upstream glucose uptake and promoting downstream glucose consumption, is proposed to synchronously evoke disulfidptosis and ferroptosis. As an example, Au nanodots and Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) are employed to regulate the SLC7A11/GSH/GPX4 axis for performing disulfidptosis- and ferroptosis-mediated tumor therapy synchronously. In this scenario, Au nanodots exhibit glucose oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit glucose uptake by downregulating glucose transporter 1, depriving glucose fundamentally. The systematical glucose deprivation limits the supplement of NADPH and suppresses cystine/cysteine transformation on the SLC7A11/GSH/GPX4 axis, thus solving the contradiction of cystine transport on disulfidptosis and ferroptosis. In addition, the efficient delivery of exogenous iron ions by FeOOH@Fe-Ap@Au NSs and self-supplied H<sub>2</sub>O<sub>2</sub> through Au nanodots-catalytic glucose oxidation facilitate intracellular Fenton reaction and therewith help to amplify ferroptosis. As a result of synchronous occurrence of disulfidptosis and ferroptosis, FeOOH@Fe-Ap@Au NSs exhibit good efficacy in an ovarian cancer therapeutic model.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"38 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-03DOI: 10.1016/j.ijplas.2025.104326
Samuel B. Inman, Kevin W. Garber, Andreas E. Robertson, Nathan K. Brown, Remi Dingreville, Brad L. Boyce
The creep behavior of 316L stainless steel at room temperature was evaluated as a function of time and applied stress using a new high-throughput approach. Several common creep models were evaluated against the observations, leading to deeper analysis of a stress-dependent modified logarithmic creep model. Within this model, multiple sources of uncertainty were compared. Aleatoric stochastic variation between samples under nominally identical conditions was identified as the primary contributor to uncertainty in creep response. Under any particular set of conditions, the sample-to-sample variability in creep strain was as high as a factor of two, highlighting the engineering importance of characterizing large statistical datasets. The model's extrapolation capabilities were assessed by comparing predictions derived from calibration on partial, shorter-duration subsets of the data. These findings underscore the importance of accounting for stochastic effects in predictive modeling of aging phenomena.
{"title":"Stochastic Room Temperature Creep of 316L Stainless Steel","authors":"Samuel B. Inman, Kevin W. Garber, Andreas E. Robertson, Nathan K. Brown, Remi Dingreville, Brad L. Boyce","doi":"10.1016/j.ijplas.2025.104326","DOIUrl":"https://doi.org/10.1016/j.ijplas.2025.104326","url":null,"abstract":"The creep behavior of 316L stainless steel at room temperature was evaluated as a function of time and applied stress using a new high-throughput approach. Several common creep models were evaluated against the observations, leading to deeper analysis of a stress-dependent modified logarithmic creep model. Within this model, multiple sources of uncertainty were compared. Aleatoric stochastic variation between samples under nominally identical conditions was identified as the primary contributor to uncertainty in creep response. Under any particular set of conditions, the sample-to-sample variability in creep strain was as high as a factor of two, highlighting the engineering importance of characterizing large statistical datasets. The model's extrapolation capabilities were assessed by comparing predictions derived from calibration on partial, shorter-duration subsets of the data. These findings underscore the importance of accounting for stochastic effects in predictive modeling of aging phenomena.","PeriodicalId":340,"journal":{"name":"International Journal of Plasticity","volume":"38 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}